Title:
METHOD FOR DETECTING ATHEROSCLEROTIC DISEASES ON THE BASIS OF SINGLE NUCLEOTIDE POLYMORPHISM AT HUMAN CHROMOSOME 5P15.3
Document Type and Number:
WIPO Patent Application WO/2011/102476
Kind Code:
A1
Abstract:
Atherosclerotic diseases such as myocardial infarction and angina pectoris are detected by analyzing the single nucleotide polymorphism on human chromosome 5p15.3, and by associating said analysis result with onset risks. Examples of the single nucleotide polymorphism on human chromosome 5p15.3 include a nucleotide corresponding to the nucleotide at nucleotide position 61 of one of the nucleotide sequences represented by SEQ ID NO: 1 to 3, and a polymorphism at a nucleotide which is in linkage disequilibrium with the aforementioned nucleotide.
Inventors:
OZAKI KOUICHI (JP)
TANAKA TOSHIHIRO (JP)
NAKAMURA YUSUKE (JP)
TANAKA TOSHIHIRO (JP)
NAKAMURA YUSUKE (JP)
Application Number:
PCT/JP2011/053542
Publication Date:
August 25, 2011
Filing Date:
February 18, 2011
Export Citation:
Assignee:
RIKEN (JP)
UNIV NIHON (JP)
TOKUSHUKAI (JP)
OZAKI KOUICHI (JP)
TANAKA TOSHIHIRO (JP)
NAKAMURA YUSUKE (JP)
UNIV NIHON (JP)
TOKUSHUKAI (JP)
OZAKI KOUICHI (JP)
TANAKA TOSHIHIRO (JP)
NAKAMURA YUSUKE (JP)
International Classes:
C12Q1/68; C12N15/09
Domestic Patent References:
| WO2006073183A1 | 2006-07-13 |
Foreign References:
| JP2008072947A | 2008-04-03 | |||
| JP2008048627A | 2008-03-06 |
Other References:
KOICHI OZAKI ET AL.: "Wagakuni no Kandomyakushikkan no SNPs no Evidence", VASCULAR BIOLOGY & MEDICINE, vol. 7, no. 1, 2006, pages 17 - 24
KOICHI OZAKI ET AL.: "Shinkin Kosoku no Identeki Risk Factor", MOLECULAR CARDIOVASCULAR MEDICINE, vol. 10, no. 6, 2009, pages 51-611 - 57-617
MYOCARDIAL INFARCTION GENETICS CONSORTIUM: "Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.", NAT. GENET., vol. 41, no. 3, 2009, pages 334 - 341
HELGADOTTIR, ANNA ET AL.: "A common variant on chromosome 9p21 affects the risk of myocardial infarction.", SCIENCE, vol. 316, 2007, pages 1491 - 1493
KOICHI OZAKI ET AL.: "Shinkin Kosoku no Identeki Risk Factor", MOLECULAR CARDIOVASCULAR MEDICINE, vol. 10, no. 6, 2009, pages 51-611 - 57-617
MYOCARDIAL INFARCTION GENETICS CONSORTIUM: "Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.", NAT. GENET., vol. 41, no. 3, 2009, pages 334 - 341
HELGADOTTIR, ANNA ET AL.: "A common variant on chromosome 9p21 affects the risk of myocardial infarction.", SCIENCE, vol. 316, 2007, pages 1491 - 1493
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (JP)
Yoshiyuki Kawaguchi (JP)
Yoshiyuki Kawaguchi (JP)
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