Title:
METHOD AND DEVICE FOR VAPORIZATION INJECTION OF HIGH VOLUMES IN GAS CHROMATOGRAPHIC ANALYSIS
Document Type and Number:
WIPO Patent Application WO2003060508
Kind Code:
A3
Abstract:
This invention concerns a method and apparatus for vaporization injection of large volumes of liquid sample (substance to be analysed + solvent) introduced by means of the needle of a syringe onto a heated vaporization chamber which is part of an injector applied to a device for gas chromatographic analysis, the sample being sent in form of a liquid band travelling through said vaporization chamber at high speed until reaching stopping and vaporization means positioned adjacent to the inlet of a capillary to collect the vapours. In order to inject large volumes without modifying the vaporization chamber and without samples parts losses, in splitless mode, a drawing up of the sample vapours from the vaporization chamber into said capillary is made by means of a local action of volume contraction, caused by recondensation of at least the solvent vapours in this capillary, said capillary being in the form of a pre-column with no stationary phase, maintained at low temperature at least during the injection.
Inventors:
MAGNI PAOLO (IT)
PORZANO THOMAS (IT)
PORZANO THOMAS (IT)
Application Number:
PCT/IB2002/005506
Publication Date:
October 09, 2003
Filing Date:
December 19, 2002
Export Citation:
Assignee:
THERMO FINNIGAN ITALIA S P A (IT)
MAGNI PAOLO (IT)
PORZANO THOMAS (IT)
MAGNI PAOLO (IT)
PORZANO THOMAS (IT)
International Classes:
G01N30/12; G01N30/16; G01N30/02; (IPC1-7): G01N30/12; G01N30/16
Domestic Patent References:
| WO1999001759A2 | 1999-01-14 |
Foreign References:
| EP0959351A2 | 1999-11-24 | |||
| EP0753739A2 | 1997-01-15 | |||
| EP0806661A1 | 1997-11-12 | |||
| US4734107A | 1988-03-29 | |||
| US5944877A | 1999-08-31 | |||
| US6093371A | 2000-07-25 |
Other References:
GROB K ET AL: "VAPORISING SYSTEMS FOR LARGE VOLUME INJECTION OR ON-LINE TRANSFER INTO GAS CHROMATOGRAPHY: CLASSIFICATION, CRITICAL REMARKS AND SUGGESTIONS", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER SCIENCE, NL, vol. 750, no. 1/2, 25 October 1996 (1996-10-25), pages 11 - 23, XP000637409, ISSN: 0021-9673
BOSBOOM J C ET AL: "LARGE-VOLUME INJECTION IN CAPILLARY GAS CHROMATOGRAPHY USING A PROGRAMMED-TEMPERATURE VAPORIZING INJECTOR IN THE ON-COLUMN OR SOLVENT-VENT INJECTION MODE", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER SCIENCE, NL, vol. 724, no. 1/2, 16 February 1996 (1996-02-16), pages 384 - 391, XP000551419, ISSN: 0021-9673
GROB K: "Injection Techniques in Capillary GC", ANALYTICAL CHEMISTRY.A, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 66, no. 20, 15 October 1994 (1994-10-15), pages 1009a - 1019a, XP002181891
BOSBOOM J C ET AL: "LARGE-VOLUME INJECTION IN CAPILLARY GAS CHROMATOGRAPHY USING A PROGRAMMED-TEMPERATURE VAPORIZING INJECTOR IN THE ON-COLUMN OR SOLVENT-VENT INJECTION MODE", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER SCIENCE, NL, vol. 724, no. 1/2, 16 February 1996 (1996-02-16), pages 384 - 391, XP000551419, ISSN: 0021-9673
GROB K: "Injection Techniques in Capillary GC", ANALYTICAL CHEMISTRY.A, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 66, no. 20, 15 October 1994 (1994-10-15), pages 1009a - 1019a, XP002181891
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