Title:
METHOD FOR DISCRIMINATING SYMPTOM OF HEPATIC DISEASE
Document Type and Number:
WIPO Patent Application WO/2016/163539
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for discriminating a clinical symptom of a hepatic disease such as non-alcoholic fatty liver disease, which is non-invasive and is highly accurate. A method for discriminating between non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH), said method comprising the steps of: (1) measuring the amounts of marker molecules contained in blood collected from a subject; (2) determining an index value from a normalized score that is calculated on the basis of the amounts of the marker molecules belonging to the same group; and (3) determining that the subject is suspected to be suffering from NASH when the index value is larger than a reference value.
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Inventors:
OKANOUE TAKESHI (JP)
YOSHIMURA KEITO (JP)
IWASAKI TSUYOSHI (JP)
YAMAZAKI KAZUTO (JP)
EBISE HAYAO (JP)
ICHIHARA JUNJI (JP)
YOSHIMURA KEITO (JP)
IWASAKI TSUYOSHI (JP)
YAMAZAKI KAZUTO (JP)
EBISE HAYAO (JP)
ICHIHARA JUNJI (JP)
Application Number:
PCT/JP2016/061609
Publication Date:
October 13, 2016
Filing Date:
April 08, 2016
Export Citation:
Assignee:
SOCIAL WELFARE ORGANIZATION SAISEIKAI IMP GIFT FOUNDATAION INC SAISEIKAI SUITA HOSPITAL OSAKA (JP)
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
G01N21/27; G01N33/68; G01N33/48; G01N33/483; G01N33/53
Domestic Patent References:
| WO2010073870A1 | 2010-07-01 | |||
| WO2009090882A1 | 2009-07-23 | |||
| WO2007122799A1 | 2007-11-01 |
Foreign References:
| JP2005519271A | 2005-06-30 | |||
| JP2007315752A | 2007-12-06 | |||
| JP2011252868A | 2011-12-15 |
Other References:
YOSHIO SUMIDA ET AL.: "Noninvasive scoring systems for the diagnosis of NASH/NAFLD", KAN TAN SUI, vol. 60, no. 6, 28 June 2010 (2010-06-28), pages 963 - 970, XP009507332
YOSHIMURA K ET AL.: "Identification of novel noninvasive markers for diagnosing nonalcoholic steatohepatitis and related fibrosis by data mining.", HEPATOLOGY., vol. 63, no. 2, February 2016 (2016-02-01), pages 462 - 473, XP055321829
YOSHIMURA K ET AL.: "Identification of novel noninvasive markers for diagnosing nonalcoholic steatohepatitis and related fibrosis by data mining.", HEPATOLOGY., vol. 63, no. 2, February 2016 (2016-02-01), pages 462 - 473, XP055321829
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Yoshiki Hasegawa (JP)
Yoshiki Hasegawa (JP)
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