Title:
METHOD FOR DISTINGUISHING AML SUBTYPES WITH ABERRANT AND PROGNOSTICALLY INTERMEDIATE KARYOTYPES
Document Type and Number:
WIPO Patent Application WO2005045433
Kind Code:
A3
Abstract:
Disclosed is a method for distinguishing AML subtypes with aberrant and prognostically intermediate karyotypes selected from trisomy 8, inv(3), t(3;3), trisomy 11, trisomy 13, trisomy 4, t(1;3), t(6;9), der(5)t(5;11), i(17), del(9q), del(12p), and/or del(20q)in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers.
Inventors:
DUGAS MARTIN (DE)
SCHOCH CLAUDIA (DE)
KOHLMANN ALEXANDER (DE)
SCHNITTGER SUSANNE (DE)
KERN WOLFGANG (DE)
HAFERLACH TORSTEN (DE)
SCHOCH CLAUDIA (DE)
KOHLMANN ALEXANDER (DE)
SCHNITTGER SUSANNE (DE)
KERN WOLFGANG (DE)
HAFERLACH TORSTEN (DE)
Application Number:
PCT/EP2004/012368
Publication Date:
August 25, 2005
Filing Date:
November 02, 2004
Export Citation:
Assignee:
UNIV MUENCHEN L MAXIMILIANS (DE)
ROCHE DIAGNOSTICS GMBH (DE)
HOFFMANN LA ROCHE (CH)
DUGAS MARTIN (DE)
SCHOCH CLAUDIA (DE)
KOHLMANN ALEXANDER (DE)
SCHNITTGER SUSANNE (DE)
KERN WOLFGANG (DE)
HAFERLACH TORSTEN (DE)
ROCHE DIAGNOSTICS GMBH (DE)
HOFFMANN LA ROCHE (CH)
DUGAS MARTIN (DE)
SCHOCH CLAUDIA (DE)
KOHLMANN ALEXANDER (DE)
SCHNITTGER SUSANNE (DE)
KERN WOLFGANG (DE)
HAFERLACH TORSTEN (DE)
International Classes:
C12Q1/68; G01N33/574; (IPC1-7): G01N33/574; C12Q1/68
Domestic Patent References:
| WO2003083140A2 | 2003-10-09 | |||
| WO2003039443A2 | 2003-05-15 |
Foreign References:
| US20030011943A1 | 2003-01-16 | |||
| EP1043676A2 | 2000-10-11 |
Other References:
KOHLMANN A ET AL: "MOLECULAR CHARACTERIZATION OF ACUTE LEUKEMIAS BY USE OF MICROARRAY TECHNOLOGY", GENES, CHROMOSOMES & CANCER, XX, XX, vol. 37, no. 4, August 2003 (2003-08-01), pages 396 - 405, XP008025253
GOLUB T R ET AL: "Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 286, no. 5439, 15 October 1999 (1999-10-15), pages 531 - 537, XP002207658, ISSN: 0036-8075
DUGAS M ET AL: "A comprehensive leukemia database: integration of cytogenetics, molecular genetics and microarray data with clinical information, cytomorphology and immunophenotyping", LEUKEMIA, MACMILLAN PRESS LTD, US, vol. 15, no. 12, December 2001 (2001-12-01), pages 1805 - 1810, XP002263731, ISSN: 0887-6924
DUGAS MARTIN ET AL: "Impact of integrating clinical and genetic information.", IN SILICO BIOLOGY, vol. 2, no. 3, 2002, pages 383 - 391, XP001179418, ISSN: 1386-6338 (ISSN print)
ALIZADEH A ET AL: "THE LYMPHOCHIP: A SPECIALIZED CDNA MICROARRAY FOR THE GENOMIC-SCALE ANALYSIS OF GENE EXPRESSION IN NORMAL AND MALIGNANT LYMPHOCYTES", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, BIOLOGICAL LABORATORY, COLD SPRING HARBOR, NY, US, vol. 64, no. 1, 1999, pages 71 - 78, XP001099007, ISSN: 0091-7451
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2001 (2001-11-16), BYRD JOHN C ET AL: "Pre-treatment cytogenetics predict initial induction success and overall survival in adult patients with de novo acute myeloid leukemia: Results from CALGB 8461", XP002274075, Database accession no. PREV200200241180
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), KLAUS MIRJAM ET AL: "Incidence and Prognostic Impact of Sole Trisomies in Acute Myeloid Leukemia (AML).", XP002274076, Database accession no. PREV200300335862
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1 December 1997 (1997-12-01), SCHOCH CLAUDIA ET AL: "The significance of trisomy 8 in de novo acute myeloid leukaemia: The accompanying chromosome aberrations determine the prognosis", XP002274077, Database accession no. PREV199800047457
GOLUB T R ET AL: "Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 286, no. 5439, 15 October 1999 (1999-10-15), pages 531 - 537, XP002207658, ISSN: 0036-8075
DUGAS M ET AL: "A comprehensive leukemia database: integration of cytogenetics, molecular genetics and microarray data with clinical information, cytomorphology and immunophenotyping", LEUKEMIA, MACMILLAN PRESS LTD, US, vol. 15, no. 12, December 2001 (2001-12-01), pages 1805 - 1810, XP002263731, ISSN: 0887-6924
DUGAS MARTIN ET AL: "Impact of integrating clinical and genetic information.", IN SILICO BIOLOGY, vol. 2, no. 3, 2002, pages 383 - 391, XP001179418, ISSN: 1386-6338 (ISSN print)
ALIZADEH A ET AL: "THE LYMPHOCHIP: A SPECIALIZED CDNA MICROARRAY FOR THE GENOMIC-SCALE ANALYSIS OF GENE EXPRESSION IN NORMAL AND MALIGNANT LYMPHOCYTES", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, BIOLOGICAL LABORATORY, COLD SPRING HARBOR, NY, US, vol. 64, no. 1, 1999, pages 71 - 78, XP001099007, ISSN: 0091-7451
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2001 (2001-11-16), BYRD JOHN C ET AL: "Pre-treatment cytogenetics predict initial induction success and overall survival in adult patients with de novo acute myeloid leukemia: Results from CALGB 8461", XP002274075, Database accession no. PREV200200241180
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), KLAUS MIRJAM ET AL: "Incidence and Prognostic Impact of Sole Trisomies in Acute Myeloid Leukemia (AML).", XP002274076, Database accession no. PREV200300335862
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1 December 1997 (1997-12-01), SCHOCH CLAUDIA ET AL: "The significance of trisomy 8 in de novo acute myeloid leukaemia: The accompanying chromosome aberrations determine the prognosis", XP002274077, Database accession no. PREV199800047457
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