Title:
METHOD FOR DETECTING MUSCLE DEGENERATIVE DISEASES, AND METHOD FOR DETERMINING THERAPEUTIC EFFICACY ON THE DISEASES
Document Type and Number:
WIPO Patent Application WO/2010/104025
Kind Code:
A1
Abstract:
Muscle degenerative diseases can be detected in the early stage and the therapeutic efficacy of a therapeutic agent and/or a therapy method for the diseases can be determined by measuring 11,15-dioxo-9α-hydroxy-2,3,4,5-tetranorprostan-1,20-dioic acid (referred to as "Tetranor-PGDM", hereinbelow) in a sample isolated from a subject.
Inventors:
URADE YOSHIHIRO (JP)
ARITAKE KOSUKE (JP)
MARUYAMA TOSHIHIKO (JP)
KAMAUCHI SHINYA (JP)
TAKEDA SHIN ICHI (JP)
NAKAMURA AKINORI (JP)
ARITAKE KOSUKE (JP)
MARUYAMA TOSHIHIKO (JP)
KAMAUCHI SHINYA (JP)
TAKEDA SHIN ICHI (JP)
NAKAMURA AKINORI (JP)
Application Number:
PCT/JP2010/053762
Publication Date:
September 16, 2010
Filing Date:
March 08, 2010
Export Citation:
Assignee:
OSAKA BIOSCIENCE INST (JP)
JAPAN GOVERNMENT (JP)
TAIHO PHARMACEUTICAL CO LTD (JP)
URADE YOSHIHIRO (JP)
ARITAKE KOSUKE (JP)
MARUYAMA TOSHIHIKO (JP)
KAMAUCHI SHINYA (JP)
TAKEDA SHIN ICHI (JP)
NAKAMURA AKINORI (JP)
JAPAN GOVERNMENT (JP)
TAIHO PHARMACEUTICAL CO LTD (JP)
URADE YOSHIHIRO (JP)
ARITAKE KOSUKE (JP)
MARUYAMA TOSHIHIKO (JP)
KAMAUCHI SHINYA (JP)
TAKEDA SHIN ICHI (JP)
NAKAMURA AKINORI (JP)
International Classes:
G01N33/53; G01N27/62; G01N30/72; G01N30/88; G01N33/15; G01N33/50
Domestic Patent References:
| WO2007007778A1 | 2007-01-18 |
Foreign References:
| JP2010002416A | 2010-01-07 | |||
| JP2005119984A | 2005-05-12 |
Other References:
TAKESHI OKINAGA ET AL.: "Induction of hematopoietic prostaglandin D synthase in hyalinated necrotic muscle fibers: its implication in grouped necrosis", ACTA NEUROPATHOL, vol. 104, no. 4, 2002, pages 377 - 384, XP008166878
WEN-LIANG SONG ET AL.: "Tetranor PGDM, an Abundant Urinary Metabolite Reflects Biosynthesis of Prostaglandin D2 in Mice and Humans", J BIOL CHEM, vol. 283, no. 2, 11 January 2008 (2008-01-11), pages 1179 - 1188, XP055097681
CATHY K. ELLIS ET AL.: "Metabolism of Prostaglandin D2 in the Monkey", J BIOL CHEM, vol. 254, no. 10, 1979, pages 4152 - 4163, XP002105896
IKUKO MOHRI ET AL.: "Inhibition of Prostaglandin D Synthase Suppresses Muscular Necrosis", AM J PATHOL, vol. 174, no. 5, May 2009 (2009-05-01), pages 1735 - 1744, XP008166859
SHINYA KAMAUCHI ET AL.: "Eshi Dobutu Model ni Okeru Prostaglandin D2 Nyouchu Taishabutsu no Hendo", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, 25 September 2009 (2009-09-25), XP008166888
See also references of EP 2407784A4
J.BIOL.CHEM, vol. 283, no. 2, 2008, pages 1179 - 1188
ACTA NEUROPATHOL, vol. 104, 2002, pages 377 - 384
KOHLER, MILSTEIN, NATURE, vol. 256, 1975, pages 495
TANPAKUSHITSU KAKUSAN KOUSO (PNE, vol. 31, 1985, pages 37 - 45
JPN. J. PHARMACOL., vol. 78, 1998, pages 1 - 10
WEN-LIANG SONG ET AL.: "Tetranor PGDM, an Abundant Urinary Metabolite Reflects Biosynthesis of Prostaglandin D2 in Mice and Humans", J BIOL CHEM, vol. 283, no. 2, 11 January 2008 (2008-01-11), pages 1179 - 1188, XP055097681
CATHY K. ELLIS ET AL.: "Metabolism of Prostaglandin D2 in the Monkey", J BIOL CHEM, vol. 254, no. 10, 1979, pages 4152 - 4163, XP002105896
IKUKO MOHRI ET AL.: "Inhibition of Prostaglandin D Synthase Suppresses Muscular Necrosis", AM J PATHOL, vol. 174, no. 5, May 2009 (2009-05-01), pages 1735 - 1744, XP008166859
SHINYA KAMAUCHI ET AL.: "Eshi Dobutu Model ni Okeru Prostaglandin D2 Nyouchu Taishabutsu no Hendo", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, 25 September 2009 (2009-09-25), XP008166888
See also references of EP 2407784A4
J.BIOL.CHEM, vol. 283, no. 2, 2008, pages 1179 - 1188
ACTA NEUROPATHOL, vol. 104, 2002, pages 377 - 384
KOHLER, MILSTEIN, NATURE, vol. 256, 1975, pages 495
TANPAKUSHITSU KAKUSAN KOUSO (PNE, vol. 31, 1985, pages 37 - 45
JPN. J. PHARMACOL., vol. 78, 1998, pages 1 - 10
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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