Title:
METHOD FOR DETERMINING THERAPEUTIC EFFICACY OF ALLERGEN IMMUNOTHERAPY
Document Type and Number:
WIPO Patent Application WO/2018/135561
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: a method for determining the therapeutic efficacy of an allergen immunotherapy on allergic rhinitis with high accuracy; and others. The fluctuation in the number of ST2+ CD4+ T cells and the fluctuation in the number of at least one type of CD4+ T cells selected from the group consisting of CD27- CD4+ T cells, CD161+ CD4+ T cells, IL-5+ CD4+ T cells and IL-13+ CD4+ T cells before and after the start of an allergen immunotherapy on allergic rhinitis are analyzed, and it is determined that the immunotherapy using an allergen is effective for an allergic rhinitis patient when both of the cells decrease.
Inventors:
IHARA FUMIE (JP)
OKAMOTO YOSHITAKA (JP)
NAKAYAMA TOSHINORI (JP)
SAKURAI DAIJU (JP)
OKAMOTO YOSHITAKA (JP)
NAKAYAMA TOSHINORI (JP)
SAKURAI DAIJU (JP)
Application Number:
PCT/JP2018/001327
Publication Date:
July 26, 2018
Filing Date:
January 18, 2018
Export Citation:
Assignee:
UNIV CHIBA NAT UNIV CORP (JP)
International Classes:
G01N33/53; C12N5/078; C12Q1/06
Other References:
SAKURAI, TAIKI: "biomarker , Effect prediction factors", MONTHLY BOOK ENTONI, vol. 193, 15 May 2016 (2016-05-15), pages 52 - 58
SUZUKI, MOTOHIKO: "Furture of sublingual immunotherapy", MONTHLY BOOK ENTONI, vol. 193, 15 May 2016 (2016-05-15), pages 60 - 67
NAKAYAMA, TOSHINORI ET AL.: "Research on establishing immunotherapy analysis, biomarker review, effectiveness of sublingual immunotherapy for cedar pollen allergy, and effect prediction method", RESEARCH REPORT ON GENERALIZATION AND ALLOTMENT, vol. 21, 2010, pages 9 - 11
YONEKURA, SYUJI ET AL.: "III. Ear-nose-and-throat clinic 2. Effectiveness evaluation from biomarker of sublingual immunotherapy for cedar pollen", ALLERGY AND IMMUNITY, vol. 22, no. 2, 15 January 2015 (2015-01-15), pages 268 - 275
SUZUKI, MOTOHIKO: "Furture of sublingual immunotherapy", MONTHLY BOOK ENTONI, vol. 193, 15 May 2016 (2016-05-15), pages 60 - 67
NAKAYAMA, TOSHINORI ET AL.: "Research on establishing immunotherapy analysis, biomarker review, effectiveness of sublingual immunotherapy for cedar pollen allergy, and effect prediction method", RESEARCH REPORT ON GENERALIZATION AND ALLOTMENT, vol. 21, 2010, pages 9 - 11
YONEKURA, SYUJI ET AL.: "III. Ear-nose-and-throat clinic 2. Effectiveness evaluation from biomarker of sublingual immunotherapy for cedar pollen", ALLERGY AND IMMUNITY, vol. 22, no. 2, 15 January 2015 (2015-01-15), pages 268 - 275
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
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