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Title:
METHOD AND DEVICE FOR FINDING TEMPERATE BACTERIOPHAGES FROM WHOLE BACTERIAL GENOME SEQUENCE AND STORAGE MEDIUM
Document Type and Number:
WIPO Patent Application WO/2020/077559
Kind Code:
A1
Abstract:
Provided are a method and device for finding temperate bacteriophages from a whole bacterial genome sequence and a storage medium containing a program capable of executing the method. The method comprises: acquiring a whole bacterial genome sequence, clustering and aligning functional elements of temperate bacteriophages to the whole bacterial genome sequence to obtain regions of the functional elements in a clustering phenomenon as suspected bacteriophage regions, the functional elements comprising a hypothetical protein element, an infestation element, an assembly element and an unknown conserved element, finding repeating sequences at both ends of the suspected bacteriophage regions to obtain integration sites of temperate bacteriophages so as to determine sequence regions of the temperate bacteriophages, and performing genome characteristic analysis on the sequence regions of the temperate bacteriophages as bacteriophage genome sequences, and outputting sequence information of functional bacteriophages.

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Inventors:
SONG WENCHEN (CN)
SUN HAIXI (CN)
XIAO MINFENG (CN)
CHENG LI (CN)
DENG ZIQING (CN)
WANG YUN (CN)
SHEN YUE (CN)
LI JUNHUA (CN)
Application Number:
PCT/CN2018/110636
Publication Date:
April 23, 2020
Filing Date:
October 17, 2018
Export Citation:
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Assignee:
BGI SHENZHEN (CN)
International Classes:
C12N7/00; C12Q1/70
Foreign References:
CN108220249A2018-06-29
Other References:
BONNIE, L. H. ET AL.: "Phage hunters: computational strategies for finding phages in large- scale omics datasets", VIRUS RESEARCH, vol. 244, January 2018 (2018-01-01), pages 110 - 115, XP055704139
Attorney, Agent or Firm:
DHC IP ATTORNEYS (CN)
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