Title:
METHOD AND DEVICE FOR EVALUATING INTRACRANIAL ACCUMULATION STATE OF AMYLOID β
Document Type and Number:
WIPO Patent Application WO/2020/261608
Kind Code:
A1
Abstract:
A device for evaluating an intracranial accumulation state of amyloid β according to one embodiment of the present invention comprises: a marker value calculation unit (22) that, on the basis of a mass analysis result obtained by a mass analysis unit (1) with respect to a targeted specimen, derives a comparison of the strength of a plurality of amyloid β-related peptides as a marker value in amyloid MS; a conversion data storage unit (23) in which there is stored a formula for converting the marker value in the amyloid MS to an SUV value in an amyloid PET examination; a conversion processing unit (24) that converts the marker value to an SUV value using the conversion formula; an assessment processing unit (25) that assesses whether the resultant SUV value belongs in either of a non-specific binding region or a specific binding region associated with the occurrence of accumulation of amyloid β; and a display processing unit (26) that displays the SUV value and the assessment result on a display unit (4). This makes it possible for a user who is used to amyloid PET examinations to easily and accurately assess whether accumulation of amyloid β is occurring on the basis of an amyloid MS detection result.
Inventors:
YAMADA YOSHIHIRO (JP)
KANEKO NAOKI (JP)
KANEKO NAOKI (JP)
Application Number:
PCT/JP2019/049554
Publication Date:
December 30, 2020
Filing Date:
December 18, 2019
Export Citation:
Assignee:
SHIMADZU CORP (JP)
International Classes:
G01N27/62; G01N33/68
Domestic Patent References:
| WO2015178398A1 | 2015-11-26 | |||
| WO2017047529A1 | 2017-03-23 | |||
| WO2012015050A1 | 2012-02-02 | |||
| WO2018176082A1 | 2018-10-04 |
Foreign References:
| JP2016536598A | 2016-11-24 | |||
| JP2018513368A | 2018-05-24 | |||
| JP2016526167A | 2016-09-01 | |||
| JP2014095714A | 2014-05-22 | |||
| US20090099783A1 | 2009-04-16 |
Other References:
WEIGAND, S. D. ET AL.: "Transforming CSF A beta 42 measures into calculated Pittsburgh Compound B units of brain A beta amyloid", ALZHEIMERS DEMENT., vol. 7, no. 2, 2011, pages 133 - 141, XP028164174
TOLEDO, J. B. ET AL.: "Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 beta -Amyloid Measures Across the Spectrum of Alzheimer Disease", JAMA NEUROL., vol. 72, no. 5, 2015, pages 571 - 581
ROJAS, ITZIAR ET AL.: "Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundacio ACE Healthy Brain Initiative (FACEHBI", ALZHEIMER'S RESEARCH & THERAPY, vol. 10, no. 1, 119, 2018, XP055778191
JANELIDZE, S. ET AL.: "Plasma beta -amyloid in Alzheimer's disease and vascular disease", SCI. REP., vol. 6, 26801, 2016
SHOKOUHI, S. ET AL.: "Reference tissue normalization in longitudinal (18)F- florbetapir positron emission tomography of late mild cognitive impairment", ALZHEIMER'S RESEARCH & THERAPY, vol. 8, no. 2, 2016, pages 1 - 12, XP055778195
OLIVEIRA, F. ET AL.: "Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of A beta species", NEUROIMAGE CLIN., vol. 20, 2018, pages 603 - 610, XP055778197
TOLEDO, J. B. ET AL.: "Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 beta -Amyloid Measures Across the Spectrum of Alzheimer Disease", JAMA NEUROL., vol. 72, no. 5, 2015, pages 571 - 581
ROJAS, ITZIAR ET AL.: "Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundacio ACE Healthy Brain Initiative (FACEHBI", ALZHEIMER'S RESEARCH & THERAPY, vol. 10, no. 1, 119, 2018, XP055778191
JANELIDZE, S. ET AL.: "Plasma beta -amyloid in Alzheimer's disease and vascular disease", SCI. REP., vol. 6, 26801, 2016
SHOKOUHI, S. ET AL.: "Reference tissue normalization in longitudinal (18)F- florbetapir positron emission tomography of late mild cognitive impairment", ALZHEIMER'S RESEARCH & THERAPY, vol. 8, no. 2, 2016, pages 1 - 12, XP055778195
OLIVEIRA, F. ET AL.: "Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of A beta species", NEUROIMAGE CLIN., vol. 20, 2018, pages 603 - 610, XP055778197
Attorney, Agent or Firm:
KYOTO INTERNATIONAL PATENT LAW OFFICE (JP)
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