Title:
METHOD FOR DIFFERENTIAL PREDICTION/DIAGNOSIS OF DIABETES AND KIT FOR PREDICTION/DIAGNOSIS OF DIABETES
Document Type and Number:
WIPO Patent Application WO/2007/055341
Kind Code:
A1
Abstract:
It is intended to provide a method for diagnosing or preliminary diagnosing diabetes which is useful for the detection or prevention of diabetes and applicable also to a multimarker system and a kit for diagnosing or preliminary diagnosing diabetes. The diagnosis or preliminary diagnosis of diabetes is carried out by selecting as a marker substance for diabetes, one or more proteins selected from the group consisting of transthyretin, apolipoprotein CII, apolipoprotein CIII, serum albumin and related substances thereof in blood and comparing the concentration thereof with that of a normal value. As a method for measuring the concentration of such a marker substance, it is preferred to use an antibody specific to the marker substance. The measurement can also be carried out by entrapping the marker substance in a carrier. With the use of the kit for diagnosing or preliminary diagnosing diabetes containing an antibody specific to a marker substance, the diagnosis or preliminary diagnosis of diabetes can be carried out more simply.
Inventors:
YOSHIKAWA TOSHIKAZU (JP)
NAITO YUJI (JP)
ARIKUNI HISASHI (JP)
AKAGIRI SATOMI (JP)
MIHARA KENICHI (JP)
OOKI TOSHICHIKA (JP)
YAMAGUCHI TSUGIHISA (JP)
MAFUNE SHOICHI (JP)
TAKAHASHI YUTAKA (JP)
NAKASHIMA YUMIKO (JP)
NAITO YUJI (JP)
ARIKUNI HISASHI (JP)
AKAGIRI SATOMI (JP)
MIHARA KENICHI (JP)
OOKI TOSHICHIKA (JP)
YAMAGUCHI TSUGIHISA (JP)
MAFUNE SHOICHI (JP)
TAKAHASHI YUTAKA (JP)
NAKASHIMA YUMIKO (JP)
Application Number:
PCT/JP2006/322506
Publication Date:
May 18, 2007
Filing Date:
November 10, 2006
Export Citation:
Assignee:
BIOMARKER SCIENCE CO LTD (JP)
YOSHIKAWA TOSHIKAZU (JP)
NAITO YUJI (JP)
ARIKUNI HISASHI (JP)
AKAGIRI SATOMI (JP)
MIHARA KENICHI (JP)
OOKI TOSHICHIKA (JP)
YAMAGUCHI TSUGIHISA (JP)
MAFUNE SHOICHI (JP)
TAKAHASHI YUTAKA (JP)
NAKASHIMA YUMIKO (JP)
YOSHIKAWA TOSHIKAZU (JP)
NAITO YUJI (JP)
ARIKUNI HISASHI (JP)
AKAGIRI SATOMI (JP)
MIHARA KENICHI (JP)
OOKI TOSHICHIKA (JP)
YAMAGUCHI TSUGIHISA (JP)
MAFUNE SHOICHI (JP)
TAKAHASHI YUTAKA (JP)
NAKASHIMA YUMIKO (JP)
International Classes:
G01N33/68; G01N33/15; G01N33/50; G01N33/53
Domestic Patent References:
| WO2003102163A2 | 2003-12-11 | |||
| WO2006073195A1 | 2006-07-13 | |||
| WO1999013336A1 | 1999-03-18 |
Foreign References:
| JP2002340890A | 2002-11-27 |
Other References:
ZHANG ET AL.: "Mining biomarkers in human sera using proteomic tools", PROTEOMICS, vol. 4, no. 1, January 2004 (2004-01-01), pages 244 - 256, XP009035651
ARIKUNI ET AL.: "Proteomics-ho ni yoru II-gata Tonyobyo Shikkan Yobo Biomarker Tansaku no Kokoromi", ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN PROGRAM KOEN YOSHISHU, 27TH, 2004, pages 811, XP003009655
ARIKUNI ET AL.: "Proteomics-ho ni yoru II-gata Tonyobyo Shikkan Yobo Biomarker Tansaku no Kokoromi", ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN PROGRAM KOEN YOSHISHU, 27TH, 2004, pages 811, XP003009655
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (Crystal Tower 2-27, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka 15, JP)
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