Title:
METHOD FOR DELIVERING BENZIDINE PROSTAGLANDINS BY INHALATION
Document Type and Number:
WIPO Patent Application WO/2000/054758
Kind Code:
A2
Abstract:
A method of delivering benzidene prostaglandins to a patient by inhalation is discussed. A benzidene prostaglandin known as UT-15 has unexpectedly superior results when administered by inhalation compared to parenterally administered UT-15 in sheep with induced pulmonary hypertension.
Inventors:
CLOUTIER GILLES (US)
CROW JAMES (US)
WADE MICHAEL (US)
PARKER RICHARD E (US)
LOYD JAMES E (US)
Application Number:
PCT/US2000/040040
Publication Date:
September 21, 2000
Filing Date:
March 17, 2000
Assignee:
UNITED THERAPEUTICS CORP (US)
CLOUTIER GILLES (US)
CROW JAMES (US)
WADE MICHAEL (US)
PARKER RICHARD E (US)
LOYD JAMES E (US)
International Classes:
A61K9/00; A61K9/12; A61K9/14; A61K31/00; A61K31/19; A61K31/192; A61K31/5578; A61L9/04; A61P9/00; A61P9/12; A61P11/00; A61P29/00; (IPC1-7): A61K31/00
Domestic Patent References:
Foreign References:
| US5153222A | 1992-10-06 | | | |
| US4306075A | 1981-12-15 | | | |
| EP0159784A1 | 1985-10-30 | | | |
Attorney, Agent or Firm:
Maebius, Stephen A. (N.W. Washington, DC, US)
Claims:
What is claimed is:
| 1. |
A method of delivering to a mammal in need thereof a therapeutically effective amount of a benzidene prostaglandin comprising administering to said mammal by inhalation a formulation which provides a therapeutically effective amount of a benzidene prostaglandin. |
| 2. |
The method of claim 1, wherein said benzidene prostaglandin is inhaled in an aerosolized form. |
| 3. |
The method of claim 2, wherein said benzidene prostaglandin is UT15. |
| 4. |
The method of claim 3, wherein said aerosolized form comprises droplets less than 10 micrometers in diameter, said droplets comprising said UT15 in a suitable pharmacologicallyacceptable liquid carrier. |
| 5. |
The method of claim 1, wherein the mammal is a human. |
| 6. |
A method for treating pulmonary hypertension in a mammal comprising delivering to said mammal an effective amount of UT15 or its pharmaceutically acceptable salt or ester by inhalation. |
| 7. |
The method of claim 6, wherein said UT15 is inhaled in an aerosolized form. |
| 8. |
The method of claim 7, wherein said aerosolized form comprises droplets less than 10 micrometers in diameter, said droplets comprising said compound in a suitable pharmacologicallyacceptable liquid carrier. |
| 9. |
The method of claim 6, wherein said UT15 is inhaled in powder form comprising particles less than 10 micrometers in diameter. |
| 10. |
The method of claim 1, wherein the formulation comprises a sustained release form of a benzidene prostaglandin. |
| 11. |
The method of claim 6, wherein said UT15 is a sustained release form. |
Description:
INTERNATIONALSEARCHREPORT Internas... al Application No PCT/US00/40040 C.(Continuation)DOCUMENTSCONSIDEREDTOBERELEVANT Category ° Citationofdocument,withindication.whereappropriate.oftherele
vantpassagesRelevanttoclaimNo. P,XWO9925357A(UNITEDTHERAPEUTICSCORP)1,3 27May1999(1999-05-27) claims1,5 3 FURTHER INFORMATION CONTINUED FROM PCTASA/210 Continuation of Box 1.2 Claims Nos.: 1,2,5,10 Present claims..... 1,2,5,10.. relate to an extremely large number of possible compounds. In fact, the term"benzidene prostaglandins" mentioned in those claims, contains so many options and variables, that a lack of clarity and conciseness within the meaning of Article 6 PCT arises to such an extent as to render a meaningful search of the claims impossible. Consequently, the search has been carried out for those parts of the application which do appear to be clear and concise, namely the compounds mentioned in the description at page 2 and the examples (UT-15), and page 9 (formula (I)).
The applicant's attention is drawn to the fact that claims, or parts of claims, relating to inventions in respect of which no international search report has been established need not be the subject of an international preliminary examination (Rule 66.1 (e) PCT). The applicant is advised that the EPO policy when acting as an International Preliminary Examining Authority is normally not to carry out a preliminary examination on matter which has not been searched. This is the case irrespective of whether or not the claims are amended following receipt of the search report or during any Chapter II procedure. INTERNATIONALSEARCHREPORT j--------------- Internas..,al Application No In. xmationonpatentfamilymembers PCT/US00/40040 PatentdocumentPublication Patent citedinsearchreportdate member(s)date US5153222A06-10-1992AT 84417 T 15-01-1993 AU 623147 B 07-05-1992 AU 3652889 A 21-12-1989 CA 1327524 A 08-03-1994 DE 68904358 D 25-02-1993 DE 68904358 T 29-07-1993 DK 299089 A 18-12-1989 EP 0347243 A 20-12-1989 ES 2045437 T 16-01-1994 GR 3006955 T 30-06-1993 HU 53524A,B 28-11-1990 JP 2040325 A 09-02-1990 KR 158870 B 01-12-1998 PT 90888A,B 29-12-1989 ZA 8904614 A 27-02-1991 US4306075A15-12-1981AU 567392 B 19-11-1987 AU 542861 B 21-03-1985 CA 1201712 A 11-03-1986 CA 1313670 A 16-02-1993 CH 648017 A 28-02-1985 CH 655308 A 15-04-1986 DE 3105588 A 10-12-1981 DE 3153390 C 14-09-1989 DE 3153460 A 11-08-1988 DE 3153474 C 31-05-1990 FR 2484413 A 18-12-1981 GB 2070596A,B 09-09-1981 GB 2121802A,B 04-01-1984 GB 2122203A,B 11-01-1984 HK 6989 A 27-01-1989 IL 61936 A 31-08-1986 IL 73113 A 31-08-1986 IT 1144901 B 29-10-1986 JP 6145085 A 24-05-1994 JP 1815722 C 18-01-1994 JP 2167248 A 27-06-1990 JP 4008427 B 17-02-1992 NL 8100959 A 01-10-1981 SE 453594 B 15-02-1988 SE 8100564 A 29-08-1981 SE 8504615 A 04-10-1985 SE 8504616 A 04-10-1985 SE 8504617 A 04-10-1985 SE 8504618 A 04-10-1985 SE 8504619 A 04-10-1985 EP0159784A30-10-1985US 4668814 A 26-05-1987 US 4683330 A 28-07-1987 CA 1241324 A 30-08-1988 DE 3570867 D 13-07-1989 JP 60208936 A 21-10-1985 ZA 8501337 A 30-10-1985 WO9925357A27-05-1999AU 1373499 A 07-06-1999 EP 1045695 A 25-10-2000 ZA 9810444 A 24-06-1999
