Title:
PIPERAZINE COMPOUND CAPABLE OF INHIBITING PROSTAGLANDIN D SYNTHASE
Document Type and Number:
WIPO Patent Application WO/2010/104024
Kind Code:
A1
Abstract:
Disclosed is a piperazine compound represented by general formula (I) or a salt thereof. [In the formula, R1 represents an alkyl group having 1 to 6 carbon atoms; R2 represents any one selected from a hydroxy group, an alkyl group having 1 to 6 carbon atoms which may have a substituent, a group -(C=O)-N(R3)(R4) and a group -(C=O)-OR5; R3 and R4 may be the same as or different from each other, and R3 and R4 independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms which may have a substituent, or R3, R4 and a nitrogen atom to which R3 and R4 are bound may together form a saturated heterocyclic group; R5 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms which may have a substituent; and n represents 1 or 2.]
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Inventors:
URADE YOSHIHIRO (JP)
KITADE MAKOTO (JP)
SHIGENO KAZUHIKO (JP)
YAMANE KEIKO (JP)
TANAKA KATSUNAO (JP)
KITADE MAKOTO (JP)
SHIGENO KAZUHIKO (JP)
YAMANE KEIKO (JP)
TANAKA KATSUNAO (JP)
Application Number:
PCT/JP2010/053760
Publication Date:
September 16, 2010
Filing Date:
March 08, 2010
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
URADE YOSHIHIRO (JP)
KITADE MAKOTO (JP)
SHIGENO KAZUHIKO (JP)
YAMANE KEIKO (JP)
TANAKA KATSUNAO (JP)
URADE YOSHIHIRO (JP)
KITADE MAKOTO (JP)
SHIGENO KAZUHIKO (JP)
YAMANE KEIKO (JP)
TANAKA KATSUNAO (JP)
International Classes:
C07D401/12; A61K31/496; A61K31/5377; A61P1/04; A61P3/04; A61P7/04; A61P9/00; A61P11/00; A61P11/06; A61P15/00; A61P15/06; A61P15/08; A61P17/00; A61P17/04; A61P17/06; A61P17/10; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P25/20; A61P25/28; A61P27/14; A61P27/16; A61P29/00; A61P35/04; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D401/14; C07D403/14
Domestic Patent References:
| WO2008122787A1 | 2008-10-16 | |||
| WO2007007778A1 | 2007-01-18 | |||
| WO2007041634A1 | 2007-04-12 | |||
| WO2008122787A1 | 2008-10-16 | |||
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| WO1999007672A1 | 1999-02-18 | |||
| WO2008023720A1 | 2008-02-28 |
Foreign References:
| JP2006508077A | 2006-03-09 | |||
| JP2001288160A | 2001-10-16 |
Other References:
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N. ENG. J. MED., vol. 315, 1986, pages 800 - 804
N. ENG. J. MED., vol. 311, 1984, pages 209 - 213
ARCH. OTOLARYNGOL HEAD NECK SURG., vol. 133, 2007, pages 693 - 700
ACTA NEUROPATHOL., vol. 104, 2002, pages 377 - 384
AIR. J PATHOL., vol. 174, no. 5, 2009, pages 1735 - 1744
IYAKUHIN NO KAIHATSU: "Development of Pharmaceuticals", vol. 7, 1990, HIROKAWA PUBLISHING, pages: 163 - 198
URADE, Y. ET AL., J. BIOL. CHEM., vol. 262, 1987, pages 3820 - 3825
MUSCLE NERVE., vol. 35, 2007, pages 43 - 48
See also references of EP 2407466A4
N. ENG. J. MED., vol. 315, 1986, pages 800 - 804
N. ENG. J. MED., vol. 311, 1984, pages 209 - 213
ARCH. OTOLARYNGOL HEAD NECK SURG., vol. 133, 2007, pages 693 - 700
ACTA NEUROPATHOL., vol. 104, 2002, pages 377 - 384
AIR. J PATHOL., vol. 174, no. 5, 2009, pages 1735 - 1744
IYAKUHIN NO KAIHATSU: "Development of Pharmaceuticals", vol. 7, 1990, HIROKAWA PUBLISHING, pages: 163 - 198
URADE, Y. ET AL., J. BIOL. CHEM., vol. 262, 1987, pages 3820 - 3825
MUSCLE NERVE., vol. 35, 2007, pages 43 - 48
See also references of EP 2407466A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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