Title:
METHOD FOR DETECTING FUSION GENE
Document Type and Number:
WIPO Patent Application WO/2011/043220
Kind Code:
A1
Abstract:
Disclosed is a method which enables the easy and swift detection of the presence of any fusion gene including unknown fusion genes. The method for detecting a fusion gene is performed on a sample separated from a living body and involves measuring the expression of one of the genes constituting the fusion gene, that can be present in the living body, in the 5' region which is upstream of the fusion point of the gene and the 3' region which is downstream thereof and comparing the expression in the 5' region with the expression in the 3' region. The fusion gene to be detected includes a fusion gene between an ALK gene and another gene.
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Inventors:
OMI KAZUYA (JP)
Application Number:
PCT/JP2010/066768
Publication Date:
April 14, 2011
Filing Date:
September 28, 2010
Export Citation:
Assignee:
FUJIREBIO KK (JP)
OMI KAZUYA (JP)
OMI KAZUYA (JP)
International Classes:
C12N15/09; C12Q1/68
Domestic Patent References:
| WO2002093130A2 | 2002-11-21 |
Foreign References:
| JP2008295444A | 2008-12-11 | |||
| JP2007535966A | 2007-12-13 | |||
| JP2004089089A | 2004-03-25 | |||
| JPH10215897A | 1998-08-18 | |||
| JP2008295444A | 2008-12-11 |
Other References:
HIROYUKI MANO: "Haigan no Atarashii Gan Idenshi -EML4-ALK Yugo Idenshi", THE LUNG PERSPECTIVES, vol. 16, no. 4, 2008, pages 76 - 78, XP008161091
NATURE, vol. 448, 2007, pages 561 - 566
CLIN. CAN. RES., vol. 14, 2008, pages 6618 - 6624
J. CLIN. ONCOL., vol. 27, 2009, pages 1 - 4
CLIN. CAN. RES., vol. 15, 2009, pages 3143 - 3149
BIOCHEM. J., vol. 420, 2009, pages 345 - 361
NATURE, vol. 448, 2007, pages 561 - 566
CLIN. CAN. RES., vol. 14, 2008, pages 6618 - 6624
J. CLIN. ONCOL., vol. 27, 2009, pages 1 - 4
CLIN. CAN. RES., vol. 15, 2009, pages 3143 - 3149
BIOCHEM. J., vol. 420, 2009, pages 345 - 361
Attorney, Agent or Firm:
TANIGAWA, Hidejiro (JP)
Mountain stream Eijiro (JP)
Mountain stream Eijiro (JP)
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