Title:
METHOD FOR DETECTING ALDOSTERONE AND RENIN
Document Type and Number:
WIPO Patent Application WO/2018/194152
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a sensor with which primary aldosteronism can be detected rapidly, simply, and with a higher degree of accuracy. The present invention provides a method for detecting aldosterone or renin in a sample, rapidly and with high sensitivity, using a multiphase polymer fine particle having, at least on a surface thereof, two or more types of polymer phases formed by accumulating each of two or more types of polymer, wherein aldosterone or renin forms a covalent bond with a first polymer phase, and a second polymer phase includes a labeling substance.
Inventors:
SATO FUMITOSHI (JP)
YABU HIROSHI (JP)
INOUE KUMI (JP)
SATO SATSUKI (JP)
NEMOTO YASUHISA (JP)
MAEDA IKUMA (JP)
YABU HIROSHI (JP)
INOUE KUMI (JP)
SATO SATSUKI (JP)
NEMOTO YASUHISA (JP)
MAEDA IKUMA (JP)
Application Number:
PCT/JP2018/016262
Publication Date:
October 25, 2018
Filing Date:
April 20, 2018
Export Citation:
Assignee:
HAPLOPHARMA INC (JP)
UNIV TOHOKU (JP)
UNIV TOHOKU (JP)
International Classes:
G01N33/533; G01N33/543
Domestic Patent References:
| WO2016134115A1 | 2016-08-25 | |||
| WO2015046444A1 | 2015-04-02 | |||
| WO2007088957A1 | 2007-08-09 |
Foreign References:
| JPH0892299A | 1996-04-09 | |||
| JP2006170853A | 2006-06-29 | |||
| JPH09504308A | 1997-04-28 | |||
| JP2010185023A | 2010-08-26 | |||
| JPS513611B1 | 1976-02-04 | |||
| JPS5239004B1 | 1977-10-03 | |||
| JP2008014791A | 2008-01-24 | |||
| JP2017084764A | 2017-05-18 | |||
| JP2877222B2 | 1999-03-31 | |||
| JPS508009B1 | 1975-04-01 |
Other References:
SUCI, PA ET AL.: "A streptavidin-protein cage Janus particle for polarized targeting and modular functionalizaion", J. AM. CHEM. SOC., vol. 131, no. 26, 2009, pages 9164 - 9165, XP009137173
YABU, H ET AL.: "Double-phase-functionalized magnetic Janus polymer microparticles containing Ti02 and Fe203 nanoparticles encapsulated in mussel-inspired amphiphilic polymers", ACS APPL. MATER. INTERFACES, vol. 6, 29 September 2014 (2014-09-29), pages 18122 - 18128, XP055558627
FAKHRUDDIN ST ET AL.: "2P014 Development of a Janus Particles-utilizing Aldosterone Immunosensor", PROCEEDINGS OF 2017 TOHOKU CONFERENCE OF CHEMICAL SOCIETY OF JAPAN; SEPTEMBER 16-17, 2017, vol. 29, 16 September 2017 (2017-09-16), pages 139, XP009517487
JOURNAL OF HYPERTENSION, vol. 33, no. 12, 2015
"GenBank", Database accession no. AAA60363.1
STEROIDS, vol. 49, 1987, pages 581 - 587
J. CLIN. INVEST., vol. 120, 1989, pages 679 - 687
J. HYPERTENS, vol. 3, no. 3, 1985, pages S275 - S278
MACROMOLECULAR RAPID COMMUNICATIONS, vol. 35, no. 20, 2014, pages 1763 - 1769
J. K. MCKENZIEJ. A. CLEMENTS, J. CLIN. ENDOCRINOL. METAB., vol. 38, no. 4, 1974, pages 622
See also references of EP 3614146A4
YABU, H ET AL.: "Double-phase-functionalized magnetic Janus polymer microparticles containing Ti02 and Fe203 nanoparticles encapsulated in mussel-inspired amphiphilic polymers", ACS APPL. MATER. INTERFACES, vol. 6, 29 September 2014 (2014-09-29), pages 18122 - 18128, XP055558627
FAKHRUDDIN ST ET AL.: "2P014 Development of a Janus Particles-utilizing Aldosterone Immunosensor", PROCEEDINGS OF 2017 TOHOKU CONFERENCE OF CHEMICAL SOCIETY OF JAPAN; SEPTEMBER 16-17, 2017, vol. 29, 16 September 2017 (2017-09-16), pages 139, XP009517487
JOURNAL OF HYPERTENSION, vol. 33, no. 12, 2015
"GenBank", Database accession no. AAA60363.1
STEROIDS, vol. 49, 1987, pages 581 - 587
J. CLIN. INVEST., vol. 120, 1989, pages 679 - 687
J. HYPERTENS, vol. 3, no. 3, 1985, pages S275 - S278
MACROMOLECULAR RAPID COMMUNICATIONS, vol. 35, no. 20, 2014, pages 1763 - 1769
J. K. MCKENZIEJ. A. CLEMENTS, J. CLIN. ENDOCRINOL. METAB., vol. 38, no. 4, 1974, pages 622
See also references of EP 3614146A4
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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