METHOD FOR DERIVING UPPER MOTOR NEURON

WIPO Patent Application WO/2017/159380

A1

The purpose of the present invention is to provide a method for producing an upper motor neuron from a pluripotent stem cell, and a pluripotent stem cell which can be converted into an upper motor neuron. This method comprises a step for culturing and causing a pluripotent stem cell to express exogenous Ngn2 and Fezl. This pluripotent stem cell contains in a chromosome thereof an exogenous nucleic acid encoding Ngn2 and an exogenous nucleic acid encoding Fezl.

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INOUE HARUHISA (JP)
IMAMURA KEIKO (JP)

PCT/JP2017/008276

September 21, 2017

March 02, 2017

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UNIV KYOTO (JP)

C12N5/10; C12N5/0793; C12Q1/02; A61K45/00; A61P21/02; A61P25/00

WO2014148646A1

2014-09-25

ZHANG,Y. ET AL.: "Rapid Single-Step Induction of Functional Neurons feom Human Pluripotent Stem Cells", NEURON, vol. 78, 2013, pages 785 - 798, XP028562742, DOI: doi:10.1016/j.neuron.2013.05.029
CHEN,B. ET AL.: "Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex", PNAS, vol. 102, no. 47, 2005, pages 17184 - 17189, XP055601668
ROUAUX,C. ET AL.: "Fezf2 directs the differentiation of corticofugal neurons from striatal progenitors in vivo", NAT NEUROSCI., vol. 13, no. 13, 2010, pages 1345 - 1347, XP055601674, ISSN: 1097-6256, DOI: 10.1038/nn.2658

IWAHASHI, Yuji (JP)

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