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Title:
METHOD FOR DISTINGUISHING AML SUBTYPES WITH RECURRING GENETIC ABERRATIONS
Document Type and Number:
WIPO Patent Application WO/2005/045434
Kind Code:
A2
Abstract:
Disclosed is a method for distinguishing AML subtypes with recurring genetic aberrations t(8;21), t(15;17), t(11q23)/MLL, inv(3)/t(3,3), inv(16), AML&lowbar komplext, trisomy 8 sole, trisomy 11 sole, trisomy 13 sole, monosomy 7 sole, del(5q) and/or del(9q) in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers.

Inventors:
HAFERLACH TORSTEN (DE)
DUGAS MARTIN (DE)
KERN WOLFGANG (DE)
KOHLMANN ALEXANDER (DE)
SCHNITTGER SUSANNE (DE)
SCHOCH CLAUDIA (DE)
Application Number:
PCT/EP2004/012460
Publication Date:
May 19, 2005
Filing Date:
November 04, 2004
Export Citation:
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Assignee:
ROCHE DIAGNOSTICS GMBH (DE)
HOFFMANN LA ROCHE (CH)
HAFERLACH TORSTEN (DE)
DUGAS MARTIN (DE)
KERN WOLFGANG (DE)
KOHLMANN ALEXANDER (DE)
SCHNITTGER SUSANNE (DE)
SCHOCH CLAUDIA (DE)
International Classes:
C12Q1/68; G01N33/574; (IPC1-7): G01N33/574; C12Q1/68
Domestic Patent References:
WO2003039443A22003-05-15
Foreign References:
EP1043676A22000-10-11
Other References:
SCHOCH CLAUDIA ET AL: "Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 99, no. 15, 23 July 2002 (2002-07-23), pages 10008-10013, XP002215484 ISSN: 0027-8424
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), SCHOCH CLAUDIA ET AL: "AML with Complex Aberrant Karyotype Can Be Distinguished from All Other AML Subtypes by Gene Expression Profiles and Are Characterized by Higher Expression of Genes Involved in DNA Repair." XP002269820 Database accession no. PREV200300335804 & BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), page Abstract No. 1204, 44th Annual Meeting of the American Society of Hematology;Philadelphia, PA, USA; December 06-10, 2002 ISSN: 0006-4971
KOHLMANN A ET AL: "MOLECULAR CHARACTERIZATION OF ACUTE LEUKEMIAS BY USE OF MICROARRAY TECHNOLOGY" GENES, CHROMOSOMES & CANCER, XX, XX, vol. 37, no. 4, August 2003 (2003-08), pages 396-405, XP008025253
HAFERLACH T ET AL: "The Diagnosis of 14 Specific Subtypes of Leukemia Is Possible Based on Gene Expression Profiles: A Study on 263 Patients with AML, ALL, CML, or CLL" BLOOD, W.B.SAUNDERS COMPAGNY, ORLANDO, FL, US, vol. 100, no. 11, 16 November 2002 (2002-11-16), page 139A, XP002263227 ISSN: 0006-4971
VIRTANEVA K ET AL: "EXPRESSION PROFILING REVEALS FUNDAMENTAL BIOLOGICAL DIFFERENCES IN ACUTE MYELOID LEUKEMIA WITH ISOLATED TRISOMY 8 AND NORMAL CYTOGENETICS" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 98, no. 3, 30 January 2001 (2001-01-30), pages 1124-1129, XP002952627 ISSN: 0027-8424
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), KOHLMANN ALEXANDER ET AL: "A Simplified and Partially Automated Target Preparation Method for Gene Expression Profiling." XP002269495 Database accession no. PREV200300367771 & BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), page Abstract No. 4287, 44th Annual Meeting of the American Society of Hematology;Philadelphia, PA, USA; December 06-10, 2002 ISSN: 0006-4971
DUGAS M ET AL: "A comprehensive leukemia database: integration of cytogenetics, molecular genetics and microarray data with clinical information, cytomorphology and immunophenotyping" LEUKEMIA, MACMILLAN PRESS LTD, US, vol. 15, no. 12, December 2001 (2001-12), pages 1805-1810, XP002263731 ISSN: 0887-6924
DUGAS MARTIN ET AL: "Impact of integrating clinical and genetic information." IN SILICO BIOLOGY, vol. 2, no. 3, 2002, pages 383-391, XP001179418 ISSN: 1386-6338 (ISSN print)
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), KOHLMANN ALEXANDER ET AL: "A Gene Expression Study of 59 Acute Myeloid Leukemia (AML) Patients with Recurrent Cytogenetic Abnormalities." XP002269490 Database accession no. PREV200300335805 & BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), page Abstract No. 1205, 44th Annual Meeting of the American Society of Hematology;Philadelphia, PA, USA; December 06-10, 2002 ISSN: 0006-4971
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), RITTER MARKUS ET AL: "Differentially Regulated Signaling Pathways in AML with Monosomy 7 and 7q-." XP002273028 Database accession no. PREV200300367793 & BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), page Abstract No. 4309, 44th Annual Meeting of the American Society of Hematology;Philadelphia, PA, USA; December 06-10, 2002 ISSN: 0006-4971
GOLUB T R ET AL: "Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring" SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 286, no. 5439, 15 October 1999 (1999-10-15), pages 531-537, XP002207658 ISSN: 0036-8075 cited in the application
YANG JIANHUA ET AL: "Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway." JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 19, 9 May 2003 (2003-05-09), pages 16797-16801, XP002273544 ISSN: 0021-9258
ALIZADEH A ET AL: "THE LYMPHOCHIP: A SPECIALIZED CDNA MICROARRAY FOR THE GENOMIC-SCALE ANALYSIS OF GENE EXPRESSION IN NORMAL AND MALIGNANT LYMPHOCYTES" COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, BIOLOGICAL LABORATORY, COLD SPRING HARBOR, NY, US, vol. 64, no. 1, 1999, pages 71-78, XP001099007 ISSN: 0091-7451
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2001 (2001-11-16), SCHOCH CLAUDIA ET AL: "AML with recurring chromosome abnormalities as defined in the new WHO-classification: Incidence of subgroups, additional genetic abnormalities, FAB subtype and age distribution in an unselected series of 1897 cytogenetically and moleculargenetically analysed AML" XP002269494 Database accession no. PREV200200241183 & BLOOD, vol. 98, no. 11 Part 1, 16 November 2001 (2001-11-16), pages 457a-458a, 43rd Annual Meeting of the American Society of Hematology, Part 1;Orlando, Florida, USA; December 07-11, 2001 ISSN: 0006-4971
Attorney, Agent or Firm:
ROCHE DIAGNOSTICS GMBH (Alexander Patent Department, Postfach 11 52 Penzberg, DE)
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Claims:
Claims
1. A method for distinguishing AML subtypes with recurring genetic aberrations t (8; 21), t (15 ; 17), t (llq23)/MLL, inv (3) /t (3; 3), inv (16), AML komplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q) in a sample, the method comprising determining the expression level of markers selected fromthe markers identifiable by their Affymetrix Identification Numbers (affy id) as defined in Tables 1, and/or 2, wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.1 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.1 having a positive fc value, is indicative for AML+11 when AML+11 is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.2 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.2 having a positive fc value, is indicative for AML+13 when AML_+13 is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.3 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.3 having a positive fc value, is indicative for AML_+8 when AML_+8 is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.4 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.4 having a positive fc value, is indicative for AML7 when AML7 is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.5 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.5 having a positive fc value, is indicative for AML5q when AML5q is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.6 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.6 having a positive fc value, is indicative for AML9q when AML 9q is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.7 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.7 having a positive fc value, is indicative for AML MLL when AML MLL is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1. 8 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1. 8 having a positive fc value, is indicative for AML inv (16) when AML inv (16) is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.9 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.9 having a positive fc value, is indicative for AML inv (3) when AML inv (3) is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.10 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.10 having a positive fc value, is indicative for AMLkomplext when AMLkomplext is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.11 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.11 having a positive fc value, is indicative for AMLnormal when AMLnormal is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.12 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.12 having a positive fc value, is indicative for AMLt (15 ; 17) when AMLt (15 ; 17) is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.13 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.13 having a positive fc value, is indicative for AML t ( ; 21) when AML t (8; 21) is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.1 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.1 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AML+13, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.2 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.2 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AML +8, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.3 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.3 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AML7, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.4 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.4 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AML5q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.5 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.5 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AML 9q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.6 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.6 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AML MLL, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.7 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.7 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AML inv (16), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.8 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.8 having a positive fc value, is indicative for the presence AML_+11 when AML_+11 is distinguished from AML inv (3), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.9 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.9 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AMLkomplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.10 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.10 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AMLnormal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.11 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.11 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AMLt (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.12 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.12 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AML t (8; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.13 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.13 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AML_+8, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.14 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.14 having a positive fc value, is indicative for the presence AML_+13 when AML_+13 is distinguished from AML7, and/or wherein a lower expression of at least one polynucleotide defined. by at least one of the numbers 1 to 50 of Table 2.15 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.15 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AML_5q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.16 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.16 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AML 9q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.17 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2. 17 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AML MLL, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.18 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.18 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AML inv (16), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.19 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.19 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AML inv (3), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.20 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.20 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AMLkomplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.21 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.21 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AMLnormal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.22 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.22 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AMLt (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.23 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.23 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AML t (8; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.24 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.24 having a positive fc value, is indicative for the presence AML_+8 when AML_+8 distinguished from AML7, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.25 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.25 having a positive fc value, is indicative for the presence AML_+8 when AML_+8 distinguished from AML5q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.26 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.26 having a positive fc value, is indicative for the presence AML+8 when AML_+8 distinguished from AML 9q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.27 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.27 having a positive fc value, is indicative for the presence AML_+8 when AML_+8 distinguished from AML MLL, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.28 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.28 having a positive fc value, is indicative for the presence AML_+8 when AML_+8 distinguished from AML inv (16), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.29 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.29 having a positive fc value, is indicative for the presence AML+8 when AML_+8 distinguished from AML inv (3), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.30 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.30 having a positive fc value, is indicative for the presence AML_+8 when AML_+8 distinguished from AMLkomplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.31 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.31 having a positive fc value, is indicative for the presence AML_+8 when AML_+8 distinguished from AMLnormal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.32 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.32 having a positive fc value, is indicative for the presence AML_+8 when AML_+8 distinguished from AML t (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.33 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.33 having a positive fc value, is indicative for the presence AML_+8 when AML_+8 distinguished from AML t (8; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.34 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.34 having a positive fc value, is indicative for the presence AML7 when AML7 distinguished from AML5q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.35 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.35 having a positive fc value, is indicative for the presence AML7 when AML_7 distinguished from AML 9q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.36 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.36 having a positive fc value, is indicative for the presence AML7 when AML_7 distinguished from AML MLL, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.37 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.37 having a positive fc value, is indicative for the presence AML7 when AML7 distinguished from AML inv (16), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2. 38 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.38 having a positive fc value, is indicative for the presence of AML7 when AML7 distinguished from AML inv (3), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.39 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2. 39 having a positive fc value, is indicative for the presence of AML7 when AML7 distinguished from AMLkomplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.40 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.40 having a positive fc value, is indicative for the presence of AML7 when AML_7 distinguished from AMLnormal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.41 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.41 having a positive fc value, is indicative for the presence of AML7 when AML7 distinguished from AML t (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.42 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.42 having a positive fc value, is indicative for the presence of AML7 when AML7 distinguished from AML t (8; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.43 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.43 having a positive fc value, is indicative for the presence ofAML5q when AML5q distinguished from AML 9q, and/or wherein' a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.44 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.44 having a positive fc value, is indicative for the presence ofAML5q when AML5q distinguished from AML MLL, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.45 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.45 having a positive fc value, is indicative for the presence ofAML5q when AML5q distinguished from AML inv (16), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.46 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.46 having a positive fc value, is indicative for the presence ofAML5q when AML5q distinguished from AML inv (3), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.47 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.47 having a positive fc value, is indicative for the presence ofAML5q when AML5q distinguished from AML komplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2. 48 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2. 48 having a positive fc value, is indicative for the presence ofAML5q when AML5q distinguished from AMLnormal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.49 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.49 having a positive fc value, is indicative for the presence ofAML5q when AML5q distinguished fromAMLt (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.50 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.50 having a positive fc value, is indicative for the presence ofAML5q when AML5q distinguished from AML t ( ; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.51 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.51 having a positive fc value, is indicative for the presence of AML 9q when AML9q distinguished from AML MLL, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.52 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.52 having a positive fc value, is indicative for the presence of AML 9q when AML 9q distinguished from AML inv (16), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.53 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.53 having a positive fc value, is indicative for the presence of AML 9q when AML9q distinguished from AML inv (3), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.54 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.54 having a positive fc value, is indicative for the presence of AML 9q when AML9q distinguished from AML komplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.55 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.55 having a positive fc value, is indicative for the presence of AML 9q when AML9q distinguished from AMLnormal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.56 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.56 having a positive fc value, is indicative for the presence of AML 9q when AML9q distinguished from AML t (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.57 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.57 having a positive fc value, is indicative for the presence of AML 9q when AML9q distinguished from AML (8 ; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.58 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2. 58 having a positive fc value, is indicative for the presence of AML MLL when AML MLL distinguished from AML inv (16), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.59 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.59 having a positive fc value, is indicative for the presence of AML MLL when AML MLL distinguished from AML inv (3) and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.60 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.60 having a positive fc value, is indicative for the presence of AML MLL when AML MLL distinguished from AMLkomplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.61 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.61 having a positive fc value, is indicative for the presence of AML MLL when AML MLL distinguished from AML normal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.62 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.62 having a positive fc value, is indicative for the presence of AML MLL when AML MLL distinguished from AML t (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.63 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.63 having a positive fc value, is indicative for the presence of AML MLL when AML MLL is distinguished from AML t (8; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.64 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.64 having a positive fc value, is indicative for the presence of AML inv (16) when AML inv (16) is distinguished from AML inv (3), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.65 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.65 having a positive fc value, is indicative for the presence ofAMLinv (16) when AML inv (16) is distinguished from AMLkomplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.66 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.66 having a positive fc value, is indicative for the presence ofAMLinv (16) when AML inv (16) is distinguished from AMLnormal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.67 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.67 having a positive fc value, is indicative for the presence ofAMLinv (16) when AML inv (16) is distinguished from AML_t (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.68 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.68 having a positive fc value, is indicative for the presence ofAMLinv (16) when AML inv (16) is distinguished from AML t (8; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.69 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.69 having a positive fc value, is indicative for the presence of AML inv (3) when AML inv (3) is distinguished from AMLkomplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.70 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.70 having a positive fc value, is indicative for the presence of AML inv (3) when AML inv (3) is distinguished from AMLnormal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.71 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.71 having a positive fc value, is indicative for the presence of AML inv (3) when AML inv (3) is distinguished from AMLt (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.72 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.72 having a positive fc value, is indicative for the presence of AML inv (3) when AML inv (3) is distinguished from AML_t (8 ; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.73 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.73 having a positive fc value, is indicative for the presence ofAMLkomplext when AMLkomplext is distinguished from AMLnormal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.74 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.74 having a positive fc value, is indicative for the presence of AML komplext when AMLkomplext is distinguished from AMLt (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.75 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.75 having a positive fc value, is indicative for the presence ofAMLkomplext when AMLkomplext is distinguished from AML t (8; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.76 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.76 having a positive fc value, is indicative for the presence ofAMLnormal when AMLnormal is distinguished from AMLt (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.77 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.77 having a positive fc value, is indicative for the presence ofAMLnormal when AMLnormal is distinguished from AML t (8; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.78 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.78 having a positive fc value, is indicative for the presence of AML t (15 ; 17) when AMLt (15 ; 17) is distinguished from AML t (8; 21).
2. The method according to claim 1 wherein the polynucleotide is labelled.
3. The method according to claim 1 or 2, wherein the label is a luminescent, preferably a fluorescent label, an enzymatic or a radioactive label.
4. The method according at least one of the claims 13, wherein the expression level of at least two, preferably of at least ten, more preferably of at least 25, most preferably of 50 of the markers of at least one of the Tables 1.1 2. 78 is determined.
5. The method according to at least one of the claims 14, wherein the expression level of markers expressed lower in a first subtype than in at least one second subtype, which differs from the first subtype, is at least 5 %, 10% or 20%, more preferred at least 50% or may even be 75% or 100%, i. e. 2fold lower, preferably at least 10fold, more preferably at least 50 fold, and most preferably at least 100fold lower in the first subtype.
6. The method according to at least one of the claims 14, wherein the expression level of markers expressed higher in a first subtype than in at least one second subtype, which differs from the first subtype, is at least 5 %, 10% or 20%, more preferred at least 50% or may even be 75% or 100%, i. e. 2fold higher, preferably at least 10fold, more preferably at least 50 fold, and most preferably at least 100fold higher in the first subtype.
7. The method according to at least one of the claims 16, wherein the sample is from an individual having AML.
8. The method according to at least one of the claims 17, wherein at least one polynucleotide is in the form of a transcribed polynucleotide, or a portion thereof.
9. The method according to claim 8, wherein the transcribed polynucleotide is a mRNA or a cDNA.
10. The method according to claim 8 or 9, wherein the determining of the expression level comprises hybridizing the transcribed polynucleotide to a complementary polynucleotide, or a portion thereof, under stringent hybridization conditions.
11. The method according to at least one of the claims 17, wherein at least one polynucleotide is in the form of a polypeptide, or a portion thereof.
12. The method according at least one of claims 8, 9 or 12, wherein the determining of the expression level comprises contacting the polynucleotide or the polypeptide with a compound specifically binding to the polynucleotide or the polypeptide.
13. The method according to claim 12, wherein the compound is an antibody, or a fragment thereof.
14. The method according to at least one of the claims 113, wherein the method is carried out on an array.
15. The method according to at least one of the claims 114, wherein the method is carried out in a robotics system.
16. The method according to at least one of the claims 115, wherein the method is carried out using microfluidics.
17. Use of at least one marker as defined in at least one of the claims 13 for the manufacturing of a diagnostic for distinguishing AML subtypes with recurring genetic aberrations t (8; 21), t (15 ; 17), t (llq23)/MLL, inv (3) /t (3; 3), inv (16), AMLkomplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q).
18. The use according to claim 17 for distinguishing AML subtypes with recurring genetic aberrations t (8; 21), t (15 ; 17), t (llq23)/MLL, inv (3) /t (3; 3), inv (l6), AML_komplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q) in an individual having AML.
19. A diagnostic kit containing at least one marker as defined in at least one of the claims 13 for distinguishing AML subtypes with recurring genetic aberrations t (8; 21), t (15 ; 17), t (llq23)/MLL, inv (3) /t (3; 3), inv (16), AML komplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q), in combination with suitable auxiliaries.
20. The diagnostic kit according to claim 19, wherein the kit contains a reference for at least one AML subtype with recurring genetic aberrations t (8; 21), t (15 ; 17), t (l lq23)/MLL, inv (3) /t (3; 3), inv (16), AMLkomplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q).
21. The diagnostic kit according to claim 20, wherein the reference is a sample or a data bank.
22. An apparatus for distinguishing AML subtypes with recurring genetic aberrations t (8; 21), t (15 ; 17), t (llq23)/MLL, inv (3) /t (3; 3), inv (16), AMLkomplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q) in a sample containing a reference data bank.
23. The apparatus according to claim 22, wherein the reference data bank is obtainable by comprising (a) compiling a gene expression profile of a patient sample by determining the expression level of at least one marker selected from the markers identifiable by their Affymetrix Identification Numbers (affy id) as defined in Tables 1, and/or 2, and (b) classifying the gene expression profile by means of a machine learning algorithm.
24. The apparatus according to claim 23, wherein the machine learning algorithm is selected from the group consisting of Weighted Voting, K Nearest Neighbors, Decision Tree Induction, Support Vector Machines, and FeedForward Neural Networks, preferably Support Vector Machines.
25. The apparatus according to at least one of the claims 2224, wherein the apparatus contains a control panel and/or a monitor.
26. A reference data bank for distinguishing AML subtypes with recurring genetic aberrations t (8; 21), t (15 ; 17), t (llq23)/MLL, inv (3) /t (3; 3), inv (16), AMLkomplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q) obtainable by comprising (a) compiling a gene expression profile of a patient sample by determining the expression level of at least one marker selected from the markers identifiable by their Affymetrix Identification Numbers (affy id) as defined in Tables 1, and/or 2, and (b) classifying the gene expression profile by means of a machine learning algorithm.
27. The reference data bank according to claim 26, wherein the reference data bank is backed up and/or contained in a computational memory chip.
Description:
Method for distinguishing AML subtypes with recurring genetic aberrations The present invention is directed to a method for distinguishing AML subtypes with recurring genetic aberrations, in particular AML subtypes t (8; 21), t (15 ; 17), t (llq23)/MLL, inv (3) /t (3; 3), inv (16), AMLkomplext (complex aberrant karyotype), trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q) by determining the expression level of selected marker genes.

Leukemias are classified into four different groups or types: acute myeloid (AML), acute lymphatic (ALL), chronic myeloid (CML) and chronic lymphatic leukemia (CLL). Within these groups, several subcategories can be identified further using a panel of standard techniques as described below. These different subcatgories in leukemias are associated with varying clinical outcome and therefore are the basis for different treatment strategies. The importance of highly specific classification may be illustrated in detail further for the AML as a very heterogeneous group of diseases. Effort is aimed at identifying biological entities and to distinguish and classify subgroups of AML which are associated with a favorable, intermediate or unfavorable prognosis, respectively. In 1976, the FAB classification was proposed by the French-American-British co-operative group which was based on cytomorphology and cytochemistry in order to separate AML subgroups according to the morphological appearance of blasts in the blood and bone marrow. In addition, it was recognized that genetic abnormalities occurring in the leukemic blast had a major impact on the morphological picture and even more on the prognosis. So far, the karyotype of the leukemic blasts is the most important independent prognostic factor regarding response to therapy as well as survival.

Usually, a combination of methods is necessary to obtain the most important information in leukemia diagnostics: Analysis of the morphology and cytochemistry of bone marrow blasts and peripheral blood cells is necessary to establish the diagnosis. In some cases the addition of immunophenotyping is mandatory to separate very undifferentiated AML from acute lymphoblastic leukemia and CLL. Leukemia subtypes investigated can be diagnosed by cytomorphology alone, only if an expert reviews the smears. However, a genetic analysis based on chromosome analysis, fluorescence in situ hybridization or RT- PCR and immunophenotyping is required in order to assign all cases into the right

category. The aim of these techniques besides diagnosis is mainly to determine the prognosis of the leukemia. A major disadvantage of these methods, however, is that viable cells are necessary as the cells for genetic analysis have to divide in vitro in order to obtain metaphases for the analysis. Another problem is the long time of 72 hours from receipt of the material in the laboratory to obtain the result.

Furthermore, great experience in preparation of chromosomes and even more in analyzing the karyotypes is required to obtain the correct result in at least 90% of cases. Using these techniques in combination, hematological malignancies in a first approach are separated into chronic myeloid leukemia (CML), chronic lymphatic (CLL), acute lymphoblastic (ALL), and acute myeloid leukemia (AML). Within the latter three disease entities several prognostically relevant subtypes have been established. As a second approach this further sub-classification is based mainly on genetic abnormalities of the leukemic blasts and clearly is associated with different prognoses.

The sub-classification of leukemias becomes increasingly important to guide therapy. The development of new, specific drugs and treatment approaches requires the identification of specific subtypes that may benefit from a distinct therapeutic protocol and, thus, can improve outcome of distinct subsets of leukemia. For example, the new therapeutic drug (STI571, Imatinib) inhibits the CML specific chimeric tyrosine kinase BCR-ABL generated from the genetic defect observed in CML, the BCR-ABL-rearrangement due to the translocation between chromosomes 9 and 22 (t (9; 22) (q34 ; ql 1)). In patients treated with this new drug, the therapy response is dramatically higher as compared to all other drugs that had been used so far. Another example is the subtype of acute myeloid leukemia AML M3 and its variant M3v both with karyotype t (15 ; 17) (q22; qll-12). The introduction of a new drug (all-trans retinoic acid-ATRA) has improved the outcome in this subgroup of patient from about 50% to 85 % long-term survivors.

As it is mandatory for these patients suffering from these specific leukemia subtypes to be identified as fast as possible so that the best therapy can be applied, diagnostics today must accomplish sub-classification with maximal precision. Not only for these subtypes but also for several other leukemia subtypes different treatment approaches could improve outcome. Therefore, rapid and precise identification of distinct leukemia subtypes is the future goal for diagnostics.

Thus, the technical problem underlying the present invention was to provide means for leukemia diagnostics which overcome at least some of the disadvantages of the prior art diagnostic methods, in particular encompassing the time-consuming and unreliable combination of different methods and which provides a rapid assay to unambiguously distinguish one AML subtype from another, e. g. by genetic analysis.

According to Golub et al. (Science, 1999, 286, 531-7), gene expression profiles can be used for class prediction and discriminating AML from ALL samples. However, for the analysis of acute leukemias the selection of the two different subgroups was performed using exclusively morphologic-phenotypical criteria. This was only descriptive and does not provide deeper insights into the pathogenesis or the underlying biology of the leukemia. The approach reproduces only very basic knowledge of cytomorphology and intends to differentiate classes. The data is not sufficient to predict prognostically relevant cytogenetic aberrations.

Furthermore, the international application WO-A 03/039443 discloses marker genes the expression levels of which are characteristic for certain leukemia, e. g.

AML subtypes and additionally discloses methods for differentiating between the subtype of AML cells by determining the expression profile of the disclosed marker genes. However, WO-A 03/039443 does not provide guidance which set of distinct genes discriminate between two subtypes and, as such, can be routineously taken in order to distinguish one AML subtype from another.

The problem is solved by the present invention, which provides a method for distinguishing AML subtypes with recurring genetic aberrations t (8; 21), t (15 ; 17), t (llq23)/MLL, inv (3) /t (3; 3), inv (16), AML_komplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q) in a sample, the method comprising determining the expression level of markers selected from the markers identifiable by their Affymetrix Identification Numbers (affy id) as defined in Tables 1, and/or 2, wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.1 having a negative fc value, and/or

a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.1 having a positive fc value, is indicative for AML+11 when AML_+llis distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.2 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.2 having a positive fc value, is indicative for AML+13 when AML+13 is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.3 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.3 having a positive fc value, is indicative for AML_+8 when AML-+8 is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.4 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.4 having a positive fc value, is indicative for AML-7 when AML-7 is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.5 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.5 having a positive fc value,

is indicative for AML5q when AML 5q is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.6 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.6 having a positive fc value, is indicative for AML9q when AML9q is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.7 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.7 having a positive fc value, is indicative for AML MLL when AML MLL is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1. 8 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.8 having a positive fc value, is indicative for AML inv (16) when AML inv (16) is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.9 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.9 having a positive fc value, is indicative for AML inv (3) when AML inv (3) is distinguished from all other subtypes, and/or wherein

a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.10 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.10 having a positive fc value, is indicative for AMLkomplext when AML komplext is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.11 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.11 having a positive fc value, is indicative for AMLnormal when AML normal is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.12 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.12 having a positive fc value, is indicative for AMLt (15 ; 17) when AMLt (15 ; 17) is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.13 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 1.13 having a positive fc value, is indicative for AML t (8; 21) when AML t (8; 21) is distinguished from all other subtypes, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.1 having a negative fc value, and/or

a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.1 having a positive fc value, is indicative for the presence AML_+11 when AML_+llis distinguished from AML_+13, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.2 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.2 having a positive fc value, is indicative for the presence AML+11 when AML +11 is distinguished from AML_+8, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.3 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.3 having a positive fc value, is indicative for the presence AML+11 when AML_+llis distinguished from AML-7, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.4 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.4 having a positive fc value, is indicative for the presence AML+11 when AML_+llis distinguished from AML_5q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.5 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.5 having a positive fc value,

is indicative for the presence AML+11 when AML+11 is distinguished from AML 9q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.6 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.6 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AML MLL, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.7 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.7 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AML inv (16), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.8 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.8 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AML inv (3), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.9 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.9 having a positive fc value, is indicative for the presence AML+11 when AML_+11 is distinguished from AML komplext, and/or wherein

a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.10 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.10 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AML_normal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.11 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.11 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AML_t (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.12 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.12 having a positive fc value, is indicative for the presence AML+11 when AML+11 is distinguished from AML_t (8; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.13 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.13 having a positive fc value, is indicative for the presence AML+13 when AML +13 is distinguished from AML +8, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.14 having a negative fc value, and/or

a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.14 having a positive fc value, is indicative for the presence AML_+13 when AML+13 is distinguished from AML-7, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.15 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.15 having a positive fc value, is indicative for the presence AML_+13 when AML+13 is distinguished from AML5q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.16 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.16 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AML 9q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.17 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.17 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AML MLL, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.18 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.18 having a positive fc value,

is indicative for the presence AML+13 when AML_+13 is distinguished from AML inv (16), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.19 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.19 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AML inv (3), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.20 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.20 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AML komplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.21 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.21 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AMLnormal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.22 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.22 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AML_t(15 ; 17), and/or wherein

a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.23 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.23 having a positive fc value, is indicative for the presence AML+13 when AML+13 is distinguished from AML t (8; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.24 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.24 having a positive fc value, is indicative for the presence AML_+8 when AML_+8 distinguished from AML-7, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.25 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.25 having a positive fc value, is indicative for the presence AML_+8 when AML+8 distinguished from AML5q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.26 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.26 having a positive fc value, is indicative for the presence AML_+8 when AML+8 distinguished from AML 9q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.27 having a negative fc value, and/or

a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.27 having a positive fc value, is indicative for the presence AML_+8 when AML +8 distinguished from AML MLL, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.28 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2. 28 having a positive fc value, is indicative for the presence AML+8 when AML_+8 distinguished from AML inv (16), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.29 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.29 having a positive fc value, is indicative for the presence AML_+8 when AML +8 distinguished from AML inv (3), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.30 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.30 having a positive fc value, is indicative for the presence AML_+8 when AML_+8 distinguished from AML komplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.31 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.31 having a positive fc value,

is indicative for the presence AML_+8 when AML+8 distinguished from AMLnormal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.32 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.32 having a positive fc value, is indicative for the presence AML_+8 when AML_+8 distinguished from AML t (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.33 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.33 having a positive fc value, is indicative for the presence AML_+8 when AML_+8 distinguished from AML-t (8; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.34 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.34 having a positive fc value, is indicative for the presence AML-7 when AML-7 distinguished from AML5q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.35 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2. 35 having a positive fc value, is indicative for the presence AML-7 when AML_-7 distinguished from AML 9q, and/or wherein

a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2. 36 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.36 having a positive fc value, is indicative for the presence AML-7 when AML-7 distinguished from AML MLL, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.37 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.37 having a positive fc value, is indicative for the presence AML-7 when AML-7 distinguished from AML inv (16), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2. 38 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2. 38 having a positive fc value, is indicative for the presence of AML-7 when AML-7 distinguished from AML inv (3), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.39 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.39 having a positive fc value, is indicative for the presence of AML-7 when AML-7 distinguished from AML_komplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.40 having a negative fc value, and/or

a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.40 having a positive fc value, is indicative for the presence of AML-7 when AML-7 distinguished from AML normal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.41 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.41 having a positive fc value, is indicative for the presence of AML-7 when AML-7 distinguished from AML t (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.42 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.42 having a positive fc value, is indicative for the presence of AML-7 when AML-7 distinguished from AML t (8; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.43 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.43 having a positive fc value, is indicative for the presence ofAML5q when AML5q distinguished from AML 9q, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.44 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.44 having a positive fc value,

is indicative for the presence ofAML5q when AML5q distinguished from AML MLL, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.45 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.45 having a positive fc value, is indicative for the presence ofAML5q when AML5q distinguished from AML inv (16), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.46 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.46 having a positive fc value, is indicative for the presence ofAML5q when AML5q distinguished from AML inv (3), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.47 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.47 having a positive fc value, is indicative for the presence of AML_5q when AML5q distinguished from AML komplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.48 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.48 having a positive fc value, is indicative for the presence ofAML5q when AML5q distinguished from AMLnormal, and/or wherein

a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.49 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.49 having a positive fc value, is indicative for the presence ofAML5q when AML5q distinguished from AML t (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.50 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.50 having a positive fc value, is indicative for the presence ofAML5q when AML5q distinguished from AML t ( ; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.51 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.51 having a positive fc value, is indicative for the presence of AML_9q when AML_9q distinguished from AML MLL, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.52 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.52 having a positive fc value, is indicative for the presence of AML 9q when AML9q distinguished from AML inv (16), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.53 having a negative fc value, and/or

a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.53 having a positive fc value, is indicative for the presence of AML 9q when AML9q distinguished from AML inv (3), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.54 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.54 having a positive fc value, is indicative for the presence of AML 9q when AML9q distinguished from AML komplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.55 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.55 having a positive fc value, is indicative for the presence of AML 9q when AML9q distinguished from AML normal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.56 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.56 having a positive fc value, is indicative for the presence of AML 9q when AML 9q distinguished from AML t (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.57 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.57 having a positive fc value,

is indicative for the presence of AML 9q when AML9q distinguished from AML (8; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.58 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.58 having a positive fc value, is indicative for the presence of AML MLL when AML MLL distinguished from AML inv (16), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.59 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.59 having a positive fc value, is indicative for the presence of AML MLL when AML MLL distinguished from AML inv (3) and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.60 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.60 having a positive fc value, is indicative for the presence of AML MLL when AML MLL distinguished from AMLkomplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.61 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.61 having a positive fc value, is indicative for the presence of AML MLL when AML MLL distinguished from AMLnormal, and/or wherein

a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.62 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.62 having a positive fc value, is indicative for the presence of AML MLL when AML MLL distinguished from AML_t (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.63 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.63 having a positive fc value, is indicative for the presence of AML MLL when AML MLL is distinguished from AML_t (8; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.64 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.64 having a positive fc value, is indicative for the presence of AML inv (16) when AML inv (16) is distinguished from AML inv (3), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.65 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.65 having a positive fc value, is indicative for the presence ofAMLinv (16) when AML inv (16) is distinguished from AMLkomplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.66 having a negative fc value, and/or

a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.66 having a positive fc value, is indicative for the presence ofAMLinv (16) when AML inv (16) is distinguished from AML normal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.67 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.67 having a positive fc value, is indicative for the presence of AML inv (16) when AML inv (16) is distinguished from AMLt (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2. 68 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2. 68 having a positive fc value, is indicative for the presence ofAMLinv (16) when AML inv (16) is distinguished from AML_t (8 ; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.69 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.69 having a positive fc value, is indicative for the presence of AML inv (3) when AML inv (3) is distinguished from AML komplext, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.70 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.70 having a positive fc value,

is indicative for the presence of AML inv (3) when AML inv (3) is distinguished from AMLnormal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.71 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.71 having a positive fc value, is indicative for the presence of AML inv (3) when AML inv (3) is distinguished from AML_t (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.72 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.72 having a positive fc value, is indicative for the presence of AML inv (3) when AML inv (3) is distinguished from AML t ( ; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.73 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.73 having a positive fc value, is indicative for the presence of AML_komplext when AMLkomplext is distinguished from AML normal, and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.74 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.74 having a positive fc value, is indicative for the presence ofAMLkomplext when AMLkomplext is distinguished from AMLt (15 ; 17), and/or wherein

a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.75 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.75 having a positive fc value, is indicative for the presence of AML komplext when AMLkomplext is distinguished from AML t ( ; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.76 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.76 having a positive fc value, is indicative for the presence ofAMLnormal when AMLnormal is distinguished from AMLt (15 ; 17), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.77 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.77 having a positive fc value, is indicative for the presence ofAMLnormal when AMLnormal is distinguished from AML_t (8 ; 21), and/or wherein a lower expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2. 78 having a negative fc value, and/or a higher expression of at least one polynucleotide defined by at least one of the numbers 1 to 50 of Table 2.78 having a positive fc value, is indicative for the presence ofAMLt (15 ; 17) when AMLt (15 ; 17) is distinguished from AML t (8; 21).

As used herein, the following definitions apply for the above used abbreviations: AML-7 AML with monosomy 7 as sole abnormality

AML-+8 AML with trisomy 8 as sole abnormality AML+11 AML with trisomy 11 as sole abnormality AML_+13 AML with trisomy 13 as sole abnormality AML-5q AML with a deletion of the long arm of chromosome 5 as sole abnormality AML9q AML with a deletion of the long arm of chromosome 9 as sole abnormality AML MLL AML with an 1 lq23/MLL-rearrangement AML inv (16) AML with an inversion 16/CBFb-SMMHC-rearrangement AML inv (3) AML with an inv (3) AML t (15; 17) AML with t (15 ; 17)/PML-RARA-rearrangement AML t (8; 21) AML with t (8; 21)/AMLl-ETO-rearrangement AML leomplext AML with a complex aberrant karyotype AMLnormal AML with normal karyotype As used herein, "all other subtypes"refer to the subtypes of the present invention, i. e. if one subtype is distinguished from"all other subtypes", it is distiguished from all other subtypes contained in the present invention.

According to the present invention, a"sample"means any biological material containing genetic information in the form of nucleic acids or proteins obtainable or obtained from an individual. The sample includes e. g. tissue samples, cell samples, bone marrow and/or body fluids such as blood, saliva, semen. Preferably, the sample is blood or bone marrow, more preferably the sample is bone marrow.

The person skilled in the art is aware of methods, how to isolate nucleic acids and proteins from a sample. A general method for isolating and preparing nucleic acids from a sample is outlined in Example 3.

According to the present invention, the term"lower expression"is generally assigned to all by numbers and Affymetrix Id. definable polynucleotides the t- values and fold change (fc) values of which are negative, as indicated in the Tables.

Accordingly, the term"higher expression"is generally assigned to all by numbers and Affymetrix Id. definable polynucleotides the t-values and fold change (fc) values of which are positive.

According to the present invention, the term"expression"refers to the process by which mRNA or a polypeptide is produced based on the nucleic acid sequence of a gene, i. e."expression"also includes the formation of mRNA upon transcription. In accordance with the present invention, the term"determining the expression level" preferably refers to the determination of the level of expression, namely of the markers.

Generally, "marker"refers to any genetically controlled difference which can be used in the genetic analysis of a test versus a control sample, for the purpose of assigning the sample to a defined genotype or phenotype. As used herein, "markers"refer to genes which are differentially expressed in, e. g. , different AML subtypes. The markers can be defined by their gene symbol name, their encoded protein name, their transcript identification number (cluster identification number), the data base accession number, public accession number or GenBank identifier or, as done in the present invention, Affymetrix identification number, chromosomal location, UniGene accession number and cluster type, LocusLink accession number (see Examples and Tables).

The Affymetrix identification number (affy id) is accessible for anyone and the person skilled in the art by entering the"gene expression omnibus"internet page of the National Center for Biotechnology Information (NCBI) (http://www. ncbi. nlm. nih. gov/geo/). In particular, the affy id's of the polynucleotides used for the method of the present invention are derived from the so-called U133 chip. The sequence data of each identification number can be viewed at http://www. ncbi. nlm. nih. gov/geo/query/acc. cgi? acc=GPL96 Generally, the expression level of a marker is determined by the determining the expression of its corresponding"polynucleotide"as described hereinafter.

According to the present invention, the term"polynucleotide"refers, generally, to a DNA, in particular cDNA, or RNA, in particular a cRNA, or a portion thereof or a polypeptide or a portion thereof. In the case of RNA (or cDNA), the polynucleotide is formed upon transcription of a nucleotide sequence which is capable of expression. The polynucleotide fragments refer to fragments preferably of between at least 8, such as 10,12, 15 or 18 nucleotides and at least 50, such as 60, 80, 100, 200 or 300 nucleotides in length, or a complementary sequence thereto, representing a consecutive stretch of nucleotides of a gene, cDNA or mRNA. In other terms, polynucleotides include also any fragment (or complementary sequence thereto) of a sequence derived from any of the markers defined above as long as these fragments unambiguously identify the marker.

The determination of the expression level may be effected at the transcriptional or translational level, i. e. at the level of mRNA or at the protein level. Protein fragments such as peptides or polypeptides advantageously comprise between at least 6 and at least 25, such as 30,40, 80,100 or 200 consecutive amino acids representative of the corresponding full length protein. Six amino acids are generally recognized as the lowest peptidic stretch giving rise to a linear epitope recognized by an antibody, fragment or derivative thereof. Alternatively, the proteins or fragments thereof may be analysed using nucleic acid molecules specifically binding to three-dimensional structures (aptamers).

Depending on the nature of the polynucleotide or polypeptide, the determination of the expression levels may be effected by a variety of methods. For determining and detecting the expression level, it is preferred in the present invention that the polynucleotide, in particular the cRNA, is labelled.

The labelling of the polynucleotide or a polypeptide can occur by a variety of methods known to the skilled artisan. The label can be fluorescent, chemiluminescent, bioluminescent, radioactive (such as 3H or 32p). The labelling compound can be any labelling compound being suitable for the labelling of polynucleotides and/or polypeptides. Examples include fluorescent dyes, such as fluorescein, dichlorofluorescein, hexachlorofluorescein, BODIPY variants, ROX, tetramethylrhodamin, rhodamin X, Canine-2, Cyanine-3, Cyanine-5, Cyanine-7, IRD40, FluorX, Oregon Green, Alexa variants (available e. g. from Molecular Probes or Amersham Biosciences) and the like, biotin or biotinylated nucleotides,

digoxigenin, radioisotopes, antibodies, enzymes and receptors. Depending on the type of labelling, the detection is done via fluorescence measurements, conjugation to streptavidin and/or avidin, antigen-antibody-and/or antibody-antibody- interactions, radioactivity measurements, as well as catalytic and/or receptor/ligand interactions. Suitable methods include the direct labelling (incorporation) method, the amino-modified (amino-allyl) nucleotide method (available e. g. from Ambion), and the primer tagging method (DNA dendrimer labelling, as kit available e. g. from Genisphere). Particularly preferred for the present invention is the use of biotin or biotinylated nucleotides for labelling, with the latter being directly incorporated into, e. g. the cRNA polynucleotide by in vitro transcription.

If the polynucleotide is mRNA, cDNA may be prepared into which a detectable label, as exemplified above, is incorporated. Said detectably labelled cDNA, in single-stranded form, may then be hybridised, preferably under stringent or highly stringent conditions to a panel of single-stranded oligonucleotides representing different genes and affixed to a solid support such as a chip. Upon applying appropriate washing steps, those cDNAs will be detected or quantitatively detected that have a counterpart in the oligonucleotide panel. Various advantageous embodiments of this general method are feasible. For example, the mRNA or the cDNA may be amplified e. g. by polymerase chain reaction, wherein it is preferable, for quantitative assessments, that the number of amplified copies corresponds relative to further amplified mRNAs or cDNAs to the number of mRNAs originally present in the cell. In a preferred embodiment of the present invention, the cDNAs are transcribed into cRNAs prior to the hybridisation step wherein only in the transcription step a label is incorporated into the nucleic acid and wherein the cRNA is employed for hybridisation. Alternatively, the label may be attached subsequent to the transcription step.

Similarly, proteins from a cell or tissue under investigation may be contacted with a panel of aptamers or of antibodies or fragments or derivatives thereof. The antibodies etc. may be affixed to a solid support such as a chip. Binding of proteins indicative of an AML subtype may be verified by binding to a detectably labelled secondary antibody or aptamer. For the labelling of antibodies, it is referred to Harlow and Lane, "Antibodies, a laboratory manual", CSH Press, 1988, Cold Spring Harbor. Specifically, a minimum set of proteins necessary for diagnosis of

all AML subtypes may be selected for creation of a protein array system to make diagnosis on a protein lysate of a diagnostic bone marrow sample directly. Protein Array Systems for the detection of specific protein expression profiles already are available (for example: Bio-Plex, BIORAD, München, Germany). For this application preferably antibodies against the proteins have to be produced and immobilized on a platform e. g. glasslides or microtiterplates. The immobilized antibodies can be labelled with a reactant specific for the certain target proteins as discussed above. The reactants can include enzyme substrates, DNA, receptors, antigens or antibodies to create for example a capture sandwich immunoassay.

For reliably distinguishing AML subtypes with recurring genetic aberrations t (8 ; 21), t (15 ; 17), t (llq23)/MLL, inv (3) /t (3; 3), inv (16), AMLkomplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q) it is useful that the expression of more than one of the above defined markers is determined. As a criterion for the choice of markers, the statistical significance of markers as expressed in q or p values based on the concept of the false discovery rate is determined. In doing so, a measure of statistical significance called the q value is associated with each tested feature. The q value is similar to the p value, except it is a measure of significance in terms of the false discovery rate rather than the false positive rate (Storey JD and Tibshirani R. Proc. Natl. Acad. Sci. , 2003, Vol.

100: 9440-5.

In a preferred embodiment of the present invention, markers as defined in Tables 1- 7 having a q-value of less than 3E-06, more preferred less than 1. 5E-09, most preferred less than 1. 5E-11, less than 1. 5E-20, less than 1. 5E-30, are measured.

Of the above defined markers, the expression level of at least two, preferably of at least ten, more preferably of at least 25, most preferably of 50 of at least one of the Tables of the markers is determined.

In another preferred embodiment, the expression level of at least 2, of at least 5, of at least 10 out of the markers having the numbers 1-10,1-20, 1-40,1-50 of at least one of the Tables are measured.

The level of the expression of the"marker", i. e. the expression of the polynucleotide is indicative of the AML subtype of a cell or an organism. The level

of expression of a marker or group of markers is measured and is compared with the level of expression of the same marker or the same group of markers from other cells or samples. The comparison may be effected in an actual experiment or in silico. When the expression level also referred to as expression pattern or expression signature (expression profile) is measurably different, there is according to the invention a meaningful difference in the level of expression. Preferably the difference at least is 5 %, 10% or 20%, more preferred at least 50% or may even be as high as 75% or 100%. More preferred the difference in the level of expression is at least 200%, i. e. two fold, at least 500%, i. e. five fold, or at least 1000%, i. e. 10 fold.

Accordingly, the expression level of markers expressed lower in a first subtype than in at least one second subtype, which differs from the first subtype, is at least 5 %, 10% or 20%, more preferred at least 50% or may even be 75% or 100%, i. e.

2-fold lower, preferably at least 10-fold, more preferably at least 50-fold, and most preferably at least 100-fold lower in the first subtype. On the other hand, the expression level of markers expressed higher in a first subtype than in at least one second subtype, which differs from the first subtype, is at least 5 %, 10% or 20%, more preferred at least 50% or may even be 75% or 100%, i. e. 2-fold higher, preferably at least 10-fold, more preferably at least 50-fold, and most preferably at least 100-fold higher in the first subtype.

In another embodiment of the present invention, the sample is derived from an individual having leukemia, preferably AML.

For the method of the present invention it is preferred if the polynucleotide the expression level of which is determined is in form of a transcribed polynucleotide.

A particularly preferred transcribed polynucleotide is an mRNA, a cDNA and/or a cRNA, with the latter being preferred. Transcribed polynucleotides are isolated from a sample, reverse transcribed and/or amplified, and labelled, by employing methods well-known the person skilled in the art (see Example 3). In a preferred embodiment of the methods according to the invention, the step of determining the expression profile further comprises amplifying the transcribed polynucleotide.

In order to determine the expression level of the transcribed polynucleotide by the method of the present invention, it is preferred that the method comprises

hybridizing the transcribed polynucleotide to a complementary polynucleotide, or a portion thereof, under stringent hybridization conditions, as described hereinafter.

The term"hybridizing"means hybridization under conventional hybridization conditions, preferably under stringent conditions as described, for example, in Sambrook, J. , et al. , in"Molecular Cloning: A Laboratory Manual" (1989), Eds. J.

Sambrook, E. F. Fritsch and T. Maniatis, Cold Spring Harbour Laboratory Press, Cold Spring Harbour, NY and the further definitions provided above. Such conditions are, for example, hybridization in 6x SSC, pH 7.0/0. 1% SDS at about 45°C for 18-23 hours, followed by a washing step with 2x SSC/0. 1% SDS at 50°C.

In order to select the stringency, the salt concentration in the washing step can for example be chosen between 2x SSC/0.1% SDS at room temperature for low stringency and 0.2x SSC/0.1% SDS at 50°C for high stringency. In addition, the temperature of the washing step can be varied between room temperature, ca. 22°C, for low stringency, and 65°C to 70° C for high stringency. Also contemplated are polynucleotides that hybridize at lower stringency hybridization conditions.

Changes in the stringency of hybridization and signal detection are primarily accomplished through the manipulation, preferably of formamide concentration (lower percentages of formamide result in lowered stringency), salt conditions, or temperature. For example, lower stringency conditions include an overnight incubation at 37°C in a solution comprising 6X SSPE (20X SSPE = 3M NaCl ; 0.2M NaH2PO4 ; 0.02M EDTA, pH 7.4), 0.5% SDS, 30% formamide, 100 mg/ml salmon sperm blocking DNA, followed by washes at 50°C with 1 X SSPE, 0. 1% SDS. In addition, to achieve even lower stringency, washes performed following stringent hybridization can be done at higher salt concentrations (e. g. 5x SSC).

Variations in the above conditions may be accomplished through the inclusion and/or substitution of alternate blocking reagents used to suppress background in hybridization experiments. The inclusion of specific blocking reagents may require modification of the hybridization conditions described above, due to problems with compatibility.

"Complementary"and"complementarity", respectively, can be described by the percentage, i. e. proportion, of nucleotides which can form base pairs between two polynucleotide strands or within a specific region or domain of the two strands.

Generally, complementary nucleotides are, according to the base pairing rules, adenine and thymine (or adenine and uracil), and cytosine and guanine.

Complementarity may be partial, in which only some of the nucleic acids'bases are matched according to the base pairing rules. Or, there may be a complete or total complementarity between the nucleic acids. The degree of complementarity between nucleic acid strands has effects on the efficiency and strength of hybridization between nucleic acid strands.

Two nucleic acid strands are considered to be 100% complementary to each other over a defined length if in a defined region all adenines of a first strand can pair with a thymine (or an uracil) of a second strand, all guanines of a first strand can pair with a cytosine of a second strand, all thymine (or uracils) of a first strand can pair with an adenine of a second strand, and all cytosines of a first strand can pair with a guanine of a second strand, and vice versa. According to the present invention, the degree of complementarity is determined over a stretch of 20, preferably 25, nucleotides, i. e. a 60% complementarity means that within a region of 20 nucleotides of two nucleic acid strands 12 nucleotides of the first strand can base pair with 12 nucleotides of the second strand according to the above ruling, either as a stretch of 12 contiguous nucleotides or interspersed by non-pairing nucleotides, when the two strands are attached to each other over said region of 20 nucleotides. The degree of complementarity can range from at least about 50% to full, i. e. 100% complementarity. Two single nucleic acid strands are said to be "substantially complementary"when they are at least about 80% complementary, preferably about 90% or higher. For carrying out the method of the present invention substantial complementarity is preferred.

Preferred methods for detection and quantification of the amount of polynucleotides, i. e. for the methods according to the invention allowing the determination of the level of expression of a marker, are those described by Sambrook et al. (1989) or real time methods known in the art as the TaqMant method disclosed in W092/02638 and the corresponding U. S. 5,210, 015, U. S.

5,804, 375, U. S. 5,487, 972. This method exploits the exonuclease activity of a polymerase to generate a signal. In detail, the (at least one) target nucleic acid component is detected by a process comprising contacting the sample with an oligonucleotide containing a sequence complementary to a region of the target nucleic acid component and a labeled oligonucleotide containing a sequence complementary to a second region of the same target nucleic acid component sequence strand, but not including the nucleic acid sequence defined by the first oligonucleotide, to create a mixture of duplexes during hybridization conditions,

wherein the duplexes comprise the target nucleic acid annealed to the first oligonucleotide and to the labeled oligonucleotide such that the 3'-end of the first oligonucleotide is adjacent to the 5'-end of the labeled oligonucleotide. Then this mixture is treated with a template-dependent nucleic acid polymerase having a 5' to 3'nuclease activity under conditions sufficient to permit the 5'to 3'nuclease activity of the polymerase to cleave the annealed, labeled oligonucleotide and release labeled fragments. The signal generated by the hydrolysis of the labeled oligonucleotide is detected and/or measured. TaqMan technology eliminates the need for a solid phase bound reaction complex to be formed and made detectable.

Other methods include e. g. fluorescence resonance energy transfer between two adjacently hybridized probes as used in the LightCycler format described in U. S.

6,174, 670.

A preferred protocol if the marker, i. e. the polynucleotide, is in form of a transcribed nucleotide, is described in Example 3, where total RNA is isolated, cDNA and, subsequently, cRNA is synthesized and biotin is incorporated during the transcription reaction. The purified cRNA is applied to commercially available arrays which can be obtained e. g. from Affymetrix. The hybridized cRNA is detected according to the methods described in Example 3. The arrays are produced by photolithography or other methods known to experts skilled in the art e. g. from U. S. 5,445, 934, U. S. 5,744, 305, U. S. 5,700, 637, U. S. 5,945, 334 and EP 0 619 321 or EP 0 373 203, or as decribed hereinafter in greater detail.

In another embodiment of the present invention, the polynucleotide or at least one of the polynucleotides is in form of a polypeptide. In another preferred embodiment, the expression level of the polynucleotides or polypeptides is detected using a compound which specifically binds to the polynucleotide of the polypeptide of the present invention.

As used herein, "specifically binding"means that the compound is capable of discriminating between two or more polynucleotides or polypeptides, i. e. it binds to the desired polynucleotide or polypeptide, but essentially does not bind unspecifically to a different polynucleotide or polypeptide.

The compound can be an antibody, or a fragment thereof, an enzyme, a so-called small molecule compound, a protein-scaffold, preferably an anticalin. In a

preferred embodiment, the compound specifically binding to the polynucleotide or polypeptide is an antibody, or a fragment thereof.

As used herein, an"antibody"comprises monoclonal antibodies as first described by Kohler and Milstein in Nature 278 (1975), 495-497 as well as polyclonal antibodies, i. e. antibodies contained in a polyclonal antiserum. Monoclonal antibodies include those produced by transgenic mice. Fragments of antibodies include F (ab') 2, Fab and Fv fragments. Derivatives of antibodies include scFvs, chimeric and humanized antibodies. See, for example Harlow and Lane, loc. cit.

For the detection of polypeptides using antibodies or fragments thereof, the person skilled in the art is aware of a variety of methods, all of which are included in the present invention. Examples include immunoprecipitation, Western blotting, Enzyme-linked immuno sorbent assay (ELISA), Enzyme-linked immuno sorbent assay (RIA), dissociation-enhanced lanthanide fluoro immuno assay (DELFIA), scintillation proximity assay (SPA). For detection, it is desirable if the antibody is labelled by one of the labelling compounds and methods described supra.

In another preferred embodiment of the present invention, the method for distinguishing WHO-classified AML subtypes is carried out on an array.

In general, an"array"or"microarray"refers to a linear or two-or three dimensional arrangement of preferably discrete nucleic acid or polypeptide probes which comprises an intentionally created collection of nucleic acid or polypeptide probes of any length spotted onto a substrate/solid support. The person skilled in the art knows a collection of nucleic acids or polypeptide spotted onto a substrate/solid support also under the term"array". As known to the person skilled in the art, a microarray usually refers to a miniaturised array arrangement, with the probes being attached to a density of at least about 10,20, 50,100 nucleic acid molecules referring to different or the same genes per cm2. Furthermore, where appropriate an array can be referred to as"gene chip". The array itself can have different formats, e. g. libraries of soluble probes or libraries of probes tethered to resin beads, silica chips, or other solid supports.

The process of array fabrication is well-known to the person skilled in the art. In the following, the process for preparing a nucleic acid array is described.

Commonly, the process comprises preparing a glass (or other) slide (e. g. chemical treatment of the glass to enhance binding of the nucleic acid probes to the glass surface), obtaining DNA sequences representing genes of a genome of interest, and spotting sequences these sequences of interest onto glass slide. Sequences of interest can be obtained via creating a cDNA library from an mRNA source or by using publicly available databases, such as GeneBank, to annotate the sequence information of custom cDNA libraries or to identify cDNA clones from previously prepared libraries. Generally, it is recommendable to amplify obtained sequences by PCR in order to have sufficient amounts of DNA to print on the array. The liquid containing the amplified probes can be deposited on the array by using a set of microspotting pins. Ideally, the amount deposited should be uniform. The process can further include UV-crosslinking in order to enhance immobilization of the probes on the array.

In a preferred embodiment, the array is a high density oligonucleotide (oligo) array using a light-directed chemical synthesis process, employing the so-called photolithography technology. Unlike common cDNA arrays, oligo arrays (according to the Affymetrix technology) use a single-dye technology. Given the sequence information of the markers, the sequence can be synthesized directly onto the array, thus, bypassing the need for physical intermediates, such as PCR products, required for making cDNA arrays. For this purpose, the marker, or partial sequences thereof, can be represented by 14 to 20 features, preferably by less than 14 features, more preferably less than 10 features, even more preferably by 6 features or less, with each feature being a short sequence of nucleotides (oligonucleotide), which is a perfect match (PM) to a segment of the respective gene. The PM oligonucleotide are paired with mismatch (MM) oligonucleotides which have a single mismatch at the central base of the nucleotide and are used as "controls". The chip exposure sites are defined by masks and are deprotected by the use of light, followed by a chemical coupling step resulting in the synthesis of one nucleotide. The masking, light deprotection, and coupling process can then be repeated to synthesize the next nucleotide, until the nucleotide chain is of the specified length.

Advantageously, the method of the present invention is carried out in a robotics system including robotic plating and a robotic liquid transfer system, e. g. using microfluidics, i. e. channelled structured.

A particular preferred method according to the present invention is as follows: 1. Obtaining a sample, e. g. bone marrow or peripheral blood aliquots, from a patient having AML 2. Extracting RNA, preferably mRNA, from the sample 3. Reverse transcribing the RNA into cDNA 4. In vitro transcribing the cDNA into cRNA 5. Fragmenting the cRNA 6. Hybridizing the fragmented cRNA on standard microarrays 7. Determining hybridization In another embodiment, the present invention is directed to the use of at least one marker selected from the markers identifiable by their Affymetrix Identification Numbers (affy id) as defined in Tables 1, and/or 2 for the manufacturing of a diagnostic for distinguishing AML subtypes with recurring genetic aberrations t (8; 21), t (15 ; 17), t (l lq23)/MLL, inv (3) /t (3; 3), inv (16), AMLkomplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q). The use of the present invention is particularly advantageous for distinguishing AML subtypes with recurring genetic aberrations t (8; 21), t (15 ; 17), t (llq23)/MLL, inv (3) /t (3; 3), inv (16), AMLkomplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q) in an individual having AML. The use of said markers for diagnosis of AML subtypes with recurring genetic aberrations t (8; 21), t (15 ; 17), t (llq23)/MLL, inv (3) /t (3; 3), inv (16), AMLkomplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q), preferably based on microarray technology, offers the following advantages: (1) more rapid and more precise diagnosis, (2) easy to use in laboratories without specialized experience, (3) abolishes the requirement for analyzing viable cells for chromosome analysis (transport problem), and (4) very experienced hematologists for cytomorphology and cytochemistry, immunophenotyping as well as cytogeneticists and molecularbiologists are no longer required.

Accordingly, the present invention refers to a diagnostic kit containing at least one marker selected from the markers identifiable by their Affymetrix Identification Numbers (affy id) as defined in Tables 1, and/or 2 for distinguishing AML subtypes with recurring genetic aberrations t (8; 21), t (15 ; 17), t (llq23)/MLL, inv (3) /t (3; 3), inv (16), AML komplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q), in combination with suitable auxiliaries.

Suitable auxiliaries, as used herein, include buffers, enzymes, labelling compounds,

and the like. In a preferred embodiment, the marker contained in the kit is a nucleic acid molecule which is capable of hybridizing to the mRNA corresponding to at least one marker of the present invention. Preferably, the at least one nucleic acid molecule is attached to a solid support, e. g. a polystyrene microtiter dish, nitrocellulose membrane, glass surface or to non-immobilized particles in solution.

In another preferred embodiment, the diagnostic kit contains at least one reference for an AML subtype with recurring genetic aberrations selected from t (8; 21), t (15 ; 17), t (llq23)/MLL, inv (3) /t (3; 3), inv (16), AMLkomplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q). As used herein, the reference can be a sample or a data bank.

In another embodiment, the present invention is directed to an apparatus for distinguishing AML subtypes with recurring genetic aberrations t (8; 21), t (15 ; 17), t (llq23)/MLL, inv (3) /t (3; 3), inv (16), AML komplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q) in a sample, containing a reference data bank obtainable by comprising (a) compiling a gene expression profile of a patient sample by determining the expression level at least one marker selected from the markers identifiable by their Affymetrix Identification Numbers (affy id) as defined in Tables 1, and/or 2, and (b) classifying the gene expression profile by means of a machine learning algorithm.

According to the present invention, the"machine learning algorithm"is a computational-based prediction methodology, also known to the person skilled in the art as"classifier", employed for characterizing a gene expression profile. The signals corresponding to a certain expression level which are obtained by the microarray hybridization are subjected to the algorithm in order to classify the expression profile. Supervised learning involves"training"a classifier to recognize the distinctions among classes and then"testing"the accuracy of the classifier on an independent test set. For new, unknown samples the classifier shall predict into which class the sample belongs.

Preferably, the machine learning algorithm is selected from the group consisting of Weighted Voting, K-Nearest Neighbors, Decision Tree Induction, Support Vector Machines (SVM), and Feed-Forward Neural Networks. Most preferably, the

machine learning algorithm is Support Vector Machine, such as polynomial kernel and Gaussian Radial Basis Function-kernel SVM models.

The classification accuracy of a given gene list for a set of microarray experiments is preferably estimated using Support Vector Machines (SVM), because there is evidence that SVM-based prediction slightly outperforms other classification techniques like k-Nearest Neighbors (k-NN). The LIBSVM software package version 2.36 was used (SVM-type: C-SVC, linear kernel (http://www. csie. ntu. edu. tw/-cjlin/libsvm/)). The skilled artisan is furthermore referred to Brown et al. , Proc. Natl. Acad. Sci. , 2000; 97: 262-267, Furey et al., Bioinformatics. 2000; 16: 906-914, and Vapnik V. Statistical Learning Theory.

New York: Wiley, 1998.

In detail, the classification accuracy of a given gene list for a set of microarray experiments can be estimated using Support Vector Machines (SVM) as supervised learning technique. Generally, SVMs are trained using differentially expressed genes which were identified on a subset of the data and then this trained model is employed to assign new samples to those trained groups from a second and different data set. Differentially expressed genes were identified applying ANOVA and t-test-statistics (Welch t-test). Based on identified distinct gene expression signatures respective training sets consisting of 2/3 of cases and test sets with 1/3 of cases to assess classification accuracies are designated. Assignment of cases to training and test set is randomized and balanced by diagnosis. Based on the training set a Support Vector Machine (SVM) model is built.

According to the present invention, the apparent accuracy, i. e. the overall rate of correct predictions of the complete data set was estimated by 10fold cross validation. This means that the data set was divided into 10 approximately equally sized subsets, an SVM-model was trained for 9 subsets and predictions were generated for the remaining subset. This training and prediction process was repeated 10 times to include predictions for each subset. Subsequently the data set was split into a training set, consisting of two thirds of the samples, and a test set with the remaining one third. Apparent accuracy for the training set was estimated by 10fold cross validation (analogous to apparent accuracy for complete set). A SVM-model of the training set was built to predict diagnosis in the independent test

set, thereby estimating true accuracy of the prediction model. This prediction approach was applied both for overall classification (multi-class) and binary classification (diagnosis X => yes or no). For the latter, sensitivity and specificity were calculated: Sensitivity = (number of positive samples predicted)/ (number of true positives) Specificity = (number of negative samples predicted)/ (number of true negatives) In a preferred embodiment, the reference data bank is backed up on a computational data memory chip which can be inserted in as well as removed from the apparatus of the present invention, e. g. like an interchangeable module, in order to use another data memory chip containing a different reference data bank.

The apparatus of the present invention containing a desired reference data bank can be used in a way such that an unknown sample is, first, subjected to gene expression profiling, e. g. by microarray analysis in a manner as described supra or in the art, and the expression level data obtained by the analysis are, second, fed into the apparatus and compared with the data of the reference data bank obtainable by the above method. For this purpose, the apparatus suitably contains a device for entering the expression level of the data, for example a control panel such as a keyboard. The results, whether and how the data of the unknown sample fit into the reference data bank can be made visible on a provided monitor or display screen and, if desired, printed out on an incorporated of connected printer.

Alternatively, the apparatus of the present invention is equipped with particular appliances suitable for detecting and measuring the expression profile data and, subsequently, proceeding with the comparison with the reference data bank. In this embodiment, the apparatus of the present invention can contain a gripper arm and/or a tray which takes up the microarray containing the hybridized nucleic acids.

In another embodiment, the present invention refers to a reference data bank for distinguishing AML subtypes with recurring genetic aberrations t (8; 21), t (15 ; 17), t (llq23)/MLL, inv (3)/t (3; 3), inv (16), AMLkomplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q) in a sample obtainable by comprising

(a) compiling a gene expression profile of a patient sample by determining the expression level of at least one marker selected from the markers identifiable by their Affymetrix Identification Numbers (affy id) as defined in Tables 1, and/or 7, and (b) classifying the gene expression profile by means of a machine learning algorithm.

Preferably, the reference data bank is backed up and/or contained in a computational memory data chip.

The invention is further illustrated in the following table and examples, without limiting the scope of the invention: TABLES 1.1-2. 78 Tables 1.1-2. 78 show AML subtype analysis of AML subtypes with recurring genetic aberrations t (8; 21), t (15 ; 17), t (llq23)/MLL, inv (3) /t (3; 3), inv (16), AMLkomplext, trisomy 8, trisomy 11, trisomy 13, monosomy 7, del (5q) and/or del (9q). The analysed markers are ordered according to their q-values, beginning with the lowest q-values.

For convenience and a better understanding, Tables 1. 1 to 2. 78 are accompanied with explanatory tables (Table 1. lA to 2. 78A) where the numbering and the Affymetrix Id are further defined by other parameters, e. g. gene bank accession number.

EXAMPLES Example 1: General experimental design of the invention and results AML is a heterogeneous disease and includes a variety of different subtypes which vary in their biology and also in their sensitivity to chemotherapy. Here, we aimed at analyzing global gene expression signatures of a comprehensive cohort of 204 AML patients with 12 different genetic aberrations. All samples were hybridized onto U133 set microarrays (Affymetrix). Differentially expressed genes were identified applying ANOVA and t-test-statistics (Welch t-test). Moreover, based on identified distinct gene expression signatures we designated respective training sets consisting of 2/3 of cases and test sets with 1/3 of cases to assess classification

accuracies. Assignment of cases to training and test set was randomized and balanced by diagnosis. Based on the training set we built a Support Vector Machine (SVM) model. First we analyzed an expanded cohort of AML with balanced chromosomal aberrations: t (8; 21) (n=25), t (15 ; 17) (n=20), t (llq23)/MLL (n=31), and inv (16) (n=25). All AML subtypes with recurrent aberrations, as classified according to the current WHO proposal, can robustly be separated by highly specific gene signatures. We observed that balanced reciprocal translocations translate into dramatic gene expression changes caused by aberrant expression of leukemia-specific fusion proteins AML1-ETO, PML-RARa, CBFß- SMMHC, as well as dysregulation of HOX gene family members induced by chimeric MLL oncogenes, respectively. SVM subtype stratification accurately predicts all 33/33 independent test cases based on a 50-gene classifier. Next, AML with inv (3) /t (3; 3) (n=18) and samples with complex aberrant karyotype (AML komplext) (n=34) were added to the cohort. In both pairwise and multiclass analyses specific expression signatures robustly distinguished inv (3) /t (3; 3) and complex aberrant karyotype cases from the other subsets. Here, the SVM was trained on 106 samples and 47/48 independent test samples were accurately diagnosed. In addition, 51 cases with rare chromosomal aberrations were analyzed: trisomy 8 (n=12), trisomy 11 (n=7), trisomy 13 (n=7), as well as monosomy 7 (n=9), del (5q) (n=7) and del (9q) (n=9). Again, SVM subset prediction accurately identified samples with balanced and complex karyotype aberrations out of this larger cohort (sensitivity: 100%). The single unbalanced abnormalities demonstrated a less accurate assignment mainly due to misclassification in- between these groups. Two del (5q) cases were classified as samples with complex aberrant karyotype, which demonstrated 5q deletions in all cases. Classification accuracy, however, may further be improved by focusing on genes located in regions with chromosomal gains or losses. It can be speculated that those rare aberrations per se are not leukemia-defining aberrations. In line with this concept, trisomy 8 and del (9q) cases can be observed in all different FAB subtypes, as well as additional aberrations accompanying balanced translocations. It is more likely that so far unknown or not explicitly analyzed molecular mutations represent primary leukemogenic alterations. In conclusion, different cytogenetic aberrations result in measurable changes in global gene expression patterns. The spectrum of differentially expressed genes ranges from dramatic changes, as observed for leukemias with disease-specific balanced chromosomal aberrations to clear but not robust signatures in AML subsets with typical but probably not disease-defining

karyotype changes. Differentially expressed genes give new insights into underlying biological features and may be exploited for diagnostic approaches.

Example 2: General materials, methods and definitions of functional annotations The methods section contains both information on statistical analyses used for identification of differentially expressed genes and detailed annotation data of identified microarray probesets.

Affymetrix Probeset Annotation All annotation data of GeneChip arrays are extracted from the NetAffx Analysis Center (internet website: www. affymetrix. com). Files for U133 set arrays, including U133A and U133B microarrays are derived from the June 2003 release.

The original publication refers to: Liu G, Loraine AE, Shigeta R, Cline M, Cheng J, Valmeekam V, Sun S, Kulp D, Siani-Rose MA. NetAffx: Affymetrix probesets and annotations. Nucleic Acids Res. 2003; 31 (1): 82-6.

The sequence data are omitted due to their large size, and because they do not change, whereas the annotation data are updated periodically, for example new information on chromomal location and functional annotation of the respective gene products. Sequence data are available for download in the NetAffx Download Center (www. affymetrix. com) Data fields: In the following section, the content of each field of the data files are described.

Microarray probesets, for example found to be differentially expressed between different types of leukemia samples are further described by additional information.

The fields are of the following types: 1. GeneChip Array Information 2. Probe Design Information 3. Public Domain and Genomic References 1. GeneChip Array Information

HG-U133 ProbeSet ID : HG-U133 ProbeSetID describes the probe set identifier. Examples are: 200007_at, 200011_s_at, 200012_x_at.

GeneChip : The description of the GeneChip probe array name where the respective probeset is represented. Examples are: Affymetrix Human Genome U133A Array or Affymetrix Human Genome U133B Array.

2. Probe Design Information Sequence Type: The Sequence Type indicates whether the sequence is an Exemplar, Consensus or Control sequence. An Exemplar is a single nucleotide sequence taken directly from a public database. This sequence could be an mRNA or EST. A Consensus sequence, is a nucleotide sequence assembled by Affymetrix, based on one or more sequence taken from a public database.

Transcript ID: The cluster identification number with a sub-cluster identifier appended.

Sequence Derived From: The accession number of the single sequence, or representative sequence on which the probe set is based. Refer to the"Sequence Source"field to determine the database used.

Sequence ID: For Exemplar sequences: Public accession number or GenBank identifier. For Consensus sequences: Affymetrix identification number or public accession number.

Sequence Source: The database from which the sequence used to design this probe set was taken.

Examples are: GenBank@, RefSeq, UniGene, TIGR (annotations from The Institute for Genomic Research).

3. Public Domain and Genomic References Most of the data in this section come from LocusLink and UniGene databases, and are annotations of the reference sequence on which the probe set is modeled.

Gene Symbol and Title: A gene symbol and a short title, when one is available. Such symbols are assigned by different organizations for different species. Affymetrix annotational data come from the UniGene record. There is no indication which species-specific databank was used, but some of the possibilities include for example HUGO: The Human Genome Organization.

MapLocation: The map location describes the chromosomal location when one is available.

UnigeneAccession : UniGene accession number and cluster type. Cluster type can be"full length"or "est", or"---"if unknown.

LocusLink: This information represents the LocusLink accession number.

Full Length Ref. Sequences: Indicates the references to multiple sequences in RefSeq. The field contains the ID and description for each entry, and there can be multiple entries per probeSet.

Example 3: Sample preparation, processing and data analysis Method 1: Microarray analyses were performed utilizing the GeneChip System (Affymetrix, Santa Clara, USA). Hybridization target preparations were performed according to recommended protocols (Affymetrix Technical Manual). In detail, at time of diagnosis, mononuclear cells were purified by Ficoll-Hypaque density centrifugation. They had been lysed immediately in RLT buffer (Qiagen, Hilden, Germany), frozen, and stored at-80°C from 1 week to 38 months. For gene expression profiling cell lysates of the leukemia samples were thawed,

homogenized (QIAshredder, Qiagen), and total RNA was extracted (RNeasy Mini Kit, Qiagen). Subsequently, 5-10 ug total RNA isolated from 1 x 107 cells was used as starting material for cDNA synthesis with oligo [ (dT) 24T7promotor] 65 primer (cDNA Synthesis System, Roche Applied Science, Mannheim, Germany). cDNA products were purified by phenol/chlorophorm/IAA extraction (Ambion, Austin, USA) and acetate/ethanol-precipitated overnight. For detection of the hybridized target nucleic acid biotin-labeled ribonucleotides were incorporated during the following in vitro transcription reaction (Enzo BioArray HighYield RNA Transcript Labeling Kit, Enzo Diagnostics). After quantification by spectrophotometric measurements and 260/280 absorbance values assessment for quality control of the purified cRNA (RNeasy Mini Kit, Qiagen), 15 ug cRNA was fragmented by alkaline treatment (200 mM Tris-acetate, pH 8.2/500 mM potassium acetate/150 mM magnesium acetate) and added to the hybridization cocktail sufficient for five hybridizations on standard GeneChip microarrays (300 ul final volume). Washing and staining of the probe arrays was performed according to the recommended Fluidics Station protocol (EukGE-WS2v4). Affymetrix Microarray Suite software (version 5.0. 1) extracted fluorescence signal intensities from each feature on the microarrays as detected by confocal laser scanning according to the manufacturer's recommendations.

Expression analysis quality assessment parameters included visiual array inspection of the scanned image for the presence of image artifacts and correct grid alignment for the identification of distinct probe cells as well as both low 3'/5' ratio of housekeeping controls (mean: 1.90 for GAPDH) and high percentage of detection calls (mean: 46.3% present called genes). The 3'to 5'ratio of GAPDH probesets can be used to assess RNA sample and assay quality. Signal values of the 3'probe sets for GAPDH are compared to the Signal values of the corresponding 5'probe set. The ratio of the 3'probe set to the 5'probe set is generally no more than 3.0. A high 3'to 5'ratio may indicate degraded RNA or inefficient synthesis of ds cDNA or biotinylated cRNA (GeneChip Expression Analysis Technical Manual, www. affymetrix. com). Detection calls are used to determine whether the transcript of a gene is detected (present) or undetected (absent) and were calculated using default parameters of the Microarray Analysis Suite MAS 5.0 software package.

Method 2: Bone marrow (BM) aspirates are taken at the time of the initial diagnostic biopsy and remaining material is immediately lysed in RLT buffer (Qiagen), frozen and stored at-80 C until preparation for gene expression analysis. For microarray analysis the GeneChip System (Affymetrix, Santa Clara, CA, USA) is used. The targets for GeneChip analysis are prepared according to the current Expression Analysis. Briefly, frozen lysates of the leukemia samples are thawed, homogenized (QIAshredder, Qiagen) and total RNA extracted (RNeasy Mini Kit, Qiagen). Normally 10 ug total RNA isolated from 1 x 107 cells is used as starting material in the subsequent cDNA-Synthesis using Oligo-dT-T7-Promotor Primer (cDNA synthesis Kit, Roche Molecular Biochemicals). The cDNA is purified by phenol-chlorophorm extraction and precipitated with 100% Ethanol over night. For detection of the hybridized target nucleic acid biotin-labeled ribonucleotides are incorporated during the in vitro transcription reaction (Enzo (g) BioArray HighYieldTM RNA Transcript Labeling Kit, ENZO). After quantification of the purified cRNA (RNeasy Mini Kit, Qiagen), 15 ug are fragmented by alkaline treatment (200 mM Tris-acetate, pH 8.2, 500 mM potassium acetate, 150 mM magnesium acetate) and added to the hybridization cocktail sufficient for 5 hybridizations on standard GeneChip microarrays. Before expression profiling Test3 Probe Arrays (Affymetrix) are chosen for monitoring of the integrity of the cRNA. Only labeled cRNA-cocktails which showed a ratio of the messured intensity of the 3'to the 5'end of the GAPDH gene less than 3.0 are selected for subsequent hybridization on HG-U133 probe arrays (Affymetrix). Washing and staining the Probe arrays is performed as described (siehe Affymetrix-Original- Literatur (LOCKHART und LIPSHUTZ). The Affymetrix software (Microarray Suite, Version 4.0. 1) extracted fluorescence intensities from each element on the arrays as detected by confocal laser scanning according to the manufacturers recommendations.

Table 1 1. One-Versus-All (OVA) 1.1 AML_+11 versus rest affy id HUGO name fc p q stn t Map Location 1230322at NFAM1-2.92 8. 18E-139. 71E-11-1. 11-16.21 22q13. 2 2 221002_s_at DC-TM4F2-2.12 1. 17E-21 9. 58E-19-0.93-15. 80 10q22. 3 3 242345_at -4. 42 9. 66E-21 6. 27E-18-0.92-15. 55 4 240389_at TRPM6-4.86 4. 21 E-34 2. 33E-30-0.81-15. 01 9q21. 13 5207430sat MSMB-4.58 1. 05E-36 2. 32E-32-0. 79-14.83 10q11. 2 6210042sat CTSZ-3.34 2. 62E-20 1. 45E-17-0.82-14. 10 20q13 7200923at LGALS3BP-7. 36 6. 85E-36 7. 56E-32-0.73-14. 01 17q25 8229168at DKFZp434K0621-2. 99 6. 64E-28 1. 63E-24-0.77-14. 00 5q35. 3 9230495at LOC150568-4.39 8. 51E-21 5. 87E-18-0.80-13. 90 2q12. 1 10 216413_at -4. 65 1. 42E-34 1. 05E-30-0.73-13. 79 11 219505_at CECR1-5.06 1. 53E-18 6. 04E-16-0.82-13. 79 22q11. 2 12 208438_s_at FGR-5.11 1. 44E-20 8. 62E-18-0.79-13. 67 1p36. 2-p36.1 13 242574_at KIAA0674 -4. 29 6. 59E-25 1.21E-21 -0. 76-13.61 9q32 14231514_at MGC15882-2.20 4. 17E-16 9.21E-14 -0. 81-13. 37 1p34. 3 15 225065_x_at MGC40157-3.29 2. 91E-16 6. 68E-14-0.81-13. 36 17p11. 2 16238730_at ARHGEF11-3.68 6. 35E-12 5. 97E-10-0.89-13. 35 1q21 17 217528_at CLCA2-4.95 4. 87E-23 5.11E-20 -0. 75-13.34 1p31-p22 18 218389_s_at APH-1A -1. 93 2. 30E-08 8. 50E-07-1.07-13. 16 1p36. 13-q31. 3 19 222134 at DDO-5.63 5. 80E-29 1. 78E-25-0.71-13. 14 6q21 20230343_at-5. 48 1. 50E-16 3. 72E-14-0.79-13. 10 21 240419_at-2. 48 1. 00E-29 3. 68E-26-0.69-13. 01 22 239023_at AF1Q -2. 77 2. 05E-16 4. 97E-14-0.78-12. 99 1q21 23 202878_s_at C1QR1 -6. 61 3. 64E-20 1. 91E-17-0.74-12. 96 20p11. 21 24238209at-3. 13 4. 22E-13 5.11E-11 -0. 82-12.77 25210248_at WNT7A-3.15 5. 95E-15 1. 10E-12-0. 78-12. 76 3p25 26 232464_at TRIMP1-1. 74 8. 28E-12 7. 62E-10-0.84-12. 76 11p15 27 223794_at DKFZP434P1735 -3. 98 3. 28E-13 4. 09E-11-0. 80-12.64 10p12. 1 28 241339_at -4. 01 5.04E-30 2.22E-26-0. 66-12.52 29 206325_at SERPINA6-2. 41 1. 37E-23 1. 90E-20-0.69-12. 52 14q32.1 30 203798_s_at VSNL1-4.56 3. 18E-24 5.41E-21 -0. 68-12.48 2p24.3 31 211743_s_at PRG2-14.31 6. 44E-29 1.78E-25-0. 65-12.32 11q12 32233705at-2. 36 1. 03E-12 1. 16E-10-0.78-12. 29 33 215112_x_at KIAA0861 -9. 64 5. 33E-22 4. 90E-19-0.68-12. 21 3q27.3 34219085sat GEM) N7-3. 40 2. 12E-09 1. 03E-07-0.87-12. 0619q13. 32 35 203561_at FCGR2A-5.57 1. 92E-22 1. 93E-19-0.66-12. 03 1q23 36221879_at MGC4809-4.75 1. 34E-16 3.36E-14 -0. 71-11. 9915q22. 2 37 242767_at -2. 68 7. 13E-11 5. 20E-09-0.80-11. 96 38 206244_at CR1-10.09 1. 39E-21 1. 10E-18-0.66-11. 96 1q32 39 228519_x_at CIRBP -1. 69 1. 39E-09 7. 26E-08-0.85-11. 94 19p13. 3 40244413_at DCAL1-6. 25 4. 78E-24 7. 54E-21-0.65-11. 94 12p13. 2 41 224132_at MGC13008-1. 70 2. 14E-08 8. 02E-07-0.92-11. 91 17p11. 2 42 224356 x at MS4A6A-5.50 5. 32E-14 7. 57E-12-0.73-11. 89 11q12. 1 43228367_at HAK-1.84 2. 20E-14 3. 48E-12-0.72-11. 87 18q21. 31 44202295sat CTSH-6.18 1. 12E-18 4. 48E-16-0.67-11. 82 15q24-q25 45235565at LOC155054-3. 99 2. 18E-19 1. 05E-16-0.67-11. 81 7q36.1 46 223816_at TSCOT-4.67 1. 24E-25 2. 48E-22-0.63-11. 79 9q32 47 241234_at -1. 88 8.41 E-09 3.50E-07-0. 88-11.78 48 243745_at -1. 80 5. 09E-17 1. 40E-14-0.68-11. 76 49 221541_at DKFZP434B044 -4. 02 1. 07E-25 2. 36E-22-0.63-11. 74 16q24. 1 50205055_at ITGAE-1. 95 1. 59E-07 4. 55E-06-0.99-11. 73 17p13 1.2 AML_+13 versus rest &num affy id HUGO name fc p q stn t Map Location 1 203949_at MPO-13.86 7. 08E-41 1. 05E-36-1.16-21. 01 17q23.1 2 203948_s_at MPO-21.66 4. 49E-50 1. 33E-45-0.98-18. 50 17q23.1 3 226141_at -5. 72 1. 33E-37 7. 90E-34-1.00-18. 26 4 224839_s_at GPT2-10.71 2. 30E-38 1. 70E-34-0.96-17. 62 16q12. 1 5222668at MGC2628-8.10 5. 68E-14 1. 57E-11-1.15-17. 15 19q13. 11 6 233255_s_at BIVM -15. 98 2. 85E-35 1. 06E-31-0.94-17. 08 13q32-q33.1 7 230206_at -10. 52 1. 31E-09 1. 62E-07-1.29-16. 15 8 203955_at KIAA0649 -8. 52 2. 19E-12 4. 56E-10-1.08-15. 71 9q34.3 9214763at THEA-4.22 6. 12E-20 3. 86E-17-0.93-15. 65 1p32. 2 10 212688_at PIK3CB-2. 94 3. 54E-13 8. 20E-11-1. 03-15.47 3q22.3 11 222664_at MGC2628-6.08 5. 03E-11 8.11E-09 -1. 11-15. 37 19q13. 11 12220416at KiAA1939-6. 01 3. 07E-16 1. 36E-13-0.96-15. 36 15q15. 3 13209739sat DXS1283E-5.27 2. 40E-31 6. 48E-28-0.84-15. 24 Xp22.3 14 205653_at CTSG-10.68 4. 15E-26 4. 24E-23-0.85-15. 13 14q11. 2 15 223319_at GPHN-14.27 3. 33E-39 3. 29E-35-0.79-14. 99 14q23.3 16 238784 at FLJ32949-6.51 7. 33E-22 5. 57E-19-0.86-14. 87 12q14. 1 17 209267_s_at BIGM103 -3. 17 8. 31E-11 1. 28E-08-1.06-14. 79 4q22-q24 18 239091_at -3. 67 4. 13E-31 1. 02E-27-0.80-14. 73 19 205780_at BIK-16. 18 1. 13E-36 4. 78E-33-0.77-14. 60 22q13. 31 20208626sat VAT1-2.81 3. 11E-13 7. 31E-11-0. 96-14.56 17q21 21217963sat NGFRAP1-9.36 3. 43E-17 1. 64E-14-0.89-14. 55 Xq22. 1 22 220773_s_at GPHN-6.77 1. 43E-09 1. 74E-07-1.10-14. 40 14q23.3 23230207sat-4. 06 2. 52E-08 2. 21 E-06-1. 21-14.31 24 242269_at DKFZp761G0122 -2. 72 9. 61 E-37 4. 75E-33-0.75-14. 29 1p36. 32 25204011_at SPRY2-7.38 2. 46E-14 7. 37E-12-0.91-14. 27 13q22.1 26204306sat CD151-6.41 1. 03E-28 1. 45E-25-0.77-14. 05 11p15. 5 27214575_s_at AZU1-11.71 6. 28E-15 2. 19E-12-0.88-14. 00 19p13. 3 28 201596 x at KRT18-10.25 1. 72E-33 5. 65E-30-0.74-13. 93 12q13 29 227711_at FLJ32942-6.06 1. 21E-13 3.13E-11 -0. 88-13. 76 12q13. 13 30206067sat WT1-21. 81 5. 56E-28 7. 48E-25-0.75-13. 70 11p13 31 209099 x at JAG1-9.11 1. 20E-17 6. 14E-15-0.82-13. 69 20p12. 1-p11. 23 32 217188_s_at C14orf1 -5. 30 3. 24E-24 2. 82E-21-0.76-13. 62 14q24.3 33205107sat EFNA4-3.91 4. 09E-14 1. 17E-11-0. 86-13. 57 1q21-q22 34 214039sat LAPTM4B-8.09 3.47E-29 6.05E-26-0. 73-13.56 8q22. 1 35 217849_s_at CDC42BPB-8.18 8. 04E-18 4. 18E-15-0.80-13. 50 14q32. 3 36 219869 s at BIGM103-3.14 9. 17E-09 8. 97E-07-1.07-13. 49 4q22-q24 37206480_at LTC4S-7.72 8. 82E-30 1. 87E-26-0.73-13. 47 5q35 38 239598_s_at FLJ20481-4.60 5. 13E-09 5. 37E-07-1.04-13. 43 16q12. 1 39 241673_x_at -5. 71 3. 14E-32 9. 29E-29-0.71-13. 40 40 219078_at FLJ10252-2.55 6. 01E-08 4. 72E-06-1.14-13. 35 1q41 41 223703_at CDA017-4.28 1. 36E-08 1. 27E-06-1.06-13. 30 10q23. 1 42 238021_s_at -7. 97 4. 82E-19 2. 86E-16-0. 78-13.30 43 232918_at -4. 27 8. 15E-29 1. 27E-25-0.71-13. 21 44 230263_s_at -4. 89 1. 04E-07 7. 57E-06-1.15-13. 17 45 238022_at -7. 44 2. 24E-20 1.51E-17 -0. 75-13.08 46 217876_at GTF3C5-3.96 2. 09E-26 2.21E-23 -0. 71-12.95 9q34 47 221848_at KIAA1847 -3. 23 1. 96E-13 4.84E-11 -0. 82-12. 95 20q13. 3 48209619_at CD74 1.68 6. 17E-08 4. 80E-06 1.07 12.80 5q32 49217975_at LOC51186-5.37 2. 75E-14 8. 08E-12-0.79-12. 79 Xq22. 1 50 227182_at MGC26847-5.02 1. 85E-17 9.27E-15 -0. 75-12.78 9q22.2 1.3 AML_+8 versus rest # affy id HUGO name fc p q stn t Map Location 1 206761_at TACTILE -6. 62 8. 85E-25 3. 36E-20-0.64-11. 75 3q13. 13 2 212259_s_at HPIP -3. 93 1. 03E-16 8. 29E-13-0.60-10. 32 1q21. 3 3 212489_at COL5A1 -5. 23 9. 15E-20 1. 74E-15-0.52-9. 799q34. 2-q34.3 4200923at LGALS3BP-4.75 1.23E-13 5. 21 E-10-0. 59-9. 74 17q25 5211907sat PARD6B-2.53 3. 99E-13 1. 52E-09-0.57-9. 42 20q13. 13 6 204116_at IL2RG -2. 42 7. 40E-11 1. 61E-07-0. 61-9. 23Xq13. 1 7235532at-4. 66 1. 92E-17 2. 44E-13-0.49-9. 16 8221286sat PACAP-6.62 1. 09E-16 8. 29E-13-0.48-8. 93 5q23-5q31 9 211743_s_at PRG2-6.67 1. 03E-12 3. 56E-09-0.54-8. 92 11q12 10 219663 s at MGC4659-2.76 6. 39E-12 2. 03E-08-0.55-8. 88 14q32. 33 11216554sat EN01-1. 47 2. 63E-09 2. 64E-06-0.64-8. 87 1 p36. 3-p36.2 12233040at-5. 25 2. 40E-16 1. 52E-12-0.46-8. 66 13 220591_s_at FLJ22843 -2. 14 5. 09E-10 7. 54E-07-0.58-8. 62 Xp11. 3 14 218731_s_at FLJ22215-3.04 1. 77E-11 4. 48E-08-0.53-8. 61 1p36. 33 15 226282_at -8. 37 9. 47E-15 5. 14E-11-0. 46-8.48 16 204468_s_at TIE -6. 64 7. 96E-11 1.61E-07 -0. 52-8. 30 1p34-p33 17205910sat CEL-3.27 1. 47E-14 6. 99E-11-0. 44-8. 21 9q34. 3 18 214436_at FBXL2-2.13 4. 23E-10 6. 70E-07-0.52-8. 13 3p22. 2 19 239933_x_at -2. 15 6. 03E-10 7. 90E-07-0.51-7. 95 20 231903_x_at KIAA1501 -2. 29 7. 97E-09 6. 06E-06-0.55-7. 94 17q21. 1 21 238726at-2. 14 2.78E-09 2.71 E-06-0.53-7. 94 22 221525_at DKFZp76112123 -1. 78 1. 55E-10 2.81E-07 -0. 48-7. 84 7p12. 3 23 216412_x_at IGL -2. 72 1. 52E-08 9. 98E-06-0.54-7. 75 22q11.1-q11. 2 24237216at-3. 18 5. 91 E-09 4. 88E-06-0.52-7. 73 25 219553_at NME7-1.59 1. 48E-08 9. 90E-06-0.52-7. 64 1q24 26 39549_at NPAS2-2.39 7. 11E-122. 08E-08-0.43-7. 60 2q11. 2 27225406at TWSG1-1.97 2. 02E-07 7. 39E-05-0.59-7. 59 18p11. 3 28209618_at CTNND2-1.94 9. 66E-10 1.11E-06 -0. 47-7. 59 5p15. 2 29 216017_s_at NAB2-2.34 3. 79E-10 6. 26E-07-0. 46-7. 57 12q13. 3-q14. 1 30 220333_at FLJ20190-2.24 9. 06E-12 2. 46E-08-0.43-7. 56 15q22. 31 31 203329_at PTPRM-3.48 2. 56E-10 4. 43E-07-0.45-7. 54 18p11. 2 32 210576_at CYP4F8-2.20 4. 50E-11 1. 07E-07-0.44-7. 53 19p13. 1 33 239594_at -2. 25 5.28E-10 7.54E-07-0. 45-7.48 34 225238_at-2. 92 2. 47E-08 1. 48E-05-0.51-7. 47 35 228907 at-2. 84 1. 27E-09 1. 42E-06-0.46-7. 44 36201379sat TPD52L2-1.81 1. 70E-08 1. 08E-05-0.49-7. 3720q13. 2-q13. 3 37 209365_s_at ECM1-1.98 5. 24E-09 4. 53E-06-0.47-7. 37 1q21 38 226807_at FLJ34243-1.78 7. 74E-07 2. 37E-04-0.62-7. 37 16q22. 3 39 214029_at-2. 66 1. 15E-08 8. 09E-06-0.49-7. 37 40 243579_at MSI2 -3. 14 9.09E-08 4.03E-05-0. 53-7.35 17q23.1 41 221948_s_at FLJ14360 -1. 69 8. 03E-111. 61E-07-0. 42-7. 28 22q11. 21 42 218999_at FLJ11000 -1. 78 2. 08E-07 7. 55E-05-0.54-7. 25 7q33 43 214177_s_at HPIP -1. 74 1. 04E-06 2. 81E-04-0. 60-7. 18 1q21. 3 44 208457 at GABRD-2.13 9. 01E-08 4.03E-05-0. 51-7. 171p36. 3 45 209911_x_at HIST1H2BD -1. 80 1. 05E-07 4. 43E-05-0.51-7. 16 6p21. 3 46 225889_at MGC17922 -1. 58 1. 17E-06 3.00E-04 -0. 60-7. 13 12p12. 3 47 206539_s_at CYP4F12 -1. 89 9. 09E-10 1. 08E-06-0.42-7. 09 19p13. 1 48220240sat C13orf11-1. 84 1. 27E-06 3. 20E-04-0.59-7. 0713q34 49 232129_s_at KIAA1813 -2. 76 8. 54E-10 1. 05E-06-0.42-7. 06 10q24 50 211071_s_at AF1Q -2. 24 5. 99E-07 1.91E-04 -0. 54-7. 00 1q21 1.4 AML_-7 versus rest # affy id HUGO name fc p q stn t Map Location 1 225002_s_at DKFZP566I1024 -2. 98 2. 48E-13 2. 24E-10-1.29-17. 63 7q11. 1 2226032at CASP2-2.21 7. 42E-16 1. 12E-12-1.16-17. 29 7q34-q35 3 200976_s_at TAX1BP1 -1. 89 3. 06E-12 1. 72E-09-1.32-17. 23 7p15 4213780at THH-4. 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75E-06-1.06-12. 25 7p15-p14 21 214473 x at PMS2L9-1.94 1. 41E-08 2. 79E-06-1.05-12. 13 7q11. 23 22226386at LOC115416-2. 21 3. 18E-09 7. 65E-07-0.97-12. 12 7p15. 3 23 222512_at NYREN18-1.85 1. 81E-10 5. 88E-08-0.89-12. 11 7q36 24 212068_s_at KIAA0515 -4. 86 4. 55E-28 3. 59E-24-0.64-12. 07 9q34.2 25209036sat MDH2-1.88 3. 96E-08 6.51E-06 -1. 10-12.03 7p12. 3-q11. 2 26 225932_s_at -1. 85 5. 79E-08 8. 86E-06-1.13-12. 02 27226364at-4. 69 8. 06E-17 1. 50E-13-0. 72-12.01 28201317sat PSMA2-1.67 3. 46E-08 5. 78E-06-1.07-11. 91 7p13 29225762xat-4. 00 6. 53E-15 8. 96E-12-0.72-11. 75 30 200977 s at TAX1 BP1-2. 13 8. 44E-08 1. 19E-05-1.12-11. 74 7p15 31 214351 x at RPL13 1.39 1. 07E-07 1. 40E-05 1.14 11.72 16q24.3 32201327sat CCT6A-1.96 6. 45E-08 9. 51 E-06-1. 09-11. 71 7p11. 1 33 218321_x_at MK-STYX-2.56 4. 38E-08 7. 15E-06-1.04-11. 63 7qu 1. 23 34 217485_x_at PMS2L1 -2. 08 1. 63E-07 1. 97E-05-1.16-11. 60 7q11-q22 35 225556_at LOC203547-1.83 1. 75E-08 3. 37E-06-0.96-11. 42 Xq28 36 219041_s_at RIP60 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Location 1 230872_s_at DKFZP434B103 -5. 94 3. 99E-39 1. 41E-34-1. 01-18.36 3p25.3 2224916at-3. 51 4. 18E-22 3. 69E-18-1.09-18. 20 3 217379_at-2. 09 1. 50E-17 4. 42E-14-1.01-16. 38 4205382sat DF-5.88 2. 32E-14 3. 85E-11-0. 98-15. 17 19p13. 3 5 216032_s_at SDBCAG84-2.84 3. 93E-11 3. 96E-08-0.97-13. 90 20pter-q12 6205366sat HOXB6-25.16 5. 77E-34 1. 02E-29-0.71-13. 51 17q21. 3 7 236091_at -3. 10 3. 79E-10 2. 84E-07-0.91-12. 84 8238021sat-6. 52 6. 09E-15 1. 40E-11-0. 74-12.20 9 238951_at -4. 84 5. 01 E-17 1. 36E-13-0.70-11. 95 10211922sat CAT-3.55 1. 26E-21 7. 42E-18-0.66-11. 88 11p13 11 200982_s_at ANXA6-3.32 2. 73E-10 2. 09E-07-0.81-11. 83 5q32-q34 12 228526at-3. 01 1.40E-07 4.71 E-05-0.98-11. 72 13 215955_x_at GRAF-5.09 7. 22E-23 8. 49E-19-0.64-11. 67 5q31 14 206967_at CCNT1 -2. 19 2. 26E-14 3. 85E-11-0. 70-11.62 12pter-qter 15223696at-2. 76 5.70E-10 3.87E-07-0. 78-11.40 16 202593_s_at MIR16 -1. 92 1. 24E-09 7. 79E-07-0. 78-11. 25 16p12-p11. 2 17231600at-6. 08 8. 00E-21 4. 03E-17-0.61-11. 15 18 228904_at -4. 89 4. 13E-19 1. 46E-15-0.61-10 : 96 19 201635_s_at FXR1-2.38 3. 32E-09 1. 77E-06-0.76-10. 87 3q28 20 215559_at ABCC6-3.76 2. 75E-19 1.08E-15 -0. 59-10.69 16p13. 1 21 208717_at OXA1L -1. 85 1. 04E-06 2. 70E-04-0.96-10. 66 14q11. 2 22236892sat-7. 71 7. 26E-18 2. 33E-14-0.58-10. 47 23208629sat HADHA-2.12 1. 84E-08 8. 40E-06-0.76-10. 45 2p23 24 220119_at EPB41L4A -2. 27 1. 62E-20 7. 15E-17-0.55-10. 32 5q22.1 25 212009_s_at STIP1 -6. 51 1. 13E-21 7. 42E-18-0.54-10. 30 11q13 26 233825 s at CD99L2-2.99 3. 42E-07 1. 02E-04-0.83-10. 26 Xq28 27 224175_s_at TRIM34 -3. 16 1. 52E-14 2. 98E-11-0. 60-10.22 11p15 28 244548_at -3. 71 9. 68E-11 8. 33E-08-0.65-10. 20 29 205899_at CCNA1 -5. 89 7. 88E-15 1.64E-11 -0. 59-10.13 13q12. 3-q13 30 200751 s at HNRPC-2.64 1. 21E-10 9.96E-08 -0. 63-9. 94 14q11. 1 31227056at-1. 82 8. 63E-07 2. 32E-04-0.82-9. 85 32226840at-1. 75 4. 36E-09 2. 26E-06-0.66-9. 76 33 211016_x_at HSPA4-1.63 1. 09E-06 2.81E-04 -0. 82-9. 71 5q31. 1-q31. 2 34 207293_s_at AGTR2-2.25 1. 50E-09 8. 96E-07-0.63-9. 62 Xq22-q23 35 200764_s_at CTNNA1 -1. 88 1. 52E-06 3.65E-04 -0. 81-9.55 5q31 36 239791_at -6. 76 4. 64E-12 5. 64E-09-0.57-9. 48 37202113sat SNX2-2.07 3. 34E-06 6. 76E-04-0.86-9. 47 5q23 38210213sat ITGB4BP-1.76 1. 34E-06 3. 36E-04-0.78-9. 37 20q12 39 231736_x_at MGST1-3.07 5. 68E-06 1.01E-03 -0. 86-9. 24 12p12. 3-p12. 1 40 205883 at ZNF145-2.38 9. 25E-08 3. 26E-05-0.67-9. 23 11q23. 1 41 208967_s_at AK2-1.93 1. 66E-08 7. 69E-06-0.63-9. 22 1p34 42 231175_at FLJ30162-4.73 6. 91E-12 8. 13E-09-0.54-9. 08 6p11. 1 43 202444_s_at KEO4 -1. 68 6. 18E-11 5. 74E-08-0.55-9. 06 10q21-q22 44206380sat PFC-4.65 3. 12E-08 1.31E-05 -0. 63-9. 04 Xp11.3-p11. 23 45 230757_at -3. 21 2. 13E-09 1. 19E-06-0. 58-9.00 46 205048_s_at PSPHL-5.70 2. 00E-14 3. 71E-11-0.50-8. 96 7q11. 2 47 238022at-4. 98 9.87E-08 3.45E-05-0. 64-8.96 48 208843_s_at GORASP2 1.53 3. 05E-05 3. 97E-03 1.04 8. 94 2p24. 3-q21. 3 49 232979_at -2. 92 1.68E-09 9.73E-07-0. 57-8.93 50 231740_at KCNJ11 -2. 89 7. 36E-13 9. 99E-10-0.51-8. 92 11p15. 1 1.6 AML_9q versus rest # affy id HUGO name fc p q stn t Map Location 1223865at SOX6-3.06 3. 52E-14 3. 43E-11-1. 03-15.23 11p15. 3 2 239856_at -3. 30 1. 11E-19 7.30E-16-0. 70-12.10 3214842sat ALB-3.21 1. 04E-16 1. 83E-13-0. 67-11. 33 4q11-q13 4236666sat-2. 91 2. 83E-18 7.47E-15 -0. 65-11.32 5 230778_at -5. 33 4. 27E-19 1. 61E-15-0. 64-11.32 6 229836_s_at NUDT4-3.95 1. 56E-13 1. 29E-10-0.71-11. 28 7244266at AKR1C1-2. 68 3. 91E-18 8. 59E-15-0.65-11. 26 10p15-p14 8 230311_s_at PRDM6-2.76 5. 89E-18 1. 19E-14-0.64-11. 11 5q23. 2 9 228119_at MGC4126-2.97 5. 72E-20 5. 02E-16-0.62-11. 103q29 10240464at-2. 14 1. 30E-10 3. 44E-08-0.77-11. 07 11 232553_at PCYT1B -4. 34 1. 35E-11 5. 72E-09-0.72-10. 91 Xp22. 12 12 236584_at -2. 58 3. 09E-19 1.36E-15 -0. 61-10.88 13 210960 at ADRA1D-2. 99 1. 29E-20 1. 70E-16-0.59-10. 78 20p13 14 237401_at ACTN1-2.13 8. 84E-11 2. 53E-08-0.73-10. 74 14q24 15230249_at KHDRBS3-5.88 9. 19E-23 2. 42E-18-0.57-10. 73 8q24.2 16 208639_x_at P5 1.74 1. 71E-07 1. 52E-05 0.99 10.71 2p25.1 17 228784_at -2. 87 1. 40E-16 2.31E-13 -0. 60-10.49 18234703at HHLA3-3.36 4. 22E-14 3. 97E-11-0. 63-10. 39 1p31. 1 19 217328_at TRB-3.21 1. 66E-11 6. 74E-09-0. 67-10. 28 7q34 20 231473_at -3. 42 8. 78E-13 5.51E-10 -0. 64-10.26 21 205561_at FLJ12242-2.30 3. 81E-10 8. 88E-08-0.69-10. 08 22q13. 1 22 229636_at RAB7-2.64 7. 04E-19 2. 32E-15-0.55-10. 05 3q21. 3 23 237767_at -3. 31 2. 18E-14 2. 39E-11-0. 59-10.04 24 241575_at -2. 79 2. 07E-12 1. 09E-09-0.62-9. 96 25222565sat PRKCN-4.89 9. 20E-19 2. 69E-15-0.54-9. 94 2p21 26239828at FLJ25791-2.59 1. 65E-12 9. 25E-10-0.61-9. 94 6q21 27 232651_at -3. 30 2. 47E-11 9. 44E-09-0.64-9. 91 28 240539_at -2. 83 5.42E-09 8.76E-07-0. 72-9.89 29209488sat RBPMS-10.53 1. 82E-19 9. 59E-16-0.53-9. 83 8p12-p11 30207470at DKFZp566H0824-3. 34 1. 32E-09 2. 56E-07-0.68-9. 77 1p36. 22 31 214899_at LOC284323-5.03 6. 33E-17 1. 19E-13-0.54-9. 72 19q13. 13 32 232869_at SRGAP2-2.25 1. 12E-15 1. 55E-12-0.55-9. 64 3p25. 3 33 230939_at-2. 21 4.39E-07 3.18E-05-0. 88-9.64 34 229413_s_at RNF3-1.90 6. 50E-08 6. 77E-06-0.77-9. 64 4pu6. 3 35 237018_at -3. 02 4.05E-08 4. 51 E-06-0. 75-9.63 36 204073_s_at C11orf9 -3. 90 8. 04E-09 1. 22E-06-0.70-9. 63 11q12-q13. 1 37 235742_at ARHC-2.97 5. 54E-09 8. 89E-07-0.68-9. 54 1p13. 1 38239477_at FLJ25200-3.92 1. 10E-13 9. 34E-11-0. 56-9. 51 3p24. 3 39 208105_at GIPR -2. 71 7. 39E-15 8. 85E-12-0.54-9. 48 19q13. 3 40 214217_at -3. 53 1. 54E-10 4. 03E-08-0.62-9. 48 41 232444_at -3. 58 1. 97E-13 1. 53E-10-0.56-9. 46 42201011_at RPN1 1.61 1. 99E-06 1. 05E-04 1.00 9. 45 3q21. 3-q25.2 43 242056_at TRIM45 -1. 89 1. 59E-08 2. 15E-06-0.70-9. 41 1p11. 2 44 241256_at -3. 50 6. 45E-09 1. 02E-06-0.67-9. 38 45 229011_at -2. 57 2. 34E-09 4. 12E-07-0.65-9. 35 46 217240_at POLR2L-2.12 1. 15E-09 2. 23E-07-0.63-9. 34 11p15 47227145_at LOXL4-1.49 3. 84E-12 1. 87E-09-0. 57-9. 32 10q24 48229280sat-3. 15 8. 07E-09 1. 22E-06-0.67-9. 30 49 209487_at RBPMS-5.88 3. 66E-18 8. 59E-15-0.49-9. 29 8p12-p11 50 229661_at SALL4-2.30 5. 65E-14 5.13E-11 -0. 54-9. 27 20q13.13-q13. 2 1.7 AML MLL versus rest # affy id HUGO name fc p q stn t Map Location 1 226517_at BCAT1-7.92 4.24E-45 9.33E-41-0. 90-16.80 12pter-q12 2 211137_s_at ATP2C1 -2. 18 2. 96E-37 1. 08E-33-0.88-15. 91 3q21-q24 3 225344_at ERAP140-3. 74 2. 17E-38 9. 55E-35-0.87-15. 87 6q22. 33 4 202746_at ITM2A -7. 69 8. 60E-39 4. 73E-35-0.83-15. 45 Xq13. 3-Xq21. 2 5 213258_at -8. 23 1. 36E-40 1. 50E-36-0. 80-15. 25 6 205453_at HOXB2-7.90 4. 90E-34 1. 35E-30-0.85-15. 22 17q21-q22 7201830saut NET1-3.58 3. 05E-31 6. 10E-28-0.87-15. 11 10p15 8205624at CPA3-11.61 6. 88E-40 5. 05E-36-0.79-15. 01 3q21-q25 9 202747_s_at ITM2A -7. 72 1. 88E-33 4. 60E-30-0.79-14. 40 Xq13. 3-Xq21. 2 10220306_at FLJ20202-3.63 8. 77E-30 1. 13E-26-0.81-14. 261p11. 1 11 213549_at PRO2730 -3. 09 1. 26E-30 2. 14E-27-0.78-14. 00 3p21. 31 12 206761_at TACTILE -11. 44 2. 73E-35 8. 57E-32-0.74-13. 91 3q13. 13 13 201829_at NET1-2.35 1. 51E-26 1. 23E-23-0.79-13. 55 10p15 14225831_at LOC148894-3.03 2. 13E-24 1. 15E-21-0.81-13. 41 1p36. 11 15 214390 s at BCAT1-6.16 2. 33E-30 3. 66E-27-0.73-13. 36 12pter-q12 16208116sat MAN1A1-3. 78 5. 01E-30 6.89E-27 -0. 73-13. 29 6q22 17225285_at-6. 52 9. 51E-26 6. 16E-23-0.77-13. 24 18 200923_at LGALS3BP-6.84 2. 29E-32 5. 05E-29-0.69-13. 14 17q25 19 225532 at LOC91768-2.89 1. 92E-28 2. 22E-25-0.73-13. 09 18q11. 1 20221760at MAN1A1-5. 00 4. 20E-31 7. 70E-28-0.70-13. 06 6q22 21 219188 s at LRP16-3.36 3. 53E-26 2. 68E-23-0.74-13. 00 11q11 22218966at MY05C-2. 29 2. 55E-24 1. 28E-21-0.75-12. 77 15q21 23 236513_at -2. 52 2. 07E-25 1. 27E-22-0.72-12. 63 24210365at RUNX1-2. 85 8. 39E-27 7. 69E-24-0.70-12. 61 21q22. 3 25205601sat HOXB5-2. 48 3. 42E-29 4. 18E-26-0.67-12. 60 17q21. 3 26 227297_at -7. 49 3. 11 E-30 4. 57E-27-0.66-12. 60 27 203544 s at STAM-2.75 2. 02E-21 7. 95E-19-0.77-12. 46 10p14-p13 28 204951_at ARHH-3.48 3. 12E-21 1. 15E-18-0.76-12. 30 4p13 29231767at HOXB4-2.80 1. 63E-25 1. 02E-22-0.69-12. 28 17q21-q22 30210665_at TFPI-7. 85 2. 62E-27 2. 62E-24-0.66-12. 22 2q31-q32. 1 31 225830_at LOC118987 -2. 65 4. 43E-26 3. 14E-23-0.67-12. 22 10q26. 12 32 214452_at BCAT1 -3. 46 2. 00E-241. 10E-21-0. 68-12.11 12pter-q12 33 210664_s_at TFPI -5. 42 8. 61E-26 5. 74E-23-0.67-12. 10 2q31-q32. 1 34 226342_at -5. 00 6. 85E-27 6. 55E-24-0.65-12. 07 35 224049_at KCNK17-2. 59 9. 67E-24 4. 73E-21-0.69-12. 05 6p21. 1 36 233849_s_at ARHGAP5 -5. 71 5. 41E-23 2. 43E-20-0.70-12. 05 14q12 37219686_at HSA250839-8.00 6. 65E-28 7.31E-25 -0. 63-11. 95 4p16. 2 38 225653_at-1. 65 4. 26E-20 1. 27E-17-0.74-11. 91 39236198_at-5. 21 9. 26E-25 5. 23E-22-0.66-11. 88 40218086_at NPDC1-8.79 1. 77E-27 1. 86E-24-0.63-11. 85 9q34. 3 41 209676_at TFPI -2. 74 2. 78E-23 1. 30E-20-0.67-11. 80 2q31-q32. 1 42 210993_s_at MADH1 -5. 91 1. 51 E-26 1.23E-23-0. 63-11. 80 4q28 43 201242_s_at ATP1B1 -3. 88 2. 84E-21 1. 10E-18-0.70-11. 80 1q22-q25 44219789_at NPR3-4.88 6. 08E-26 4. 18E-23-0.64-11. 78 5p14-p13 45 227461_at STN2-3.67 1. 44E-26 1. 23E-23-0.62-11. 73 14q31. 1 46242051 at-2. 99 7. 57E-23 3. 27E-20-0.66-11. 66 47 220104 at ZAP-2.46 8. 01 E-21 2. 80E-18-0.70-11. 64 7q34 48207850_at CXCL3-7.95 2. 86E-26 2. 25E-23-0.61-11. 534q21 49232424at PRDM16-10.91 4. 32E-26 3. 14E-23-0.61-11. 49 1p36. 23-p33 50 236251_at -3. 66 1. 38E-22 5. 83E-20-0.65-11. 45 1.8 AML inv (16) versus rest # affy id HUGO name fc p q stn t Map Location 1 202370_s_at CBFB-2.73 8. 75E-38 1. 39E-34-1.25-20. 97 16q22.1 2 214651_s_at HOXA9-12.45 4. 68E-59 1. 19E-54-1.07-20. 19 7p15-p14 3 235753 at-7. 69 1. 43E-58 1. 82E-54-1.02-19. 54 4227567at-4. 27 1. 40E-28 6. 27E-26-1.21-18. 93 5 209905at HOXA9-34. 12 3.72E-55 3.16E-51-0. 99-18.78 7p15-p14 6226352at-5. 67 4. 86E-43 1. 77E-39-1.01-18. 26 7 225055_at DKFZp667M2411-4.12 1. 25E-27 5. 04E-25-1.13-17. 80 17q11. 2 8 217963_s_at NGFRAP1 -12. 29 4. 06E-45 1. 72E-41-0.93-17. 29 Xq22. 1 9 213737_x_at -2. 42 4. 29E-29 2. 14E-26-1.05-17. 19 10206847sat HOXA7-4.50 9. 82E-38 1. 47E-34-0.95-16. 97 7p15-p14 11 201669_s_at MARCKS-11.49 1. 71 E-47 1. 09E-43-0.89-16. 90 6q22.2 12 211031_s_at CYLN2-6.76 4. 12E-46 2. 10E-42-0. 89-16. 81 7q11. 23 13 222786 at C4S-2-3.19 3. 17E-39 5. 77E-36-0.92-16. 66 7p22 14 200985_s_at CD59-7.54 1. 16E-40 2. 46E-37-0.89-16. 47 11p13 15 225102_at LOC152009 -4. 26 7. 70E-32 5. 60E-29-0.95-16. 34 3q21. 3 16 219218_at FLJ23058-5.81 1. 53E-42 4. 87E-39-0.87-16. 24 17q25. 3 17 223044_at SLC11A3 -8. 53 1. 14E-38 1. 94E-35-0.88-16. 08 2q32 18 228497_at FLIPT1 -4. 79 3. 06E-42 8. 64E-39-0.85-16. 02 1p13. 1 19 223471_at RAB31P -3. 27 4.34E-24 1.18E-21-1. 01-15.72 20200984sat CD59-3.54 9. 73E-34 8. 26E-31-0.88-15. 65 11p13 21 212463at-5. 52 3.28E-41 8.35E-38-0. 83-15.62 22 224952_at DKFZP564D166 -3. 76 1. 11E-21 2.47E-19-1. 05-15. 60 17q23. 3 23229215_at ASCL2-6.22 1. 34E-35 1. 63E-32-0.86-15. 55 11p15. 5 24 209406_at BAG2-4.03 2. 50E-36 3. 18E-33-0.84-15. 41 6p12. 3-p11. 2 25 241985_at FLJ37870-5.50 4. 11 E-31 2. 76E-28-0.88-15. 32 5q13. 3 26 235521_at HOXA3-12.20 5. 30E-41 1. 23E-37-0.80-15. 29 7p15-p14 27241706_at LOC144402-5.16 6. 93E-31 4. 41 E-28-0. 88-15. 27 12q11 28 213779_at LOC129080-3.00 8. OOE-29 3. 70E-26-0.89-15. 24 22q12. 1 29 218414_s_at NUDE1 -2. 16 1. 04E-23 2. 80E-21-0.97-15. 23 16p13. 11 30230894sat-9. 49 7. 31 E-37 1. 03E-33-0.83-15. 23 31 235391_at LOC137392-8.31 1. 71E-40 3. 35E-37-0.79-15. 16 8q21. 3 32213002 at MARCKS-3. 18 2. 13E-36 2. 85E-33-0.78-14. 65 6q22. 2 33 204198 s at RUNX3-4.76 3. 10E-28 1. 36E-25-0.84-14. 48 1p36 34 213241_at -4. 05 1. 85E-35 2. 04E-32-0.76-14. 29 35 200983_x_at CD59-6.02 7. 49E-35 7. 34E-32-0.76-14. 22 11p13 36213908at-5. 73 1. 68E-35 1. 94E-32-0.76-14. 22 37 216920_s_at TRGV9-4.08 1. 58E-29 8. 56E-27-0.80-14. 14 7p15 38 218477_at PTD011 -2. 78 1. 05E-24 3. 10E-22-0. 85-14.11 6p12. 1 39218332at BEX1-13.76 2. 27E-35 2. 31 E-32-0. 74-13. 94 Xq21-q23 40204160sat ENPP4-7.15 7. 72E-34 6. 89E-31-0.74-13. 91 6p12. 3 41 204197_s_at RUX3 -3. 18 6.79E-31 4. 41 E-28-0. 77-13.91 1p36 42 226817_at -5. 11 2.22E-35 2. 31 E-32-0. 73-13.87 43 228365_at LOC144402-7.22 2. 42E-26 8. 54E-24-0.80-13. 84 12q11 44 210425_x_at GOLGIN-67 -3. 63 1. 32E-321. 02E-29-0. 74-13. 7915q11. 2 45 226134_s_at -4. 76 1. 01 E-30 6.12E-28-0. 76-13.77 46 215806 x at TRGC2-3.82 1. 86E-27 7. 08E-25-0.78-13. 66 7p15 47 201670_s_at MARCKS-12.82 1. 58E-34 1. 49E-31-0. 72-13. 66 6q22.2 48 218927_s_at C4S-2-5.23 8. 75E-29 3. 98E-26-0.76-13. 63 7p22 49 213353_at ABCA5-3.10 7. 39E-19 1. 28E-16-0.93-13. 63 17q24.3 50 232051_at MGC10992-3.99 2. 74E-32 2. 05E-29-0.73-13. 60 16q12. 2 1.9 AML inv (3) versus rest &num affy id HUGO name fc p q stn t Map Location 1205382sat DF-5.03 5. 80E-28 5. 27E-24-0.93-15. 77 19p13. 3 2 204301_at KIAA0711 -5. 88 1. 75E-33 4. 78E-29-0.74-13. 84 8p23.2 3 212318_at TRN-SR-2.14 8. 47E-15 5. 37E-12-0.99-13. 36 7q32.2 4 204082_at PBX3-4.10 3. 30E-25 1. 43E-21-0.75-13. 17 9q33-q34 5204647_at HOMER3-4.12 1. 89E-25 1. 03E-21-0.74-13. 13 19p13. 11 6210115_at RPL39L-4.99 4. 32E-32 5. 89E-28-0.69-13. 123q27 7 204921_at GAS8-2.52 4. 73E-24 1.61E-20 -0. 74-12.91 16q24.3 8 230480_at HIWI2 -2. 92 2. 13E-20 4. 15E-17-0.78-12. 81 11q21 9201186at LRPAP1-2.47 2. 62E-17 2. 74E-14-0.75-11. 91 4p16. 3 10226789_at-2. 40 2. 20E-13 1. 07E-10-0.87-11. 78 11 231300 at LOC90835-2.70 2.59E-14 1. 53E-11-0. 82-11.77 16p11. 2 12204548_at STAR-5.56 1. 32E-23 3. 99E-20-0.65-11. 74 8p11. 2 13 205624_at CPA3-5.67 1. 67E-23 4. 56E-20-0.65-11. 70 3q21-q25 14 236892_s_at -7. 87 5. 82E-27 3. 97E-23-0.61-11. 68 15213844_at HOXA5-5.20 1. 44E-19 2. 45E-16-0.69-11. 67 7p15-p14 16203746sat HCCS-1.52 5. 11E-22 1. 16E-18-0.65-11. 51 Xp22.3 17 223703_at CDA017-2.18 9. 16E-16 7. 80E-13-0. 73-11.31 10q23. 1 18 239791_at -6. 83 3. 67E-25 1. 43E-21-0.59-11. 27 19 209122_at ADFP-3.09 4. 76E-15 3. 17E-12-0.73-11. 12 9p21. 3 20 228293_at LOC91614-5.42 3. 24E-14 1. 88E-11-0. 74-11. 03 all3 21200700sat KDELR2-2.24 2. 84E-12 9. 94E-10-0.81-10. 84 7p22.2 22 205131_x_at SCGF-4. 53 6. 09E-19 9. 22E-16-0.62-10. 79 19q13. 3 23218865at FLJ22390-6.03 2. 12E-22 5.26E-19 -0.56 -10.53 1q42. 11 24 201940_at CPD-2.02 9. 72E-14 5. 03E-11-0. 69-10.42 17p11. 1-q11. 2 25 210783_x_at SCGF-4.24 1. 70E-16 1. 55E-13-0.60-10. 14 19q13. 3 26208967sat AK2-2.06 1. 51E-14 9.35E-12 -0. 64-10.14 1p34 27 219551_at TRAITS -2. 32 1. 73E-12 6. 56E-10-0.70-10. 11 3q13. 33 28 226071_at DKFZP434K1772 -2. 62 1. 23E-18 1. 77E-15-0.56-10. 04 1q21. 2 29202487sat H2AV-1.90 5. 51E-10 9. 22E-08-0.88-9. 96 7p13 30 200897_s_at KIAA0992 -7. 82 1. 40E-20 2. 94E-17-0.52-9. 944q32. 3 31 210140_at CST7-3.04 1. 01E-15 8. 34E-13-0.59-9. 94 20p11. 21 32 229116_at -4. 17 1. 10E-19 2.00E-16 -0. 53-9.89 33 203421_at PIG11 -3. 08 2. 33E-18 3. 17E-15-0.55-9. 85 11p11. 2 34 218681_s_at SDF2L1 -1. 89 6. 06E-14 3. 30E-11-0. 62-9. 83 22q11. 21 35 204332_s_at AGA-1.69 2. 31E-12 8.41E-10 -0. 67-9. 78 4q32-q33 36227929at-5. 54 5. 87E-18 7. 27E-15-0.54-9. 76 37 201069_at MMP2-3.72 5. 25E-19 8. 42E-16-0.51-9. 59 16q13-q21 38 202954_at UBE2C-2.10 1. 34E-12 5. 20E-10-0. 63-9. 50 20q13. 11 39 208284_x_at GGT1-1.79 1. 05E-15 8. 38E-13-0.55-9. 48 22q11. 23 40 218829_s_at KIAA1416 -2. 11 2. 01E-13 9.96E-11 -0. 60-9. 47 8q12. 1 41 226123_at LOC286180-2.80 1. 31E-11 3.71E-09 -0. 66-9. 458q12. 1 42208795sat MCM7-1.98 1. 67E-10 3. 30E-08-0.72-9. 42 7q21. 3-q22.1 43 222955_s_at HT011 -1. 82 1. 14E-15 8. 86E-13-0.54-9. 40Xq26. 1 44212820_at RC3-2.35 1. 97E-13 9. 95E-11-0. 59-9. 39 15q15. 3 45244166at-3. 57 9. 78E-14 5. 03E-11-0. 58-9.35 46221804sat HT011-1. 95 1. 02E-12 4. 20E-10-0.60-9. 35Xq26. 1 47 223609_at ASP-2.11 2. 16E-11 5. 78E-09-0.65-9. 31 2p11. 2 48 231736_x_at MGST1-2.85 6. 13E-10 9. 94E-08-0.76-9. 31 12p12. 3-p12. 1 49 210006_at DKFZP5640243-1.60 4. 06E-11 1.01E-08 -0. 66-9. 29 3p21. 1 50 240093_x_at -4. 83 2. 72E-18 3. 54E-15-0. 49-9.25 1.10 AML_komplext versus rest &num affy id HUGO name fc p q stn t Map Location 1 227056at-2. 59 1.66E-22 7. 19E-19-1. 03-15.00 2 223318_s_at MGC10974-3.00 8. 74E-26 1. 14E-21-0.86-14. 14 19p13. 3 3235502at PPP2CA-2.97 1. 15E-22 7. 19E-19-0.74-12. 44 5q23-q31 4 222229_x_at -1. 45 6. 12E-15 4. 19E-12-1.10-12. 13 5205382sat DF-3.38 2.87E-21 9. 31 E-18-0. 73-12.05 19p13. 3 6223157_at MGC3232-1.69 1. 19E-17 3. 10E-14-0.79-11. 66 4q12 7 200093_s_at - HG-U133B HINT1 -1. 79 4. 30E-15 3. 14E-12-0.90-11. 39 5q31. 2 8218645_at ZNF277-2.02 4. 35E-15 3. 14E-12-0.81-10. 89 7q31. 1 9 223276_at NID67 -2. 07 2. 98E-16 4. 31E-13-0.72-10. 77 5q33.1 10202659_at PSMB10-2.50 1. 07E-15 1. 16E-12-0.72-10. 5516q22. 1 11 200608_s_at RAD21 1.62 8. 80E-13 3. 36E-10 0.99 10.45 8q24 12223592sat MGC13061-1.91 6. 67E-17 1. 44E-13-0.65-10. 39 17q11. 2 13218220at C12orf10-1. 78 2. 83E-16 4. 31E-13-0.67-10. 37 12q13 14 208826_x_at HINT1 -1. 50 6. 64E-14 3. 75E-11-0. 79-10. 32 5q31. 2 15 208646_at RPS14 -2. 08 2. 20E-13 1. 06E-10-0.76-9. 935q31-q33 16 218436_at SIL1 -2. 44 1. 65E-13 8.25E-11 -0. 73-9.85 5q31 17 226142_at GLIPR1 -2. 58 1. 69E-15 1. 57E-12-0.62-9. 81 12q21. 1 18 231840_x_at LOC90624-1.98 2. 94E-15 2. 55E-12-0.61-9. 69 5q31. 1 19222902sat FLJ21144 1.76 7. 28E-12 1.78E-09 0. 91 9. 681p34. 1 20 202413_s_at USP1 1.74 8. 57E-12 1. 95E-09 0. 91 9. 62 1p32.1-p31. 3 21 222983_s_at PAIP2 -1. 53 2. 23E-12 6. 91E-10-0.77-9. 51 5q31. 3 22 223591_at MGC13061-1.70 9. 89E-15 6. 43E-12-0.60-9. 42 17q11. 2 23217729sat AES-1.81 8. 88E-14 4. 81 E-11-0. 63-9. 38 19p13. 3 24227708at EEF1A1-1. 72 1. 26E-12 4. 41E-10-0.71-9. 37 6q14. 1 25 227878_s_at MGC10974-1.49 1. 55E-13 8.05E-11 -0. 64-9. 37 19p13. 3 26211495xat TNFSF13-1.92 1. 09E-14 6. 73E-12-0.57-9. 20 17p13. 1 27 201377_at NICE-4 1.88 5. 60E-11 9.22E-09 0.97 9. 18 1q21. 3 28217846_at QARS-1.49 1. 35E-11 2.83E-09 -0. 78-9. 15 3p21.3-p21. 1 29 226656_at CRTAP-2.15 7. 34E-12 1. 78E-09-0.72-9. 08 3p22 30 217751_at LOC51064-1.93 1. 75E-12 5. 68E-10-0.64-8. 98 7q34 31 207721_x_at HINT1 -1. 59 9. 74E-12 2. 15E-09-0.71-8. 96 5q31. 2 32 200092_s_at - HG-U133A HINT1 -1. 51 1. 59E-11 3. 18E-09-0.71-8. 88 5q31. 2 33216032sat SDBCAG84-1.88 5. 93E-13 2. 49E-10-0.57-8. 74 20pter-q12 34 236892_s_at -4. 06 2. 66E-16 4.31E-13 -0. 47-8.74 35212085at SLC25A6-1.75 2. 06E-11 3. 94E-09-0.68-8. 72 Xp22. 32 and Yp 36 228083_at CACNA2D4-3.63 3. 82E-16 4. 96E-13-0.47-8. 68 12pu3. 33 37 200974_at ACTA2-1.92 5. 01E-13 2. 25E-10-0.56-8. 67 10q23. 3 38 209190_s_at DIAPH1 -1. 69 1. 43E-12 4.88E-10 -0. 58-8.65 5q31 39 209619_at CD74-1.77 2. 22E-12 6.91E-10 -0. 59-8.65 5q32 40 229693_at -1. 88 7. 39E-12 1. 78E-09-0.62-8. 64 41 201977_s_at KIAA0141 -1. 61 3. 95E-11 6. 93E-09-0.69-8. 60 5q31. 3 42 224821_at MGC15429-1.77 1. 08E-11 2.31E-09 -0. 63-8. 59 3p21. 31 43205639_at AOAH-2.48 4. 02E-14 2.37E-11 -0. 50-8. 56 7p14-p12 44 207844_at IL13 -2. 39 8. 41E-12 1. 95E-09-0.61-8. 53 5q31 45 239797_at -3. 73 1. 45E-15 1. 45E-12-0.46-8. 53 46 224936_at EIF2S3 -1. 43 4. 84E-11 8. 17E-09-0.68-8. 53 Xp22. 2-p22.1 47 227153_at IMMP2L -2. 05 8. 33E-13 3. 28E-10-0.54-8. 51 7q31 48 204222_s_at GLIPR1 -2. 34 5. 19E-13 2. 25E-10-0.53-8. 48 12q21. 1 49 224368_s_at NDRG3-1.92 1. 41E-11 2. 90E-09-0.61-8. 44 20q11. 21-q11. 23 50 226781_at -4. 02 7. 71E-16 9. 12E-13-0.44-8. 44 1.11 AML normal versus rest # affy id HUGO name fc p q stn t Map Location 1 239791_at 5.86 3. 08E-25 9.71E-21 0.71 11.96 2 236892_s_at 5.86 1. 40E-24 2.21E-20 0.68 11.64 3228904at 4.22 1.47E-23 1. 55E-19 0.66 11.32 4 205600_x_at HOXB5 1.82 4. 40E-23 3. 46E-19 0. 59 10. 83 17q21. 3 5 205601_s_at HOXB5 2.13 1. 05E-20 6.64E-17 0. 55 10.11 17q21. 3 6205366sat HOXB6 4.08 2. 14E-20 1. 13E-16 0.55 10.05 17q21. 3 7219304sat SCDGF-B 2.25 5. 75E-20 2. 59E-16 0.57 10.03 11q22. 3 8 213110_s_at COL4A5 3.71 4. 58E-19 1.37E-15 0.58 9. 88 Xq22 9 205453_at HOXB2 2.34 1. 05E-19 3.94E-16 0. 53 9. 78 17q21-q22 10231767_at HOXB4 2.12 4.78E-19 1.37E-15 0. 54 9. 68 17q21-q22 11 209679_s_at LOC57228-2.08 1. 12E-19 3. 94E-16-0.51-9. 65 12qu3. 12 12224968_at MGC15407 1.59 6. 98E-19 1.83E-15 0.53 9. 59 2p16. 1 13224773at NAV1-2.80 2. 28E-17 5. 52E-14-0.50-9. 08 14 200093_s_at - HG-U133B HINT1 1.31 2. 92E-17 6. 57E-14 0.48 8. 94 5q31. 2 15230743_at 1.90 3. 85E-16 7. 58E-13 0. 52 8.84 16235587_at LOC202781 1.65 3. 14E-16 6. 60E-13 0. 51 8. 837q36. 3 17236738_at 4.72 1. 50E-15 2. 49E-12 0.58 8.80 18 203591_s_at CSF3R-1.93 6. 02E-16 1. 12E-12-0.47-8. 59 1p35-p34. 3 19225553at 1.50 1. 67E-15 2.63E-12 0. 47 8.48 20 200951_s_at CCND2-1.99 1. 34E-15 2. 34E-12-0.45-8. 41 12p13 21 219694_at FLJ11127-2. 21 1. 92E-15 2. 89E-12-0.44-8. 33 5p15. 2 22 235818_at -3. 07 5. 78E-15 7. 93E-12-0.45-8. 25 23 201020_at YWHAH -1. 51 5. 58E-15 7. 93E-12-0.43-8. 1822q12. 3 24200696sat GSN-1.58 7. 64E-15 1.00E-11 -0. 43-8. 13 9q33 25 226098_at KIAA1374 1.75 5. 76E-14 6. 26E-11 0.46 8. 03 3q25. 33 26232979_at 2.32 5. 36E-14 6. 10E-11 0.45 8.00 27238058_at 1.72 5. 42E-14 6. 10E-11 0.45 7.98 28218645_at ZNF277 1.39 3. 41E-14 4.30E-11 0.42 7. 94 7q31. 1 29219890at CLECSF5-2.69 5. 42E-14 6.10E-11 -0. 43-7.92 7q33 30 225945_at VIK 1.38 7. 46E-14 7. 84E-11 0.43 7. 87 7q11. 21 31 227796_at FLJ34231 1.42 8. 63E-14 8.78E-11 0.43 7. 84 5q35. 3 32 243579_at MSI2 2.38 3. 13E-13 2.46E-10 0. 47 7. 81 17q23. 1 33 227754_at 1.51 1.28E-13 1.18E-10 0.43 7.81 34 226134_s_at 2.11 1.86E-13 1.59E-10 0.44 7.79 35 218742_at HPRN-1.65 9. 66E-14 9. 23E-11-0. 41-7. 76 16p13. 3 36 227224_at FLJ25604 1.77 2. 54E-13 2.05E-10 0. 44 7. 75 1q24. 2 37224935_at 1.26 9. 65E-14 9.23E-11 0.41 7.75 38 235753_at 1.90 1.40E-13 1.26E-10 0.41 7.72 39224772at NAV1-2. 07 1. 66E-13 1. 45E-10-0.41-7. 70 40 204351_at S100P -2. 25 1. 91E-13 1. 59E-10-0. 40-7. 66 4p16 41 230894_s_at 2.17 3. 28E-13 2.52E-10 0.42 7.65 42 203329_at PTPRM-3.02 4. 16E-13 2. 98E-10-0. 43-7. 65 18p11. 2 43236728at FLJ39485 1.71 5. 13E-13 3. 44E-10 0. 43 7. 63 5q14. 3 44207111_at EMR1 2.18 6. 19E-13 4. 06E-10 0. 43 7. 62 19p13. 3 45 227672_at -1. 56 4. 01 E-13 2. 94E-10-0.41-7. 58 46 227584_at -2. 12 3. 65E-13 2. 74E-10-0.40-7. 57 47 208826_x_at HINT1 1.23 4. 41 E-13 3. 09E-10 0. 41 7. 575q31. 2 48 204779_s_at HOXB7 2.68 7. 95E-13 4.93E-10 0. 42 7. 56 17q21. 3 49206289_at HOXA4 1.77 4. 74-E-13 3.25E-10 0. 40 7. 55 7p15-p14 50216973sat HOXB7 2.48 8. 83E-13 5. 15E-10 0. 42 7. 53 17q21. 3 1.12 AML_t (15; 17) versus rest &num affy id HUGO name fc p q stn t Map Location 1 209732_at CLECSF2-26.63 3.18E-101 5.98E-97-1. 59-30.31 12p13-p12 2204425at ARHGAP4-17. 16 1. 56E-92 1. 46E-88-1.57-29. 56 Xq28 3211990at HLA-DPA1-9. 45 9. 98E-61 2. 09E-57-1.51-27. 03 6p21. 3 4 205771_s_at AKAP7-10.50 1. 18E-66 3. 69E-63-1.37-25. 18 6q23 5 213587_s_at LOC155066-5.54 1. 61E-70 6. 05E-67-1.33-24. 83 7q36. 1 6 213147_at HOXA10 -14. 12 1. 03E-76 6. 46E-73-1.29-24. 42 7p15-p14 7 214651_s_at HOXA9-132.38 1. 86E-74 8. 74E-71-1.27-23. 75 7p15-p14 8201923at PRDX4-6.35 4. 10E-36 1. 04E-33-1.40-22. 97 Xp22. 13 9 204362_at SCAP2-12.92 8. 14E-60 1. 39E-56-1.23-22. 72 7p21-p15 10 241742_at PRAM-1-6.63 8. 04E-53 7. 56E-50-1.18-21. 55 19p13. 2 11 217848_s_at PP -4. 09 2. 57E-25 2. 25E-23-1.45-21. 35 10q11. 1-q24 12 201137 s at HLA-DPB1-9.04 1. 34E-59 2. 10E-56-1. 12-21.01 6p21. 3 13 213150_at HOXA10 -26. 78 8. 64E-62 2. 32E-58-1.07-20. 37 7p15-p14 14 201719_s_at EPB41L2 -11. 72 4. 38E-60 8. 23E-57-1. 07-20. 33 6q23 15 225639_at SCAP2-10.47 6. 58E-40 2. 21 E-37-1. 17-20.32 7p21-p15 16 204563_at SELL-5.93 4. 57E-39 1. 48E-36-1.17-20. 21 1q23-q25 17 235753_at -9. 03 6. 56E-61 1. 54E-57-1.06-20. 12 18 227598_at LOC113763-4. 24 3. 28E-34 7. 09E-32-1.19-19. 95 7q35 19 211991_s_at HLA-DPA1 -13. 65 5. 75E-57 7. 21 E-54-1. 05-19. 80 6p21. 3 20 210145_at PLA2G4A-6.78 1. 14E-49 7. 95E-47-1.07-19. 69 1q25 21 216899_s_at SCAP2-6.00 1. 96E-42 8. 56E-40-1.11-19. 69 7p21-p15 22 200931_s_at VCL-3.84 2. 14E-28 2. 49E-26-1. 24-19. 61 10q22. 1-q23 23 205453_at HOXB2-13.30 8. 24E-59 1. 19E-55-1. 03-19. 60 17q21-q22 24209905at HOXA9-344. 80 1. 18E-57 1. 58E-54-1.05-19. 53 7p15-p14 25 204361_s_at SCAP2-9.07 3. 29E-37 9. 22E-35-1. 09-18. 96 7p21-p15 26 232617_at CTSS-4.96 7. 73E-50 5. 82E-47-1.02-18. 88 1q21 27201669sat MARCKS-33.06 5. 67E-55 6. 66E-52-1.00-18. 82 6q22.2 28209448_at HTATIP2-6. 82 6. 46E-48 3. 68E-45-1.01-18. 71 11p15. 1 29229041sat-22. 40 6. 83E-55 7. 55E-52-0.98-18. 70 30 217478_s_at HLA-DMA-4.97 4. 37E-31 7. 03E-29-1.12-18. 65 6p21. 3 31 225386_s_at LOC92906-19.67 4. 11 E-54 4. 29E-51-0.97-18. 47 2p22.2 32 201753_s_at ADD3-5.54 3. 13E-31 5. 20E-29-1.10-18. 37 10q24. 2-q24.3 33204069at ME) S1-13. 76 1. 37E-53 1. 36E-50-0.96-18. 36 2p14-p13 34236554_x_at EVER2-3.63 1. 80E-22 1. 11E-20-1. 25-18. 32 17q25. 3 35 206847_s_at HOXA7-5.96 2. 14E-38 6. 59E-36-1.03-18. 25 7p15-p14 36227353_at EVER2-3.77 1. 32E-20 6. 88E-19-1. 29-18. 11 17q25.3 37 204661_at CDW52-14.51 1. 69E-48 1. 03E-45-0.96-17. 95 1p36 38 203948_s_at MPO 3.47 7. OOE-16 2. 20E-14 1.64 17.93 17q23.1 39 236322_at-5. 85 7.96E-27 8.27E-25-1. 12-17.91 40 34210_at CDW52-18.36 4. 86E-50 3. 98E-47-0.95-17. 89 1p36 41 226106_at ZFP26-4.42 4. OOE-36 1. 03E-33-1.02-17. 87 11p15. 3 42 207375_s_at IL15RA -4. 58 9. 12E-26 8. 29E-24-1.13-17. 86 10p15-p14 43 210538_s_at BIRC3 -7. 28 2. 64E-50 2. 26E-47-0.94-17. 86 11q22 44243618sat LOC152485-8.81 6. 90E-50 5.41E-47 -0. 94-17. 83 4q31. 1 45238949_at FLJ31951-7.52 1. 43E-36 3. 74E-34-1.01-17. 80 5q33. 3 46 213844_at HOXA5-20.22 2. 44E-51 2. 19E-48-0.93-17. 80 7p15-p14 47214797_s_at PCTK3-4.64 5. 01E-23 3. 30E-21-1.18-17. 75 1q31-q32 48 228113_at STAT3-3.99 2. 71 E-24 2. 07E-22-1.15-17. 74 17q21 49238058_at-3. 21 6. 17E-46 3. 22E-43-0.95-17. 69 50 226077_at FLJ31951-5.31 8. 88E-32 1. 55E-29-1.04-17. 61 5q33.3 1.13 AML_t (8; 21) versus rest # affy id HUGO name fc p q stn t Map Location 1 214651_s_at HOXA9-117.42 4. 34E-75 1.18E-70 -1.29 -24. 00 7p15-p14 2 213147_at HOXA10-10.26 6. 91 E-67 9. 43E-63-1.22-22. 83 7p15-p14 3 221581_s_at WBSCR5 -6. 33 3. 73E-54 1. 27E-50-1.17-21. 367q11. 23 4 225615_at LOC126917-6.32 1. 24E-53 3. 37E-50-1.15-20. 99 1p36. 13 5213150at HOXA10-34.97 2. 02E-63 1. 84E-59-1.11-20. 90 7p15-p14 6 205453_at HOXB2-17.98 4. 35E-62 2. 97E-58-1.07-20. 45 17q21-q22 7 235753_at -8. 55 2. 53E-60 1. 38E-56-1.05-19. 98 8209905at HOXA9-334.01 4. 79E-58 1. 87E-54-1.07-19. 69 7p15-p14 9 217963_s_at NGFRAP1 -18. 52 1. 42E-58 6. 44E-55-1.02-19. 54 Xq22. 1 10 206847_s_at HOXA7-4.95 8. 41E-49 1. 64E-45-1.01-18. 73 7p15-p14 11 215087_at -3. 57 2.37E-47 4.30E-44-1. 01-18.58 12204069at MEtS1-13. 32 7. 83E-54 2. 38E-50-0. 97-18. 46 2p14-p13 13 226865_at -6. 03 1. 05E-49 2. 60E-46-0.93-17. 61 14 228365_at LOC144402-7.20 6. 65E-49 1. 51 E-45-0. 91-17. 27 12q11 15 213844_at HOXA5-13.21 7. 93E-49 1. 64E-45-0.90-17. 19 7p15-p14 16 204494_s_at DKFZP434H132 -3. 04 1. 15E-35 1. 08E-32-0.97-17. 0515q22. 33 17 224764_at ARHGAP10 -6. 11 1. 37E-44 2. 20E-41-0.90-16. 90 10 18 204495_s_at DKFZP434H132 -3. 13 5. 25E-40 7. 16E-37-0.92-16. 80 15q22. 33 19 206310_at SPINK2 -53. 98 4. 87E-46 8.32E-43 -0. 89-16. 67 4q12 20 208890 s at PLXNB2-3.84 2. 34E-30 1. 25E-27-0.98-16. 4822q13. 33 21 208091_s_at DKFZP564K0822 -5. 58 5. 26E-35 4. 63E-32-0.93-16. 43 7p14. 1 22 203017_s_at SSX2IP -3. 74 3. 86E-32 2. 39E-29-0.93-16. 12 23 235521_at HOXA3-16.43 2. 22E-43 3. 19E-40-0.85-15. 97 7p15-p14 24241370at-2. 81 3. 55E-34 2. 85E-31-0.90-15. 96 25208146sat CPVL-13.29 1. 18E-43 1. 78E-40-0.83-15. 93 7p15-p14 26238077_at MGC27385-3.37 6. 03E-29 2.61E-26 -0. 94-15. 86 3p21. 1 27233955_x_at HSPC195-3.11 1. 55E-32 1. 03E-29-0.90-15. 77 5q31. 3 28 238455 at-4. 08 7. 73E-39 9. 59E-36-0.84-15. 60 29 243806_at -3. 97 1. 17E-36 1. 23E-33-0.85-15. 49 30224516sat HSPC195-3.30 1. 95E-37 2. 13E-34-0.84-15. 49 5q31. 3 31241706at LOC144402-5. 16 1. 18E-31 6. 88E-29-0.88-15. 41 12q11 32 227995_at -7. 43 7. 46E-40 9. 69E-37-0.79-15. 02 33 227853_at -2. 90 8. 85E-22 1.90E-19 -0. 99-15.00 34 224049_at KCNK17 -2. 92 4. 84E-36 4. 72E-33-0.81-14. 93 6p21. 1 35 222996_s_at HSPC195 -2. 54 2. 25E-32 1. 46E-29-0.83-14. 87 5q31. 3 36 203680_at PRKAR2B-5.16 3. 83E-36 3. 87E-33-0.80-14. 85 7q22-q31. 1 37 217975_at LOC51186-6.63 2. 72E-32 1. 73E-29-0.82-14. 68 Xq22. 1 38 238756 at-3. 59 4.56E-33 3.19E-30-0. 81-14.67 39 203741_s_at ADCY7 -4. 41 2. 72E-29 1. 22E-26-0. 84-14. 64 16q12-q13 40213908at-5. 94 1. 95E-37 2. 13E-34-0.77-14. 58 41 204030_s_at SCHIP1 -13. 53 1. 17E-37 1. 39E-34-0.76-14. 48 3q25. 33 42 230894_s_at -6. 46 3. 10E-34 2. 57E-31-0.78-14. 36 43 236297 at-3. 26 7. 93E-33 5. 41E-30-0. 78-14.23 44 209500_x_at TNFSF13-3.17 3. 51E-251. 21E-22-0. 85-14. 17 17p13. 1 45 202510_s_at TNFAIP2 -2. 96 3.19E-30 1.64E-27-0. 79-14.10 14q32 46 226134_s_at -4. 32 7.55E-34 5.57E-31-0. 75-14.04 47240572sat-3. 48 6.08E-25 2. 0OE-22-0. 83-13.97 48 229971_at GPR114 -5. 87 9. 46E-28 3. 74E-25-0.80-13. 92 16q12. 2 49211597_s_at HOP-9.36 1. 77E-35 1. 61E-32-0. 73-13. 90 4q11-q12 50 228904_at -8. 85 6. 54E-35 5. 57E-32-0.73-13. 80 Table 2 2. All-Pairs (AP) 2.1 AML_+11 versus AML_+13 # affy id HUGO name fc p q stn t Map Location 1 201462 at KIAA0193 19.96 4. 07E-05 5. 89E-02 3.37 10.13 7p14. 3-p14. 1 2 215067_x_at 3.01 2.94E-06 3.03E-02 2.45 8.99 3220987sat SNARK-3.59 9. 20E-06 3.10E-02 -2. 44-8. 74 1 q32. 1 4 208820_at PTK2-106.68 1. 36E-04 9. 29E-02-3.19-8. 608q24-qter 5 225745_at -5. 31 4.56E-06 3.03E-02-2. 30-8.47 6229838_at NUCB2 3.03 2. 30E-05 4. 42E-02 2.42 8. 4511p15. 1-p14 7 232946sat 2.27 2.85E-06 3.03E-02 2.20 8.24 8228910at KA ! 1 3.73 1. 34E-05 3.51E-02 2.23 8. 07 11P11. 2 9 223467_at RASD1-22.75 1. 82E-04 9. 72E-02-2.78-8. 03 17p11. 2 10 230443_at NHP2L1 4.59 5.19E-06 3.03E-02 2.14 7. 95 22q13. 2-q13. 31 11 228046_at LOC152485 3.41 7.70E-06 3.03E-02 2.11 7. 81 4q31. 1 12238498_at 3.47 7.74E-06 3.03E-02 2.10 7.78 13 208151_x_at DDX17 3.02 5.45E-06 3.03E-02 2.07 7. 7322q13. 1 14 230263sat 3.92 7.98E-06 3.03E-02 2.01 7.49 15219241_x_at SSH-3 2.15 8. 22E-05 8. 76E-02 2.19 7. 49 11q13. 1 16218840sat FLJ10631 2.50 7. 37E-05 8. 29E-02 2.15 7. 44 11q13. 2 17 230102_at ETV5-5. 11 1. 35E-04 9. 29E-02-2.21-7. 36 3q28 18204985sat MGC2650 2. 59 1. 14E-05 3. 45E-02 1.96 7. 32 19q13. 32 19223960sat C16orf5 2. 73 1. 39E-05 3. 51E-02 1.97 7. 30 16p13. 3 20 219678 x_at DCLRE1C 1. 65 2. 57E-05 4. 59E-02 1.98 7. 24 lops3 21 211855_s_at SLC25A14 3. 51 1. 69E-05 3. 96E-02 1.86 6. 95 Xq24 22208855sat STK24-2.26 2. 33E-05 4. 42E-02-1.87-6. 91 13q31. 2-q32.3 23230180at DDX17 1. 77 1. 94E-05 4. 20E-02 1.85 6. 9022q13. 1 24 213241_at -3. 28 5. 15E-05 6. 90E-02-1.90-6. 88 25 227354_at -4. 65 2.13E-04 9.92E-02-2. 07-6.87 26 203955_at KIAA0649 10.40 2. 97E-04 1. 09E-01 2.08 6. 749q34. 3 27215580at 2.95 1.89E-04 9.79E-02 1.96 6.67 28208742sat SAP18-1.78 1. 53E-04 9. 29E-02-1.93-6. 67 13q11 29207821sat PTK2-3.99 1. 65E-04 9. 40E-02-1.93-6. 67 8q24-qter 30228885_at MGC21981 17.94 5. 36E-04 1. 18E-01 2.34 6. 64 9q21.11 31 220925_at FLJ21613 2. 45 1. 02E-04 9. 29E-02 1.86 6. 63 9q21. 33 32211085sat STK4 2. 34 2. 97E-05 4. 75E-02 1.76 6. 57 20q11.2-q13. 2 33 236208_at 2. 49 2. 83E-05 4. 75E-02 1.75 6.56 34 220041_at FLJ12768 2. 80 3. 49E-05 5. 30E-02 1.72 6.41 3q29 35203633 at CPT1A 3. 01 5. 23E-05 6. 90E-02 1.72 6. 37 11q13.1-q13. 2 36 209225_x_at KPNB2 2. 05 5. 95E-05 7. 53E-02 1.72 6. 35 5q13. 1 37 201952_at ALCAM 3. 93 4. 87E-04 1. 14E-01 1.98 6. 30 3q13. 1 38 213147 at HOXA10 2. 95 6. 93E-05 8. 09E-02 1.70 6. 26 7p15-p14 39 211584_s_at NPAT 3. 64 1.31E-04 9. 29E-02 1.74 6. 2611q22-q23 40200650sat LDHA 1. 49 8. 36E-05 8. 76E-02 1.70 6.24 11p15. 4 41 224044_at MIRO-1 3. 66 1.31E-04 9. 29E-02 1.73 6.23 17q11. 2 42 218856_at TNFRSF21-11.19 7. 32E-04 1. 21E-01-2. 10-6.19 6p21. 1-12.2 43 223314_at DC-TM4F2-2.64 1. 91E-04 9. 79E-02-1.75-6. 17 10q22. 3 44207237_at KCNA3-5.22 1. 53E-04 9. 29E-02-1.70-6. 11 1p13. 3 45 218909_at RPS6KC1 2. 40 1. 35E-04 9. 29E-02 1.68 6.09 1q41 46 232085_at MAPK8IP3 -2. 44 6. 46E-05 7. 85E-02-1.64-6. 09 16pu3. 3 47226764_at LOC152485 7. 40 2.91E-04 1. 08E-01 1.73 6. 024q31. 1 48213703at LOC150759 3. 67 1. 94E-04 9. 79E-02 1.66 5. 96 2q11. 1 49 213069_at KIAA1237 -5. 45 2. 58E-04 1.00E-01 -1. 68-5. 94 3q21. 2 50 238536_at 1.81 1. 51E-04 9. 29E-02 1.62 5.91 2.2 AML_+11 versus AML_+8 # affy id HUGO name fc p q stn t Map Location 1222490at RPC5 2.69 4. 79E-08 1. 21E-03 2.26 9. 75 16p12. 3 2242026at-1. 89 1. 70E-07 1. 74E-03-2.16-9. 18 3 228926_s_at SMARCA2-1. 77 2. 83E-07 1. 78E-03-2.12-8. 94 9p22. 3 4 241234_at -2. 02 2. 07E-07 1. 74E-03-1.98-8. 55 5 225595 at 8.64 5.98E-05 9.97E-03 2.22 8.07 6 224132_at MGC13008-1.98 1. 14E-06 3. 76E-03-1.88-7. 95 17p11. 2 7 240963_x_at -1.83 6.23E-07 3. 14E-03-1.82-7. 86 8 242885_at -1.69 1.22E-06 3. 76E-03-1.76-7. 60 9 240854_x_at -1.83 9.19E-07 3. 76E-03-1.74-7. 58 10228910at KA) 1 3. 03 2.16E-05 8.11E-03 1.83 7. 3811p11. 2 11 232442_at -1. 99 2.82E-06 4.54E-03-1. 74-7.35 12 226148_at HSPC063 2. 43 2. 73E-05 8. 57E-03 1.82 7. 31 11q24. 3 13 241454_at -1.90 1.34E-06 3. 76E-03-1.67-7. 27 14 228519_x_at CIRBP -1. 85 3.60E-06 4.54E-03-1. 72-7. 26 19p13. 3 15 228473_at MSX1-2. 00 2.38E-06 4.54E-03-1. 68-7. 20 4p16. 3-p16. 1 16 242341_x_at LOC132158-2.56 1. 88E-06 4. 32E-03-1.65-7. 18 3p21. 31 17229949_at 2. 40 1. 38E-05 7. 23E-03 1.73 7.16 18 232037_at PUNC-1.84 1. 68E-06 4. 23E-03-1.64-7. 13 15q22. 3-q23 19238569at GABBR1-2.27 7. 24E-06 6.01E-03 -1. 73-7. 11 6p21. 31 20 235340_at CAPN3-1.67 7. 35E-06 6. 01 E-03-1. 68-7. 10 15q15. 1-q21. 1 21 229118_at DNCH1-2.43 3.08E-06 4.54E-03-1. 63-7. 06 14q32. 3-qter 22225516at-1. 95 2.62E-06 4.54E-03-1. 63-7.05 23 238730_at ARHGEF11-5. 00 1. 11 E-05 7.20E-03-1. 75-7. 03 1q21 24 229056_at LOC90313-3.82 2.38E-06 4.54E-03-1. 60-6. 97 17q11. 1 25 242353_at -1. 79 3.48E-06 4.54E-03-1. 60-6.93 26243230at-6. 18 1.59E-05 7.51 E-03-1.72-6. 86 27 228646_at LOC151242-1.90 4. 55E-06 4. 78E-03-1.60-6. 86 2q32. 1 28239560at-2. 08 3.02E-06 4.54E-03-1. 58-6.85 29 231117_at LOC90050-1.82 1. 38E-05 7. 23E-03-1.68-6. 82 14q32. 13 30236080at-2. 09 3.64E-06 4.54E-03-1. 55-6.74 31 243615_at-1. 71 3.78E-06 4.54E-03-1. 55-6.74 32 232464_at TRIMP1 -1. 97 1. 50E-05 7.51E-03 -1. 65-6. 72 11p15 33 241711_at -3. 80 4. 05E-06 4.61E-03 -1. 53-6.66 34233770at-3. 70 4. 21 E-06 4. 61 E-03-1. 52-6.64 35 226744_at MGC3329 2.01 1. 29E-05 7. 23E-03 1.55 6.60 17p13. 3 36 205778_at KLK7-4.49 1. 56E-05 7.51E-03 -1. 60-6. 59 19q13. 33 37239727at-2. 13 5. 32E-06 5. 36E-03-1.50-6. 52 38 223000_s_at F11R 2. 77 2. 96E-05 8. 57E-03 1.56 6. 49 1q21.2-q21. 3 39 241131_at -2. 43 6.61 E-06 6.01 E-03-1.48-6. 44 40244003at-1. 96 7.39E-06 6. 01 E-03-1. 48-6.43 41 233965_at LOC255480-3.39 1.22E-05 7.23E-03-1. 49-6.41 12q24.21 42235770at-2. 20 6. 71 E-06 6. 01 E-03-1. 47-6.41 43 244339 at-2. 09 2. 09E-05 7. 99E-03-1.54-6. 38 44239606at-2. 62 7. 03E-06 6. 01E-03-1. 46-6.38 45231559_at NNMT-2.28 1. 03E-05 7.10E-03 -1. 48-6. 3511q23. 1 46241189_at-1. 86 1. 04E-05 7.10E-03 -1. 47-6.32 47 225719_s_at -1.80 8.06E-06 6. 35E-03-1.44-6. 30 48 214194_at DIS3 1.67 1.27E-05 7.23E-03 1.46 6. 30 13q21. 32 49 233285_at -2. 63 8. 73E-06 6. 66E-03-1.44-6. 27 50236349_at-1. 84 1.66E-05 7. 51 E-03-1. 46-6.26 2.3 AML_+11 versus AML-7 # affy id HUGO name fc p q stn t Map Location 1 238498_at 6.90 5.82E-06 2.58E-02 3.11 10.98 2 214756_x_at PMS2L8 2. 05 8.43E-08 1.61E-03 2.72 10. 74 7q22 3214526xat PMS2L8 2. 03 1.09E-07 1.61E-03 2.64 10.47 7q22 4 226336_at PPIA 2.57 6.98E-06 2.58E-02 2.18 8. 34 7p13-p11. 2 5227069at 2.50 5.26E-06 2.58E-02 2.13 8.23 6 214743_at CUTL1 2.37 1. 02E-04 8. 45E-02 2.44 8.07 7q22 7222796at K) AA0632 4.16 3.37E-06 2.58E-02 2.05 8.04 7q22.1 8 226344_at KIAA1789 3.40 4. 01E-05 6. 99E-02 2.21 7. 97 Xq21 9 226148_at HSPC063 2. 53 3. 43E-05 6. 57E-02 2.12 7. 79 11q24. 3 10221073sat CARD4 1. 79 2. 76E-05 6. 43E-02 2. 01 7. 54 7p15-p14 11 210707_x_at PMS2L5 2.20 3. 04E-05 6. 43E-02 2.02 7. 54 7q11-q22 12 201462_at KIAA0193 4.11 5. 28E-05 7. 44E-02 2.02 7. 39 7p14.3-p14. 1 13229949_at 2.88 5.96E-06 2.58E-02 1.84 7.28 14216843_x_at 2. 16 6. 99E-05 7. 94E-02 1.99 7.24 15214473_x_at PMS2L9 2. 43 1. 24E-04 8. 83E-02 2.04 7. 16 7q11. 23 16 217485_x_at PMS2L1 1. 99 1. 05E-05 3. 45E-02 1.82 7. 157q11-q22 17 225002_s_at DKFZP56611024 2. 39 4. 96E-05 7. 44E-02 1.91 7. 13 7q11. 1 18208073_x_at TTC3 2.10 6.64E-06 2.58E-02 1.76 7. 0321q22. 2 19225595_at 5. 20 6. 94E-05 7. 94E-02 1.90 7.02 20 202591_s_at SSBP1 1. 78 5. 90E-05 7. 72E-02 1.85 6.92 7q34 21227301at CCT6A 4. 22 6. 56E-05 7. 94E-02 1.80 6. 77 7p11. 1 22 219571_s_at GIOT-3 3.25 2. 61E-04 1. 02E-01 1.98 6. 71 7p22. 2 23 203633_at CPT1A 2. 72 8. 57E-05 8. 45E-02 1.78 6. 6511q13. 1-q13. 2 24 213147_at HOXA10 3. 27 3. 55E-05 6. 57E-02 1.66 6. 48 7p15-p14 25 236533 at DDEF1-2. 03 2. 05E-05 6. 08E-02-1.63-6. 44 8q24. 1-q24.2 26210962sat AKAP9 3. 93 5. 10E-04 1. 13E-01 2.04 6. 437q21-q22 27240180_at 3.98 2.73E-04 1.04E-01 1.82 6.38 28222992sat NDUFB9-1. 89 1. 04E-04 8. 45E-02-1.75-6. 38 8q13. 3 29217753sat RPS26 2. 03 3. 04E-05 6. 43E-02 1.61 6. 36 12q13 30 242026_at -1.63 6.00E-05 7. 72E-02-1.67-6. 35 31 217969_at MAGED1 1. 87 9. 43E-05 8. 45E-02 1.65 6. 27 Xp11. 23 32 213151_s_at CDC10 1. 70 8. 40E-05 8. 45E-02 1.64 6. 26 7p14.3-p14. 1 33 240270_x_at LOC283728-1.71 2. 97E-05 6. 43E-02-1.58-6. 25 15q25. 1 34 216525_x_at PMS2L3 2. 49 4.77E-04 1.13E-01 1.88 6. 23 7q11-q22 35226987_at HUMAGCGB 1. 66 8. 40E-05 8. 45E-02 1.61 6. 183p21. 31 36 205541_s_at GSPT2 1.97 4. 51E-05 7.41E-02 1.54 6. 08 Xp11.23-p11. 21 37201259sat SYPL 2. 06 1. 36E-04 8. 83E-02 1.61 6. 077q22. 1 38225845at 2. 49 4. 38E-04 1. 13E-01 1.76 6.06 39214100xat WBSCR20C 4. 13 4. 33E-04 1. 13E-01 1.74 6. 04 7qu 1. 23 40 226572_at 1.58 9.37E-05 8.45E-02 1.56 6.01 41 213018_at ODAG 2. 31 2.29E-04 1.00E-01 1.62 5. 98 7q21-q22 42212079sat MLL 2. 80 3. 89E-04 1. 13E-01 1.68 5. 9511q23 43225935_at 2.71 5.88E-04 1.14E-01 1.76 5.93 44 200977_s_at TAX1BP1 2. 081. 90E-041. 00E-01 1.57 5.91 7p15 45224847_at 4. 10 4. 48E-04 1. 13E-01 1.69 5.91 46 218601_at URG4 2. 74 7. 24E-05 7. 94E-02 1.50 5. 87 7p13 47209805at PMS2 3.21 9.74E-05 8.45E-02 1.50 5.85 7p22 48 223162_s_at LCHN 2. 73 1. 42E-04 8. 83E-02 1.52 5.83 7q34 49 213670_x_at WBSCR20C 3. 78 2.24E-04 1.00E-01 1.55 5. 80 7q11. 23 50 224851_at 5. 05 6. 45E-04 1. 16E-01 1.71 5.79 2.4 AML_+11 versus AML_5q affy id HUGO name fc p q stn t Map Location 1214000sat RGS10-7. 27 1.63E-06 3.27E-02-2. 91-10.49 10q25 2 232946_s_at 2.01 1. 25E-05 3. 27E-02 2.66 9.28 3 201871_s_at LOC51035 2.48 1. 32E-05 3. 27E-02 2.28 8. 21 11q12. 2 4 212062_at ATP9A -25. 77 1. 79E-04 5. 65E-02-2.88-8. 1220q13. 11-q13. 2 5 231593_at -1.86 2.30E-05 3. 27E-02-2.23-7. 95 6 212906 at KIAA1201-2. 63 7. 25E-06 3. 27E-02-2.09-7. 7711q24. 1 7208679sat ARPC2 1. 85 2. 70E-05 3. 27E-02 2. 15 7. 69 2q36. 1 8 214863at-3. 06 9.03E-06 3.27E-02-2. 06-7.65 9 200005_at-HG-U133B EIF3S7 2.23 1.30E-05 3.27E-02 2.04 7. 51 22q13. 1 10 212711_at DKFZp434G2311-1.55 2.53E-05 3.27E-02-2. 07-7. 50 9q34. 3 11214351xat RPL13 1.84 2.37E-05 3.27E-02 1.94 7. 14 16q24. 3 12236270at-1. 87 8.18E-05 4.74E-02-2. 04-7.14 13230180_at DDX17 2.13 1.35E-05 3.27E-02 1.91 7. 13 22q13. 14 231848_x_at 1 10 17q11. ZNF207 1.81 1.43E-05 3.27E-02 1.91 7. 16 208826_x_at 2 15222047sat ARS2-1.71 1.50E-05 3.27E-02-1. 90-7. 08 7q21 HINT1 1.62 2.99E-05 3.27E-02 1.91 7. 01 5q31. 2 17229024at-3. 29 2. 52E-05 3.27E-02-1. 87-6.91 18 235704 at LOC57228-2.28 5. 96E-05 4. 55E-02-1.92-6. 89 12q13. 12 19 217379_at 3.37 4. 18E-04 7. 10E-02 2.32 6.85 20 200093_s_at - HG-U133B HINT1 1. 92 5. 37E-05 4. 31E-02 1.89 6. 83 5q31. 2 21 200093_s_at-HG-U133A HINT1 1. 86 1.85E-05 3.27E-02 1. 82 6. 825q31. 2 22 217945_at BTBD1-1. 99 2. 05E-05 3. 27E-02-1.80-6. 75 15q24 23222267at FLJ14803-4.36 3. 15E-05 3. 29E-02-1.82-6. 73 7q32. 3 24 229404at DERM01-2. 28 2.34E-05 3.27E-02-1. 80-6.72 2q37.3 25222527sat FLJ10290 2. 90 7. 59E-05 4. 71E-02 1.86 6. 68 5q33. 1 26 226975_at FLJ25070 2.76 2. 31 E-05 3.27E-02 1.78 6.67 1p21 27217528at CLCA2-7.80 4. 93E-04 7. 46E-02-2.21-6. 60 1p31-p22 28 200936_at RPL8 1. 88 5.29E-05 4.31E-02 1.79 6. 57 8q24. 3 29 208728_s_at CDC42 -2. 15 7. 65E-05 4. 71 E-02-1. 81-6. 55 1 p36. 1 30 226835_s_at 2.19 2.89E-05 3.27E-02 1.75 6.55 31 207721_x_at HINT1 2.05 2.87E-05 3.27E-02 1.75 6. 54 5q31. 2 32 227545_at -2. 62 2.46E-04 6.32E-02-1. 93-6.52 33 200072_s_at - HG-U133A HNRPM-1.72 2.96E-05 3. 27E-02-1. 74-6. 49 19p13.3-p13. 2 34 232523_at MEGF10 -2. 87 9. 29E-05 4. 74E-02-1.79-6. 47 5q33 35 228519_s_at CIRBP -1. 90 2. 84E-04 6. 35E-02-1.92-6. 45 19p13. 3 36 224657_at MIG-6-2. 66 9. 44E-05 4. 74E-02-1.78-6. 421p36. 12-36.33 37 223839_s_at SCD-3.30 4. 89E-05 4. 20E-02-1.74-6. 42 10q23-q24 38206782sat DNAJC4 3. 07 8. 98E-05 4. 74E-02 1.77 6. 4011q13 39 202843_at DNAJB9-2.58 4. 10E-05 3. 76E-02-1.72-6. 40 7q31 40 222501-s-at RIP60-2. 24 4. 22E-05 3. 76E-02-1.72-6. 39 7q36. 1 41 226236_at QP-C 1. 83 3. 72E-05 3. 73E-02 1.71 6. 38 5q31. 1 42240236at-3. 21 4. 13E-05 3. 76E-02-1.70-6. 35 43 211666_x_at RPL3 1. 61 3.53E-04 6. 62E-02 1.91 6. 3322q13 44221505at LANPL-2.11 6. 45E-05 4. 57E-02-1.71-6. 31 1q21. 2 45 230189_x_at DKFZP586J1624 -2. 16 2. 71E-04 6. 35E-02-1.83-6. 26 9q34. 3 46221002sat DC-TM4F2-3.10 6. 88E-04 8. 36E-02-2.13-6. 2610q22. 3 47 239489_at -1.74 1.33E-04 5.11E-02 -1. 75-6.26 48 229050_s_at 4. 31 2. 79E-04 6. 35E-02 1.82 6.25 49 212874 at APOE-2.30 6. 36E-05 4. 57E-02-1.68-6. 23 19q13. 2 50 200072_s_at - HG-U133B HNRPM-1.69 7. 08E-05 4.71E-02 -1. 68-6. 21 19p13. 3-p13. 2 2.5 AML_+11 versus AML_9q &num affy id HUGO name fc p q stn t Map Location 1 218389_s at APH-1A-2. 19 1.48E-08 4.85E-04-2. 96-11.79 1p36. 13-q31. 3 2 222593_s_at FLJ13117 2.04 2. 72E-06 1. 12E-02 2.47 9. 40 12q13. 12 3203168at CREBL1-2. 39 2. 67E-07 4. 39E-03-2.30-9. 19 6p21. 3 4230180at DDX17 2.27 9. 17E-071. 00E-02 2.19 8. 67 22q13. 1 5 206851_at RNASE3-9.81 3. 12E-06 1. 14E-02-2.13-8. 27 14q24-q31 6217780at PTD008-1. 65 2. 39E-06 1. 12E-02-2.06-8. 11 19p13. 13 7 208612_at GRP58-1.82 4. 05E-06 1. 33E-02-2.05-8. 02 15q15 8 238498_at 4.16 2. 72E-06 1. 12E-02 2.01 7.94 9200080sat-HG-U133A H3F3A-1. 45 1. 67E-06 1. 12E-02-1.97-7. 87 1q41 10206111_at RNASE2-4.53 2. 64E-06 1. 12E-02-1.96-7. 80 14q24-q31 11 227082 at 4. 79 6. 40E-06 1. 58E-02 1.98 7.73 12231300_at LOC90835-2.54 7. 13E-06 1.58E-02 -1.95 -7.57 16p11. 2 13229312sat GKAP42 2. 59 2. 67E-05 2. 84E-02 2.00 7. 52 9q21. 32 14 225595_at 5.95 6.04E-05 3.18E-02 2.00 7.30 15 226975_at FLJ25070 2. 38 3. 15E-05 3. 14E-02 1.92 7. 26 1p21 16220403 s at P53AIP1 3. 90 1. 01E-05 1. 75E-02 1.84 7. 23 11q24 17 222490_at RPC5 2. 08 4. 66E-06 1. 39E-02 1.80 7. 20 16p12. 3 18 208532_x_at 2.59 1.34E-05 1.98E-02 1.86 7.20 19222565sat PRKCN 12.61 3. 38E-04 6. 20E-02 2.44 7. 17 2p21 20 201011_at RPN1-2.17 3. 54E-05 3. 14E-02-1.89-7. 14 3q21. 3-q25.2 21 218448_at C20ofr11 -1. 95 7. 23E-06 1. 58E-02-1.78-7. 08 20q13. 33 22 223422_s_at DKFZP564B1162 -3. 54 6. 08E-06 1. 58E-02-1.76-7. 03 4q21. 3 23218376sat M) CAL-3. 61 8. 29E-06 1. 63E-02-1.75-6. 96 6q21 24 216548_x_at -4. 00 4.52E-05 3.14E-02-1. 88-6.93 25 212973_at RPIA 2-. 65 1. 19E-05 1. 86E-02-1.75-6. 91 2p11. 1 26200909sat RPLP2 1. 31 1. 16E-05 1. 86E-02 1.74 6. 8811p15. 5-p15. 4 27236208at 2.13 5.29E-05 3.14E-02 1.81 6.84 28210156sat PCMT1-2.10 8. 41E-06 1. 63E-02-1.70-6. 826q24-q25 29 221488_s_at LOC51596-1.56 4.47E-05 3.14E-02-1. 83-6. 81 6pter-p21. 31 30 218724_s_at TGIF2 1.82 9.78E-06 1.75E-02 1.70 6. 80 20q11.2-q12 31 222040_at HNRPA1 -1. 94 1.43E-05 1.98E-02-1. 71-6. 78 12q13. 1 32230629sat EP400 2. 01 1. 97E-05 2. 16E-02 1.71 6. 73 12q24.33 33 218233_s_at C6orf49 -1. 55 1.48E-05 1.98E-02-1. 68-6. 67 6p21. 31 34 33322_i_at SFN-1.28 6.25E-05 3. 21 E-02-1. 76-6. 561p35. 3 35213370sat SFMBT-2.34 5.27E-05 3.14E-02-1. 74-6. 56 3p21. 31 36 221739_at IL27w -1. 62 1.64E-05 1.98E-02-1. 65-6. 56 19p13. 3 37 217927_at SPC12-1.57 1.60E-05 1.98E-02-1. 64-6. 52 3p21. 31 38 214264_s_at C14orf143 -3. 06 5.83E-05 3.14E-02-1. 72-6. 4914q32. 11 39216274sat SPC18-1.96 3.87E-05 3.14E-02-1. 68-6. 4715q24. 3 40 224502_s_at KIAA1191 1.88 4.19E-05 3.14E-02 1.66 6. 455q35. 3 41 203938_s_at TAF1C -1.75 1.82E-05 2. 06E-02-1.62-6. 45 16q24 42210042sat CTSZ-3.94 1. 40E-04 4.61E-02 -1. 85-6. 4420q13 43201290_at SPC18-1.84 1.57E-05 1.98E-02-1. 61-6. 4415q24. 3 44212079sat MLL 3. 38 1. 90E-04 5. 33E-02 1.79 6. 4311q23 45 210434_x_at JTB-1.36 1.69E-05 1.98E-02-1. 60-6. 40 1q21 46208728sat CDC42-2.14 3.53E-05 3.14E-02-1. 62-6. 33 1 p36. 1 47229115_at DNCH1 2. 81 1. 09E-04 4. 44E-02 1.68 6. 3314q32. 3-qter 48 200886_s_at PGAM1-2.41 5.14E-05 3.14E-02-1. 64-6. 32 10q25. 3 49 210161_at NFATC1 3. 85 2. 84E-04 6. 14E-02 1.79 6. 30 18q23 50222759_at CGI-85 1.71 3.66E-05 3.14E-02 1.60 6. 2711q13. 11q13.2 2.6 AML_+11 versus AML MLL &num affy id HUGO name fc p q stn t Map Location 1 238498_at 8.06 8. 71E-06 4. 46E-04 2.84 11.57 2 218604_at MAN1 2. 01 3. 69E-10 8. 20E-07 1.74 10. 49 12q14 3228083_at CACNA2D4-16. 73 7. 63E-12 1. 63E-07-1.64-10. 10 12p13. 33 4 212414_s_at SEPT6 2.38 1. 19E-08 7.32E-06 1.72 9. 97 Xq24 5 212459_x_at SUCLG2-6.63 5. 17E-11 2.21E-07 -1. 60-9. 94 3p14. 2 6 204951_at ARHH 3. 51 1. 42E-07 3. 09E-05 1.77 9.83 4p13 7 226550_at 3.80 3. 99E-07 6.07E-05 1.82 9.82 8228046at LOC152485 4.66 4.36E-06 2. 81 E-04 2.01 9. 77 4q31.1 9215772xat SUCLG2-6.78 4. 69E-11 2.21E-07 -1. 55-9. 69 3pu4. 2 10 221841_s_at -7. 55 1. 42E-11 1. 63E-07-1.53-9. 65 11 213156_at 3. 96 3. 29E-05 1. 08E-03 2.24 9.29 12 225185_at MRAS-3.54 3. 85E-11 2.21E-07 -1. 45-9. 15 3q22. 3 13200886sat PGAM1-2.80 5. 77E-11 2. 21E-07-1. 45-9. 14 10q25. 3 14 214789_x_at SRP46 2. 60 1.67E-06 1.51E-04 1.71 9. 06 11q22 15 214835_s_at SUCLG2-6.62 3. 10E-10 8. 18E-07-1.44-9. 00 3p14. 2 16 201105_at LGALS1-4.24 2. 70E-09 2. 48E-06-1.45-8. 86 22q13. 1 17 204029_at CELSR2-1.84 7. 10E-10 1. 16E-06-1. 42-8. 84 1p21 18 227082_at 4.22 2.85E-05 9. 81 E-04 1.91 8.63 19218217_at RISC-7. 20 1. 88E-10 6. 16E-07-1.36-8. 6217q23. 1 20 206440_at LIN7A -13. 09 4. 29E-10 8. 20E-07-1.40-8. 61 12q21 21 225157_at MONDOA 1. 95 5. 86E-06 3. 38E-04 1.67 8. 56 12q21. 31 22 222490_at RPC5 2. 03 2. 12E-07 3. 86E-05 1.48 8. 50 16p12. 3 23 204971_at CSTA-5.40 8. 58E-10 1. 18E-06-1.36-8. 49 3q21 24 208073_x_at TTC3 2.05 5. 81E-06 3. 36E-04 1.65 8. 4721q22. 2 25209696at FBP1-10. 25 7. 79E-10 1. 18E-06-1.38-8. 43 9q22. 3 26 219889_at FRAT1-2. 89 3. 21E-10 8. 18E-07-1.33-8. 42 10q24. 1 27 230322_at NFAM1 -3. 31 4. OOE-10 8. 20E-07-1.34-8. 41 22q13. 2 28225386sat LOC92906-10.69 4. 97E-10 8. 78E-07-1.32-8. 35 2p22. 2 29 202449_s_at RXRA-3.46 8. 76E-10 1. 18E-06-1. 32-8. 28 9q34. 3 30 244413 at DCAL1-15. 31 1. 62E-09 1. 89E-06-1.38-8. 27 12pu3. 2 31 222593 s at FLJ13117 1. 97 5. 69E-07 7. 64E-05 1.46 8. 26 12q13. 12 32226063at-3. 05 1. 65E-09 1. 89E-06-1.31-8. 19 33224516sat HSPC195 5. 42 6. 97E-05 1. 79E-03 1.93 8. 16 5q31. 3 34 238452_at FLJ31052-8.84 2. 14E-09 2. 14E-06-1.35-8. 15 1q23. 1 35213258_at 7. 60 1.11E-04 2.43E-03 2. 11 8.12 36 202391_at BASP1-6.76 1. 81E-09 1. 89E-06-1.28-8. 03 5p15. 1-p14 37 201462_at KIAA0193 5. 15 3. 32E-05 1. 09E-03 1.69 7. 97 7p14. 3-p14. 1 38204608at ASL-3.63 1. 61E-08 8. 30E-06-1.30-7. 96 7cen-q11. 2 39 219991_at SLC2A9-2.80 2. 32E-09 2. 22E-06-1.27-7. 96 4p16-p15. 3 40 226879_at MGC15619-3.92 1. 45E-09 1. 84E-06-1.26-7. 94 12q24. 11 41 222759_at CGI-85 1. 84 5. 88E-09 4. 24E-06 1.27 7. 92 11q13. 2 42 219071_x_at LOC51236-1.80 1. 81E-09 1. 89E-06-1.25-7. 898q24. 3 43213370sat SFMBT-2.16 3. 11E-09 2. 74E-06-1.25-7. 88 3p21. 31 44 236080_at -2. 00 1. 23E-07 2. 88E-05-1.31-7. 81 45223716sat ZNF265 2. 21 2. 64E-05 9. 33E-04 1.58 7. 75 1p31 46205684sat FLJ20686 2.65 6. 51E-05 1.71E-03 1.72 7. 73 9p21. 3 47 232546_at TP73-2.70 3. 15E-08 1. 22E-05-1.25-7. 69 1p36. 3 48 238263_at -3. 42 3. 92E-09 3. 22E-06-1.21-7. 66 49213622_at COL9A2-3.32 3. 66E-09 3.11E-06 -1. 20-7. 621p33-p32 50218265at SBP2 1. 49 6. 89E-08 1. 98E-05 1.25 7. 61 9q22. 1 2. 7AML+11 versus AML inv (16) # affy id HUGO name fc p q stn t Map Location 1 201497_x_at MYH11 -27. 22 4. 00E-11 3.24E-07-2. 11-11.14 16p13. 13-p13. 12 2 221841_s_at -8. 18 5. 65E-12 1.37E-07-1. 95-11.03 3238498_at 6. 40 7. 27E-06 4. 34E-04 2.65 10. 94 4209365sat ECM1-4. 18 1. 95E-11 2. 37E-07-1.86-10. 53 1q21 5203973_s at CEBPD-4.88 5. 32E-08 1. 32E-05-2.00-10. 34 8p11. 2-p11. 1 6 236646_at FLJ31166-6.08 3.49E-10 6.62E-07-1. 85 -10.23 12p13. 31 7 212459_x_at SUCLG2-6.32 4. 01E-10 6.94E-07-1. 84-10. 17 3p14. 2 8 209376_x_at SFRS2IP 1. 96 2. 30E-06 1. 99E-04 2.20 10.16 12q12 9 215772_x_at SUCLG2-6.06 1. 08E-09 1. 14E-06-1. 83-10. 05 3pu4. 2 10201462at KtAA0193 16.74 4. 32E-05 1. 48E-03 2.99 10.03 7p14. 3-p14. 1 11 34210 at CDW52-5.17 1.07E-10 5.36E-07-1. 78-10.00 1p36 12210139sat PMP22-26.94 4.41 E-10 6.94E-07-1. 91-9.97 17p12-p11. 2 13 203074_at ANXA8-2.23 1. 10E-10 5.36E-07-1. 76-9.90 10q11. 2 14201739_at SGK-7.64 1. 06E-09 1. 14E-06-1.77-9. 77 6q23 15242738sat-4. 13 2.80E-10 6.62E-07-1. 74-9.76 16 223280 x at MS4A6A-10.44 2.36E-10 6.62E-07-1. 76-9. 73 11q12. 1 17 221059_s_at CHST6-4.62 2. 83E-10 6.62E-07-1. 71-9. 62 16q22 18226148_at HSPC063 3. 38 2.41E-05 9. 96E-04 2.41 9. 61 11q24. 3 19 208816_x_at ANXA2P2-2.96 2. 38E-09 1. 73E-06-1.74-9. 58 9p13 20224724_at SULF2-14.13 2.97E-10 6.62E-07-1. 71-9. 53 20q12-13. 2 21 224356 x at MS4A6A-10.70 5. 67E-10 8. 09E-07-1.72-9. 45 11q12. 1 22 228910_at KAI1 4. 20 3. 73E-05 1. 35E-03 2.47 9. 41 11p11. 2 23206868at STARD8-2.98 2.72E-10 6. 62E-07-1. 66-9. 38 Xq12 24 205419_at EBI2 -4. 64 3.18E-10 6.62E-07-1. 66-9. 3513q32. 2 25222593sat FLJ13117 2. 10 6.81E-07 8. 27E-05 1.86 9. 31 12q13. 12 26 201590_x_at ANXA2-4.23 7. 00E-09 3. 54E-06-1.70-9. 28 15q21-q22 27203329at PTPRM-10.52 1. 21E-091. 18E-06-1. 71-9. 24 18p11. 2 28 204661_at CDW52-4.39 5. 35E-09 2. 95E-06-1.68-9. 23 1p36 29 226697_at LOC92689-3.58 4.57E-10 6.94E-07-1. 64-9.23 4p14 30227567_at 5.29 3.37E-05 1.26E-03 2.33 9.21 31 202283_at SERPINF1 -14. 15 9. 70E-10 1. 14E-06-1.68-9. 19 17p13. 1 32217168sat HERPUD1-3.28 3.54E-10 6.62E-07-1. 62-9. 15 16q12. 2-q13 33230629sat EP400 2. 50 6. 44E-06 3. 99E-04 1.98 9. 11 12q24. 33 34 210427_x_at ANXA2-3.99 5. 97E-09 3. 15E-06-1.65-9. 09 15q21-q22 35 217849_s_at CDC42BPB-7.54 1. 69E-09 1. 40E-06-1.62-9. 06 14q32. 3 36 223385_at CYP2S1 -2. 89 1. 94E-09 1. 48E-06-1.62-9. 04 19q13. 1 37 205076_s_at CRA-11.01 2. 92E-09 2. 03E-06-1.71-9. 001q12-q21 38219505at CECR1-7.14 1. 45E-09 1. 33E-06-1.63-8. 97 22q11. 2 39 232724_at MS4A6A-4.07 8. 50E-10 1. 09E-06-1.60-8. 9511q12. 1 40 216438_s_at SC5DL-1. 35 8.02E/10 1. 08E-06-1.56-8. 83 11 q23. 3 41 205859 at LY86-7.95 1. 73E-09 1. 40E-06-1.57-8. 83 6p24. 3 42213147_at HOXA10 5.23 3. 08E-05 1. 18E-03 2.11 8. 80 7p15-p14 43230322_at NFAM1-3.77 1. 96E-09 1. 48E-06-1.58-8. 76 22q13. 2 44 202944_at NAGA-4.34 1. OOE-09 1. 14E-06-1.55-8. 76 22q13-qter 45201005at CD9-6.23 1. 21E-09 0. 18E-06-1.55-8. 73 12p13. 3 46 237896_at -2. 27 5. 87E-09 3. 15E-06-1.57-8. 71 47 208438 s at FGR-6.10 2. 42E-09 1. 73E-06-1.57-8. 67 1p36.2-p36 1 48200782at ANXA5-5.67 1. 53E-09 1. 33E-06-1.52-8. 57 4q28-q32 49 242026_at-1. 71 1. 53E-09 1. 33E-06-1.52-8. 57 50210042sat CTSZ-3.94 3. 71E-09 2. 44E-06-1.54-8. 51 20q13 2.8 AML_+11 versus AML inv (3) # affy id HUGO name fc p q stn t Map Location 1208310sat FSTL1 2. 45 4. 62E-05 1. 03E-02 1.94 7. 88 3q13. 33 2 238498_at 2.83 1.93E-05 7.92E-03 1.83 7.87 3 217484_at CR1-1.98 1. 13E-07 1. 40E-03-1.54-7. 69 1q32 4 230788_at AIGnT -8. 77 1. 18E-07 1. 40E-03-1.54-7. 65 6p24 5214000sat RGS10-4. 88 1. 51E-07 1. 40E-03-1.50-7. 47 10q25 6227379_at MGC44669-1.96 3.63E-07 2. 01 E-03-1. 50-7. 40 6p22. 2 7225065xat MGC40157-2.55 2. 22E-07 1. 54E-03-1.45-7. 26 17p11. 2 8204140at TPST1-2. 48 4. 46E-07 2. 06E-03-1.40-6. 98 7q11 21 9203060sat PAPSS2-9.22 1. 80E-06 3. 83E-03-1.48-6. 90 10q23-q24 10202878sat C1QR1-5. 70 8. 90E-07 2. 74E-03-1.41-6. 90 20p11. 21 11 201462 at KIAA0193 3. 03 1. 87E-04 1. 78E-02 1.77 6. 84 7p14. 3-p14. 1 12214756xat PMS2L8 1. 61 7. 39E-07 2. 74E-03 1.36 6.76 7q22 13 228926_s_at SMARCA2-1. 55 8. 44E-07 2. 74E-03-1.36-6. 76 9p22. 3 14 230322_at NFAM1-2.56 1. 29E-06 3. 58E-03-1.35-6. 64 22q13. 2 15 212318_at TRN-SR 2. 48 2. 36E-04 1. 97E-02 1.70 6. 59 7q32. 2 16232972at FLJ11724-1. 48 1. 42E-06 3. 58E-03-1.31-6. 5017q24. 1 17200909sat RPLP2 1. 32 3. 96E-06 5. 22E-03 1.33 6. 4911p15. 5-p15. 4 18 203217_s_at SIAT9 -1.89 8.67E-06 6. 27E-03-1.34-6. 43 2p11. 2 19 238201 at-1. 84 1. 67E-06 3. 83E-03-1.29-6. 43 20 201259_s_at SYPL 2.06 1.66E-04 1.70E-02 1.54 6.38 7q22.1 21 226556_at 2.44 2. 31E-05 8. 36E-03 1.37 6.38 22221002sat DC-TM4F2-2.22 4. 62E-06 5. 77E-03-1.35-6. 38 10q22. 3 23 208820_at PTK2-50.15 6. 87E-06 6. 27E-03-1.47-6. 37 8q24-qter 24216503sat 2.61 5.03E-05 1.06E-02 1.41 6.36 25 214526_x_at PMS2L8 1.64 2. 11E-06 3. 89E-03 1. 28 6. 36 7q22 26 223184 s at AGPAT3-2.81 1. 99E-06 3. 89E-03-1.26-6. 3021q22. 3 27 208073_x_at TTC3 1. 70 2. 70E-05 8. 68E-03 1.35 6. 29 21q22. 2 28 241173_at -2. 59 2.26E-06 3.91 E-03-1.26-6. 29 29 243560at-2. 24 1.58E-05 7. 52E-03-1. 32-6.27 30210868sat LCE-2.81 3. 46E-06 4. 97E-03-1.27-6. 24 4q25 31 220482_s_at DELGEF 4. 24 3. 18E-04 2. 13E-02 1.58 6. 20 11p14. 3 32 219895_at FLJ20716-6.24 2. 73E-06 4. 44E-03-1.23-6. 17 Xq24 33 219241 x at SSH-3 1. 80 2. 35E-04 1. 97E-02 1.49 6. 13 11q13. 1 34203633_at CPT1A 2. 38 1. 49E-04 1. 63E-02 1.42 6. 0911q13. 1-q13. 2 35 221841_s_at -5. 22 3. 35E-06 4. 97E-03-1.22-6. 09 36 218840 s at FLJ 10631 2. 18 6.51E-05 1. 17E-02 1.34 6. 07 all3. 2 37 220471_s_at FLJ21269-3.04 3. 59E-06 4. 97E-03-1.21-6. 05 6q25. 1 38 213488 at DKFZP586B2420-3.08 7. 79E-06 6. 27E-03-1.26-6. 03 2q37. 3 39203645-s-at CD163-12.20 1. 18E-05 6. 94E-03-1.32-6. 02 12p13. 3 40 213147_at HOXA10 2.48 1.29E-04 1.59E-02 1.37 6. 00 7p15-p14 41 230772at-2. 34 5.05E-06 5.77E-03-1. 20-5.99 42204316at RGS10-1. 85 6. 20E-06 6. 13E-03-1.22-5. 98 10q25 43 232946_s_at 1.79 8. 81E-06 6. 27E-03 1.22 5.98 44 208690_s_at PDLIM1 -4. 96 5.40E-06 5.77E-03-1. 19-5. 95 10q22-q26. 3 45 205992_s_at IL15 -6. 86 1. 01E-05 6. 69E-03-1.25-5. 95 4q31 46201829at NET1-2. 61 7. 52E-06 6. 27E-03-1.20-5. 94 10p15 47 234797_at -1.68 1.10E-05 6. 76E-03-1.21-5. 92 48 227069_at 1. 87 3. 23E-05 8. 80E-03 1.25 5.92 49 238955_at FLJ30574-1. 80 1. 74E-05 7. 85E-03-1.22-5. 90 2q33. 1 50205076sat CRA-2.41 5.58E-06 5.77E-03-1. 18-5. 88 1q12-q21 2.9 AML_+11 versus AML komplext # affy id HUGO name fc p q stn t Map Location 1 218389_s_at APH-1A -2. 45 6.13E-15 9. 85E-11-2. 15-13.59 1p36. 13-q31. 3 2 211666_x_at RPL3 1. 51 5. 79E-12 4. 65E-08 1.64 10. 38 22q13 3229039at SYN2-3.38 1. 82E-11 9. 76E-08-1.46-9. 34 3p25 4 214351_x_at RPL13 1. 75 1. 04E-07 1. 39E-05 1. 62 9. 29 16q24. 3 5202876sat PBX2-2.81 4. 51E-11 1.8E-07 -1. 41-9. 01 6p21. 3 6206868at STARD8-2.80 2. 04E-10 5. 46E-07-1.42-8. 97 Xq12 7236080at-2. 21 4. 15E-09 2. 54E-06-1.47-8. 96 8 226835_s_at 2.25 6.39E-06 1. 11E-04 1.75 8.85 9 232037_at PUNC-2.25 1. 18E-10 3. 79E-07-1.39-8. 85 15q22. 3-q23 10 200094_s_at - HG-U133A EEF2 1.47 2.21E-07 1.88E-05 1.54 8. 8319pter-q12 11 226523_at PCSK7-1. 92 1. 66E-09 1. 88E-06-1.39-8. 69 11q23-q24 12230839_at HRMT1L3-2. 43 9. 45E-09 3. 38E-06-1.41-8. 61 12pu3. 3 13 212491_s_at DNAJC8-2.00 1. 32E-07 1. 46E-05-1.43-8. 41 1p35. 2 14 235706 at CPM-3.51 1. 45E-09 1.88E-06 -1. 32-8. 35 12q15 15 231172_at -1. 95 1. 22E-09 1. 88E-06-1.32-8. 33 16 231629 x at KLK3-1.84 2. 49E-09 2.00E-06 -1. 32-8. 29 19q13. 41 17 230279_at -2. 32 7. 93E-10 1. 59E-06-1.30-8. 28 18226975_at FLJ25070 2. 94 6. 95E-06 1. 16E-04 1.59 8. 25 1p21 19 218131_s_at p66alpha -2. 19 2. 38E-09 2.00E-06 -1. 30-8. 21 19p13. 11 20 238135_at AGTRAP-3.23 3. 09E-08 6. 91 E-06-1. 35-8. 20 1p36.21 21 208826_x_at HINT1 1. 74 9. 96E-06 1. 46E-04 1.60 8. 18 5q31. 2 22217846_at QARS 1. 84 8. 97E-06 1. 37E-04 1.59 8. 173p21. 3-p21. 1 23 200093_s_at - HG-U133A HINT1 1. 83 5. 34E-06 1. 01E-04 1.54 8. 16 5q31. 2 24238730at ARHGEF11-5. 70 9. 98E-10 1. 78E-06-1.29-8. 131q21 25 200074_s_at - HG-U133B RPL14 1.53 1. 89E-06 5. 60E-05 1.47 8. 13 3p22-p21. 2 26221002sat DC-TM4F2-3.17 1. 68E-09 1. 88E-06-1.32-8. 11 10q22. 3 27564at GNA11-2. 28 7. 55E-10 1. 59E-06-1.26-8. 10 19p13. 3 28 207721_x_at HINT1 1.96 8.50E-06 1. 32E-04 1.54 8. 02 5q31. 2 29 229949_at 2. 48 2. 09E-05 2. 24E-04 1.62 7.99 30 234294_x_at p66alpha -1. 99 1. 53E-07 1.57E-05 -1. 34-7. 97 19p13. 11 31 241215_at -3. 53 2. 12E-09 1. 93E-06-1.25-7. 97 32225480at-1. 901. 34E-091. 88E-06-1.24-7. 92 33221494_x_at M9 1. 55 1.92E-07 1.75E-05 1.33 7. 9019q13. 13 34238307at-2. 091. 31 E-064. 73E-05-1.39-7. 89 35218350sat GMNN-3.72 9. 07E-09 3. 38E-06-1.26-7. 886p22. 1 36 242945_at DKFZp434F2322 -2. 34 1. 81E-09 1. 88E-06-1.22-7. 82 17q24. 3 37 230107_at -2. 49 7. 54E-08 1.25E-05 -1. 28-7.79 38 227844_at PFKM-2.47 1. 88E-09 1. 88E-06-1.22-7. 79 12q13. 3 39 229626 at-3. 34 6.94E-09 3.22E-06-1. 23-7.78 40 242345_at -5. 58 3.42E-09 2.32E-06-1. 24-7.77 41 242333_at -2. 23 2.16E-09 1.93E-06-1. 22-7.76 42 203092_at TIMM44 -4.20 4.91E-09 2. 76E-06-1.22-7. 76 19p13.3-p13. 2 43235029at MGC14799-2.43 5. 57E-09 2. 89E-06-1.21-7. 69 8p11. 1 44 232464_at TRIMP1-2. 37 4. 05E-09 2. 54E-06-1.22-7. 69 11p15 45 217427_s_at HIRA -6. 22 2. 96E-09 2. 26E-06-1.20-7. 6722q11. 21 46 237078_at -2. 95 5.40E-09 2.89E-06-1. 22-7.63 47 201995_at EXT1-3.33 3.47E-09 2.32E-06-1. 19-7. 59 8q24. 11-q24. 13 48 226236_at QP-C 1. 85 1. 86E-05 2. 09E-04 1.48 7. 58 5q31. 1 49238209at-5. 55 6.59E-09 3. 21 E-06-1. 22-7.58 50 237896_at -2. 71 3.46E-09 2.32E-06-1. 18-7.58 2.1 AML_+11 versusAML_normal # affy id HUGO name fc p q stn t Map Location 1 205055_at ITGAE -2. 23 4. 76E-11 1.06E-08-1. 26-13.10 17p13 2200923at LGALS3BP-10.78 3.96E-24 9.30E-20-0. 94-12.03 17q25 3 235749_at UGCGL2-5.98 1. 01E-13 8.16E-11 -0. 98-11.27 13q32.1 4230322at NFAM1-2. 68 1. 47E-14 1. 44E-11-0. 96-11.25 22q13. 2 5 229168_at DKFZp434K0621 -2. 46 8.82E-18 4.15E-14-0. 85-10. 60 5q35. 3 6238730at ARHGEF11-3. 75 1. 30E-14 1. 33E-11-0. 87-10.43 1q21 7 242345_at -4 66 9.68E-19 7. 59E-15-0. 82-10.37 8 214835_s_at SUCLG2-6.04 1. 16E-09 1.31E-07 -0. 98-10. 34 3p14. 2 9221002sat DC-TM4F2-1.89 1.16E-16 3. 41 E-13-0. 83-10.32 1 Oq22. 3 10 242574_at KIAA0674 -4. 49 7.94E-19 7.59E-15-0. 81-10. 26 9q32 11 212459_x_at SUCLG2-5.42 1. 02E-08 7. 67E-07-1.00-10. 13 3p14. 2 12 219085_s_at GEMIN7 -3.36 6.46E-11 1. 34E-08-0.91-10. 10 19q13. 32 13 216413_at -4. 58 3. 86E-18 2. 27E-14-0.76-9. 81 14230495_at LOC150568-4.24 1. 31E-163. 43E-13-0.77-9. 69 2q12. 1 15 228519_x_at CIRBP -1. 66 1. 22E-10 2. 30E-08-0.87-9. 68 19p13. 3 16 215772_x_at SUCLG2-5.17 2. 85E-08 1.76E-06 -0. 95-9. 58 3p14. 2 17 238058_at -2. 34 4. 40E-11 9. 94E-09-0.84-9. 57 18225065_x_at MGC40157-2.52 1. 60E-10 2. 85E-08-0.86-9. 56 17p11. 2 19 231514 at MGC15882-2. 09 1. 18E-14 1. 26E-11-0. 78-9. 56 1p34. 3 20207430sat MSMB-4.72 1. 87E-17 7. 33E-14-0.74-9. 55 10q11. 2 21239023at AF1Q-2. 64 9. 31E-151. 04E-11-0. 77-9.47 1q21 22 217528 at CLCA2-4.54 3. 42E-16 7.00E-13 -0. 75-9. 45 1p31-p22 23 242767 at-2. 65 3. 42E-12 1. 28E-09-0.80-9. 44 24 224132_at MGC13008-1. 62 8. 74E-09 6. 74E-07-0.90-9. 44 17p11. 2 25 21838_s_at APH-1A -1. 79 3. 75E-09 3.46E-07 -0. 89-9. 43 1p36. 13-q31. 3 26222134_at DDO-5.78 7. 51E-17 2. 52E-13-0. 73-9. 35 6q21 27210042sat CTSZ-3. 38 3.57E-16 7.00E-13 -0. 74-9. 34 20q13 28238452_at FLJ31052-4.17 2. 20E-16 5. 18E-13-0.73-9. 331q23. 1 29 232464_at TRIMP1 -1. 70 8. 14E-13 4. 56E-10-0.78-9. 30 11p15 30 243943_x_at -3. 32 1.26E-13 9. 05E-11-0. 77-9.30 31 223861_at DKFZP434A1315 -4. 00 5. 66E-12 1. 82E-09-0.79-9. 28 1q21. 2 32 209706_at NKX3-1-2. 39 6.04E-12 1. 87E-09-0.79-9. 26 8p21 33 213823_at HOXA11 -4. 36 3. 75E-11 8. 83E-09-0.80-9. 24 7p15-p14 34 224461_s_at AMID -5. 75 3. 92E-16 7. 09E-13-0. 72-9. 22 10q22 1 35227750_at TRAD-1.74 1. 27E-13 9. 05E-11-0. 76-9. 20 3q21. 2 36212169_at FKBP9-1.82 1. 33E-07 6.21E-06 -0. 94-9. 19 7p11. 1 37 242718_at -2. 78 6. 05E-12 1. 87E-09-0.78-9. 19 38208438sat FGR-4.89 2. 27E-15 3. 14E-12-0.72-9. 081p36. 2-p36.1 39 203029_s_at PTPRN2-7.10 1. 15E-15 1. 70E-12-0.71-9. 07 7q36 40206907_at TNFSF9-2.67 1. 36E-12 6. 70E-10-0.75-9. 04 19p13. 3 41 210248_at WNT7A-2.93 2. 11E-131. 42E-10-0.74-8. 99 3p25 42238209at-2. 87 1. 76E-12 7. 96E-10-0.75-8. 98 43219505at CECR1-5. 28 2. 64E-15 3. 43E-12-0.71-8. 97 22q11. 2 44 210549_s_at CCL23 -24. 91 8. 97E-16 1. 51E-12-0.69-8. 92 17q12 45240389_at TRPM6-4.67 1. 05E-15 1. 65E-12-0.69-8. 91 9q21. 13 46232340at-1. 722. 34E-092. 30E-07-0.81-8. 86 47 206325_at SERPINA6 -2. 44 2. 77E-15 3. 43E-12-0.69-8. 82 14q32. 1 48 230323_at -5. 20 4. 67E-14 4. 22E-11-0. 70-8.79 49 235842_at -3. 44 7.21 E-11 1. 48E-08-0.76-8. 77 50203798sat VSNL1-5.26 3. 03E-15 3. 57E-12-0.68-8. 742p24. 3 2.11 AML_+11 versus AML_t (15; 17) &num affy id HUGO name fc p q stn t Map Location 1 212953_x_at CALR-3.23 1.80E-13 4.05E-09-2. 76-14.31 19p13. 3-p13. 2 2214450at CTSW-5.15 1.06E-12 6.38E-09-2. 79-14.15 11q13. 1 3 38487 at STAB1-6.85 6. 69E-13 6.38E-09-2. 70-13.89 3p21. 31 4214575sat AZU1-10.34 1.13E-12 6.38E-09-2. 52-13.07 19p13. 3 5226550at 6.75 1.05E-06 1.28E-04 2.99 12.54 6 214789_x_at SRP46 4. 93 7. 04E-07 9. 85E-05 2.93 12.53 11q22 7 200654_at P4HB-2.56 4.72E-10 9. 11 E-07-2. 50-12.50 17q25 8 238498_at 14.22 8. 59E-06 4.81E-04 49 218604_at MAN1 3.57 12.48 85 1.60E-11 2. 07 4q31.1 7. 18E-08 2.40 12.37 12q14 10205382sat DF-4.64 1. 06E-10 2.98E-07-2. 42-12.31 19p13. 3 11 229168at DKFZp434K0621-9. 05 1.79E-10 4.47E-07-2. 58-12.11 5q35.3 12228046_at LOC152485 8.40 1. 58E-05 7. 20E-04 3.81 12. 13 233072_at KIAA1857 -12.34 3.73E-11 1.

92 Xq28 40E-07-2.36-11. 93 9q34 14204425at ARHGAP4 20.63 1. 68E-05 7. 52E-04 3.75 11. 15 215067_x_at 16 217716_s_at SEC61A1 -2. 3.25 4.86E-10 9. 11E-07 2.30 11.64 17 221739_at 28 4. 65E-11 1. 49E-07-2.18-11. 29 3q21. 3 IL27w -1. 88 4.15E-10 9. 11E-07 -2. 20-11.20 19p13. 3 18213147_at HOXA10 21.86 3. 04E-05 1.11E-03 3.59 10. 96 7p15-p14 I9205541sat GSPT2 4.40 9. 87E-07 1. 25E-04 2.47 10. 94 Xp11. 23-p11. 21 20 204150_at STAB1-8.44 7. 13E-10 1.15E-06-2. 06-10. 37 3p21. 31 21 205614_x_at MST1-10.96 2. 11 E-09 1.98E-06-2. 12-10.24 3p21 22 241383_at -5. 27 1.08E-09 1. 31E-06-2. 03-10.17 23 208612_at GRP58-2.20 3.60E-09 3. 00E-06-1. 98-10.05 15q15 24 218724_s_at TGIF2 2.56 6. 93E-08 2. 14E-05 2.06 10. 04 20q11. 2-q12 25 201666_at TIMP1 -5. 29 6. 30E-10 1. 09E-06-1.92-9. 96Xp11. 3-p11. 23 26 201462_at KIAA0193 15.01 3.87E-05 1. 31E-03 2.85 9. 87 7p14.3-p14. 1 27 209573_s_at C18orf1 -8. 19 1. 89E-09 1. 85E-06-1.93-9. 73 18p11. 2 28205663at PCBP3-3.78 9. 05E-10 1. 27E-06-1.87-9. 7021q22. 3 29238022at-5. 22 4.82E-09 3.56E-06-1. 89-9.65 30 212509_s_at -6. 92 1. 10E-09 1. 31E-06-1. 85-9.60 31 236787_at -10. 61 3.87E-09 3. 11 E-06-1. 92-9.55 32 203484_at SEC61G -2. 11 9. 06E-10 1. 27E-06-1.83-9. 53 7p11. 2 33 AFFX- ACTB -1. 48 1.08E-09 1. 31E-06-1. 83-9. 48 7p15-p12 HSAC07/X003513at- HG-U133B 34 216320_x_at -9. 52 4.90E-09 3.56E-06-1. 89-9.42 35 243099 at NFAM1-3.41 1. 61E-09 1. 65E-06-1.82-9. 38 22q13. 2 36 208532_x_at 2.39 3. 11E-09 2. 69E-06 1.82 9.37 37 230322_at NFAM1-2.62 1. 29E-09 1. 46E-06-1.80-9. 33 22q13. 2 38 201004_at SSR4-2.26 1. 46E-09 1. 56E-06-1.79-9. 28 Xq28 39225547_at 1.62 9. 91E-09 5. 87E-06 1.81 9.24 40 222423_at NDFIP1 5.07 4. 90E-05 1. 53E-03 2.51 9. 13 5q31. 3 41 230629_s_at EP400 2. 75 1. 52E-06 1. 61 E-04 1.96 9. 10 12q24. 33 42212082sat MYL6-1.59 1. 37E-07 3. 33E-05-1.84-9. 08 12qu3. 13 43 225971_at 3. 39 1. 25E-05 6. 05E-04 2.15 9.08 44 225065_x_at MGC40157-8.23 1. 90E-08 9. 48E-06-1.89-9. 05 17p11. 2 45219837_s_at C17-15.85 1. 52E-08 7. 96E-06-1.85-9. 04 4p16-p15 46 226148 at HSPC063 3.58 4. 19E-06 3. 17E-04 2.00 8. 97 11q24. 3 47 AFFX-ACTB-1. 39 3. 08E-09 2. 69E-06-1.72-8. 957p15-p12 HSAC07/X00351_3_at - HG-U133A 48 201023_at TAF7 2. 58 4. 30E-06 3. 22E-04 1.98 8.90 5q31 49 200068sat-HG-U133B CANX-1. 60 1. 26E-08 6. 93E-06-1.74-8. 89 5q35 50 210845_s_at PLAUR-6.54 4. 23E-09 3. 29E-06-1.71-8. 84 19q13 2.12 AML_+11 versus AML_t (8; 21) # affy id HUGO name fc p q stn t Map Location 1 238498_at 7.97 1. 01E-05 8. 11E-04 3.07 11.63 2 AFFX-ACTB-1. 41 4. 59E-11 1. 01E-06-1. 97-10.99 7p15-p12 HSAC07/X00351_3_at - HG-U 133A 3 213147_at HOXA10 15.70 3. 13E-05 1. 56E-03 3.28 10.71 7p15-p14 4213940sat FNBP1 2. 56 8. 44E-07 1. 87E-04 2.16 10.37 9q34 5228827at-87. 69 4.56E-10 3. 28E-06-1. 96-10.02 6 206940_s_at POU4F1 -48. 88 1. 34E-09 4. 61E-06-1. 88-9. 49 13q21. 1-q22 7204316at RGS10-2. 03 1. 79E-10 1. 96E-06-1.67-9. 43 10q25 8 219678_x_at DCLRE1C 1. 77 1. 47E-09 4. 61E-06 1.69 9. 38 10p13 9 205529_s_at CBFA2T1 -15. 26 2. 19E-09 5. 97E-06-1.80-9. 23 8q22 10 204880_at MGMT-3.39 5. 97E-09 9. 36E-06-1.68-9. 21 10q26 11 221879_at MGC4809-5.51 5. 97E-10 3. 28E-06-1.61-9. 04 15q22. 2 12 212063_at CD44 1. 99 1.21E-07 5. 43E-05 1.70 8. 9711p13 13233705at-3. 15 9. 61E-10 4. 22E-06-1.61-8. 97 14 229406_at -10. 21 2. 45E-09 5. 97E-06-1.66-8. 94 15228910_at KAI1 3.55 4. 72E-05 1. 92E-03 2.24 8. 81 11p11. 2 16 214450_at CTSW 6.35 4. 92E-05 1. 96E-03 2.22 8. 74 11q13. 1 17218604_at MAN1 1. 75 1. 24E-08 1. 13E-05 1.57 8. 64 12q14 18224516sat HSPC195 5.74 1. 13E-04 3. 09E-03 2.59 8. 575q31. 3 19 211341_at POU4F1 -234. 63 9. 72E-09 1. 09E-05-1.70-8. 5413q21. 1-q22 20 201288_at ARHGDIB -1. 42 4. 63E-09 7. 82E-06-1.53-8. 54 12p12. 3 21 220000_at SIGLEC5 -4. 00 1. 22E-08 1. 13E-05-1.52-8. 42 19q13. 3 22 205528_s_at CBFA2T1 -39. 23 1. 14E-08 1. 13E-05-1.60-8. 40 8q22 23 AFFX-ACTB-1. 42 4. 33E-09 7. 82E-06-1.47-8. 29 7p15-p12 HSAC07/X00351_3_at- HG-U133B 24228367at HAK-1.96 3. 59E-09 7. 82E-06-1.47-8. 27 18q21. 31 25 216438_s_at SC5DL-1.37 4. 08E-09 7. 82E-06-1.45-8. 17 11q23. 3 26235753_at 10.29 1.83E-04 3.93E-03 2.69 8.08 27 230279_at -2. 23 7. 39E-091. 01 E-05-1. 43-8. 07 28214202_at 2. 27 2. 18E-06 3. 43E-04 1.59 8.06 29 226148_at HSPC063 2. 67 2. 19E-05 1. 23E-03 1.77 8. 05 11qu4. 3 30228046_at LOC152485 2.94 1.37E-05 9.67E-04 1.72 8. 044q31. 1 31 223716_s_at ZNF265 2. 31 2.11E-05 1. 22E-03 1.76 8. 02 1p31 32 209376_x_at SFRS2IP 1. 77 1. 25E-06 2. 41 E-04 1.55 8. 00 12q12 33 229168_at DKFZp434K0621 -3. 77 2. 08E-08 1. 57E-05-1.48-8. 00 5q35. 3 34209168at-4. 14 6. 96E-09 1.01E-05 -1. 41-7.98 35 233587_s_at -5.75 1.71E-08 1. 44E-05-1.45-7. 95 36229189sat LOC93622-2.64 3. 32E-08 2. 03E-05-1.42-7. 89 4p16. 1 32 216832_at CBFA2T1 -2. 03 9. 04E-09 1. 09E-05-1.40-7. 89 8q22 38224811_at 1. 99 3. 63E-06 4. 54E-04 1.57 7.87 39228253_at PRSS25-4.16 9. 41E-09 1. 09E-05-1.39-7. 86 2p12 40211728sat HYAL3-4.02 9. 93E-09 1. 09E-05-1.39-7. 84 3p21. 3 41 228499_at PFKFB4-2.73 2.59E-07 8. 51 E-05-1. 45-7.81 3p21-p22 42231334_at-6. 31 1. 12E-08 1. 13E-05-1.38-7. 78 43222759_at CGI-85 1. 77 2. 72E-08 1. 86E-05 1.39 7. 77 11q13. 2 44 226523_at PCSK7-1. 80 5. 42E-08 2. 92E-05-1.40-7. 77 11q23-q24 45 214651_s_at HOXA9 139.47 2. 54E-04 4. 67E-03 2.85 7. 687 7p15-p14 46232227at-7. 68 3. 18E-08 2. 03E-05-1.40-7. 67 47 244576_at -2. 30 1. 58E-08 1. 39E-05-1.35-7. 65 48 242341_x_at LOC132158 -2. 50 6. 35E-07 1. 60E-04-1.43-7. 64 3p21. 31 49 242845_at -5. 53 1. 78E-08 1. 45E-05-1.35-7. 63 50 230322_at NFAM1-2.62 1. 88E-08 1. 47E-05-1.34-7. 59 22q13. 2 2.13 AML+13 versus AML+8 affy id HUGO name fc p q stn t Map Location 1223467at RASD1 11. 06 1.97E-04 9.91E-02 2.30 7.53 17p11. 2 2225365_at FLJ25952 3. 15 6. 17E-05 8. 95E-02 1.94 7. 40 13q12. 11 3201908at DVL3-1. 69 9. 67E-06 6. 97E-02-1.63-6. 89 3q27 4 230206_at -12. 73 1. 40E-05 6. 97E-02-1.66-6. 77 5 208806 at 1. 72 3. 43E-06 6. 97E-02 1.55 6.74 6222146sat TCF4 4. 06 2. 59E-05 8. 95E-02 1.61 6. 67 18q21. 1 7226002at GAB1 3. 57 3. 44E-04 1. 09E-01 1.88 6. 52 4q31. 1 8 225745_at 2. 67 3. 10E-05 8. 95E-02 1.55 6.45 9212386at 5.96 3.30E-04 1.08E-01 1.82 6.44 10201029sat CD99 1. 81 1. 16E-05 6. 97E-02 1.49 6. 43 Xp22. 32 11 239598_s_at FLJ20481-4.16 1. 33E-05 6. 97E-02-1.47-6. 29 16qu2. 1 17_at MRPL49 1. 46 1. 24E-05 6. 97E-02 1.44 6. 24 11q13 ! 81at GNA12 4. 17 5. 46E-04 1. 17E-01 1.86 6. 22 7p22-p21 41_at-2. 04 1. 50E-05 6. 97E-02-1.43-6. 18 183-at 2.41 4.13E-04 1.09E-01 1.73 6.16 16 225157_at MONDOA 2. 10 5.21E-05 8.95E-02 1.45 6. 05 12q21. 31 17228353xat KtAA1959 2. 97 1. 14E-04 9. 08E-02 1.44 5. 8811q24. 1 18 212387_at 4.08 4. 10E-04 1.09E-01 1.58 5.87 19 238462_at KIAA1959 3.84 2.85E-04 1.08E-01 1.51 5. 83 11q24. 1 20 207237_at KCNA3 4. 08 2. 22E-04 1. 05E-01 1.43 5. 70 1p13. 3 21 210874_s_at FUS2-3.25 2. 72E-05 8. 95E-02-1.31-5. 70 3p21. 3 22 224044_at MIRO-1-3. 68 4. 38E-05 8. 95E-02-1.32-5. 65 17q11. 2 23218341at FLJ11838-2. 35 4. 27E-05 8. 95E-02-1.31-5. 62 1 p34. 1 24 212382_at 3. 93 1. 47E-04 9. 20E-02 1.35 5.57 25 235061_at DKFZp761G058 2. 72 1. 66E-04 9. 89E-02 1.35 5. 54 4q22. 1 26200608sat RAD21-1. 62 3. 76E-05 8. 95E-02-1.27-5. 52 8q24 27 216266_s_at BIG1 -2. 05 5. 14E-05 8. 95E-02-1.28-5. 51 8q13 28227001at-4. 30 1. 20E-04 9. 08E-02-1.37-5. 50 29 219013_at GALNT11 -3. 16 3. 91E-05 8. 95E-02-1.26-5. 507q34-q36 30 230207_s_at -4. 59 1. 11E-04 9. 08E-02-1.35-5. 48 31 218919_at FLJ14007 -1. 73 6. 98E-05 8. 95E-02-1.29-5. 47 8q21. 12 32227501at-3. 07 4. 25E-05 8. 95E-02-1.25-5. 47 33216268sat JAG1-6. 62 7.80E-05 8.95E-02-1. 30-5. 4620p12. 1-p11. 23 34 212688_at PIK3CB -2. 59 1. 12E-04 9. 08E-02-1.32-5. 42 3q22. 3 35 208151_x_at DDX17 -3. 42 7. 31E-05 8. 95E-02-1.27-5. 40 22q13. 1 36 210007 s at GPD2-1.78 5. 19E-05 8. 95E-02-1.23-5. 362q24. 1 37 222352_at 2. 10 7.10E-05 8. 95E-02 1.23 5.34 38218482_at DC6-2.07 1. 91E-04 9.91E-02-1. 36-5. 328q23. 2 39 202955_s_at BIG1 -1.70 8.58E-05 8.95E-02-1.25 -5. 31 8q13 40244868at-3. 53 6. 61 E-05 8.95E-02-1. 22-5.29 41 225545_at EEF2K-1. 49 1. 26E-04 9. 19E-02-1.24-5. 27 16pu2. 3 42 201848_s_at BNIP3 -2.06 7.11E-05 8. 95E-02-1.21-5. 2514q11. 2-q12 43 204807_at TMEM5-2.19 1. 09E-04 9. 08E-02-1.23-5. 25 12qu4. 1 44229114_at 3. 80 7. 16E-04 1. 24E-01 1.39 5.25 45 214937_x_at PCM1 -1.86 1.16E-04 9. 08E-02-1.25-5. 25 8p22-p21. 3 46 221949 at LOC222070-2.45 8.09E-05 8.95E-02-1. 20-5.20 7p13 47227696_at LAT1-3TM 2. 29 8. 59E-04 1. 29E-01 1.39 5. 20 16p12 48 218942_at FLJ22055-3.82 7. 56E-05 8. 95E-02-1.19-5. 19 12q13. 13 49204530sat TOX 2. 47 3. 93E-04 1. 09E-01 1.29 5. 198q11. 23 50225789_at CENTG3-3.11 7. 48E-05 8. 95E-02-1.19-5. 187q36. 1 2.14 AML+13 versus AML-7 # affy id HUGO name fc p q stn t Map Location 1 214743_at CUTL1 1. 90 1.50E-06 2.11E-02 2.78 10. 49 7q22 2205429saut MPP6 4.19 5. 41E-07 2.01E-02 2.41 9. 49 7p15 3 227459_at 4.48 3.43E-06 2. 11E-02 2.45 9.31 4201816saut GBAS 2. 25 9. 73E-06 3. 29E-02 2.13 8. 12 7p12 5226691at KtAA1856 2.42 4. 82E-06 2.20E-02 2.04 7. 977p22. 2 6 217853_at TEM6 3.92 1. 64E-05 4. 69E-02 2.10 7. 93 7p15. 1 7 217753_s_at RPS26 2.01 1. 72E-06 2.11E-02 1.98 7. 90 12q13 8209036saut MDH2 2. 11 2. 37E-05 5. 58E-02 2.10 7. 82 7p12.3-q11. 2 9200950at ARPC1A 2. 33 2. 90E-06 2. 11E-02 1.91 7. 627q22. 1 10244534_at ZRF1 1. 81 3. 99E-06 2. 11 E-02 1.92 7. 587q22-q32 11 238315_s_at MGC45586-4.15 3. 51E-02 2.11E-02-1. 86-7. 43 19q13. 12 12 224681_at GNA12 7. 58 2. 94E-04 1. 38E-01 2.34 7. 20 7p22-p21 13211998_at H3F3B 1. 95 5. 33E-06 2. 20E-02 1.78 7. 1317q25 14 222751_at FLJ22313 2. 10 4. 57E-05 6. 96E-02 1.90 7. 12 7p14. 1 15225666_at FLJ14624 2. 20 8. 72E-06 3. 24E-02 1.79 7. 1013q32. 3 16208820at PTK2 6.85 1.57E-04 1.14E-01 2.01 7. 00 8q24-qter 17208445sat BAZ1B 3.87 2. 31E-05 5. 58E-02 1.74 6. 80 7q11. 23 18 209256_s_at KIAA0265 3. 69 9.14E-05 8.71E-02 1.84 6. 787q32. 2 19235061_at DKFZp761G058 3. 06 2. 13E-04 1. 25E-01 1.90 6. 654q22. 1 20 224719_s_at LOC113246 -2. 62 1. 21E-05 3. 75E-02-1.67-6. 65 12pu 3. 31 21214756xat PMS2L8 2.13 6. 96E-05 7. 94E-02 1.76 6.64 7q22 22 208688_x_at EIF3S9 1. 82 6. 92E-05 7. 94E-02 1.75 6. 61 7p22. 3 23213409sat RHEB2 1. 80 4. 23E-05 6. 96E-02 1.70 6.57 7q36 24 232231_at 3. 90 3. 79E-04 1. 47E-01 1.99 6.54 25 212386_at 5. 44 4. 13E-04 1. 47E-01 1.92 6.38 26 223732_at SLC23A2 3. 37 2. 40E-05 5. 58E-02 1.61 6. 38 5q31.2-q31. 3 27223065sat STARD3NL 2. 21 4. 42E-05 6. 96E-02 1.63 6. 37 7p14-p13 28212074_at UNC84A 3.60 4. 11E-04 1. 47E-01 1.87 6.29 7p22. 3 29 221737_at GNA12 4. 20 4. 95E-04 1. 52E-01 1.90 6. 25 7p22-p21 30 227904_at FLJ21939-2.76 4. 22E-05 6. 96E-02-1.60-6. 24 3p23 31 217028_at CXCR4 1. 63 3. 03E-05 6. 25E-02 1.56 6.20 2q21 32 201338 x at GTF3A 1.70 4. OOE-05 6. 96E-02 1.56 6. 15 13q12.3-q13. 1 33 226694_at AKAP2 4. 70 2. 73E-04 1. 34E-01 1.71 6. 14 9q31-q33 34 211919_s_at CXCR4 1. 85 2. 62E-05 5. 72E-02 1.53 6.13 2q21 35 233255_s_at BIVM -21. 14 2. 60E-04 1. 32E-01-1.86-6. 10 13q32-q33. 1 3641220at MSF 1. 86 1.11E-04 9. 34E-02 1.59 6. 0717q25 37204021sat PURA-2.34 5. 28E-05 7. 26E-02-1.55-6. 06 5q31 38 230207_s_at -4. 61 1.54E-04 1.14E-01-1. 64-6.00 39225775at 3. 06 4. 98E-04 1. 52E-01 1.75 5.99 40 230719_at 4. 06 4. 69E-05 6. 96E-02 1.51 5.98 41 219431_at FLJ20896 -2. 59 1. 19E-04 9. 82E-02-1.57-5. 92 4q31. 21 42 209201_X_at CXCR4 1.93 4. 21E-05 6. 96E-02 1.48 5. 90 2q21 43230206at-11. 89 2. 10E-04 1.25E-01-1. 64-5.90 44222146sat TCF4 2.61 2. 10E-04 1.25E-01 1.57 5. 87 18q21. 1 45239213_at SERPINB1-3. 07 1. 04E-04 9. 34E-02-1.52-5. 85 6p25 46 203462_x_at EIF3S9 1. 57 7. 80E-05 8. 27E-02 1.49 5. 84 7p22. 3 47212387_at 3.83 5.29E-04 1.55E-01 1.68 5.83 48 203955_at KIAA0649 -7. 84 1.99E-04 1.25E-01-1. 59-5. 82 9q34. 3 49222352_at 2. 38 4. 92E-05 7. 03E-02 1.44 5.78 50 220239_at SBBI26 2.41 3.99E-04 1.47E-01 1.59 5.74 7p15. 3 2.15 AML_+13 versus AML_5q &num affy id HUGO name fc p q stn t Map Location 1 230206_at -13. 93 1. 96E-05 1. 28E-01-2.72-9. 27 2217963sat NGFRAP1-17. 98 6. 92E-05 1. 33E-01-2.91-9. 01 Xq22. 1 3213228at PDE8B-2.49 5. 05E-06 7. 23E-02-2.19-8. 10 5q13. 2 4 227177_at -5. 27 9.97E-05 1.45E-01-2. 47-8.01 5 225789_at CENTG3-3.78 3.86E-06 7.23E-02-2. 14-7.99 7q36.1 6 212889_x_at PLINP-1 -3.07 6.63E-06 7. 23E-02-2.11-7. 85 19p13. 12 7 212062_at ATP9A-15.13 1. 10E-04 1. 45E-01-2. 24-7. 50 20q13. 11-q13. 2 8 204159_at CDKN2C -3. 52 4. 10E-05 1. 28E-01-2.09-7. 451p32 9227490at WDFY2 2. 25 1. 57E-05 1. 28E-01 2.02 7. 42 13q14. 12 10217975_at LOC51186-8.30 2. 65E-04 1. 93E-01-2.24-7. 07 Xq22. 1 11 206770_s_at SLC35A3-1. 83 4. 09E-05 1. 28E-01-1.91-6. 95 1p21 12 238337_s_at -2. 19 2.70E-05 1. 28E-01-1.77-6. 61 13 222664_at MGC2628-5.69 2. 43E-04 1. 93E-01-1.88-6. 42 19q13. 11 14201345sat UBE2D2 1.93 4.77E-05 1.28E-01 1.73 6. 41 5q31. 3 15218926_at MYNN-1.83 4.37E-05 1.28E-01-1. 72-6. 40 3q26. 31 16 215193_x_at HLA-DRB1 3.09 1.08E-04 1.45E-01 1.73 6. 266p21. 3 17 202797_at SACM1L -2. 54 7. 69E-05 1. 33E-01-1.70-6. 25 3P21. 3 18223374sat B3GALT3-2.90 5. 19E-05 1.28E-01-1. 68-6.24 3q25 19 218198_at DDX32-1.66 5.86E-05 1.28E-01-1. 67-6. 20 10q26. 2 20225144_at-3. 13 5.15E-05 1.28E-01-1. 64-6.13 21 202371_at FLJ21174-2.43 5.35E-05 1.28E-01-1. 64-6. 13 Xq22. 1 22213970at-1. 79 5.52E-05 1.28E-01-1. 63-6.09 23 241319_at -2. 23 6.36E-05 1.30E-01-1. 62-6.05 24 204949_at ICAM3-2. 10 4. 09E-04 2. 16E-01-1.77-5. 99 19p13. 3-p13. 2 25 218942_at FLJ22055-5.66 2. 44E-04 1. 93E-01-1.69-5. 96 12q13. 13 26 226895_at GEMIN7 -1. 68 7. 73E-05 1. 33E-01-1.59-5. 93 19q13. 32 27230263sat-4. 56 2.73E-04 1.94E-01-1. 68-5.91 28 208654_s_at CD164-2.48 8. 19E-04 2. 38E-01-1.90-5. 89 6q21 29 243589_x_at -2. 94 9.13E-05 1.45E-01-1. 54-5.77 30 200651_at GNB2L1 1.31 9.77E-05 1.45E-01 1.54 5. 76 5q35. 3 31 214313_s_at IF2 -2.44 1.11E-04 1.45E-01-1. 53-5. 71 2p11. 1-q11. 1 32 228073_at C20orf147 -1.97 1.28E-04 1. 58E-01-1.50-5. 61 20p11. 1 33203675_at NUCB2-2.24 1. 51E-04 1. 59E-01-1. 51-5. 5911p15. 1-p14 34 209619_at CD74 2. 05 7. 95E-04 2. 38E-01 1.68 5.56 5q32 35 209312_x_at HLA-DRB1 2.40 1.43E-04 1.58E-01 1.49 5. 556p21. 3 36 209707_at PIGK-2. 51 1.31 E-04 1.58E-01-1. 48-5. 53 1 p31. 1 37 218772_x_at FLJ10493-2. 57 1.42E-04 1.58E-01-1. 48-5. 53 9q31. 2 38 232744_x_at 84 1. 45E-04 1.58E-01-1. 46-5.46 39 237193_s_at -3. 51 5.08E-04 2.24E-01-1. 54-5.43 40 222270_at KiAA1387 -2. 64 2. 50E-04 1. 93E-01-1.47-5. 41 2p16. 1 41 202211_at ARFGAP3-1. 81 1. 79E-04 1. 83E-01-1.45-5. 39 22q13. 2-q13. 3 42200602at APP-3.23 7. 43E-04 2. 38E-01-1.57-5. 38 21q21. 3 43 200984 s at CD59-2.80 4.33E-04 2. 21 E-01-1. 50-5. 36 11p13 44 231869_at KIAA1586 -1. 96 1.89E-04 1.83E-01-1. 43-5. 35 6p11. 1 45228093_at FLJ30663-2.25 2. 06E-04 1. 92E-01-1.44-5. 35 19q13. 11 46 209267_s_at BIGM103 -3. 41 1. 19E-03 2. 45E-01-1.65-5. 334q22-q24 47 225330 at MGC18216-2.82 7. 48E-04 2. 38E-01-1.54-5. 30 15q26. 3 48213076_at ITPKC -1. 51 2. 18E-04 1. 93E-01-1.42-5. 30 19q13. 1 49 229808_at CHAF1A-3. 12 1.90E-04 1.83E-01-1. 42-5. 30 19p13. 3 50 204011_at SPRY2-5.90 9. 50E-04 2. 38E-01-1.57-5. 29 13q22. 1 2.16 AML_+13 versus AML 9q # affyid HUGO name fc p q stn t Map Location 1 221848_at KIAA1847 -4. 98 1.62E-06 6.20E-03-2. 83-10.38 20q13. 3 2 203282_at GBE1 -5. 55 2. 41E-06 7. 38E-03-2.54-9. 47 3p12. 3 3 208653_s_at CD164-3.68 7.77E-07 6.20E-03-2. 43-9.44 6q21 4 206851_at RNASE3-17.26 5. 18E-06 1. 10E-02-2. 63-9. 42 14q24-q31 5203168at CREBL1-1.98 1.57E-06 6.20E-03-2. 44-9. 31 6p21. 3 6 225745_at 4.23 2. 68E-05 1. 59E-02 2.65 9.19 7231300at LOC90835-3.38 1.92E-06 6. 51 E-03-2. 35-9. 00 16p11. 2 8 230207sat-3. 91 7.64E-07 6.20E-03-2. 20-8.72 9 220416 at KIAA1939-8. 93 1. 18E-05 1. 35E-02-2.46-8. 71 15q15. 3 10 212688_at PIK3CB -3. 99 1. 19E-05 1. 35E-02-2.38-8. 543q22. 3 11 230206_at -10. 62 3. 76E-06 1. 05E-02-2. 17-8. 35 12205429sat MPP6 3.85 1. 16E-06 6.20E-03 2.04 8.17 7p15 13 205084_at BAP29-2.97 1.23E-06 6.20E-03-2. 03-8. 13 7q22. 2 14228353_x at KIM1959 5.16 7. 57E-05 2. 55E-02 2.36 8. 0811q24. 1 15 221923_s_at NPM1 -1.97 5.72E-06 1.10E-02 -2. 10-8.07 5q35 16 205401_at AGPS-2.09 1.33E-06 6.20E-03-2. 01-8.02 2q31 17210156sat PCMT1-2.78 1.53E-06 6.20E-03-1. 99-7. 956q24-q25 18 203955_at KIAA0649-9. 35 1. 35E-05 1. 39E-02-2.12-7. 89 9q34. 3 19203675_at NUCB2-4. 23 2. 19E-05 1. 52E-02-2.06-7. 6011p15. 1-p14 20222668 at MGC2628-10.38 3. 39E-05 1. 79E-02-2.14-7. 59 19q13. 11 21206111at RNASE2-4.79 5. 62E-06 1. 10E-02-1.90-7. 49 14q24-q31 22 218743_at FLJ11749-6.64 1. 92E-05 1. 52E-02-2.00-7. 47 17q25. 3 23230263sat-5. 38 1. 12E-05 1. 35E-02-1.92-7. 40 24 229838_at NUCB2-3.16 2. 45E-05 1. 56E-02-1.99-7. 3811p15. 1-p14 25210007sat GPD2-2.21 6. 78E-06 1. 22E-02-1.86-7. 33 2q24. 1 26 204670_x_at HLA-DRB5 2. 87 5. 75E-06 1. 10E-02 1.85 7. 31 6p21. 3 27 212173_at AK2-4. 19 3. 03E-05 1. 66E-02-1.97-7. 28 1 p34 28208626sat VAT1-2. 72 2. 25E-05 1. 53E-02-1.93-7. 25 17q21 29218061at MEA-2.26 4. 89E-06 1. 10E-02-1.80-7. 19 6p21.3-p21. 1 30202371 at FLJ21174-3.70 2. 13E-05 1. 52E-02-1.86-7. 08Xq22. 1 31 224025_s_at GSA7-5.62 9. 84E-06 1. 35E-02-1.78-7. 03 3p25. 2 32221972sat Cab45-2.04 1. 57E-05 1. 50E-02-1.79-7. 01 1p36. 33 33 209619_at CD74 2. 07 3. 14E-05 1. 68E-02 1.86 6.99 5q32 34 244293_at 2. 72 3. 74E-05 1. 85E-02 1.83 6.97 35 225677_at BAP29-2.33 8. 57E-06 1. 35E-02-1.75-6. 97 7q22. 2 36210150sat LAMA5-4. 79 5. 82E-05 2. 19E-02-1.93-6. 96 20q13.2-q13. 3 37218840sat FLJ10631-2. 01 1. 12E-05 1. 35E-02-1.76-6. 9311q13. 2 38209707_at PIGK-3. 64 1. 17E-05 1. 35E-02-1.76-6. 93 1p31. 1 39 213896_x_at KIAA0974 -6. 05 2. 09E-05 1. 52E-02-1.77-6. 86 10q22. 2 40208855sat STK24 2. 00 6. 03E-05 2. 19E-02 1.83 6. 8513q31. 2-q32.3 41 211733_x_at SCP2-1.93 8. 03E-06 1. 35E-02-1.71-6. 84 1p32 42 209439_s_at PHKA2-2.58 1. 07E-05 1. 35E-02-1.71-6. 81 Xp22. 2-p22.1 43 224923_at TTC7 2. 13 2. 93E-05 1. 64E-02 1.76 6.80 2p21 44 218942 at FLJ22055-3.95 1. 78E-05 1. 52E-02-1.72-6. 77 12q13. 13 45 217780_at PTD008 -1. 86 2. 18E-05 1. 52E-02-1.71-6. 72 19p13. 13 46 222352_at 2.62 1.37E-05 1.39E-02 1.69 6.72 47222294sat-3. 70 2. 11E-05 1. 52E-02-1.72-6. 71 48 204561_x_at APOC2-32.08 1. 53E-04 3. 55E-02-2.18-6. 69 19q13. 2 49 203960_s_at LOC51668 -2. 15 1. 14E-05 1. 35E-02-1.66-6. 65 1 p32. 1-p33 50 219431_at FLJ20896 -2. 42 2. 38E-05 1. 56E-02-1.70-6. 64 4q31. 21 2.17 AML_+13 versus AML MLL # affyid HUGO name fc p q stn t Map Location 1205429sat MPP6 4.93 5. 47E-07 1.41E-04 2.16 11.04 7p15 2204082at PBX3-5.01 3. 95E-11 5. 80E-07-1. 55-9. 52 9q33-q34 3223703at CDA017-6.94 1. 80E-11 5. 28E-07-1.50-9. 47 10q23. 1 4 226517_at BCAT1 7.04 2. 66E-05 1. 74E-03 2.22 9. 39 12pter-q12 5 211998_at H3F3B 2.23 1.79E-07 6. 41 E-05 1.65 9. 26 17q25 6225745_at 4.22 2. 81E-05 1.81e-03 2.16 9.23 7221036saut PSFL-2.26 6. 53E-11 6. 40E-07-1.43-9. 0015q21. 3 8213908at-7. 46 9. 75E-11 7. 16E-07-1.40-8. 83 9230263sat-5. 62 1. 72E-10 9. 84E-07-1.39-8. 79 10230207sat-4. 27 2. 01E-10 9. 84E-07-1.39-8. 74 11 228497_at FLIPT1 -6. 79 3. 46E-10 1. 27E-06-1.39-8. 62 1p13. 1 12 219078_at FLJ10252-2.84 2. 97E-10 1. 25E-06-1.35-8. 52 1q41 13222668at MGC2628-10.72 3. 93E-10 1. 28E-06-1.36-8. 51 19q13. 11 14 212173_at AK2-6.25 5. 38E-10 1. 36E-06-1.37-8. 47 1p34 15 230075_at RAB39B 3. 78 5. 87E-06 6. 82E-04 1.63 8.40 16 220416_at KIAA1939 -6. 91 5. 54E-10 1. 36E-06-1.33-8. 33 15q15. 3 17 209905_at HOXA9-8.26 8. 50E-10 1. 59E-06-1.32-8. 33 7p15-p14 18 225804_at MGC32124-2.29 4. 49E-08 2. 44E-05-1.39-8. 31 17p13. 3 19 217691_x_at SLC16A3 -2. 50 4. 49E-10 1. 32E-06-1.31-8. 31 17q25 20 214651_s_at HOXA9-5.23 2. 42E-07 7. 55E-05-1.43-8. 267p15-p14 21 218007_s_at RPS27L-2.66 6. 69E-10 1.51E-06 -1. 31-8. 26 15q21. 3 22 206440_at LIN7A-10. 93 7. 26E-10 1. 52E-06-1.31-8. 23 12q21 23223126sat C1orf21 5. 22 4. 02E-05 2. 25E-03 1.82 8.23 1q25 2441220at MSF 2. 37 3. 09E-05 1. 92E-03 1.76 8. 20 17q25 25225285_at 5.12 2.35E-06 3.60E-04 1.50 8.15 26 227001_at -3. 77 9. 66E-10 1. 59E-06-1.28-8. 08 27225386sat LOC92906-6.72 9. 76E-10 1. 59E-06-1.27-8. 062p22. 2 28 218271_s_at PARL-2.39 9. 65E-10 1. 59E-06-1.27-8. 063q27. 3 29 235753_at -4. 52 8.66E-09 8. 01 E-06-1. 31-8.05 30234978_at FLJ38932-2. 71 1. 21E-09 1. 87E-06-1.27-8. 0311q14. 3 31222664_at MGC2628-8.35 1. 58E-092. 32E-06-1.28-8. 0019q13. 11 32 224345_x_at E2IG5 -2. 14 4. 14E-09 5. 07E-06-1.27-7. 94 3q21. 1 33218553sat MGC2628-2.52 6. 32E-097. 09E-06-1.26-7. 8319q13. 11 34224839sat GPT2-11. 98 4. 45E-09 5. 22E-06-1.28-7. 83 16q13. 1 35 229838_at NUCB2-2.80 2. 16E-09 3. 03E-06-1.23-7. 80 11p15. 1-p14 36208820_at PTK2 12. 13 1.41E-04 4. 98E-03 1.99 7. 758q24-qter 37203517_at MTX2-2.90 1. 24E-07 4. 90E-05-1.29-7. 742q31. 2 38 220942-x_at E2IG5 -2. 14 6. 52E-09 7. 09E-06-1.23-7. 73 3q21. 1 39230206at-10. 70 2. 62E-09 3. 50E-06-1.22-7. 73 40227929at-15. 70 7. 78E-09 7. 67E-06-1.26-7. 66 41222146sat TCF4 5.14 1. 95E-05 1. 44E-03 1.51 7. 64 18q21. 1 42 225157_at MONDOA 2. 29 8. 84E-05 3. 67E-03 1.75 7. 64 12q21. 31 43 213622_at COL9A2-3.36 3. 53E-09 4. 50E-06-1.21-7. 64 1p33-p32 44 213737_x_at -2. 04 7. 21E-07 1. 68E-04-1.32-7. 63 45 216417_x_at HOXB9-3.22 1. 14E-08 9. 86E-06-1.22-7. 63 17q21. 3 46 219869_s_at BIGM103 -2. 72 1. 73E-08 1.35E-05-1. 22-7. 58 4q22-q24 47 221004_s_at ITM2C 3. 69 8. 16E-06 8. 33E-04 1.42 7.57 2q37 48 213147_at HOXA10-3.23 2. 67E-08 1. 79E-05-1.22-7. 55 7p15-p14 49 227182 at MGC26847-6.78 7.31 E-09 7. 67E-06-1.22-7. 55 9q22. 2 50 226550_at 3.41 1.87E-05 1.40E-03 1.46 7.47 2.18 AML_+13 versus AML inv (16) # affy id HUGO name fc p q stn t Map Location 1 203949_at MPO-23.07 8. 91 E-24 3. 11E-19-5. 39-30.34 17q23.1 2 203948_s_at MPO-36.13 8. 11E-19 1. 41E-14-4. 19-22.84 17q23.1 3 217849_s_at CDC42BPB-14. 75 3. 69E-12 3.21E-08 -2. 13-11. 7414q32. 3 4 202747_s_at ITM2A -9. 11 2. 57E-12 2. 98E-08-2.01-11. 34 Xq13. 3-Xq21. 2 5 201497_x_at MYH11 -26. 21 4. 88E-11 1.70E-07-2. 18-11.20 16p13. 13-p13. 12 6230207sat-4. 67 1. 03E-11 5.92E-08-1. 97-11.09 7231310at-5. 03 4. 73E-11 1.70E-07-1. 97-10.96 8201596xat KRT18-12.19 3. 45E-11 1. 50E-07-2.02-10. 94 12q13 9 227711_at FLJ32942 -7. 68 6.74E-12 4.70E-08-1. 93-10. 88 12q13. 13 10 230206_at -12. 36 1. 19E-11 5.92E-08-1. 87-10.59 11 208806 at 2. 16 2. 93E-09 4. 44E-06 1.93 10.39 12 226141_at -8. 02 2.43E-10 5.28E-07-1. 88-10.09 13 201496_x at MYH11-7. 09 6. 28E-11 1. 99E-07-1.75-9. 88 16p13. 13-p13. 12 14 202746_at ITM2A -6. 15 9. 86E-11 2. 86E-07-1.75-9. 88 Xq13. 3-Xq21. 2 15204011_at SPRY2-13.92 2.38E-10 5.28E-07-1. 80-9. 8613q22. 1 16230263sat-5. 62 1. 52E-10 4. 07E-07-1.73-9. 75 17 213241_at 6.99 5.22E-05 5.18E-03 2.88 9.70 18236738_at-11. 52 1. 78E-10 4. 44E-07-1.72-9. 61 19 228058 at LOC124220-5.56 6. 73E-10 1. 30E-06-1.69-9. 43 16p13. 3 20 202016_at MEST-5. 52 4. 95E-10 1. 01 E-06-1. 68-9.34 7q32 21215116sat DNM1-5.40 7. 58E-10 1. 39E-06-1.69-9. 28 9q34 22224764at ARHGAP10-4. 94 1. 02E-09 1. 78E-06-1.59-8. 95 10 23 204044_at QPRT-3.20 1. 35E-09 2. 25E-06-1.58-8. 87 16p12. 1 24230075_at RAB39B 4. 25 5. 28E-06 1. 17E-03 1.88 8.85 25 200951_s_at CCND2-3.74 1. 86E-09 2. 95E-06-1.58-8. 84 12p13 26 214797_s_at PCTK3 2. 86 1. 33E-05 2. 07E-03 1.90 8. 60 1q31-q32 27209365sat ECM1-2.89 6. 17E-09 7. 96E-06-1.52-8. 48 1q21 28 225789_at CENTG3-3.42 2. 70E-06 7. 48E-04-1.72-8. 47 7q36. 1 29 200953_s_at CCND2-2.20 7. 86E-09 8. 88E-06-1.52-8. 45 12p13 30 204306 s at CD151-8.78 7. 74E-09 8. 88E-06-1.57-8. 43 11p15. 5 31 210609_s_at PIG3 -4. 08 6. 65E-08 5. 04E-05-1.54-8. 37 2p24. 1 32222862sat AK5-35.22 1. 53E-08 1. 53E-05-1.61-8. 30 1p31 33 209099_x_at JAG1-10.95 5. 62E-09 7. 53E-06-1.49-8. 28 20p12. 1-p11. 23 34 229309_at -10. 75 4. 46E-09 6. 22E-06-1.46-8. 22 35 209098_s_at JAG1 -6. 18 4. 39E-09 6. 22E-06-1.46-8. 21 20p12.1-p11. 23 36 239791_at 5.01 6. 73E-05 6. 20E-03 2.02 8.15 37 218364_at LRRFIP2-2. 16 3. 62E-08 3. 08E-05-1.47-8. 13 3p21. 33 38 219078_at FLJ10252-2.46 8. 86E-09 9. 65E-06-1.44-8. 09 1q41 39 209975_at CYP2E1 -5. 68 6. 51 E-098. 10E-06-1. 41-7. 9910q24. 3-qter 40 207961_x_at MYH11 -21. 93 3. 30E-08 2. 87E-05-1.56-7. 97 16p13.13-p13. 12 41208033sat ATBF1-3.76 7. 90E-09 8. 88E-06-1.41-7. 95 16q22. 3-q23.1 42 219890_at CLECSF5-8.69 3. 19E-08 2. 87E-05-1.50-7. 91 7q33 43222668at MGC2628-8.20 1. 15E-08 1. 18E-05-1.41-7. 90 90q13. 11 44 34210_at CDW52-3.96 2. 17E-07 1. 23E-04-1.46-7. 87 1p36 45 203074_at ANXA8-1. 83 2. 29E-08 2. 15E-05-1.41-7. 86 10q11. 2 46208626sat VAT1-2. 85 1. 10E-08 1. 16E-05-1.39-7. 85 17q21 47242738sat-2. 49 1. 69E-08 1. 64E-05-1.40-7. 84 48 223467 at RAS D 1 14.41 2. 14E-04 1.32E-02 2.54 7. 82 17p11. 2 49208820_at PTK2 10.17 1. 51E-04 1.08E-02 2.01 7. 598q24-qter 50 241525_at LOC200772-77.89 7. 84E-08 5. 58E-05-1.49-7. 59 2q37. 3 2.19 AML_+13 versus AML inv (3) &num affy id HUGO name fc p q stn t Map Location 1217963sat NGFRAP1-18. 23 1. 94E-08 3. 54E-04-2.01-9. 41 Xq22. 1 2230206at-10. 57 1. 06E-08 3. 54E-04-1.75-8. 74 3 201462_at KIAA0193 -6. 59 4. 60E-08 4. 80E-04-1.64-8. 14 7p14. 3-p14. 1 4230207sat-3. 87 5. 27E-08 4. 80E-04-1.58-7. 90 5 202888_s_at ANPEP-2.92 3. 84E-07 1. 26E-03-1.70-7. 80 15q25-q26 6 223136_at AIG-1 -5. 01 7. 26E-08 5. 29E-04-1.55-7. 766q24. 1 7 211919_s_at CXCR4 2.36 1.86E-07 9.68E-04 1.52 7. 56 2q21 8 213564_x_at LDHB-1.30 1.72E-07 9.68E-04-1. 52-7. 54 12p12.2-p12. 1 9 206295_at IL18 -4. 26 3. 77E-07 1. 26E-03-1.57-7. 53 11q22. 2-q22.3 10 213061_s_at LOC123803 1. 70 3. 38E-07 1. 26E-03 1.50 7. 40 16p13. 11 11 226694_at AKAP2 9.83 1. 89E-04 2. 73E-02 2.07 7. 37 9q31-q33 12225745_at 2. 60 9.61E-05 2.08E-02 1.85 7.33 1335617_at MAPK7 1.99 3. 43E-05 1. 40E-02 1.64 7. 15 17p11. 2 14217975_at LOC51186-12.15 1. 32E-06 2. 67E-03-1.56-7. 14Xq22. 1 15217691_x_at SLC16A3-2.06 3. 50E-07 1. 26E-03-1.41-7. 0517q25 16 209201 x at CXCR4 2. 42 1. 29E-06 2. 67E-03 1.43 7.02 2q21 17230263sat-4. 83 4. 16E-07 1. 26E-03-1.40-6. 99 18219837sat C17-16.54 1. 49E-06 2.67E-03 -1. 49-6. 97 4p16-p15 19 201030_x_at LDHB-1.40 1. 43E-05 7. 97E-03-1.51-6. 93 12p12. 2-p12. 1 20 227182_at MGC26847-8.30 1. 84E-06 2. 92E-03-1.49-6. 91 9q22. 2 21200950at ARPC1A 1. 92 5.83E-06 5.31E-03 1.41 6. 73 7q22. 1 22226865at-5. 72 1. 42E-06 2. 67E-03-1.38-6. 72 23222664at MGC2628-6.05 1. 38E-06 2. 67E-03-1.37-6. 6819q13. 11 24 222761_at DIVM -7. 94 2. 19E-06 3. 32E-03-1.39-6. 64 13q32-q33. 1 26 228497_at FLIPT1 -2. 97 9. 54E-07 2. 67E-03-1.32-6. 61 1p13. 1 26 201596_x_at KRT18 -20. 47 4. 29E-06 4. 73E-03-1.50-6. 60 12q13 27202371_at FLJ21174-3.63 1. 52E-06 2. 67E-03-1.33-6. 55 Xq22. 1 28226763at DKFZp43400515-6.16 2. 77E-06 3. 48E-03-1.37-6. 53 2q31. 3 29 227573_s_at -6. 26 2. 45E-06 3. 43E-03-1.35-6. 52 30 231902_at LOC152485 -2. 85 1. 29E-06 2. 67E-03-1.30-6. 494q31. 1 31 37408_at MRC2-2.63 1. 54E-06 2. 67E-03-1.30-6. 46 17q23. 3 32 211998_at H3F3B 1.80 3. 71E-06 4. 22E-03 1.31 6. 41 17q25 33 214462 at SOCS4-2.26 1. 82E-06 2. 92E-03-1.29-6. 40 18q22. 2 34 205411_at STK4-1.85 2. 77E-06 3. 48E-03-1.30-6. 35 20q11. 2-q13. 2 35208742sat SAP18 1. 73 1. 49E-04 2. 55E-02 1. 50 6. 30 13q11 36225330at MGC18216-3. 04 2. 87E-06 3. 49E-03-1.26-6. 25 15q26. 3 37218212sat MOCS2-4.05 2.71 E-06 3. 48E-03-1.26-6. 25 5q11 38 209267_s_at BIGM103 -3. 52 4. 64E-06 4. 94E-03-1.29-6. 24 4q22-q24 39 244623_at -4. 05 8.28E-06 6.21 E-03-1.28-6. 23 40 234107 s at HARS2-2.82 2. 40E-06 3. 43E-03-1. 24 -6.22 20p11. 23 41 221973_at LOC150759 -3. 17 5. 53E-06 5. 16E-03-1.28-6. 152q11. 1 42 226764_at LOC152485 -6. 97 3. 19E-06 3. 75E-03-1. 24-6. 154q31. 1 43201242sat ATP1B1-5. 41 5. 10E-06 5. 03E-03-1.26-6. 13 1q22-q25 44 212688_at PIK3CB -3. 29 7. 14E-06 5. 97E-03-1.28-6. 11 3q22. 3 45224681at GNA12 3. 87 6. 62E-04 5. 01E-02 1.79 6. 11 7p22-p21 46 239791_at 3.01 8. 63E-05 1.99E-02 1.37 6.10 47222668at MGC2628-8.25 7. 21E-06 5. 97E-03-1.28-6. 09 19q13. 11 48 209256_s_at KIAA0265 2.89 1. 88E-04 2. 73E-02 1.44 6. 08 7q32. 2 49 233255_s_at BIVM -37. 82 1. 20E-05 7. 55E-03-1.38-6. 07 13q32-q33. 1 50 202747_s_at ITM2A -5. 34 5. 11E-06 5. 03E-03-1.21-6. 00 Xq13.3-Xq21. 2 2.2 AML_+13 versus AML_komplext # affy id HUGO name fc p q stn t Map Location 1 209619_at CD74 2. 82 3.36E-13 3.71E-09 2.84 16.95 5q32 2 222902_s_at FLJ21144 -2. 38 4. 07E-13 3. 71 E-09-1. 79-11.35 1 p34. 1 3208806at 2.21 1.85E-09 1.47E-06 1.85 10.95 4200608sat RAD21-1.92 1. 22E-09 1.31E-06 -1. 64-9.93 8q24 5239598sat FLJ20481-5.21 1. 85E-11 1. 12E-07-1.50-9. 55 16q12. 1 6214763at THEA-7.52 3. 30E-11 1. 51E-07-1. 53-9. 49 1p32. 2 7 204670_x_at HLA-DRB5 2. 42 8. 28E-08 1. 64E-05 1.61 9. 28 6p21. 3 8 218364_at LRRFIP2-2. 61 8. 04E-11 2. 44E-07-1.45-9. 22 3p21. 33 9206060sat PTPN22-4.39 7. 28E-11 2. 44E-07-1.39-8. 92 1p13. 3-p13. 1 10 226531_at FLJ14466-3.36 1. 75E-09 1. 45E-06-1.43-8. 88 12q24. 31 11 217963_s_at NGFRAP1 -15. 18 3. 08E-10 6. 24E-07-1.37-8. 60 Xq22. 1 12209804at DCLRE1A-4. 79 2. 16E-10 5. 38E-07-1. 33-8. 51 10q25. 1 13 208010_s_at PTPN22-3.91 2. 36E-10 5. 38E-07-1.33-8. 48 1p13. 3-p13. 1 14 212160_at XPOT-2.05 3. 46E-10 6. 32E-07-1.32-8. 41 12 15 203949_at MPO-12.24 7. 33E-10 9. 55E-07-1.33-8. 32 17q23. 1 16 230263_s_at -6. 25 4. 09E-10 6. 78E-07-1.29-8. 28 17 218472 s at PELO-4.54 4. 60E-10 6. 99E-07-1.29-8. 26 5q11. 2 18 227904_at FLJ21939-3.49 5. 37E-10 7. 53E-07-1.29-8. 23 3p23 19 203678_at KIAA1018 -2. 10 1. 07E-09 1. 30E-06-1.28-8. 13 15q13. 1 20 232744_x_at -3. 09 1. 14E-09 1. 30E-06-1.24-7. 94 21 204852_s_at PTPN7-2.43 5. 70E-09 3. 16E-06-1.26-7. 92 1q32. 1 22244552at-3. 58 1. 63E-09 1. 45E-06-1.24-7. 90 23230206at-11. 271. 36E-091. 38E-06-1.23-7. 88 24203208sat CHPPR-2.82 1. 18E-08 5. 02E-06-1.26-7. 878q12. 1 25211950_at RBAF600-2.36 1. 47E-09 1.41E-06 -1. 23-7. 871p36. 13 26213134_x_at BTG3-4.33 5. 01E-09 3. 04E-06-1.24-7. 82 21q21.1-q21. 2 27 220773_s_at GPHN-7.95 1. 70E-09 1. 45E-06-1.22-7. 82 14q23. 3 28 218341_at FLJ11838 -2. 40 1. 44E-08 5. 64E-06-1.25-7. 781p34. 1 29203282at GBE1-3. 44 4. 52E-09 2.84E-06 -1.22 -7.75 3p12. 3 30212629sat PRKCL2-3.29 2. 13E-09 1. 62E-06-1. 21-7. 75 1 p22. 2 31 210462_at BLZF1-6.71 3. 78E-09 2. 52E-06-1.23-7. 72 1q24 32205036_at LSM6-2.09 3. 41E-09 2. 39E-06-1.21-7. 704q31. 21 33 206175_x_at ZNF222-5.70 2. 98E-09 2. 18E-06-1. 20-7. 65 19q13. 2 34211998_at H3F3B 2. 07 1. 48E-07 2. 18E-05 1.27 7. 6517q25 35204328at EVER1-2. 47 1. 03E-07 1. 79E-05-1.26-7. 6417q25. 3 36205548sat BTG3-4.17 3. 43E-08 8. 91E-06-1. 23-7. 6321q21. 1-q21. 2 37 209340_at UAP1-2.62 3. 66E-08 9. 28E-06-1.23-7. 63 1 q23. 1 38 204351_at S100P -9. 16 5. 23E-09 3. 08E-06-1.22-7. 62 4p16 39204064_at THOC1-2.44 1. 00E-07 1. 76E-05-1.25-7. 61 18p11. 32 40206550sat NUP155-2.22 5. 86E-09 3. 16E-06-1.19-7. 58 5p13. 1 41 236539_at PTPN22-5.06 3. 87E-09 2. 52E-06-1.18-7. 55 1p13.3-p13. 1 42 217975_at LOC51186-9.44 7. 49E-09 3. 69E-06-1.21-7. 53 Xq22. 1 43 201263_at TARS-2.25 6. 31 E-08 1. 39E-05-1.22-7. 50 5p13. 2 44200984sat CD59-3.17 1. 22E-08 5. 05E-06-1. 18-7. 47 11p13 45220926sat C1orf22-5. 15 9. 92E-094. 76E-06-1.20-7. 461q24-q25 46 227334_at FLJ37318-2. 66 1. 55E-08 5. 64E-06-1.18-7. 45 10q22. 2 47 202200_s_at SRPK1 -2. 92 5. 89E-09 3. 16E-06-1.16-7. 42 6p21. 3-p21. 2 48 209523_at TAF2-2.16 2. 09E-08 6. 57E-06-1.18-7. 42 8q24. 12 49 218114_at GGA1 -1. 94 1. 98E-08 6. 44E-06-1.17-7. 38 22q13. 31 50 221848_at KIAA1847 -4. 86 1. 08E-08 4. 84E-06-1.18-7. 37 20q13. 3 2.21 AML_+13 versus AML-normal &num affy id HUGO name fc p q stn t Map Location 1 203955_at KIAA0649 -10. 26 1. 77E-18 1. 68E-15-1.37-15. 88 9q34.3 2 233255_s_at BIVM -19. 10 1. 89E-31 5. 75E-27-1.17-14. 99 13q32-q33.1 3 224839_s_at GPT2-11.20 6.76E-30 1.03E-25-1. 13-14.45 16q12. 1 4 203949_at MPO-11.09 1. 50E-26 1. 52E-22-1.08-13. 67 17q23.1 5217963sat NGFRAP1-10.46 7. 48E-21 1. 08E-17-1.12-13. 60 Xq22. 1 6 212688_at PIK3CB -3. 07 2. 35E-17 1. 88E-14-1.11-13. 10 3q22. 3 7 209267_s_at BIGM103 -3. 47 4. 22E-16 2.79E-13-1. 12-13.01 4q22-q24 8 216141_at -5. 75 3.27E-26 2.48E-22-1. 01-12.96 9 220416 at KIAA1939-6. 47 3.58E-20 4.54E-17-1. 06-12.92 15q15. 3 10220773sat GPHN-6.84 1. 28E-11 3. 03E-09-1.21-12. 85 14q23. 3 11 209739_s_at DXS1283E-6.10 5.24E-26 3.18E-22-1. 00-12. 85 Xp22.3 12 213110 s at COL4A5-11.80 9. 51 E-26 4. 82E-22-0. 99-12. 72 Xq22 13 238021_s_at -11. 01 3.02E-24 1. 31E-20-1. 00-12.66 14213844_at HOXA5-7.77 8. 51E-14 3. 60E-11-1. 12-12. 59 7p15-p14 15227001at-3. 67 4.89E-12 1.32E-09-1. 14-12.38 16205107sat EFNA4-4.28 8. 27E-18 6. 98E-15-1.01-12. 13 1q21-q22 17 230206_at -9. 35 2. 62E-11 5.58E-09-1. 13-12.05 18217975_at LOC51186-5.82 7. 47E-17 5. 28E-14-1.01-12. 00 Xq22. 1 19 219078_at FLJ10252 -2. 62 2. 38E-10 3. 88E-08-1.15-11. 97 1q41 20 226763_at DKFZp43400515-4. 38 6. 69E-11 1.27E-08-1. 13-11. 97 2q31. 3 21 238022at-9. 47 1.62E-22 4.48E-19-0. 94-11.92 22242476at-3. 07 6.33E-14 2. 83E-11-1. 04-11.91 23 238784_at FLJ32949 -8. 15 7.99E-23 2. 43E-19-0. 93-11.84 12q14. 1 24216920sat TRGV9-5.12 3. 74E-15 2. 14E-12-1.01-11. 84 7p15 25203948sat MPO-15.41 1. 95E-23 7. 42E-20-0.92-11. 82 17q23. 1 26212173_at AK2-3.51 9. 14E-13 2. 90E-10-1.05-11. 78 1p34 27 242269_at DKFZp761G0122 -3. 56 2. 61 E-23 8.83E-20-0. 92-11.72 1 p36. 32 28 219479_at KDELC1 -15. 39 3. 59E-22 8. 39E-19-0. 91-11.63 13q33 29223703at CDA017-4. 32 9. 39E-11 1. 70E-08-1.09-11. 56 10q23. 1 30208626sat VAT1-2. 58 3.78E-13 1.37E-10-1. 01-11.51 17q21 31 204082_at PBX3-3.02 1.12E-19 1. 31E-16-0. 92-11.44 9q33-q34 32200923at LGALS3BP-8.68 3.30E-22 8. 36E-19-0. 89-11. 35 17q25 33 215806 x at TRGC2-5.22 4. 05E-13 1. 43E-10-1.00-11. 34 7p15 34 222668_at MGC2628-6. 79 1. 12E-14 5. 78E-12-0.97-11. 33 19q13. 11 35206480_at LTC4S-7. 79 7. 28E-22 1. 58E-18-0.89-11. 325q35 36205653_at CTSG-10.96 3. 73E-21 5. 67E-18-0.89-11. 31 14q11. 2 37222664_at MGC2628-5. 14 5. 37E-11 1. 06E-08-1.05-11. 29 19q13. 11 38 219869_s_at BIGM103 -3. 16 2. 26E-11 5. 01E-09-1. 03-11. 26 4q22-q24 39 239598_s_at FLJ20481 -4. 51 6. 30E-11 1.21E-08 -1. 04-11.22 16q12. 1 40232424_at PRDM16-25.39 9.57E-22 1.94E-18-0. 88-11. 18 1p36. 23-p33 41 239091_at -4. 28 1.09E-21 2.08E-18-0. 87-11. 14 42 236738_at -45. 68 1.37E-21 2.46E-18-0. 87-11.11 43 235391_at LOC137392 -5.33 3.59E-21 5. 67E-18-0.87-11. 10 8q21. 3 44 235438_at -41. 83 1.92E-21 3.24E-18-0. 87-11.07 45 242426_at LOC145957-9. 51 1. 07E-20 1. 48E-17-0. 87 -11.05 15q23 46209619_at CD74 1.67 1.32E-09 1.78E-07 1.06 10. 98 5q32 47 239791_at -4. 09 1.24E-20 1.64E-17-0. 86-10.97 48229838_at NUCB2-2.58 2. 40E-11 5. 25E-09-0.99-10. 95 11p15. 1-p14 49218801at UGCGL2-4.77 2. 87E-13 1.08E-10-0. 92-10.71 13q32.1 50218007sat RPS27L-2.30 1. 06E-08 1. 10E-06-1.08-10. 70 15q21. 3 2.22 AML_+13 versus AMLt (15 ; 17) &num affy id HUGO name fc p q stn t Map Location 1 203949_at MPO-30.39 2.06E-19 5.48E-15-6. 00-30.27 17q23.1 2 203948_s_at MPO-64.98 7.49E-17 9.95E-13-5. 50-26.38 17q23.1 3209619_at CD74 6. 42 5.51E-15 3.66E-11 4.14 21. 04 5q32 4 212953_x_at CALR-5.35 5. 41E-15 3.66E-11 -3. 41-17.49 19p13. 3-p13. 2 5 206871_at ELA2-13.81 9. 41E-15 5. 00E-11-3. 39-17.48 19p13. 3 6 38487_at STAB1 -15.23 2.93E-13 9. 72E-10-3.20-15. 93 3p21. 31 7 204670_x_at HLA-DRB5 8. 34 2. 32E-08 8. 32E-06 3.55 15. 896p21. 3 8214450at CTSW-11.30 6.15E-14 2.72E-10-3. 08-15. 77 11q13. 1 9 214575_s_at AZU1-28.78 2.83E-13 9.72E-10-3. 08-15.48 19p13. 3 10 2338022_at -21. 32 1.79E-12 4.33E-09-3. 06-14.98 11 205382sat DF-9.47 1.65E-12 4.33E-09-2. 84-14.56 19p13. 3 12205624_at CPA3-13.72 3. 68E-12 7. 53E-09-2.67-13. 47 3q21-q25 13 219869_s_at BIGM103 -5. 60 1.62E-12 4.33E-09-2. 58-13. 29 4q22-q24 14224839sat GPT2-30.28 4. 52E-11 7. 07E-08-2.77-13. 08 16q12. 1 15 233072_at KIAA1857 -26. 11 4. 14E-11 6.88E-08-2. 71-12.97 9q34 16 231736 x at MGST1-5. 53 9.93E-11 1.32E-07-2. 49-12.60 12p12. 3-p12. 1 17 210788_s_at retSDR4-3.16 3. 65E-12 7.53E-09-2. 42-12.52 14q22.3 18 224918_x_at MGST1-4.80 1.77E-09 1.24E-06-2. 51-12.36 12p12. 3-p12. 1 19214797sat PCTK3 7.37 4. 58E-06 3. 58E-04 3.11 12.06 1q31-q32 20208806at 3.09 6. 92E-11 9.68E-08 2.31 11.86 21208852sat CANX-3. 50 1.42E-11 2. 69E-08-2.28-11. 84 5q35 22 201596_x_at KRT18 -31. 80 2.96E-10 3.14E-07-2. 53-11.80 12q13 23 203675_at NUCB2-4.25 1. 76E-11 3. 12E-08-2.22-11. 51 11p15.1-p14 24 200654_at P4HB-3.08 7.91 E-08 1. 95E-05-2.42-11. 40 17q25 25204150_at STAB1-16.90 3. 85E-10 3.93E-07-2. 36-11. 383p21. 31 26 220798_x_at FLJ11535 -6. 48 4. 85E-11 7.16E-08-2. 14-11.11 19p13. 3 27 225545_at 1. 80 2. 54E-09 1. 57E-06 2. 21 11.08 28229168at DKFZp434K0621-6. 55 1. 38E-10 1.65E-07-2. 11-10.81 5q35.3 29 200986_at SERPING1 -14. 98 8.69E-10 6.87E-07-2. 23-10. 80 11q12-q13. 1 30209312xat HLA-DRB1 9. 37 1. 51E-05 7. 85E-04 2.84 10. 63 6p21. 3 31 200953sat CCND2-3.22 1.46E-10 1.65E-07-2. 04-10.55 12p13 32 219431_at FLJ20896-3. 22 1. 13E-10 1. 43E-07-2.03-10. 53 4q31. 21 33 221004_s_at ITM2C -2. 62 1.49E-10 1.65E-07-2. 00-10.41 2q37 34210140_at CST7-10.18 7. 25E-10 6.22E-07-2. 06-10. 35 20p11. 21 35230075_at RAB39B 5. 83 1. 04E-05 6. 07E-04 2.58 10.29 36 207375_s_at IL15RA 5. 53 1. OOE-05 5. 94E-04 2.57 10.27 10p15-p14 37 210338_s_at HSPA8-6.33 9. 59E-10 7. 27E-07-1.99-10. 08 11q24. 1 38220773sat GPHN-10.91 7. 04E-10 6. 22E-07-1.98-10. 07 14q23.3 39238021sat-14. 17 1.87E-09 1.27E-06-2. 03-10.06 40217853_at TEM6 6. 88 2. 28E-05 1. 04E-03 2.70 10. 047p15. 1 41 225532_at LOC91768-5.21 8. 11E-10 6.73E-07-1. 97-10.03 18q11. 1 42 204918_s_at MLLT3 4.34 1. 85E-05 9.00E-04 2.57 9.92 9p22 43 205653_at CTSG-24.10 4. 58E-09 2. 43E-06-2.06-9. 87 14q11. 2 44200656sat P4HB-5.76 5. 25E-10 5. 14E-07-1.91-9. 86 17q25 45 220987_s_at SNARK 4.20 1. 25E-05 6. 86E-04 2.44 9. 84 1q32. 1 46 214763_at THEA-7.04 3. 35E-09 1.90E-06 -2. 00-9. 82 1 p32. 2 47 214315_x_at CALR-2.89 5. 42E-10 5. 14E-07-1.89-9. 81 19p13. 3-p13. 2 48219837_s_at C17-184.51 7. 78E-09 3. 57E-06-2.15-9. 754p16-p15 49200951sat CCND2-5.09 6. 78E-10 6. 21E-07-1. 88-9. 73 12p13 50 210254_at MS4A3-12.38 3. 00E-09 1. 74E-06-1.93-9. 65 11q12 2.23 AML+13 versus AML t (8; 21) # affyid HUGO name fc p q stn t Map Location 1 203949_at MPO-27.89 5.16E-18 1.64E-13-3. 88-21.18 17q23.1 2 203948_s_at MPO-47.50 2.60E-14 4.13E-10-2. 98-15.68 17q23.1 3222668at MGC2628-11.24 3. 42E-12 3.62E-08-2. 04-11. 44 19q13. 11 4217868sat DREV1 2. 39 1. 45E-06 4. 13E-04 2.40 10.99 16p13-p12 5228827at-131. 93 4.30E-10 1.95E-06-2. 00-10.07 6228058_at LOC124220-6.54 6. 47E-11 4. 38E-07-1.77-9. 9816p13. 3 7 219869_s_at BIGM103 -3. 02 9. 08E-10 3. 61E-06-1. 80-9. 91 4q22-q24 8206871_at ELA2-11.69 6. 90E-11 4. 38E-07-1.75-9. 85 19p13. 3 9 211998_at H3F3B 2.18 7. 97E-07 2. 78E-04 2.00 9. 77 17q25 10 211728 s at HYAL3-7.57 1. 75E-10 9. 27E-07-1.68-9. 463p21. 3 11 205529_s_at CBFA2T1 -23. 42 1. 29E-09 3. 77E-06-1.80-9. 42 8q22 12 206940_s_at POU4F1 -35. 03 1. 54E-09 3. 77E-06-1.84-9. 41 13q21.1-q22 13217853_at TEM6 5.69 1. 31E-05 1.90E-03 2.14 9. 28 7pu 5. 1 14204604at PFTK1-3. 01 3.06E-09 5. 41 E-06-1. 68-9. 27 7q21-q22 15229406at-14. 24 1. 37E-09 3. 77E-06-1.72-9. 23 16 219078_at FLJ10252-2.51 2. 13E-09 4. 84E-06-1.59-8. 89 1q41 17 233072_at KIAA1857 -12. 15 2. 61E-09 4. 89E-06-1.62-8. 83 9q34 18222664at MGC2628-8. 57 1. 45E-09 3. 77E-06-1.59-8. 8319q13. 11 19 219185_at SIRT5 -2. 76 1. 57E-08 1. 66E-05-1.59-8. 73 6p23 20 210150_s_at LAMA5 -4. 86 1. 54E-09 3. 77E-06-1.56-8. 72 20q13.2-q13. 3 21 208091_s_at DKFZP564K0822 7.35 7.53E-05 5.72E-03 2.31 8. 59 7p14. 1 22 208806_at 2. 06 6. 07E-09 8. 76E-06 1.54 8.57 23 211341_at POU4F1-158. 55 1. 01E-08 1. 23E-05-1.69-8. 5213q21. 1-q22 24 220987_s_at SNARK 2.92 3. 38E-05 3. 42E-03 2.00 8. 46 1q32. 1 25210874sat FUS2-5.10 2. 47E-09 4. 89E-06-1.50-8. 453p21. 3 26222146sat TCF4 5.57 5. 53E-05 4. 63E-03 2.11 8. 45 18q21. 1 27 205528_s_at CBFA2T1 -37. 84 1. 21E-08 1.41E-05 -1. 64-8. 42 8q22 28 203859_s_at PALM-6.21 2. 59E-09 4. 89E-06-1.48-8. 36 19p13. 3 29 37005_at NBL1-2. 90 4. 96E-09 7. 89E-06-1.48-8. 25 1 p36. 3-p36.2 30 204351_at S100P -9. 78 9. 49E-09 1. 23E-05-1. 51-8. 24 4p16 31 230100_x_at PAK1 2. 31 1. 63E-05 2. 11E-03 1.80 8. 2411q13-q14 32 219256_s_at FLJ20356 2. 96 2. 41E-05 2. 73E-03 1.83 8. 19 4p16. 1 33 229848_at ZNF10-6.04 4. 44E-09 7. 42E-06-1.44-8. 15 12q24. 33 34219837_s_at C17-28.27 1. 79E-08 1. 77E-05-1.53-8. 144p16-p15 35 208855_s_at STK24 2. 45 1. 1 BE-05 1. 76E-03 1.72 8. 11 13q31. 2-q32.3 36213241_at 4. 54 2. 32E-05 2. 67E-03 1.79 8.09 37208626sat VAT1-3.97 1.24E-08 1. 41 E-05-1. 47-8. 0817q21 38 210254_at MS4A3-7.01 5. 47E-09 8. 27E-06-1.43-8. 08 11q12 39 239707_at FLJ25217 -8. 85 1. 53E-08 1. 66E-05-1.48-8. 06 17p11. 2 40223467_at RASD1 19.90 1. 84E-04 1.01E-02 2.50 7. 9617p11. 17p11.2 41 223703 at CDA017-4. 24 8. 84E-09 1.22E-05 -1. 40-7. 92 10q23. 1 42 207081_s_at PIK4CA 1. 82 5. 31E-06 9. 82E-04 1.60 7. 90 22q11. 21 43 214763_at THEA-5.67 2. 48E-08 2.25E-05 -1. 45-7. 81 1p32.2 44 209267_s_at BIGM103 -2. 88 9. 68E-09 1. 23E-05-1.39-7. 854q22-q24 45230263sat-4. 73 1. 63E-08 1. 67E-05-1.38-7. 76 46218786at-3. 02 2. 27E-08 2. 16E-05-1.38-7. 76 47 221902_at -6. 49 2. 94E-08 2. 39E-05-1.41-7. 74 48 204852_s_at PTPN7-2.39 2. 68E-08 2. 37E-05-1.38-7. 73 1 q32. 1 49218553sat MGC2628-2.26 1. 26E-07 7. 13E-05-1.40-7. 67 19q13. 11 50227711_at FLJ32942-8.02 2. 84E-08 2. 38E-05-1.38-7. 66 12q13. 13 2.24 AML_+8 versus AML-7 # affy id HUGO name fc p q stn t Map Location 1 213893_x_at PMS2L5 2. 19 2. 18E-07 7. 33E-03 1.82 8. 22 7q11-q22 2 208688_x_at EIF3S9 1. 91 6. 94E-07 7. 78E-03 1.68 7. 59 7p22. 3 3 214473_x_at PMS2L9 1. 70 6. 59E-07 7. 78E-03 1.64 7. 46 7q11. 23 4 214526_x_at PMS2L8 1. 85 1. 19E-06 8. 41 E-03 1.58 7. 16 7q22 5 205778_at KLK7 5. 83 8. 08E-06 1. 43E-02 1.68 7.07 19q13. 33 6 238315_s_at MGC45586-3.19 1. 70E-06 8. 41E-03-1. 54-7. 01 19q13. 12 7 225002_s_at DKFZP566I1024 3. 14 9. 11 E-06 1. 53E-02 1.67 7. 01 7q11. 1 8 203462_x_at EIF3S9 1. 76 1. 75E-06 8. 41E-03 1.53 6. 95 7p22. 3 9226336_at PPIA 2. 18 1. 66E-06 8. 41E-03 1.51 6. 90 7p13-p11. 2 10 203198_at CDK9-1.99 1. 22E-05 1. 67E-02-1.58-6. 81 9q34. 1 11 215667_x_at PMS2L5 1. 75 7. 87E-06 1. 43E-02 1. 55 6.80 7q11-q22 12 237642_at 1.58 2. 81E-06 1. 05E-02 1.44 6.60 13 201812_s_at TOM7 1. 67 2. 60E-06 1. 05E-02 1.44 6. 59 7p15. 3 14 213018_at ODAG 2. 00 3. 87E-06 1. 30E-02 1.40 6. 42 7q21-q22 15 217485_x_at PMS2L1 2. 09 6. 36E-06 1. 34E-02 1.43 6. 427q11-q22 16205690sat G10 1. 84 4. 38E-06 1. 34E-02 1.39 6.37 7q22.1 17 223065 s at STARD3NL 2. 27 5. 37E-06 1. 34E-02 1.40 6. 36 7p14-p13 18 226385_s_at LOC115416 2. 32 6. 03E-06 1. 34E-02 1.40 6. 34 7p15. 3 19227651_at NAC1-1.52 4. 99E-06 1. 34E-02-1.38-6. 33 19p13. 12 20 220099_s_at CGI-59 2.09 5. 61E-06 1. 34E-02 1.37 6. 26 7q34 21 216843_x_at 1. 92 1. 29E-05 1. 67E-02 1.41 6.24 22 213345 at NFATC4-3.72 1. 82E-05 2. 18E-02-1.38-6. 14 14q11. 2 23 212475_at KIAA0241 2.91 7.56E-06 1.43E-02 1.34 6. 12 7p15. 3 24213097sat ZRF1 2. 69 2. 30E-05 2. 67E-02 1.39 6. 08 7q22-q32 25218200sat NDUFB2 2.19 1.26E-05 1.67E-02 1.35 6. 08 7q34 26213360sat POM121 1.86 1. 00E-05 1.60E-02 1.30 5. 97 7q11. 23 27225437sat MGC22916 1. 47 1. 08E-05 1. 65E-02 1.30 5. 967p22. 3 28224416sat EG1-2.05 4. 44E-05 4. 15E-02-1.37-5. 93 4p16 29220261sat ZDHHC4 2.08 1.17E-05 1.67E-02 1.29 5. 91 7p22. 2 30 201327_s_at CCT6A 2. 06 3.51E-05 3.81E-02 1.32 5. 80 7p11. 1 31 234339 s at GLTSCR2-2.07 1. 55E-05 1. 93E-02-1.25-5. 75 19q13. 3 32 214756 x at PMS2L8 1. 95 2. 45E-05 2. 74E-02 1.28 5.74 7q22 33 218600 at MGC10986-2.54 3. 88E-05 3. 95E-02-1.29-5. 72 17q24. 1 34 208445 s at BAZ1B 4. 90 5. 52E-05 4. 58E-02 1.32 5. 68 7qu 1. 23 35AFFX-r2-Ec-bioC-3at-HG-U133B 1. 51 5. 84E-05 4. 67E-02 1.30 5.64 36 201973_s_at CGI-43 1. 71 3. 64E-05 3. 82E-02 1.23 5. 537p22. 2 37226386at LOC115416 2.22 7. 60E-05 5. 79E-02 1.26 5. 45 7p15. 3 38 216526_x_at PMS2L3 1. 71 5. 26E-05 4. 53E-02 1.22 5. 447q11-q22 39222512at NYREN18 2. 06 1.20E-04 6.51E-02 1.30 5.41 7q36 40 207401_at PROX1 2. 02 4.16E-05 4.00E-02 1.18 5. 39 1q32. 2-q32.3 41 212700_x_at KIAA0356 -2. 20 1. 66E-04 7. 26E-02-1.25-5. 34 17q21. 31 42203630sat COG5 2. 21 4. 02E-05 3. 98E-02 1.16 5.32 7q31 43 209256_s_at KIAA0265 3. 55 1.16E-04 6.51E-02 1.22 5. 28 7q32. 2 44 203476_at TPBG-5.45 5. 93E-04 1. 29E-01-1.46-5. 27 6q14-q15 45238529at 1.85 4. 71E-05 4. 28E-02 1.14 5.24 46 224281_s_at NEUGRIN -1. 94 1. 22E-04 6. 51E-02-1. 18-5. 21 15q26. 1 47 200076_s_at - HG-U133B MGC2749 -1. 60 5. 08E-05 4. 50E-02-1.14-5. 21 19p13. 11 48233070at-4. 41 1. 92E-04 7. 47E-02-1.21-5. 19 49 212212_s_at DKFZP586J0619 1. 66 5. 59E-05 4. 58E-02 1.13 5. 19 7p22. 3 50222823at C9orf12 1.55 1. 13E-04 6.51E-02 1.18 5. 19 9q21. 33-q22.31 2.25 AML_+8 versus AML_5q &num affy id HUGO name fc p q stn t Map Location 1 228526at 3.75 1.72E-07 5.94E-03 2. 05 8.81 2 208717_at OXA1L 2. 07 7.71E-07 1. 33E-02 1.78 7. 7214q11. 2 3212062at ATP9A-8.57 1. 55E-04 1. 54E-01-1.97-7. 10 20q13.11-q13. 2 4 222548_s_at FLJ20373-3.06 6. 34E-05 1. 28E-01-1.80-7. 02 2q11. 2 5 202259_s_at CG005 -2. 10 2. 91E-06 3. 36E-02-1.60-6. 97 13q12-q13 6 222270_at KIAA1387 -2. 75 4. 03E-04 1. 96E-01-1.91-6. 482p16. 1 7 201811_x_at SH3BP5-3.69 1. 56E-04 1. 54E-01-1.65-6. 36 3p24. 3 8 213228_at PDE8B-1. 77 8. 39E-06 7. 25E-02-1.46-6. 345q13. 2 9 202843_at DNAJB9-2.58 2. 07E-05 1. 11E-01-1. 48-6. 30 7q31 10218132sat LENG5-1.63 1. 09E-05 7. 51E-02-1. 42-6. 1719q13. 4 11 214000_s_at RGS10-2.34 2. 87E-05 1. 11E-01-1. 45-6. 14 10q25 12 242957_at FLJ32009-3.17 7. 76E-05 1. 28E-01-1.49-6. 09 11q12. 2 13204567sat ABCG1-3. 10 2. 41E-04 1. 77E-01-1.60-6. 0921q22. 3 14 223556 at HELLS-2.21 7. 94E-05 1. 28E-01-1.47-6. 03 10q24. 2 15 205849_s_at UQCRB 1. 55 4. 15E-05 1. 20E-01 1.38 5.89 8q22 16200936at RPL8 1.91 2. 90E-05 1.11E-01 1.37 5. 898q24. 3 17218552at FLJ10948 2. 14 2.63E-05 1.11E-01 1.36 5. 86 1p32. 3 18 234998_at -1. 98 7.72E-05 1.28E-01-1. 40-5.84 19 204367_at SP2-2.13 3. 45E-04 1. 92E-01-1.49-5. 72 17q21. 32 20 225621_at FLJ14511-2.17 5.75E-05 1.28E-01-1. 34-5. 71 9q22. 33 21224899sat DKFZp564K142-1. 803. 82E-051. 20E-01-1.32-5. 70 Xq13.1-q13. 2 22215884sat UBQLN2-1. 90 1. 26E-04 1. 50E-01-1.37-5. 66 Xp11. 23-p11. 1 23 220988_s_at C1QTNF3 -1.62 3.52E-05 1. 20E-01-1.30-5. 63 5p13-p12 24 213951_s_at HUMGT198A-2.31 9.09E-05 1.28E-01-1. 31-5. 54 17q12-q21 25 208243_s_at CNR1 -2. 09 2. 19E-04 1. 72E-01-1.37-5. 546q14-q15 26 2268738_at -2. 09 5.07E-05 1.28E-01-1. 28-5.54 27210596at DKFZp564K142-2. 74 5. 54E-04 2. 18E-01-1.46-5. 51 Xq13. 1-q13. 2 28 216432_at -2. 56 3.33E-04 1.92E-01-1. 37-5.43 29223304at DKFZp761N0624-4. 42 6. 91E-04 2. 20E-01-1.47-5. 43 7q34 30209705at-1. 71 5.63E-05 1.28E-01-1. 24-5.38 31 211063_s_at NCK1-2.02 1. 66E-04 1. 56E-01-1.29-5. 37 3q21 32202113sat SNX2 2.34 9.17E-05 1.28E-01 1.26 5. 33 5q23 33 218277_s_at FLJ22060-1.97 5. 42E-04 2. 15E-01-1.37-5. 30 17q23. 2 34 224473_x_at KIAA1813 -1.55 1.25E-04 1.50E-01 -1. 24-5. 2810q24 35 200764_s_at CTNNA1 1.99 9.27E-05 1.28E-01 1.24 5.27 5q31 36218902at NOTCH1-3. 04 1. 16E-03 2. 56E-01-1.50-5. 26 9q34. 3 37 222422_s_at NDFIP1 2.22 7.58E-05 1. 28E-01 1.22 5.26 5q31. 3 38222527sat FLJ10290 2.25 6.83E-05 1.28E-01 1.20 5. 23 5q33. 1 39206648_at HSPC059-2.52 1. 03E-04 1. 36E-01-1.21-5. 23 19q13. 12 40200864sat RAB11A-1. 82 4. 84E-04 2. 09E-01-1.32-5. 22 15q21. 3-q22.31 41 201938_at CDK2AP1 -2. 00 6.53E-04 2.20E-01-1. 35-5.20 12q24.31 42 234148_at 4.39 1.30E-04 1.50E-01 1.24 5.20 43208608sat SNTB1 3.64 1.67E-04 1.56E-01 1.24 5. 158q23-q24 44 204010_s_at KRAS2-2.19 2. 30E-04 1. 75E-01-1.23-5. 13 12p12. 1 45 214500_at H2AFY 3.68 9.03E-05 1.28E-01 1.17 5. 10 5q31. 3-q32 46217963sat NGFRAP1-3.37 1. 51E-04 1.54E-01-1. 19-5. 09Xq22. 1 47 207049 at SCN8A-1.65 2. 33E-04 1.75E-01 -1. 21-5. 09 12q13 48 213337_s_at SOCS1 -2. 37 4. 86E-04 2.09E-01 -1. 26-5. 07 16pu3. 13 49 225710_at -1. 94 3. 93E-04 1. 96E-01-1.24-5. 06 50 212287_at JJAZ1 -1.84 8.32E-04 2. 30E-01-1.31-5. 03 17q11. 2 2.26 AML_+8 versus AML_9q # affyid HUGO name fc p q stn t Map Location 1 231949_at 1. 90 9. 59E-07 1. 36E-02 1.62 7.34 2242326at 1. 90 1. 38E-06 1. 36E-02 1.59 7.20 3201548sat PLU-1-1.93 8. 97E-07 1. 36E-02-1.55-7. 12 1q32. 1 4 239856_at 3.75 9.26E-06 2.03E-02 1.71 7.10 5238743_at 1. 79 3. 54E-06 2. OOE-02 1.53 6.84 6235340at CAPN3 1. 72 5.83E-06 2.00E-02 1.53 6. 80 15q15.1-q21.1 7226226 at LOC120224 2. 12 1. 87E-06 1. 38E-02 1.49 6. 79 11q24. 3 8222125sat PH-4-1. 76 5.54E-06 2.00E-02 -1. 49-6. 68 3p21. 31 953071sat FLJ22222-2.23 8. 09E-06 2.00E-02 -1. 44-6. 46 17q25. 3 10235297_at 1. 58 4. 06E-06 2. OOE-02 1.39 6.38 11 235828_at LOC153768 1. 84 1.71E-05 2. 19E-02 1.43 6.29 5q32 12 201938 at CDK2AP1-1.71 6. 97E-06 2.00E-02 -1. 35-6. 19 12q24. 31 13237541_at 2. 59 6. 68E-06 2. OOE-02 1.34 6.15 14230724sat FLJ10726 1.59 1. 03E-05 2. 05E-02 1.36 6. 13 11q23. 2 15 239641_at 1. 74 1. 24E-05 2. 13E-02 1.36 6.12 16232932_at 1.62 9.57E-06 2.03E-02 1.34 6.10 17234272_at 2.17 8.07E-06 2. 00E-02 1.33 6.07 18 218438_s_at EG1 -1. 80 3. 77E-05 2.73E-02 -1. 37-5. 97 4p16 19206851at RNASE3-3.81 1. 77E-05 2. 19E-02-1.31-5. 92 14q24-q31 20 242455 at POU3F2 1. 70 1. 19E-05 2. 13E-02 1.29 5.91 6q16 21 226258_at LOC196394 2. 94 1. 59E-05 2. 19E-02 1.28 5. 83 12p11. 21 22 233965_at LOC255480 2. 42 1. 35E-05 2. 13E-02 1.27 5. 81 12q24. 21 23234250_at 2. 49 1. 36E-05 2. 13E-02 1.27 5. 81 24241263_at 2.29 1.64E-05 2.19E-02 1.27 5.78 25227764_at LOC130574 1. 53 2. 28E-05 2. 51 E-02 1.29 5. 782q23. 3 26 203314_at PGPL-1. 91 3. 44E-05 2. 62E-02-1.29-5. 76 Xp22. 33 27244293_at 2.02 1.74E-05 2.19E-02 1.26 5.75 28 204481 at BRPF1-1.69 2. 61E-05 2. 62E-02-1.27-5. 743p26-p25 29241281_at 2. 49 2. 16E-05 2. 51 E-02 1.25 5.68 30 216504_s_at BIGM103 -1. 63 2. 99E-05 2. 62E-02-1.26-5. 68 4q22-q24 31 240430at 2.10 2.69E-05 2.62E-02 1.24 5.60 32229301at FLJ20618 1. 80 2.23E-05 2.51E-02 1.22 5. 58 22q12. 2 33 235016at 3.02 2.86E-05 2.62E-02 1.22 5.53 34 231623_at MGC13034 1.68 3. 10E-05 2.62E-02 1.21 5. 51 5q13. 1 35241131_at 1.96 2.72E-05 2.62E-02 1.20 5.49 36222491_at FLJ32731 1. 81 5. 85E-05 3. 16E-02 1.23 5. 48 8p11. 1 37202371at FLJ21174-2.34 1. 54E-04 3. 43E-02-1.30-5. 47 Xq22. 1 38239873_at 2.29 2.84E-05 2.62E-02 1.19 5.47 39 233657 at 2. 00 4. 05E-05 2. 86E-02 1.21 5.46 40 231006_at MGC44294 1.87 3.05E-05 2.62E-02 1.19 5. 46 15q26. 2 41 234956_at 1.50 3.27E-05 2.62E-02 1.19 5.45 42208653sat CD164-2.14 3.19E-05 2.62E-02-1. 19-5.44 6q21 43 228657_at KIF1B 1. 95 9. 92E-05 3. 37E-02 1.27 5. 43 1p36. 2 4 225992_at MLLT10 -1. 86 1. 03E-04 3. 37E-02-1.25-5. 42 10p12 45 228797_at 1.71 3.53E-05 2.62E-02 1.19 5.42 46203368at CRELD1-1. 63 1. 95E-04 3. 64E-02-1.29-5. 40 3p25. 3 47 234721_s_at P450RAI-2 1. 68 6.09E-05 3. 16E-02 1.21 5.39 2p12 48 214271_x_at RPL12 1.20 3.35E-05 2.62E-02 1.18 5.39 9q34 49230116_at LOC90133 1. 68 7. 30E-05 3. 29E-02 1. 22 5. 373q26. 1 50234486at OR51B2 1. 55 5. 80E-05 3. 16E-02 1.18 5. 33 11p15 2.27 AML_+8 versus AML MLL affy id HUGO name fc p q stn t Map Location 1203372sat SOCS2-8.36 8. 11E-09 2. 40E-04-1. 08-7. 19 12q 2204082at PBX3-2.66 2.78E-08 4. 11E-04-1. 02-6. 80 9q33-q34 3 235753_at -2. 93 6. 75E-08 6. 66E-04-1.00-6. 65 4 244413_at DCAL1 -5. 22 9. 47E-08 7. 01 E-04-0. 96-6. 42 12p13. 2 5 215154_at -2. 55 2. 90E-07 1. 23E-03-0.95-6. 26 6 216554_s_at ENO1 -1. 54 2. 46E-07 1. 23E-03-0.91-6. 12 1p36. 3-p36.2 7 210184_at ITGAX -3. 40 2.81E-07 1. 23E-03-0.92-6. 11 16p11. 2 8211012sat PML 2. 73 2. 32E-05 1. 96E-02 1.14 6. 1015q22 9212250at 1.53 2.69E-06 5. 31E-03 0.96 6.02 10 205612_at MMRN-10.20 7. 87E-07 2. 33E-03-0.94-5. 98 4q22 11 206847 s at HOXA7-2.48 8. 42E-07 2. 33E-03-0.91-5. 97 7p15-p14 12240929_at 1.63 9. 21E-06 1.30E-02 0.99 5.91 13 225102 at LOC152009-2.49 6. 39E-07 2. 33E-03-0.87-5. 84 3q21. 3 14 206062_at GUCA1A-2. 23 8. 67E-07 2. 33E-03-0.86-5. 78 6p21. 1 15 203373 at SOCS2-5.44 1. 63E-06 3. 73E-03-0.88-5. 77 12q 16217816sat PCNP 1.43 1. 10E-05 1. 42E-02 0.93 5. 67 3q12. 3 17 226676 at EHZF-3.90 1. 64E-06 3. 73E-03-0.83-5. 56 18q11. 1 18 200608_s_at RAD21 1. 56 2.90E-05 2.01E-02 0. 94 5.51 8q24 19 201745_at PTK9 1.73 2. 11E-05 1. 95E-02 0.92 5. 50 12q12 20 212173_at AK2-2.79 2. 07E-06 4. 37E-03-0.82-5. 50 1 p34 21 235521_at HOXA3-4.10 3.27E-06 6.05E-03-0. 80-5.35 7p15-p14 22 219889 at FRAT1-1.98 4. 62E-06 7. 60E-03-0.81-5. 34 10q24. 1 23 218048 at BUP-1.90 3. 95E-06 6. 88E-03-0.80-5. 33 10pter-q22. 1 24201067at PSMC2 1.52 1.68E-05 1.83E-02 0.85 5. 32 7q22. 1-q22.3 25236349at 1.48 2. 19E-05 1. 96E-02 0.84 5.22 26 236293 at 2.24 6.38E-05 3. 00E-02 0.91 5.22 27 231967_at CGI-72 1. 74 6. 68E-05 3. 09E-02 0. 91 5. 21 8q24. 3 28 215498_s_at MAP2K3 1.90 3. 49E-05 2. 15E-02 0. 86 5. 20 17q11. 2 29228528at 1.83 5. 12E-05 2.61E-02 0.88 5.18 30225775_at 2.92 1. 42E-04 4. 06E-02 0.99 5.18 31 214500_at H2AFY-2.68 7. 41E-06 1. 15E-02-0.78-5. 16 5q31. 3-q32 32226775_at DC6 1.42 1.46E-05 1.73E-02 0.79 5. 12 8q23.2 33225516at 1. 59 3. 98E-05 2. 26E-02 0. 83 5.10 34221934sat FLJ10496-1.63 7. 80E-061. 15E-02-0. 76-5. 103p21. 31 35223628at DKFZp434N035-3. 25 1. 11E-05 1. 42E-02-0.78-5. 07 22q11. 21 36225625at ANXA2-2.04 1.73E-05 1.83E-02-0. 78-5. 06 15q21-q22 37229056at LOC90313 2.07 3. 77E-05 2. 26E-02 0.81 5. 03 17q11.1 38218823sat FLJ20038 2. 01 2.32E-04 5.11E-02 1.00 5. 01 8p21. 1 39202823at TCEB1 2.03 1. 15E-04 3. 71E-02 0.88 5. 00 8q13. 3 40236858sat RUNX2-10.06 1. 97E-05 1. 90E-02-0. 84-4. 99 6p21 41 205472 s at DACH-3.06 1. 24E-05 1. 53E-02-0.74-4. 94 13q22 42 235471 at 1.50 2.97E-05 2. 01 E-02 0.77 4.92 43 236555 at 1.29 1.80E-05 1.84E-02 0.73 4.88 44 220793 at SAGE-8.52 2. 30E-05 1. 96E-02-0.77-4. 88 Xq28 45 226677_at EHZF -4. 00 1. 64E-05 1. 83E-02-0.73-4. 87 18q11. 1 46 217259_at 4. 54 3. 43E-04 5. 84E-02 1.01 4.86 47216856sat DLEU2-3.72 1. 99E-05 1. 90E-02-0.73-4. 83 13q14. 3 48 212479_s_at FLJ13910 1. 65 4. 32E-05 2. 32E-02 0.75 4. 82 2p11. 1 49 203007_x_at LYPLA1 1. 49 1. 07E-04 3. 63E-02 0.81 4. 82 8q11. 23 50 218172_s_at PRO2577 1.67 1. 43E-04 4. 06E-02 0.83 4. 81 8q24. 13 2.28 AML_+8 versus AML inv (16) # affy id HUGO name fc p q stn t Map Location 1209365sat ECM1-4.38 1. 18E-12 3. 67E-08-2.01-11. 80 1q21 2 201497_x_at MYH11 -32. 51 4. 17E-11 4.34E-07-2. 18-11.28 16p13. 13-p13. 12 3 34210_at CDW52-4.20 3. 31E-11 4.34E-07-1. 56-9. 49 1p36 4204661at CDW52-3. 82 1. 06E-10 6. 63E-07-1.51-9. 171p36 5 202746_at ITM2A -5. 83 1. 01E-10 6. 63E-07-1.50-9. 14 Xq13.3-Xq21. 2 6 220591_s_at FLJ22843-3.37 4. 09E-10 1. 63E-06-1.51-8. 99 Xp11. 3 7227567at 3. 38 4. 47E-08 7. 34E-05 1.62 8.88 8 202747_s_at ITM2A -5. 41 3. 14E-10 1. 63E-06-1.45-8. 77 Xq13.3-X21. 2 9205330at MN1-9. 14 3. 91E-09 1. 02E-05-1.57-8. 71 22q12. 1 10203329at PTPRM-7.47 2. 27E-09 6. 44E-06-1.50-8. 64 18p11. 2 11 201496_x_at MYH11 -5. 69 4. 18E-10 1. 63E-06-1.41-8. 56 16p13. 13-p13. 12 12 200951 s at CCND2-3.38 6. 62E-10 2. 29E-06-1.38-8. 41 12p13 13 201005_at CD9-5.50 1. 88E-09 5. 87E-06-1.36-8. 18 12p13. 3 14 212358_at CLIPR-59-18. 62 2. 53E-08 4. 64E-05-1.56-8. 08 19q13. 12 15 202283_at SERPINF1-6. 75 4. 88E-09 1. 17E-05-1.34-7. 99 17p13. 1 16 201029 s at CD99-1.76 5. 31E-07 5. 49E-04-1.47-7. 83 Xp22. 32 17 207961_x_at MYH11 -16. 06 4. 47E-08 7. 34E-05-1.51-7. 82 16p13. 13-p13. 12 18 201739 at SGK-3.77 7. 62E-09 1. 70E-05-1.30-7. 82 6q23 19202499sat SLC2A3-2.87 8. 91E-09 1. 85E-05-1.24-7. 51 12p13. 3 20241525at LOC200772-33.67 1. 03E-07 1. 52E-04-1.42-7. 442q37. 3 21 231310at-4. 09 2. 11 E-07 2.74E-04-1. 31-7.44 22229215_at ASCL2 7.12 1. 02E-05 3. 21E-03 1.61 7. 21 11p15. 5 23202016at MEST-3.49 2. 53E-08 4. 64E-05-1.18-7. 14 7q32 24 223385_at CYP2S1-2. 09 7. 52E-08 1. 17E-04-1.14-6. 87 19q13. 1 25 200953_s_at CCND2-2.36 5.28E-07 5.49E-04-1. 18-6.81 12p13 26202340xat NR4A1-3. 96 1. 07E-07 1. 52E-04-1.12-6. 76 12q13 27 208033 s at ATBF1-3.43 1. 34E-07 1. 82E-04-1.10-6. 68 16q22. 3-q23.1 28 241706_at LOC144402 5. 86 2. 08E-05 5. 40E-03 1.47 6. 65 12qu 1 29 225055_at DKFZp667M2411 3. 32 9. 33E-06 3. 06E-03 1.29 6.58 17q11. 2 30 225547 at 1. 39 7. 80E-06 2. 85E-03 1.24 6.49 31 201067_at PSMC2 1. 61 4. 60E-06 1. 99E-03 1.19 6. 48 7q22. 1-q22.3 32 223769 x at HT036 1. 69 3. 55E-06 1. 65E-03 1.16 6. 43 1p34. 1 33 225868_at TRIM47-5. 55 7. 11 E-07 6. 52E-04-1.12-6. 41 34 223593_at KATII -2. 91 2. 77E-07 3. 46E-04-1.04-6. 34 4q33 35 201324_at EMP1 -5. 36 4. 55E-07 5. 25E-04-1.06-6. 34 12p12. 3 36 201432_at CAT 2. 05 1.36E-05 4.11E-03 1.22 6. 29 11p13 37 226282_at -18. 56 1. 47E-06 9. 87E-04-1.15-6. 27 38 219371_s_at KLF2-2.73 4. 12E-07 4. 94E-04-1.02-6. 22 19p13.13-p13. 11 39 208891_at DUSP6-2.15 6. 94E-07 6. 52E-04-1.04-6. 22 12q22-q23 40 227486 at NT5E-5.05 5. 46E-07 5. 49E-04-1.03-6. 20 6q14-q21 41 207216_at TNFSF8-2.49 5. 40E-07 5. 49E-04-1.01-6. 13 9q33 42222333_at FLJ36525-1.58 1. 17E-06 8.81E-04 -1. 03-6. 123p21. 31 43 226120 at TTC8 2. 20 8. 79E-06 2. 95E-03 1.12 6. 10 14q31. 3 44 206956 at BGLAP-2.87 9. 56E-07 8. 05E-04-1.02-6. 09 1q25-q31 45 212771 at LOC221061-3.88 5. 86E-07 5.71E-04 -1. 00-6. 0910p13 46 203939_at NT5E-13.73 2. 46E-06 1. 36E-03-1.13-6. 08 6q14-q21 47216554sat EN01-1. 66 1. 04E-06 8. 35E-04-1.02-6. 051p36. 3-p36.2 48 223144 s at FLJ10342-1.99 8. 84E-07 7. 65E-04-1.00-6. 02 6q15 49 216241_s_at TCEA1 1.61 1. 97E-05 5. 20E-03 1.15 6. 01 3p22-p21. 3 50210139_s at PMP22-3.96 8. 76E-07 7. 65E-04-0.99-6. 00 17p12-p11. 2 2.29 AML+8 versus AML inv (3) &num affy id HUGO name fc p q stn t Map Location 1 231903_x_at KIAA1501 -3. 39 3. 76E-08 1. 09E-03-1.51-8. 00 17q21. 1 2 206478_at KIAA0125 -6. 75 3. 45E-06 1. 45E-02-1.32-6. 48 14q32. 33 3220261sat ZDHHC4 2. 05 6. 07E-06 1. 45E-02 1.23 6. 29 7p22. 2 4201829at NET1-2.30 1. 65E-06 1. 45E-02-1.15-6. 19 10p15 5 203462_x_at EIF3S9 1.71 2. 81E-06 1. 45E-02 1.12 6. 027p22. 3 6230896at-6. 40 4. 89E-06 1. 45E-02-1.15-6. 01 7204082at PBX3 3. 23 2. 78E-05 1. 77E-02 1.25 6. 00 9q33-q34 8226807at FLJ34243-2.91 1. 06E-05 1. 45E-02-1.15-5. 84 16q22. 3 9 201811_x_at SH3BP5-4.06 9. 15E-06 1. 45E-02-1.12-5. 803p24. 3 10 206781 at DNAJC4-2.17 1. 42E-05 1. 45E-02-1.12-5. 77 11q13 11 218552 at FLJ10948 2. 15 1. 80E-05 1. 45E-02 1.13 5. 76 1p32. 3 12 225591_at FBXO25 2.42 1.86E-05 1. 45E-02 1.13 5. 76 8p23. 3 13 207268_x_at ABI-2 -1. 55 3.94E-06 1.45E-02-1. 05-5.73 2q33 14 202600_s_at NRIP1 -3. 58 1.70E-05 1.45E-02-1. 17-5. 72 21q11. 2 15206589_at GFI1 3.09 1. 17E-05 1.45E-02 1. 08 5. 70 1p22 16 200904_at HLA-E-2.24 5.98E-06 1.45E-02-1. 04-5. 65 6p21. 3 17213893_x at PMS2L5 1.70 8.89E-06 1.45E-02 1.05 5. 63 7q11-q22 18204530sat TOX-3.17 1.28E-05 1.45E-02-1. 07-5. 60 8q11. 23 19 212250_at 1.51 8.36E-06 1.45E-02 1.04 5.59 20 204247_s_at CDK5 3.21 2.76E-05 1.77E-02 1.06 5.47 7q36 21201830sat NET1-2.57 1.76E-05 1.45E-02-1. 05-5. 47 10p15 22 211916_s_at MYO1A -1. 45 9.52E-06 1.45E-02-1. 00-5. 44 12q13-q15 23 220377_at C14orf110 -6. 39 1.77E-05 1.45E-02-1. 04-5. 43 14q32. 33 24203476at TPBG-5.59 3. 51E-05 1. 98E-02-1.13-5. 436q14-q15 25 217975_at LOC51186-4.11 1. 61 E-05 1.45E-02-1. 03-5. 43 Xq22.1 26 222494_at C14orf116 -1. 85 2. 59E-05 1. 74E-02-1.06-5. 41 14q31. 3 27215346_at TNFRSF5-3.26 1.07E-05 1.45E-02-0. 99-5. 38 20q12-q13. 2 28 217979 at NET-6-3.75 1.15E-05 1.45E-02-0. 99-5. 377p21. 1 29225567at-2. 85 1.67E-05 1.45E-02-1. 01-5.37 30 205690 s at G10 1.64 1.24E-05 1.45E-02 0.98 5. 367q22. 1 31 212318 at TRN-SR 2. 31 1. 30E-04 2. 60E-02 1.17 5. 34 7q32. 2 32 227432_s_at INSR 2.91 1. 20E-04 2. 58E-02 1.15 5. 34 19p13. 3-p13. 2 33224609at CTL2-3.79 1. 17E-051. 45E-02-0. 98-5. 3419p13. 1 34 205514_at FLJ11191 -2. 43 1. 70E-05 1. 45E-02-1.00-5. 33 19q13. 41 35 221458_at HTR1F -2. 02 1. 70E-05 1. 45E-02-0.99-5. 32 3p12 36232114_at TRALPUSH-3. 23 1. 26E-05 1. 45E-02-0.98-5. 32 3q25.1 37 202439_s_at IDS -1.95 1.65E-05 1. 45E-02-0.99-5. 32 Xq28 38209354at TNFRSF14-1. 78 1.61E-05 1. 45E-02-0.99-5. 31 1p36. 3-p36.2 39219033at FLJ21308 3. 15 1. 42E-04 2. 62E-02 1.17 5. 30 5q11. 1 40 211252_x_at PTCRA-1.57 1. 75E-05 1. 45E-02-0.99-5. 306p21. 3 41 208688_x_at EIF3S9 1. 64 1. 56E-05 1. 45E-02 0. 97 5. 29 7p22. 3 42 202805_s_at ABCC1 -2. 17 1. 77E-05 1. 45E-02-0.98-5. 28 16p13. 1 43 217963_s_at NGFRAP1 -3. 41 1. 38E-05 1. 45E-02-0.96-5. 28 Xq22. 1 44 205376_at INPP4B -6. 67 5. 60E-05 2. 05E-02-1.10-5. 24 4q31.1 45 37384_at PPM1F -2. 14 1. 97E-05 1. 50E-02-0.97-5. 22 22q11. 22 46 225611_at KIAA0303 -3. 19 2. 12E-05 1. 53E-02-0.96-5. 19 5q12. 3 47201973_s_at CGI-43 1. 64 5. 55E-05 2. 05E-02 1.01 5. 197p22. 2 48 236117_at -3. 18 1. 69E-05 1. 45E-02-0.95-5. 18 49205330_at MN1-7.17 6. 62E-05 2. 18E-02-1.10-5. 18 22q12. 1 50 210715_s_at SPINT2 -2. 60 2. 30E-05 1. 62E-02-0.96-5. 17 19q13. 1 2.30 AML+8 versus AML komplext # affyid HUGO name fc p q stn t Map Location 1222229xat 1. 53 6. 44E-08 1. 73E-04 1.33 8.12 2 222902_s_at FLJ21144-1.96 9. 33E-09 1. 53E-04-1.19-7. 781p34. 1 3208697_s_at EIF3S6 1. 35 4. 75E-07 4. 42E-04 1.20 7. 24 8q22-q23 4201548sat PLU-1-2. 01 2. 94E-08 1. 73E-04-1.08-7. 141q32. 1 5 210715_s_at SPINT2 -2. 78 1. 43E-08 1. 53E-04-1.04-7. 02 19q13. 1 6 209188_x_at DR1 -1.62 4.30E-08 1. 73E-04-0.99-6. 67 1 p22. 1 7 244741_s_at -3. 31 4. 61E-08 1. 73E-04-0.98-6. 63 8209050sat RALGDS-2.35 8. 00E-08 1. 73E-04-0.99-6. 57 9q34. 3 9 205849_s_at UQCRB 1. 46 1. 05E-06 6. 07E-04 1. 05 6.54 8q22 10 229900_at CD109-2.75 7. 87E-08 1. 73E-04-0.97-6. 51 6q13 11 212692_s_at LRBA-2.72 7. 15E-08 1. 73E-04-0.96-6. 48 4q31.22-q31. 23 12 211743_s_at PRG2-15.09 1. 78E-07 2. 24E-04-1.02-6. 47 11q12 13 207654 x at DR1-1.58 8. 07E-08 1. 73E-04-0.95-6. 43 1p22. 1 14 244552_at-2. 71 1. 01 E-07 1.80E-04 -0. 95-6.40 15 201830_s_at NET1-2.38 9. 34E-08 1. 80E-04-0.94-6. 38 10p15 16 225635_at -1.82 1.30E-07 1. 95E-04-0.95-6. 35 17 226545_at 3.71 1. 31 E-07 1. 95E-04-0.93-6. 29 18217979at NET-6-4.49 1. 44E-07 1. 95E-04-0.92-6. 25 7p21. 1 19239047_at-2. 12 1. 46E-07 1. 95E-04-0.92-6. 25 20 209911_x_at HIST1H2BD -2. 51 2. 85E-07 3.21E-04 -0. 92-6. 13 6p21. 3 21239250at LOC147947-2.50 2. 26E-07 2. 69E-04-0.90-6. 12 19q13. 43 22203329at PTPRM-8.45 6. 14E-07 5. 26E-04-0.96-6. 08 18p11. 2 23220591sat FLJ22843-2.54 3. 45E-07 3. 69E-04-0.90-6. 05 up11. 3 24 208646_at RPS14 2.04 4. 60E-06 1. 52E-03 0.98 6. 02 5q31-q33 25 216652_s_at -1.55 3.98E-07 4. 06E-04-0.88-5. 96 26214109at LRBA-2.39 6. 71 E-07 5. 32E-04-0.91-5. 96 4q31.22-q31. 23 27 203544 s at STAM-2.40 4. 71E-07 4. 42E-04-0. 88-5. 93 10p14-p13 28 227847_at -1.59 5.75E-07 5. 13E-04-0.86-5. 85 29 216035-x_at TCF7L2-2.33 1. 26E-06 6.91E-04 -0. 88-5. 8210q25. 3 30223991sat GALNT2-1.83 6. 61E-07 5. 32E-04-0.86-5. 81 1q41-q42 31 224821_at MGC15429 2. 08 2. 78E-05 3. 10E-03 1.03 5. 78 3p21. 31 32219870at FLJ12668-2.65 7. 65E-07 5. 85E-04-0.85-5. 76 16p13. 2 33205159at CSF2RB-3.29 8. 70E-07 5. 87E-04-0.85-5. 75 22q13. 1 34 215071_s_at HIST1H2AC -3. 16 8. 36E-07 5. 87E-04-0.85-5. 73 6p21. 3 35 201829 at NET1-2.11 8. 61E-07 5. 87E-04-0.84-5. 73 10p15 36 223387 at ZFYVE1-1. 70 8. 79E-07 5. 87E-04-0.84-5. 72 14q22-q24 37 218340_s_at FLJ10808 -1. 79 9. 04E-07 5. 87E-04-0.84-5. 71 4q13. 2 38 202804 at ABCC1-2.17 9. 83E-07 6. 07E-04-0.84-5. 70 16p13. 1 39 234294_x_at p66alpha -1. 58 3. 46E-06 1. 32E-03-0.88-5. 69 19p13. 11 40 202600_s_at NRIP1 -2. 27 1. 04E-06 6. 07E-04-0.84-5. 68 21q11. 2 41 226181_at TUBE-1. 93 1. 03E-06 6. 07E-04-0.84-5. 67 6q21 42 237364_at KIAA1615 -3.35 1.11E-06 6. 23E-04-0.83-5. 65 19q13. 13 43 202746_at ITM2A -3. 79 2. 07E-06 1.01E-03 -0. 84-5. 59 Xq13.3-Xq21. 2 44 210462_at BLZF1 -3. 49 1. 62E-06 8. 69E-04-0.82-5. 55 1q24 45218581_at ABHD4-1.81 1. 78E-06 9.11E-04 -0. 81-5. 51 14q11. 1 46244740at-4. 45 1.79E-06 9. 11E-04-0. 81-5.51 47 38269_at PRKD2 -2. 04 2. 52E-06 1. 13E-03-0. 82-5. 50 19q13. 2 48203346sat M96-1. 87 1. 96E-06 9. 76E-04-0.81-5. 491p22. 1 49 208691 at TFRC-1.86 2. 19E-06 1. 02E-03-0.80-5. 453q26. 2-qter 50201922at YR-29 1. 55 2. 35E-05 2. 89E-03 0. 90 5. 45 5q13. 2 2.31 AML +8 versus AMLnorma ! &num affy id HUGO name fc p q stn t Map Location 1 200923at LGALS3BP-6. 90 1. 90E-18 7.02E-14-0. 80-10. 22 17q25 2213110sat COL4A5-4. 54 1. 75E-13 1. 54E-09-0.75-9. 08 Xq22 3 243579_at MSI2 -4. 57 2. 07E-13 1. 54E-09-0.74-9. 02 17q23. 1 4 206761_at TACTILE -7. 41 1. 26E-15 2.34E-11 -0.68 -8.84 3q13. 13 5225406at TWSG1-2. 15 6. 51E-09 9. 27E-06-0.83-8. 48 18p11. 3 6 212489_at COL5A1 -4. 14 3. 44E-14 4. 25E-10-0.65-8. 38 9q34.2-q34. 3 7214436at FBXL2-2.38 4. 20E-12 1. 94E-08-0.69-8. 373p22. 2 8 225238_at -3. 72 7. 31E-12 3.01E-08 -0. 69-8.29 9211907sat PARD6B-2.75 5. 32E-13 3. 28E-09-0.65-8. 21 20q13. 13 10235124at-1. 81 4. 12E-10 1. 02E-06-0.70-8. 02 11 225889 at MGC17922-1.73 8. 45E-09 1. 12E-05-0.74-7. 89 12q 12. 3 12 219553_at NME7-1. 82 1. 53E-11 5. 16E-08-0.64-7. 86 1q24 13 225240sat-3. 16 2.67E-09 4.50E-06-0. 70-7.77 14235532at-5. 21 1. 26E-12 6. 66E-09-0.59-7. 68 15221286sat PACAP-6.72 1. 27E-11 4.71E-08 -0. 56-7. 28 5q23-5q31 16 215071_s_at HIST1H2AC -2. 89 4. 77E-09 7. 36E-06-0.63-7. 25 6p21. 3 17 212259_s_at HPIP -3. 49 5. 26E-11 1. 50E-07-0.57-7. 24 1q21. 3 18 243010_at MSI2 -2. 25 9. 63E-10 2. 10E-06-0. 60-7. 2317q23. 1 19228907at-3. 54 7. 88E-11 2. 08E-07-0.56-7. 14 20 231903_x_at KIAA1501 -2. 45 1. 17E-09 2.41E-06 -0. 59-7. 11 17q21. 1 21205910sat CEL-4.34 3. 38E-11 1. 04E-07-0. 54 -7. 10 9q34.3 22 209014_at MAGED1-1.87 1. 19E-08 1. 42E-05-0.62-7. 04Xp11. 23 23 216412_x_ag IGL -2. 78 8. 84E-09 1. 13E-05-0.61-7. 00 22q11.1-q11. 2 24 228654_at LOC139886-2.05 1. 75E-07 1. 12E-04-0.67-6. 98 Xq11. 1 25 228988_at ZNF6-4.42 4. 78E-10 1. 11E-06-0. 56-6. 97 Xq13-q21. 1 26 214177_s_at HPIP -1. 79 2. 17E-07 1.21E-04 -0. 68-6. 95 1 q21. 3 27 239623at-2. 83 4.50E-08 3.70E-05-0. 63-6.94 28 216554_s_at ENO1 -1.38 1.37E-07 9. 04E-05-0.64-6. 86 1 p36. 3-p36.2 29 223506_at LOC84524 -1.65 2.26E-07 1. 25E-04-0.66-6. 85 2q13 30 224968_at MGC15407-1. 85 1. 70E-06 5. 23E-04-0.74-6. 81 2p16. 1 31 220885sat CENPJ-1.64 5.76E-08 4.35E-05-0. 61-6.81 13q12. 12 32 238726at-2. 32 1.38E-09 2.69E-06-0. 55-6.79 33 225102 at LOC152009-2.17 1. 92E-07 1. 16E-04-0.63-6. 73 3q21. 3 34 226807_at FLJ34243-1. 80 2. 76E-07 1. 46E-04-0.64-6. 72 16q22. 3 35225237sat-2. 62 3. 87E-07 1. 82E-04-0.64-6. 67 36228092at CREM-1.70 3. 48E-06 9. 15E-04-0.76-6. 66 10p12.1-p11. 1 37 209958_s_at B1 -2. 93 2. 21E-09 3. 90E-06-0.52-6. 57 7p14 38 204116_at IL2RG -2. 18 1. 64E-08 1. 74E-05-0.55-6. 56 Xq13. 1 39 220240_s_at C13orf11 -1.86 5.59E-07 2. 30E-04-0.63-6. 55 13q34 40 237216at-3. 34 8. 24E-09 1. 12E-05-0.53-6. 52 41 214029_at -2. 77 1. 32E-08 1. 53E-05-0.54-6. 51 42 226098_at KIAA1374 -2. 03 4. 26E-07 1. 92E-04-0.62-6. 51 3q25. 33 43 227943_at -2.11 2.0E-08 2. 09E-05-0.55-6. 49 44220591sat FLJ22843-1.81 6. 31E-07 2. 46E-04-0.62-6. 47 Xp11. 3 45213620sat) CAM2-1. 95 4.21 E-07 1. 92E-04-0.61-6. 45 17q23-q25 46 209911_x_at HIST1H2BD -1.91 2.36E-08 2. 36E-05-0.53-6. 406p21. 3 47212250_at 1.45 1.83E-05 2.90E-03 0.87 6.40 48 221525_at DKFZp761I2123 -1. 81 5. 43E-09 8. 04E-06-0.51-6. 37 7p12. 3 49208457_at GABRD-2.23 3. 80E-08 3.61E-05 -0. 54-6. 37 1p36. 3 50 227565_at -1.95 5.46E-07 2. 27E-04-0.60-6. 36 2.32 AML+8 versus AMLt (15 ; 17) &num affy id HUGO name fc p q stn t Map Location 1214450at CTSW-12.17 1. 32E-13 1. 11 E-09-3. 18-16.47 11q13. 1 2212953rat CALR-3.98 6. 41E-15 1. 62E-10-2. 77-15. 38 19p13. 3-p13. 2 3 38487_at STAB1-10.43 4.56E-14 5.76E-10-2. 45-13. 74 3p21. 31 4 221004_s_at ITM2C -5.23 1.11E-12 7.00E-09 -2. 10-11. 85 2q37 5205624at CPA3-10.17 1. 62E-12 8. 17E-09-2. 11-11. 84 3q21-q25 6 233072_at KIAA1857 -14. 26 1. 23E-11 5. 18E-08-2.12-11. 61 9q34 7225547_at 2.03 7.40E-10 1.35E-06 2.07 10.99 8212509sat-6. 369. 07E-11 3.27E-07-1. 95-10.66 9 206761_at TACTILE -17.64 1.49E-09 2.11E-06 -2. 17-10. 58 3q13. 13 10 204150_at STAB1-11. 85 1. 84E-10 5. 15E-07-1.91-10. 39 3p21. 31 11 238365sat-4. 68 2. 93E-10 7.41 E-07-1.79-9. 87 12 201029 s at CD99-2.05 1. 77E-09 2. 35E-06-1.82-9. 86 Xp22. 32 13 200953_s_at CCND2-3.46 1. 73E-10 5. 15E-07-1.67-9. 44 12p13 14 214315 x at CALR-2.39 7. 51E-10 1. 35E-06-1.71-9. 43 19p13. 3-p13. 2 15 200951_s_at CCND2-4.60 6. 17E-10 1. 30E-06-1.70-9. 42 12p13 16 209344_at TPM4-10.91 8. 48E-09 6. 69E-06-1.86-9. 36 19p13. 1 17 236787_at -6. 91 1. 38E-08 9. 68E-06-1.88-9. 21 18 241383_at -3. 96 3. 35E-09 3. 78E-06-1.72-9. 21 19 219869_s_at BIGM103 -2. 61 5. 33E-10 1. 22E-06-1.60-9. 05 4q22-q24 20212481sat TPM4-6.15 1. 25E-08 9. 06E-06-1.72-8. 91 19p13. 1 21 200986 at SERPING1-6. 36 2. OOE-09 2. 52E-06-1.60-8. 85 11q12-q13. 1 22 205349 at GNA15-3.06 8. 60E-10 1. 45E-06-1.56-8. 81 19p13. 3 23242520sat-5. 54 3.44E-09 3.78E-06-1. 59-8.75 24221253sat MGC3178-2.69 1. 35E-09 2.11E-06 -1. 55-8. 736p24. 3 25219837_s at C17-11.34 1. 89E-08 1. 22E-05-1.66-8. 65 4p16-p15 26 201825_s_at CGI-49 -2. 46 1. 51E-09 2.11E-06 -1. 52-8.60 1q44 27 205614_x_at MST1 -4. 85 1. 11E-08 8. 21 E-06-1. 57-8.49 3p21 28 214177_s_at HPIP -3. 10 9. 61E-09 7. 36E-06-1.56-8. 481q21. 3 29214789_x_at SRP46 3. 09 5. 43E-08 2. 74E-05 1.59 8. 46 11q22 30229168at DKFZp434K0621-3. 41 3. 83E-09 4. 03E-06-1.49-8. 36 5q35. 3 31 211934_x_at G2AN-2.83 2. 69E-09 3. 24E-06-1.48-8. 35 11q12. 2 32217716sat SEC61A1-1. 95 8. 02E-09 6. 69E-06-1.47-8. 23 3q21. 3 33 205663 at PCBP3-3.47 5. 42E-09 4. 89E-06-1.46-8. 22 21q22. 3 34 205771_s_at AKAP7 12.23 4.03E-06 6.75E-04 2.04 8.21 6q23 35 206703_at CHRNB1-3.47 6. 10E-09 5. 31E-06-1. 47-8. 20 17p13. 1 36210788sat retSDR4-2.12 4. 38E-09 4. 26E-06-1.45-8. 17 14q22. 3 37 220798 x at FLJ11535-2.72 4. 38E-09 4. 26E-06-1. 44-8. 15 19p13. 3 38 227999_at LOC170394 2. 81 2. 59E-07 9. 63E-05 1.58 8. 15 10q26. 3 39 209831 x at DNASE2-2.66 5. 41 E-09 4. 89E-06-1.44-8. 11 19p13. 2 40216320xat-4. 50 4.54E-08 2.34E-05-1. 54-8.10 41 208552_s_at CANX-2.32 8. 39E-09 6. 69E-06-1.44-8. 08 5q35 42 225653 at-1. 97 1. 77E-08 1. 17E-05-1.47-8. 06 43 238022_at -4. 56 2. 41E-08 1. 46E-05-1.45-8. 02 44 224794_s_at CerCAM -5. 78 4. 07E-08 2. 14E-05-1.50-8. 02 9q34. 13 45 210755_at HGF-10.85 1. 01 E-07 4. 62E-05-1.55-7. 93 7q21. 1 46204116_at IL2RG-6. 45 1. 31E-075. 79E-05-1.59-7. 93 Xq13. 1 47 219090_at SLC24A3-13.41 1. 47E-07 6. 40E-05-1.61-7. 92 20p13 48 204897_at PTGER4 4. 23 2. 10E-07 8. 42E-05 1.48 7. 83 5p13. 1 49 213147_at HOXA10 15.52 7. 89E-06 9. 97E-04 2.00 7. 75 7p15-p14 50223828sat LGALS12-9.62 1. 66E-07 7. 01E-05-1. 53-7. 75 11q13 2.33 AML_+8 versus AML t (8; 21) # affy id HUGO name fc p q stn t Map Location 1 228827at-99. 89 4.52E-10 1.37E-05-2. 00-10.04 2 206940_s_at POU4F1 -45. 04 1. 38E-09 2. 09E-05-1.87-9. 47 13q21. 1-q22 3205529sat CBFA2T1-14. 86 2. 12E-09 2. 13E-05-1.72-9. 17 8q22 4 211341 at POU4F1-240. 74 9. 70E-09 7. 34E-05-1.70-8. 54 13q21. 1-q22 5 205528_s_at CBFA2T1 -28. 26 1. 42E-08 8. 62E-05-1.60-8. 34 8q22 6 206761_at TACTILE -12. 10 2. 22E-08 8. 76E-05-1.47-8. 02 3q13. 13 7 232227_at -7. 33 3. 47E-08 1. 17E-04-1.34-7. 62 8 213147 at HOXA10 11. 15 9. 71 E-06 4. 32E-03 1.84 7. 51 7p15-p14 9 204116_at IL2RG -3. 28 2. 16E-08 8. 76E-05-1.26-7. 47 Xq13. 1 10 242845_at -4. 92 2. 32E-08 8. 76E-05-1.23-7. 35 11 239641_at 1.79 5.02E-08 1.27E-04 1.21 7.22 12 204811_s at CACNA2D2-6.56 1. 24E-07 2. 50E-04-1.30-7. 223p21. 3 13225547 at 1. 48 8. 38E-07 9. 76E-04 1.28 7.11 14 229002_at MGC20262-3.32 4. 75E-08 1.27E-04-1. 18-7. 06 9q34. 3 15 233072_at KIAA1857 -6. 64 4. 81E-08 1.27E-04-1. 14-6.92 9q34 16 203859 s at PALM-3.48 6. 25E-08 1. 45E-04-1.13-6. 84 19p13. 3 17201281 at ADRM1-1. 97 1. 17E-07 2. 50E-04-1.11-6. 69 20q13. 33 18 241706_at LOC144402 5. 87 2.09E-05 7.01E-03 1.47 6. 66 12q11 19 223991 s at GALNT2-2.21 1. 73E-07 3. 27E-04-1.10-6. 62 1q41-q42 20 213194_at ROBO1 -40. 47 8. 26E-07 9. 76E-04-1.28-6. 58 3p12 21216241sat TCEA1 1. 79 2. 32E-06 1. 63E-03 1.16 6. 51 3p22-p21. 3 22 236787-at -2. 60 3. 27E-07 5.21E-04 -1. 10-6.51 23 228058_at LOC124220-3.02 3. 63E-07 5. 49E-04-1.08-6. 49 16p13. 3 24 201015_s_at JUP-5.18 2. 40E-07 4. 12E-04-1.06-6. 45 17q21 25 200639_s_at YWHAZ 1.63 1.33E-06 1.25E-03 1.11 6. 438q23. 1 26225329at-2. 61 2. 45E-07 4. 12E-04-1.05-6. 39 27 212895_s_at ABR 2. 97 2. 53E-05 7. 65E-03 1.31 6.30 17p13. 3 28227298_at 1.62 2.55E-06 1.68E-03 1.10 6.27 29202242at TM4SF2-4.03 4. 91E-07 7. 07E-04-1.04-6. 26 Xq11. 4 30 216831_s_at CBFA2T1 -33. 99 1. 82E-06 1. 42E-03-1.23-6. 25 8q22 31 204990_s_at ITGB4 -3. 34 1. 07E-06 1. 13E-03-1.09-6. 23 17q11-qter 32 235468_at -4. 61 5. 20E-07 7. 16E-04-1.03-6. 20 33 225653_at -1.70 5.60E-07 7. 36E-04-1.03-6. 20 34 226775_at DC6 1. 49 2. 17E-06 1. 60E-03 1.07 6. 188q23. 2 35 217816_s_at PCNP 1.59 1.12E-06 1.13E-03 1.03 6. 15 3q12. 3 36201592_at EIF3S3 1. 30 8. 44E-06 3. 93E-03 1.13 6. 148q23. 3 37203188_at B3GNT6 1. 60 2.00E-06 1.51E-03 1.05 6. 13 11q13. 1 38221581sat WBSCR5 6. 65 6.51E-05 1. 42E-02 1.47 6. 10 7q11. 23 39204086 at PRAME-6. 95 1. 11E-06 1.13E-03-1. 03-6. 08 22q11. 22 40 231334 at-3. 02 8. 19E-07 9. 76E-04-0.99-6. 01 41 232306 at CDH26-6.72 2. 24E-06 1. 62E-03-1.05-5. 98 20q13. 2-q13. 33 42 220227_at FLJ22202-1. 89 8. 89E-07 9. 97E-04-0.98-5. 96 20q13. 33 43 233587_s_at -3. 18 1. 17E-06 1. 14E-03-0.97-5. 89 44 212250_at 1. 65 1.63E-06 1.37E-03 0.97 5.87 45 229406_at -4. 64 1.60E-06 1.37E-03-0. 97-5.86 46214651 s at HOXA9 113.84 1. 13E-04 1. 86E-02 1.66 5. 84 7p15-p14 47 37005_at NBL1 -2. 23 1.37E-06 1.25E-03-0. 96-5. 83 1p36. 3-p36.2 48 204960 at PTPRCAP-2.96 1. 50E-06 1. 34E-03-0.96-5. 82 11q13. 3 49 204021 s at PURA 2. 66 2. 26E-05 7. 19E-03 1.09 5.81 5q31 50201067at PSMC2 1. 67 3. 16E-06 1. 99E-03 0.98 5. 80 7q22. 1-q22.3 2.34 AML-7 versus AML5q &num affy id HUGO name fc p q stn t Map Location 1 22099_s_at CGI-59 -2. 60 2. 08E-08 6.33E-04-2. 83-11.31 7q34 2 213151_s_at CDC10-2.22 5. 96E-07 6.05E-03-2. 85-10. 87 7p14. 3-p14. 1 3206860sat FLJ20323-2.07 4.68E-07 6.05E-03-2. 32-9. 197p22-p21 4 226032at CASP2-3.04 8.52E-05 7.24E-02-2. 63-8.52 7q34-q35 5214863at-2. 74 1.25E-06 9. 51 E-03-2. 02-8.08 6211724xat FLJ20323-2.05 7. 25E-06 2. 36E-02-2.06-7. 97 7p22-p21 7 224719_s_at LOC113246 2.92 5.74E-06 2.18E-02 2.05 7.91 12p13. 31 8218601at URG4-3.34 4. 02E-06 1. 75E-02-2. 00-7. 83 7p13 9214351 x_at RPL13 1.81 5. 81E-05 6. 80E-02 2.15 7. 71 16q24. 3 10242673_at-1. 99 3. 63E-06 1. 75E-02-1.93-7. 66 11 222047 s at ARS2-1. 84 3. 74E-06 1. 75E-02-1.91-7. 59 7q21 12 222985 at YWHAG-2.45 9. 31E-06 2. 36E-02-1.95-7. 59 7q11. 23 13 201453_x_at RHEB2-2.22 8. 99E-06 2. 36E-02-1.93-7. 54 7q36 14 208882 s at DD5-2.05 2. 24E-05 4. 30E-02-1.86-7. 16 8q22 15201258_at RPS16 1.79 8.56E-05 7.24E-02 1.91 6. 99 19q13. 1 16200976sat TAX1BP1-2. 03 2. 30E-04 9. 36E-02-2.02-6. 86 7p15 17 200651_at GNB2L1 1. 43 8. 06E-06 2. 36E-02 1.71 6. 845q35. 3 18 229932_at -3. 08 3. 41E-05 5.19E-02-1. 73-6.70 19218132sat LENG5-1.76 1. 10E-05 2. 56E-02-1.67-6. 68 19q13. 4 20 201978_s_at KIAA0141 4.20 2. 01 E-054. 30E-02 1.69 6. 645q31. 3 21 244534 at ZRF1-2.02 3.23E-05 5.17E-02-1. 70-6.61 7q22-q32 22230426at DLD-1. 93 2. 98E-05 5. 04E-02-1.69-6. 60 7q31-q32 23213025at FLJ20274-2.19 2. 26E-05 4. 30E-02-1.67-6. 59 16p13. 11 24212062at ATP9A-6. 93 1. 29E-04 9. 06E-02-1.80-6. 58 20q13.11-q13. 2 25213360sat POM121-2. 22 9.50E-05 7.81E-02 -1. 74-6. 50 7q11. 23 26 225932_s_at -1.97 1.46E-04 9. 26E-02-1. 75-6. 44 27 214743 at CUTL1-2.43 5. 30E-04 1. 05E-01-2.02-6. 38 7q22 28201816sat GBAS-2.21 2. 15E-04 9. 36E-02-1.71-6. 22 7p12 29 220018_at HAKAI -2. 83 3. 62E-04 9. 69E-02-1.79-6. 21 7q22. 2 30 200060_s_at- HG-U133A RNPS1-1.77 6. 29E-05 7. 03E-02-1.58-6. 16 16p13. 3 31 211746_x_at PSMA1 -1. 50 1. 25E-04 9. 04E-02-1.61-6. 11 11p15. 1 32 202843 at DNAJB9-2.80 2. 98E-05 5. 04E-02-1.53-6. 10 7q31 33224767_at 3.91 5. 81E-05 6. 80E-02 1.57 6.09 34 200883_at UQCRC2 2.47 4. 91E-05 6. 50E-02 1.54 6. 04 16pu2 35 226691_at KIAA1856-3. 02 4. 46E-04 1. 03E-01-1.75-6. 03 7p22. 2 36201316at PSMA2-1. 79 3. 97E-05 5. 75E-02-1.51-6. 01 7p13 37 222772 at MEF-2-2.30 2. 73E-04 9. 36E-02-1.64-5. 97 15q15. 2 38 217753_s_at RPS26-2.02 7.37E-05 7.24E-02-1. 52-5. 95 12q13 39204871at MTERF-2.44 1. 48E-04 9. 26E-02-1.57-5. 94 7q21-q22 40 223626 x at FAM14A 2. 19 4. 80E-05 6. 50E-02 1.49 5. 92 14q32. 13 41 204658 at HSU53209-2.56 5. 79E-04 1. 05E-01-1.73-5. 88 7p15. 3 42212826sat SLC25A6 1. 58 1. 80E-04 9. 36E-02 1.56 5.87 Xp22.32 and Yp 43 212287 at JJAZ1-2.16 2. 79E-04 9. 36E-02-1.60-5. 86 17q11. 2 44 204591 at CHL1-5.20 2. 03E-04 9. 36E-02-1.56-5. 85 3p26. 1 45226336_at PPIA-2. 34 3. 14E-04 9. 36E-02-1.58-5. 78 7p13-p11. 2 46213097_s_at ZRF1-2. 38 2. 55E-04 9. 36E-02-1.55-5. 787q22-q32 47216032sat SDBCAG84 3. 55 2. 83E-04 9. 36E-02 1.64 5. 7820pter-q12 48 209095 at DLD-2.71 2. 62E-04 9. 36E-02-1.55-5. 77 7q31-q32 49200005_at-HG-U133B EIF3S7 2. 08 7. 75E-05 7. 24E-02 1.47 5. 77 22q13. 1 50223304at DKFZp761N0624-5. 39 5. 39E-04 1. 05E-01-1.65-5. 77 7q34 2.35 AML_-7 versus AML_9q # affy id HUGO name fc p q stn t Map Location 1 201405sat COPS6-2.48 6.45E-08 1.99E-03-2. 49-10.34 7q22.1 2201317_s_at PSMA2-1.96 2. 02E-07 2.11E-03 -2. 39-9. 83 7p13 3 220018_at HAKAI-2. 94 5. 64E-07 2. 66E-03-2.36-9. 56 7q22. 2 4 219041_s_at RIP60 -3. 05 7. 89E-07 2. 66E-03-2.32-9. 367q36. 1 5 218389_s_at APH-1A -1.91 1.27E-07 1. 99E-03-2.11-8. 951p36. 13-q31. 3 6 217720_at LOC51142-1. 52 4. 83E-07 2. 66E-03-2.01-8. 45 7p11. 1 7209036sat MDH2-2.43 5. 01E-06 6.83E-03 -2. 14-8. 38 7p12.3-q11. 2 8201812sat TOM7-2.01 9. 63E-07 2. 74E-03-2.00-8. 30 7p15. 3 9 226385_s_at LOC115416 -2. 41 4. 81 E-07 2. 66E-03-1.94-8. 20 7p15. 3 10 213460_x_at WBSCR20C-3.28 1. 59E-06 3. 56E-03-1.95-8. 08 7q11. 23 11 201552_at LAMP1-1. 98 7. 99E-07 2. 66E-03-1.83-7. 78 13q34 12 201973_s_at CGI-43 -1.71 7.99E-07 2. 66E-03-1.83-7. 78 7p22. 2 13 218378 s at FLJ13902-2.61 1. 57E-05 1. 38E-02-2.03-7. 76 7q22.1 14203168_at CREBL1-2. 11 8. 48E-07 2. 66E-03-1.83-7. 746p21. 3 15 213404 s at RHEB2-2.17 1. 22E-06 3. 20E-03-1.82-7. 69 7q36 16201260sat SYPL-2.51 1. 78E-06 3. 72E-03-1.82-7. 64 7q22.1 17 213151_s_at CDC10 -1. 65 1. 34E-06 3. 24E-03-1.77-7. 50 7p14.3-p14. 1 18226336_at PPIA-2. 25 3. 14E-06 5. 07E-03-1.76-7. 34 7p13-p11. 2 19 218321_x_at MK-STYX-2.99 1. 09E-05 1. 10E-02-1.82-7. 32 7q11. 23 20231300at LOC90835-2.84 2.81 E-06 5. 07E-03-1.73-7. 27 16p11. 2 21 208612_at GRP58-1.54 2. 08E-06 4. 08E-03-1.70-7. 22 15q15 22202961sat ATP5J2-2.16 2. 94E-06 5. 07E-03-1.71-7. 21 7q22.1 23224680at-2. 59 5. 45E-06 7.11E-03 -1. 71-7.10 24 220099_s_at CGI-59 -2. 65 1. 58E-05 1. 38E-02-1.75-7. 04 7q34 2590610at LRRN1-1. 91 3. 24E-06 5. 07E-03-1.66-7. 02 7q22 26202605_at GUSB-4.46 5. 99E-05 2. 23E-02-1.89-6. 97 7q21.11 27 201091 s at CBX3-2.28 4. 10E-06 6. 13E-03-1.64-6. 92 7p15.2 28 214743 at CUTL1-2.15 6. 84E-05 2.31E-02 -1. 89-6. 90 7q22 29 225321_s_at PILR -2. 89 2. 43E-05 1. 70E-02-1.73-6. 87 7q22.1 30 217773 s at NDUFA4-1. 84 4. 66E-06 6. 64E-03-1.61-6. 81 7p21. 3 31 214526 x at PMS2L8-2.16 3. 89E-05 1.91E-02 -1. 73-6.75 7q22 32218008at FLJ10099-1.91 1. 96E-05 1. 51E-02-1. 64-6. 67 7q11. 21 33 208688_x_at EIF3S9 -1. 95 2. 91E-05 1. 79E-02-1.67-6. 667p22. 3 34 211747 s at LSM5-2.32 6. 55E-06 7.90E-03 -1. 57-6. 65 7pu4. 3 35 202904_s_at LSM5-2.77 1. 56E-05 1. 38E-02-1.61-6. 62 7p14. 3 36 36545_s_at KIAA0542 -1.84 6.43E-06 7. 90E-03-1.56-6. 61 22q12. 2 37 208921_s_at SRI -2. 04 6.90E-05 2. 31 E-02-1. 73-6. 58 7q21. 1 38 214351_x_at RPL13 1. 52 3.53E-05 1.91E-02 1.65 6. 5716q24. 3 39 213360_s_at POM121-1.75 7. 91 E-06 9. 08E-03-1.56-6. 57 7q11. 23 40 214756_x_at PMS2L8-2.10 2. 20E-05 1. 59E-02-1.60-6. 54 7q22 41 201453_x_at RHEB2-2.19 1. 97E-05 1. 51 E-02-1. 58-6.49 7q36 42 213893_x_at PMS2L5-2.61 8. 63E-05 2. 52E-02-1.72-6. 477q11-q22 43 220261 s at ZDHHC4-2.38 2. 23E-05 1. 59E-02-1.57-6. 45 7p22. 2 44 202854 at HPRT1-1. 79 8. 11 E-06 9. 08E-03-1.52-6. 44 Xq26. 1 45224281_s_at NEUGRIN 2. 17 6. 62E-05 2. 31 E-02 1.67 6. 4415q26. 1 46 226975_at FLJ25070 2. 01 1. 26E-05 1. 20E-02 1.53 6. 421p21 47 226691_at KIAA1856 -2. 65 5. 04E-05 2. 02E-02-1.61-6. 397p22. 2 48 205084 at BAP29-1. 98 01E-051. 06E-02-1.51-6. 397q22. 2 49 217485_x_at PMS2L1 -2. 23 3. 85E-05 1. 91 E-02-1. 59-6. 39 7q11-q22 50 217934_x_at STUB1 -1.49 2.62E-05 1. 72E-02-1.56-6. 37 16p13. 3 2.36 AML-7 versus AML MLL # affy id HUGO name fc p q stn t Map Location 1 213893 x at PMS2L5-2.89 2.28E-13 6.64E-09-1. 66-10.76 7q11-q22 2209036 s at MDH2-2.21 1. 63E-12 1. 58E-08-1.62-10. 42 7p12. 3-q11. 2 3200976sat TAX1BP1-1. 86 1. 01E-12 1. 47E-08-1.60-10. 34 7p15 4 225002_s_at DKFZP566I1024 -3. 87 7. 25E-12 4. 22E-08-1.53-9. 79 7q11.1 5214756xat PMS2L8-2.41 1. 16E-11 4. 84E-08-1.51-9. 70 7q22 6 216843_x_at -2. 50 5. 62E-12 4.10E-08 -1. 49-9.65 7214526rat PMS2L8-2.32 1. 00E-11 4. 84E-08-1.46-9. 44 7q22 8236398sat-7. 76 2. 40E-11 8. 75E-08-1.45-9. 29 9 214651_s_at HOXA9 -5. 42 5. 54E-10 8. 97E-07-1.48-9. 24 7p15-p14 10222512at NYREN18-2.16 3. 19E-11 1. 03E-07-1.40-9. 05 7q36 11 213737_x_at -2. 28 1.92E-09 2.08E-06-1. 46-9.03 12 202605_at GUSB-3.79 3. 74E-11 1. 06E-07-1.39-9. 01 7q21.11 13 209905_at HOXA9-9.32 4. 01E-11 1. 06E-07-1.39-8. 98 7p15-p14 14 225932_s_at -1. 88 5. 29E-10 8. 97E-07-1.42-8. 96 15 215667_x_at PMS2L5-2.23 8. 63E-10 1. 20E-06-1.43-8. 95 7q11-q22 16214473 x_at PMS2L9-2.19 8. 70E-11 2.11E-07 -1. 36-8. 77 7q11. 23 17 217485_x_at PMS2L1 -2. 41 1. 34E-10 3.01E-07 -1. 34-8.68 7q11-q22 18 208445_s_at BAZ1B -4. 31 9. 48E-10 1. 20E-06-1.36-8. 62 7q11. 23 19 216525 x at PMS2L3-2.26 2. 94E-10 6. 12E-07-1.29-8. 34 7q11-q22 20239896at-2. 98 3. 19E-10 6. 20E-07-1.28-8. 29 21 224680at-2. 46 9.56E-09 6.34E-06-1. 33-8.22 22218460at FLJ20397-2.66 4. 58E-10 8. 35E-07-1.26-8. 19 7p22. 3 23231365at HOXA9-7.77 2. 33E-09 2. 34E-06-1.32-8. 087p15-p14 24201405sat COPS6-2.35 7. 03E-10 1. 08E-06-1.24-8. 05 7q22.1 25226386at LOC115416-2. 40 8. 74E-10 1. 20E-06-1.23-7. 98 7p15. 3 26 224948 at MRPS24-1. 71 4. 88E-09 4. 32E-06-1.26-7. 98 7p14 27 226032_at CASP2-2.15 1. 12E-09 1. 36E-06-1.24-7. 967q34-q35 28213150at HOXA10-6. 79 9. 28E-10 1. 20E-06-1.23-7. 957p15-p14 29 218321_x_at MK-STYX-2.69 1. 75E-09 1. 96E-06-1.23-7. 94 7q11. 23 30 217773_s_at NDUFA4-1. 79 4. 20E-07 1. 14E-04-1.37-7. 93 7p21. 3 31 202961_s_at ATP5J2-2.13 1. 63E-08 9. 69E-06-1.27-7. 92 7q22. 1 32210707xat PMS2L5-2.10 1. 40E-09 1. 63E-06-1.22-7. 91 7q11-q22 33 226364_at -7. 93 2.92E-09 2.84E-06-1. 26-7. 89 34 216111_x_at POM121-1.89 2. 82E-07 8. 40E-05-1.34-7. 84 7q11. 23 35 213147_at HOXA10-3. 59 6. 12E-09 5. 04E-06-1.22-7. 767p15-p14 36228765at-2. 32 2. 13E-09 2.21E-06 -1. 19-7.70 37 226385_s_at LOC115416 -2. 32 1. 41E-08 8. 92E-06-1.21-7. 65 7pu 5. 3 38218200sat NDUFB2-2.37 3. 53E-09 3. 32E-06-1.18-7. 64 7q34 39 223328 at MGC3195-2.54 6. 79E-08 2. 96E-05-1.24-7. 62 7q22. 1 40 217842 at CGI-59-2. 79 6. 23E-09 5. 04E-06-1.18-7. 58 7q34 41 201327 s at CCT6A-1. 98 6. 69E-09 5. 27E-06-1.16-7. 49 7p11. 1 42 217853 at TEM6-3.66 4. 57E-09 4. 16E-06-1.15-7. 47 7p15. 1 43 221581_s_at WBSCR5-2.75 1. 55E-08 9. 44E-06-1.17-7. 47 7q11. 23 44211200sat FGR-3.92 8. 40E-09 5. 98E-06-1.15-7. 42 1p36. 2-p36.1 45201272at AKR1B1-2. 76 9. 39E-09 6. 34E-06-1.16-7. 39 7q35 46221073sat CARD4-1. 62 1. 22E-08 7. 92E-06-1.15-7. 38 7p15-p14 47 208921_s_at SRI -1.82 5.93E-09 5. 04E-06-1.14-7. 36 7q21.1 48227651at NAC1 1. 56 4. 25E-07 1. 14E-04 1.23 7. 33 19p13. 12 49 201812 s at TOM7-1. 64 3. 72E-07 1. 03E-04-1.22-7. 32 7p15. 3 50204082at PBX3-3.20 6. 97E-09 5. 35E-06-1.13-7. 32 9q33-q34 2.37 AML-7 versus AML inv (16) # affy id HUGO name fc p q stn t Map Location 1 201497_x_at MYH11 -26. 22 4. 86E-11 8.01E-07 -2. 17-11.19 16p13. 13-p13. 12 2 225002_s_at DKFZP566I1024 -2.77 1.46E-11 4.83E-07-1. 75-10. 19 7q11. 1 3202605at GUSB-2.67 4. 12E-09 9.58E-06 -1. 79-9. 85 7q21. 11 4 219041_s_at RIOP60 -2. 43 5. 38E-10 2. 85E-06-1.59-9. 18 7q36. 1 5209365sat ECM1-3. 65 9. 94E-10 3. 75E-06-1.56-8. 99 1q21 6201327saut CCT6A-2.13 5. 07E-10 2. 85E-06-1.54-8. 95 7p11. 1 7218200sat NDUFB2-2.38 1. 02E-09 3. 75E-06-1.53-8. 83 7q34 8 243244_at -4. 10 5. 46E-10 2. 85E-06-1.52-8. 82 9 225935_at -2. 38 5. 79E-10 2. 85E-06-1.50-8. 72 10 202016_at MEST-6.54 6. 06E-10 2. 85E-06-1.49-8. 70 7q32 11 225640_at 1. 86 2. 77E-07 2. 08E-04 1.63 8.59 12 202185 at PLOD3-2.29 5. 1 OE-09 9. 89E-06-1.51-8. 59 7q22 13 214351 x at RPL13 1. 44 1. 88E-09 5. 64E-06 1. 47 8. 50 16q24. 3 14 201496_x_at MYH11 -4. 14 1. 42E-09 4. 67E-06-1.44-8. 38 16p13. 13-p13. 12 15 201317 s at PSMA2-1.69 3. 03E-09 8. 34E-06-1.43-8. 29 7p13 16 229309_at -8.11 7.20E-09 1. 25E-05-1.43-8. 11 17222862sat AK5-20.09 2. 25E-08 3. 09E-05-1.55-8. 11 1p31 18 227249_at NUDE1 -1. 97 3. 44E-09 8. 74E-06-1.38-8. 06 16p13. 11 19 226691 at KIAA1856-2. 47 4. 65E-09 9. 58E-06-1.38-8. 02 7p22. 2 20201005at CD9-5.63 4. 45E-09 9. 58E-06-1.36-7. 95 12p13. 3 21207961xat MYH11-20. 85 3. 47E-08 3. 94E-05-1.57-7. 95 16p13. 13-p13. 12 22 224049 at KCNK17-2.79 6. 00E-09 1. 10E-05-1.35-7. 85 6p21. 1 23 201564_s_at FSCN1 -3. 57 1. 63E-08 2. 44E-05-1.38-7. 83 7p22 24 212358_at CLIPR-59 -13. 60 3. 18E-08 3. 94E-05-1. 42-7. 77 19q13. 12 25222582at PRKAG2-2.46 1. 04E-08 1.72E-05 -1.33 -7.74 7q35-q36 26227856_at FLJ39370 5. 67 1.91E-05 3. 66E-03 1. 75 7. 69 4q25 27223967at ARP5-5.90 2.51 E-08 3.31 E-05-1.37-7. 69 19p13. 2 28219308sat AK5-7.07 4. 25E-08 4. 67E-05-1.40-7. 66 1p31 29 228899_at CUL1 -2. 22 1. 76E-08 2. 53E-05-1.32-7. 61 7q36. 1 30 226032_at CASP2-1. 84 1. 27E-08 1. 99E-05-1. 30-7. 58 7q34-q35 31 223065_s_at STARD3NL-2.29 3. 23E-08 3. 94E-05-1.32-7. 57 7p14-p13 32 223299_at LOC90701 3. 12 1.63E-05 3.31E-03 1.61 7. 44 18q21. 31 33 229202_at 3. 91 2. 70E-05 4. 39E-03 1.69 7.41 34 214743_at CUTL1-1. 78 3. 35E-08 3. 94E-05-1.27-7. 32 7q22 35 208688_x_at EIF3S9 -1. 52 3. 53E-06 1. 16E-03-1.40-7. 26 7p22. 3 36226705at FGFR1-1.73 1. 83E-07 1. 47E-04-1.26-7. 13 8p11. 2-p11. 1 37215116sat DNM1-2.98 5. 38E-08 5. 55E-05-1.23-7. 13 9q34 38210962sat AKAP9-2.17 4. 73E-08 5. 03E-05-1.22-7. 107q21-q22 39 209975_at CYP2E1 -5. 04 6. 54E-08 6. 54E-05-1.22-7. 06 10q24. 3-qter 40219132at PEU2 3. 36 1. 56E-05 3. 24E-03 1.45 7. 0314q21 41 212074_at UNC84A-2.39 7. 47E-08 7. 04E-05-1.20-6. 99 7p22. 3 42230161at-2. 74 5. 49E-07 2. 87E-04-1.25-6. 98 43 202070_s_at IDH3A -2. 10 1. 07E-07 9. 53E-05-1.22-6. 98 15q25. 1-q25.2 44 202283_at SERPINF1 -4. 81 6. 74E-08 6. 54E-05-1.20-6. 97 17p13. 1 45 238147_at TRIM46 -2. 25 3. 55E-07 2. 32E-04-1.23-6. 95 1q21. 3 46200060sat-HG-U133B RNPS1-1. 49 8. 63E-08 7.91E-05 -1. 18-6. 89 16p13. 3 47 243286_at -2. 73 3. 58E-07 2. 32E-04-1.21-6. 88 48217809at BZW2-2.12 2. 59E-07 1. 99E-04-1.19-6. 837p21. 1 49 205419_at EBI2 -3. 20 5. 03E-07 2.80E-04 -1. 21-6. 81 13q32. 2 50226975_at FLJ25070 2.19 2. 01E-06 7. 99E-04 1.25 6. 80 1 p21 2.38 AML-7 versus AML inv (3) # affy id HUGO name fc p q stn t Map Location 1 206478_at KIAA0125 -4. 72 9. 56E-06 7. 88E-02-1.15-5. 79 14q32. 33 2 210933_s_at FSCN1-2.45 8. 61E-06 7. 88E-02-1.07-5. 58 7p22 3 217019_at -2. 74 1. 51 E-05 7. 88E-02-1.09-5. 52 4 201258_at RPS16 1. 34 1. 03E-05 7. 88E-02 1.06 5. 50 19q13. 1 5220668sat DNMT3B-2.68 1. 39E-05 7. 88E-02-1.05-5. 44 20q11. 2 6220583at FLJ22596-1.55 1. 39E-05 7. 88E-02-1.04-5. 41 11q13. 3 7244332at-2. 84 1. 72E-05 7. 88E-02-1.05-5. 38 8225563at LOC255967-1.94 1. 79E-05 7. 88E-02-1.03-5. 32 13q12. 13 9 208532_x_at -2. 23 1. 71E-04 1.82E-01-1. 09-5.15 10 210086_at HR-1.82 3. 55E-05 1. 17E-01-1.01-5. 13 8p21. 2 11 216947_at DES-3.10 3. 62E-05 1. 17E-01-0.99-5. 08 2q35 12 232899_at -1. 53 3.66E-05 1.17E-01-0. 97-5.01 13 222992 s at NDUFB9 1. 62 4. 37E-04 2. 19E-01 1.13 4. 98 8q13. 3 14 211597_s_at HOP-4.51 9.72E-05 1.82E-01-1. 06-4. 984q11-q12 15 219275 at PDCD5 1. 69 3. 12E-04 2. 07E-01 1.08 4. 96 19q12-q13. 1 16 214351_x_at RPL13 1. 27 5. 48E-05 1. 61E-01 0.94 4. 87 16q24. 3 17 220443_s_at VAX2-2.03 1.13E-04 1.82E-01-0. 97-4. 85 2p13 18216546sat-2. 91 7.46E-05 1.82E-01-0. 95-4.83 19212251_at 1.42 8.25E-05 1.82E-01 0.92 4.76 20 223161_at LCHN-1.77 1.74E-04 1.82E-01-0. 93-4. 66 7q34 21 204525_at KIAA0783 -1. 73 9. 01E-05 1.82E-01-0. 90-4. 66 7p21. 3 22 239072_at 2. 81 8. 53E-04 2. 34E-01 1.09 4.65 23 33646_g_at GM2A 1. 80 7. 55E-04 2. 32E-01 1.06 4. 65 5q31. 3-q33.1 24213780at THH-4.51 2.15E-04 1.82E-01-1. 02-4. 65 1q21. 3 25 224576_at KIAA1181 -2. 87 1. 31E-04 1.82E-01-0. 92-4. 645q35. 2 26 223479_s_at C2orf9 1.53 3.94E-04 2.19E-01 0.97 4. 62 2q13 27 228587_at -3. 20 2.17E-04 1.82E-01-0. 98-4.60 28226762at-2. 09 1. 17E-04 1.82E-01-0. 89-4.58 29 200657_at SLC25A5 1.27 1.17E-04 1.82E-01 0.88 4. 56 Xq24-q26 30 204304_s_at PROML1 -6. 36 2. 39E-04 1. 91E-01-0.95-4. 54 4p15. 33 31 230929_s_at UBE2J2-2.32 1.33E-04 1.82E-01-0. 88-4. 54 1p36. 33 32 224751_at -1. 80 1.66E-04 1.82E-01-0. 89-4. 53 33 202876_s_at PBX2-2.37 1.67E-04 1.82E-01-0. 89-4. 51 6p21. 3 34 217979 at NET-6-2.57 1.34E-04 1.82E-01-0. 87-4. 51 7p21. 1 35 239595_at -2. 63 1.36E-04 1.82E-01-0. 87-4.50 36 216291_at -2. 56 1.35E-04 1.82E-01-0. 87-4.50 37226790_at 1.72 4.09E-04 2.19E-01 0.93 4.49 38 228149_at FLJ31818 -1. 91 1.42E-04 1.82E-01-0. 86-4. 49 7q31. 1 39 221263_s_at SF3b10 1.51 1.77E-04 1.82E-01 0.87 4. 486q24. 1 40 238498_at -2. 43 1.49E-04 1.82E-01-0. 86-4.47 41 219884 at LHX6-4.26 2.14E-04 1.82E-01-0. 89-4. 46 9q33. 3 42 226032_at CASP2-1.54 1.79E-04 1.82E-01-0. 87-4. 46 7q34-q35 43 221288 at GPR22-2.47 2.02E-04 1.82E-01-0. 87-4. 43 7q22-q31. 1 44 237472at 3.06 9.54E-04 2.34E-01 0.98 4.41 45217809at BZW2-2.00 1.89E-04 1.82E-01-0. 85-4. 40 7p21. 1 46219342at CAS1-1. 78 1.80E-04 1.82E-01-0. 85-4. 39 7q21. 3 47 225954_s_at MIDN -1. 98 1.82E-04 1.82E-01-0. 84-4. 39 19p13. 3 48218672_at MGC3180 1. 96 7. 29E-04 2. 32E-01 0.94 4. 39 1q21. 2 49220201at MNAB-2.00 2.19E-04 1.82E-01-0. 85-4.38 9q34 50 204916at RAMP1-2. 86 2. 57E-04 1. 99E-01-0.87-4. 37 2q36-q37. 1 2.39 AML_-7 versus AML komplext &num affy id HUGO name fc p q stn t Map Location 1 214351_x_at RPL13 1. 72 2.05E-13 3. 79E-09 1.76 11.39 16q24.3 2 218389_s_at APH-1A -2.14 2.77E-11 1. 71E-07-1. 70-10.72 1p36. 13-q31. 3 3 221073_s_at CARD4-1.94 2. 37E-12 2. 19E-08-1.53-10. 01 7p15-p14 4212826sat SLC25A6 1. 72 4. 57E-10 1. 69E-06 1.45 9.20 Xp22.32 and Yp 5 220099_s_at CGI-59 -2.19 1.65E-08 9. 93E-06-1.43-8. 70 7q34 6202876sat PBX2-3.00 1. 31 E-10 6. 07E-07-1.32-8. 60 6p21. 3 7234339sat GLTSCR2 2. 44 4. 63E-07 6. 38E-05 1.52 8. 54 19q13. 3 8200997at RBM4-2.04 1. 25E-09 2. 56E-06-1.29-8. 31 11q13 9211724xat FLJ20323-1. 924. 13E-094. 75E-06-1.24-7. 97 7p22-p21 10 225932_s_at -1.98 1.04E-09 2. 56E-06-1.21-7. 93 11 214743 at CUTL1-1.92 1.07E-09 2.56E-06-1. 21-7.91 7q22 12201453_x_at RHEB2-2.13 8. 45E-09 6. 24E-06-1.24-7. 91 7q36 13 217846 at QARS 1. 59 6. 60E-08 2. 07E-05 1.29 7. 89 3p21. 3-p21. 1 14 208445_s_at BAZ1B -5. 77 1.12E-09 2.56E-06-1. 20-7. 85 7q11. 23 15207844_at IL13 3. 57 5. 15E-06 3. 14E-04 1. 50 7.81 5q31 16 54970_at DKFZp76112123-2. 02 6. 60E-09 5. 64E-06-1.20-7. 73 7p12. 3 17 222999 s at CCNL2-1.92 1. 62E-093. 00E-06-1. 18-7. 731p36. 33 18225644_at FLJ33814-2. 75 2. 52E-09 3. 58E-06-1.19-7. 72 22q12. 1 19 201458 s at BUB3-2.12 6. 72E-09 5. 64E-06-1.20-7. 69 10q26 20 212031 at S164-2.13 4. 44E-08 1. 65E-05-1.23-7. 65 14q24. 3 21214700xat DKFZP434D193-2. 57 2. 39E-09 3. 58E-06-1.17-7. 64 2q23. 3 22 217427_s_at HIRA -5. 78 2. 19E-09 3. 58E-06-1.16-7. 63 22q11. 21 23 226975_at FLJ25070 2. 49 4. 82E-07 6. 42E-05 1.29 7.61 1p21 24206860sat FLJ20323-1. 92 1.08E-08 7. 41 E-06-1. 18-7. 58 7p22-p21 25206550sat NUP155-2.36 5. 46E-09 5.31E-06-1. 16-7. 55 5p13. 1 26226386at LOC115416-2. 31 3. 30E-09 4. 33E-06-1.15-7. 52 7p15. 3 27 213151_s_at CDC10 -1. 74 7. 61E-09 5. 97E-06-1.16-7. 507p14. 3-p14. 1 28 225437 s at MGC22916-1.92 3. 52E-09 4. 33E-06-1.14-7. 48 7p22. 3 29 225935_at-2. 50 4.37E-09 4.75E-06-1. 14-7.43 30 212491_s_at DNAJC8 -1. 82 2. 26E-07 4. 53E-05-1.21-7. 40 1 p35. 2 31 222843_at FIGNL1-2. 75 5. 03E-09 5. 16E-06-1.13-7. 38 7p12. 1 32 241681_at -2. 11 9. 12E-09 6. 48E-06-1.13-7. 37 33 200976_s_at TAX1BP1 -1. 94 6. 48E-09 5. 64E-06-1.13-7. 36 7p15 34200657_at SLC25A5 1.40 3.44E-08 1.39E-05 1.15 7. 33Xq24-q26 35 200074_s_at - HG-U133B RPL14 1.35 1.94E-08 1.05E-05 1.14 7. 32 3p22-p21. 2 36 206095_s_at FUSIP1 -2. 08 7. 76E-09 5. 97E-06-1.12-7. 29 1p36.11 37223396at DC32-1. 91 2. 08E-08 1. 07E-05-1.13-7. 28 7q11. 23 38 211746_x_at PSMA1 -1. 49 1.97E-08 1.05E-05-1. 12-7. 26 11p15. 1 39203092at T) MM44-5. 09 5. 42E-08 1. 85E-05-1.14-7. 24 19p13. 3-p13. 2 40 226762_at -2.51 1.39E-08 8. 83E-06-1.11-7. 20 41 224481_s_at HECTD1 -1. 79 4. 05E-07 5. 84E-05-1.18-7. 19 14q12 42217734sat WDR6-2. 24 1. 96E-08 1. 05E-05-1.11-7. 1915q21 43 225610_at URF2-1.94 2. 62E-08 1. 23E-05-1.10-7. 12 9p24. 1 44 201258_at RPS16 1.43 3.46E-08 1.39E-05 1.10 7. 10 19q13. 1 45 226434 at MGC22793-2.18 1. 31 E-088. 64E-06-1.08-7. 097q22. 1 46 205545_x_at DNAJC8-1. 69 3. 42E-07 5. 42E-05-1.15-7. 09 1 p35. 2 47 200086_s_at - HG-U133B COX4I1 1. 61 1. 25E-06 1. 30E-04 1.20 7. 06 16q22-qter 48 223065_s_at STARD3NL-2.32 2. 94E-08 1. 29E-05-1.09-7. 06 7p14-p13 49 201973_s_at CGI-43 -1.68 8.41E-08 2. 37E-05-1.11-7. 057p22. 2 50 212351_at EIF2B5 -1. 90 2. 23E-08 1.10E-05 -1. 08-7. 05 3q27. 3 2.4 AML-7 versus AMLnorma ! # affy id HUGO name fc p q stn t Map Location 1 200976sat TAX1BP1-1. 99 2. 87E-15 4.45E-12-1. 66-17.48 7p15 2 225002_s_at DKFZP566I1024 -2. 96 6.78E-16 1.24E-12-1. 41-15. 47 7q11. 1 3214743_at CUTL1-2. 00 2. 81E-19 1. 09E-15-1.30-15. 14 7q22 4 213893_x_at PMS2L5-2.44 6. 00E-13 5.63E-10-1. 43-14.76 7q11-q22 5 224751 at-2. 42 2. 11E-15 3.45E-12-1. 34-14.76 6226032at CASP2-2.35 3. 23E-22 2. 50E-18-1.21-14. 62 7q34-q35 7210962sat AKAP9-2.51 2. 37E-12 1. 79E-09-1. 36-13. 98 7q21-q22 8 225935_at -2. 48 6.22E-14 7. 13E-11-1. 23-13.39 9225932sat-1. 98 2.06E-09 5.32E-07-1. 49-13.25 10 218378_s_at FLJ13902-2.61 6. 87E-20 3. 04E-16-1.09-13. 17 7q22. 1 11 216843_x_at -2. 11 3.75E-12 2.58E-09-1. 25-13.05 12 214473_x_at PMS2L9-2.15 6.94E-12 4.48E-09-1. 23-12. 807q11. 23 13 200977_s_at TAX1BP1 -2. 33 7.17E-10 2.16E-07-1. 34-12.67 7p15 14 216525 x at PMS2L3-2.13 7. 19E-15 9.28E-12-1. 11-12.56 7q11-q22 15226529at FLJ11273-3. 18 6. 35E-15 8. 94E-12-1. 09-12. 44 7p21. 3 16 214526_x_at PMS2L8-2.00 8. 81E-11 4. 14E-08-1.24-12. 42 7q22 17226336_at PPIA-2. 42 2.48E-09 6. 00E-07 -1. 34-12. 29 7p13-p11. 2 18 201682 at PMPCB-1.75 1. 70E-13 1.81E-10 -1. 07-11.90 7q22-q32 19231365at HOXA9-5.78 2. 32E-23 7. 18E-19-0.91-11. 78 7p15-p14 20226386at LOC115416-2. 42 6. 81E-13 6.20E-10-1. 07-11. 75 7p15. 3 21 209036sat MDH2-1.94 8.66E-10 2.53E-07-1. 21-11.71 7p12. 3-q11. 2 22213780at THH-4.11 5. 68E-23 8. 80E-19-0. 91-11.71 1q21. 3 23235521at HOXA3-8.39 1. 20E-16 3. 10E-13-0. 98-11.66 7p15-p14 24218321xat MK-STYX-2.76 2. 70E-10 1.01E-07 -1. 16-11. 60 7q11. 23 25 208921_s_at SRI -1. 79 6.77E-12 4.46E-09-1. 07-11.52 7q21. 1 26 217485_x_at PMS2L1 -2. 14 1.08E-08 2.05E-06-1. 28-11. 50 7q11-q22 27 225238_at -6. 22 1. 81E-22 1.87E-18-0. 89-11.43 28225556at LOC203547-1. 98 1. 25E-11 7. 91 E-09-1. 07-11. 42 Xq28 29 239237_at -3. 29 4. 61E-18 1.59E-14-0. 93-11.38 30201327sat CCT6A-2. 00 6. 42E-09 1. 34E-06-1.22-11. 30 7p11. 1 31 201317 s at PSMA2-1.71 6. 26E-10 1. 96E-07-1.13-11. 28 7p13 32239896at-2. 55 5. 27E-11 2.68E-08-1. 07-11.21 33 202591_s_at SSBP1-1. 77 7. 85E-11 3. 80E-08-1.06-11. 11 7q34 34213097sat ZRF1-2.40 1. 90E-08 3. 37E-06-1.24-11. 09 7q22-q32 35201405sat COPS6-2.09 1. 15E-09 3. 12E-07-1.12-11. 07 7q22. 1 36231175_at FLJ30162-9. 79 5.43E-20 2. 80E-16-0. 86-10. 95 6p11. 1 37 227754_at -2. 19 1.62E-12 1.27E-09-0. 97-10.81 38 222742 s at FLJ14117-2.33 4. 09E-11 2. 15E-08-1.01-10. 78 7q22.1 39 210707_x_at PMS2L5-1.96 4.85E-09 1.04E-06-1. 11-10. 70 7q11-q22 40 214457-at HOXA2-6. 67 4.62E-20 2.80E-16-0. 83-10.70 7p15-p14 41 223065sat STARD3NL-2.36 4. 21 E-08 6.73E-06-1. 21-10.69 7p14-p13 42 242673_at-2. 19 1. 61 E-10 6.76E-08-1. 01-10.64 43 228476_at KIAA1407 -3. 36 5. 78E-16 1. 12E-12-0.88-10. 62 3q13. 2 44 217809 at BZW2-2.42 3.54E-09 7.94E-07-1. 09-10.62 7p21. 1 45221073sat CARD4-1.64 3. 38E-09 7. 65E-07-1.08-10. 54 7p15-p14 46214756xat PMS2L8-1.98 1. 03E-07 1. 38E-05-1.24-10. 53 7q22 47218200sat NDUFB2-2.17 8.34E-08 1.16E-05-1. 22-10.50 7q34 48 208688_x_at EIF3S9 -1. 77 8. 28E-09 1. 63E-06-1.09-10. 46 7p22.3 49 219041_s_at RIP60 -2. 33 6.06E-10 1.92E-07-1. 01-10.41 7q36.1 50 214351_x_at RPL13 1. 36 3. 07E-08 5. 12E-06 1.14 10. 38 16q24. 3 2.41 AML_-7 versus AML t (15 ; 17) # affy id HUGO name fc p q stn t Map Location 1 2'12953 x at CALR-3.68 2. 61E-14 6. 81E-10 -2. 82-15.07 19p13. 3-p13. 2 2214450at CTSW-9.10 5.29E-14 6. 91 E-10-2. 65-14.24 11q13. 1 3 205382_s_at DF -4. 91 1. 98E-10 8.61E-07 -2. 19-11. 46 19p13. 3 4 200977 s at TAX1 BP1-2. 62 2. 44E-11 2. 12E-07-2.03-10. 90 7p15 5221253sat MGC3178-3.11 3. 59E-10 9. 39E-07-2.04-10. 53 6p24.3 6 201825_s_at CGI-49 -3. 67 1. 61 E-10 8.39E-07-1. 88-10.08 1q44 7 217716_s_AT SEC61A1 -1. 96 1.30E-10 8.39E-07-1. 86-10. 04 3q21. 3 8 55093_at CSGIcA-T -2. 02 2. 64E-10 8.61E-07 -1. 84-9. 847q36. 1 9 200986_at SERPING1 -7. 57 1. 98E-09 2. 72E-06-1.92-9. 82 11q12-q13. 1 10 200976_s_at TAX1BP1 -2. 32 1. 23E-09 1. 78E-06-1.89-9. 79 7p15 11 212509sat-5. 07 3. 24E-10 9.39E-07-1. 83-9.79 12 222742_s_at FLJ14117 -2. 68 2. 52E-10 8.61E-07 -1. 81-9. 74 7q22. 1 13212826sat SLC25A6 1.66 4. 71E-09 4. 92E-06 1.86 9. 68 Xp22. 32 and Yp 14 217225 x at LOC283820-2.22 8. 11E-10 1.41E-06 -1. 81-9. 66 16p13. 13 15 225002_s_at DKFZP566I1024 -3. 46 1. 12E-09 1. 78E-06-1.84-9. 65 7qu 1. 1 16208852sat CANX-2.56 4. 04E-10 9. 60E-07-1.80-9. 65 5q35 17 201004 at SSR4-2.18 7. 61E-10 1. 41E-06-1. 81-9.61 Xq28 18 38487_at STAB1 -4. 57 2. 89E-09 3. 50E-06-1.81-9. 54 3p21. 31 19 208612 at GRP58-1.87 5. 50E-10 1. 20E-06-1.75-9. 44 15q15 20224680at-3. 03 6. 65E-10 1. 34E-06-1.73-9. 31 21 218476at POMT1-2. 43 5.43E-09 5.36E-06-1. 77-9.31 9q34.1 22 205614_x_at MST1 -7.11 2.94E-09 3. 50E-06-1.77-9. 24 3p21 23 209732_at CLECSF2 36.27 1. 49E-05 1. 09E-03 2.89 9.24 12p13-p12 24 241383_at -3. 96 3. 48E-09 3. 96E-06-1.75-9. 16 25 219837 s at C17-18.59 1. 26E-08 9. 70E-06-1.84-9. 12 4p16-p15 26 224839_s_at GPT2 -5.12 1.18E-09 1. 78E-06-1.68-9. 05 16q12. 1 27 238058 at 2.96 7.24E-06 7.14E-04 2.23 9.04 28 218378_s_at FLJ13902-2.72 3. 97E-09 4. 32E-06-1.71-9. 00 7q22. 1 29205624at CPA3-5. 98 6. 16E-09 5. 75E-06-1.70-9. 00 3q21-q25 30204150at STAB1-5. 55 2. 44E-09 3. 18E-06-1.64-8. 81 3p21. 31 31 201622_at p100 -2. 07 3. 75E-08 2. 13E-05-1.70-8. 79 7q31. 3 32 200757sat CALU-4.02 8.55E-09 7.20E-06-1. 65-8.66 7q32 33202185at PLOD3-3.52 1. 01E-08 8. 23E-06-1.64-8. 60 7q22 34 238022_at -4. 63 2. 70E-08 1. 76E-05-1.63-8. 54 35 232008_s_at BBX 2. 48 5. 68E-07 1. 34E-04 1.75 8. 53 3q13. 1 36223486at HSPC135 2. 25 1.28E-07 4. 66E-05 1.67 8. 51 3q13. 2 37 201069 at MMP2-17.56 6. 29E-08 2. 89E-05-1.83-8. 50 16q13-q21 38AFFX-r2-Ec-bioC-5at-HG-U133A-2. 17 1.93E-08 1.40E-05-1. 64-8.48 39206914_at CRTAM 4. 57 1. 02E-06 1. 96E-04 1.75 8. 4411q22-q23 40 208730_x_at RAB2 2. 12 5.01E-06 5. 74E-04 1.90 8. 43 8q12. 1 41 225640_at 2.11 2.66E-08 1.76E-05 1.60 8.40 42218200sat NDUFB2-2.63 5.55E-09 5.36E-06-1. 56-8.40 7q34 43 216843_x_at -2.18 7. 37E-09 6. 42E-06-1.56-8. 36 44229739sat 3.51 4.82E-07 1. 21E-04 1.69 8.36 45AFFX-r2-Ec-bioC-3at-HG-U133A-2. 06 2.84E-08 1.81E-05-1. 62-8.33 46 210755_at HGF-19.15 5. 37E-08 2. 76E-05-1.67-8. 32 7q21. 1 47 205771_s_at AKAP7 8.95 2. 13E-05 1. 43E-03 2.19 8.32 6q23 48 201405_s_at COPS6-2.22 6. 53E-09 5.88E-06 -1.54 -8.30 7q22. 1 49211990at HLA-DPA1 9.70 2. 54E-05 1. 59E-03 2.23 8. 256p21. 3 50 203484_at SEC61G -2.56 1.11E-07 4.21E-05 -1. 60-8. 24 7pu 1. 2 2.42 AML-7 versus AML_t (8; 21) &num affy id HUGO name fc p q stn t Map Location 1204020at PURA 3. 28 4. 49E-09 1. 94E-05 1.89 10.28 5q31 2 228827 at-104. 69 4.47E-10 1.21E-05 -1. 99-10.05 3206940sat POU4F1-48. 75 1.34E-09 1. 21E-05-1. 87-9. 49 13q21. 1-q22 4 205529_s_at CBFA2T1 -15. 39 1.99E-09 1. 21E-05-1. 73-9. 19 8q22 5 225002_s_at DKFZP566I1024 -3. 32 1.33E-09 1. 21E-05-1. 52-8.71 7q11. 1 6 211341_at POU4F1 -231. 00 9. 72E-09 3.26E-05 -1.69 -8.54 13q21.1-q22 7239896at-2. 48 2.01 E-09 1. 21 E-05-1. 45-8.41 8 238147_at TRIM46 -2. 66 3. 92E-09 1. 94E-05-1.46-8. 41 1q21. 3 9205528sat CBFA2T1-36. 27 1. 23E-08 3. 72E-05-1.63-8. 41 8q22 10204021sat PURA 3. 68 5. 70E-06 1. 68E-03 1.73 8.13 5q31 11 226032 at CASP2-2. 11 6. 36E-09 2. 40E-05-1.39-7. 98 7q34-q35 12224680at-2. 30 1. 07E-07 1. 34E-04-1.38-7. 71 13 232227_at -6. 75 4.88E-08 9.71 E-05-1.41-7. 65 14 242845_at -4. 94 2. 17E-08 5.95E-05 -1. 31-7.55 15 203198 at CDK9 2. 15 4. 44E-06 1. 48E-03 1.44 7. 34 9q34. 1 16 202185 at PLOD3-2.05 1. 64E-07 1. 72E-04-1.29-7. 30 7q22 17229406at-6. 31 3. 13E-08 7. 88E-05-1.24-7. 25 18 202605 at GUSB-2.49 6. 72E-08 1. 13E-04-1.24-7. 17 7q21. 11 19 203859_s_at PALM-3.40 4. 57E-08 9. 71 E-05-1. 22-7. 13 19p13. 3 20230370xat MK-STYX-2.57 4.88E-08 9. 71 E-05-1. 22-7. 12 7q11. 23 21 209168at-3. 07 5.63E-08 9.99E-05-1. 23-7.11 22 218321 x at MK-STYX-2.72 5. 15E-08 9. 71E-05-1. 21-7. 07 7qu 1. 23 23 201825_s_at CGI-49 -2. 88 8. 56E-08 1. 28E-04-1.21-7. 03 1 q44 24201405sat COPS6-1.92 9. 31E-08 1. 28E-04-1.20-6. 997q22. 1 25 204811 s at CACNA2D2-5.30 2. 73E-07 2. 35E-04-1.30-6. 973p21. 3 26230650at-3. 24 7.65E-08 1. 21E-04-1. 19-6.94 27232008sat BBX 1. 97 4. 46E-06 1. 48E-03 1.33 6. 94 3q13. 1 28 214351_x_at RPL13 1.39 9. 10E-08 1. 28E-04 1.18 6. 88 16q24. 3 29 204658_at HSU53209 -1.96 9.92E-08 1. 30E-04-1.18-6. 86 7p15. 3 30226705at FGFR1-1. 86 1. 22E-07 1. 42E-04-1.17-6. 80 8p11.2-p11. 1 31 207202_s_at NR1I2 -4. 13 1. 19E-07 1. 42E-04-1.16-6. 78 3q12-q13. 3 32 208445_s_at BAZ1B -3. 80 1. 67E-07 1. 72E-04-1.16-6. 75 7q11. 23 33 218236_s_at PRKCN 7. 29 1.11E-04 1. 20E-02 1.74 6.71 2p21 34 206622 at TRH-26.77 5. 58E-07 3. 66E-04-1.27-6. 70 3q13. 3-q21 35 204073_s_at C11orf9 -4. 40 1. 71E-07 1. 72E-04-1.16-6. 7011q12-q13. 1 36 54970_at DKFZp76112123-1. 99 1. 69E-07 1. 72E-04-1.15-6. 68 7p12. 3 37 235468_at-4. 94 2. 54E-07 2. 26E-04-1.16-6. 66 38209170sat GPM6B-13.39 4. 43E-07 3. 26E-04-1.19-6. 64 Xp22. 2 39209036sat MDH2-1.86 1. 77E-07 1. 73E-04-1.14-6. 637p12. 3-q11. 2 40 223299 at LOC90701 2. 65 2. 62E-05 4. 45E-03 1.36 6. 61 18q21. 31 41 225321_s_at PILR -2. 43 1. 95E-07 1. 83E-04-1.13-6. 61 7q22. 1 42 213194_at ROBO1 -41. 39 8. 06E-07 4. 54E-04-1.24-6. 55 3p12 43 216843_x_at -1.83 2.27E-07 2. 08E-04-1.12-6. 54 44 229116at-11. 78 8. 29E-07 4.54E-04-1. 22-6.52 45 223575_at KIAA1549 -3. 57 2.96E-07 2. 41 E-04-1.12-6. 51 7q34 46225056at-6. 36 5. 95E-07 3. 82E-04-1.16-6. 50 47221073sat CARD4-1.85 3. 54E-07 2. 81E-04-1. 13-6. 497p15-p14 48224443at MGC14801-4. 76 2. 87E-07 2. 40E-04-1.11-6. 48 1q32. 2 49 20096_s_at TAX1BP1 -1. 72 3. 66E-07 2. 83E-04-1.12-6. 46 7p15 50213015_at 1.85 1. 71E-05 3.40E-03 1.27 6.45 2.43 AML_5q versus AML_9q # affy id HUGO name fc p q stn t Map Location 1 211709sat SCGF-7.28 4.04E-08 1.06E-03-2. 68-10.70 19q13. 3 2208736at ARPC3-1.90 2. 03E-07 2. 65E-03-2.40-9. 56 12q24. 11 3229932at 3. 68 2.21E-05 4. 18E-02 2.01 7.59 4 203938_s_at TAF1C -1.94 3.77E-06 3. 15E-02-1.86-7. 42 16q24 5 236895 at 2.65 6.02E-06 3.15E-02 1.83 7.26 6212062at ATP9A 10.60 1. 28E-04 7. 30E-02 2.09 7. 25 20q13.11-q13. 2 7217751at LOC51064-2.26 5. 47E-06 3. 15E-02-1.79-7. 14 7q34 8 237081_at 2.25 7.33E-06 3.20E-02 1.72 6.90 9 202113_s_at SNX2-2.45 1. 78E-05 3. 87E-02-1.76-6. 85 5q23 10214863at 2. 77 1. 06E-05 3. 87E-02 1.72 6.82 11 208639 x at P5-2.05 6. 27E-05 6. 95E-02-1.81-6. 802p25. 1 12 201978_s_at KIAA0141 -3. 23 1. 27E-05 3. 87E-02-1.67-6. 67 5q31. 3 13 236294_at 2. 08 1. 72E-05 3. 87E-02 1.68 6.64 14 229024 at 2. 68 5. 60E-05 6. 95E-02 1.74 6.64 15 239856_at 3. 723. 31E-048. 16E-02 1.99 6.62 16 206851_at RNASE3-4. 12 1.74E-05 3. 87E-02-1.66-6. 56 14q24-q31 17 208674_x_at DDOST-1.87 2. 65E-05 4.61E-02 -1. 67-6. 51 1p36. 1 18200095xat-HG-U133A RPS10 1. 34 1. 75E-05 3. 87E-02 1.63 6. 476p21. 31 19 204561 x at APOC2-16.50 1. 82E-04 7. 38E-02-2.00-6. 46 19q13. 2 20 240191 at 2. 44 4. 24E-05 5. 83E-02 1.66 6.45 21 227679 at 1.70 4. 11E-05 5. 83E-02 1.60 6.28 22 208646_at RPS14-2.66 2. 24E-05 4. 18E-02-1.56-6. 24 5q31-q33 23 225383 at ZNF275 1. 83 2. 34E-04 7. 90E-02 1.67 6. 10 Xq28 24 232781_at 1. 65 1. 47E-04 7. 30E-02 1.60 6.03 25 229611 at LMLN 1.61 3. 61E-05 5. 74E-02 1.51 6.03 3 26 202843_at DNAJB9 2. 02 1. 73E-04 7. 38E-02 1.59 5.98 7q31 27 207974_s_at SKP1A -1.99 3.73E-05 5. 74E-02-1.48-5. 92 5q31 28 201049 s at RPS18 1. 28 6. 07E-05 6. 95E-02 1.50 5. 91 6p21. 3 29231764_at CHRAC1 1.57 1. 21E-04 7.30E-02 1.52 5. 868q24. 3 30232491_at 2. 73 2. 13E-04 7. 77E-02 1.56 5.84 31 208717-at OXALL-1. 99 1. 21 E-04 7.30E-02-1. 52-5. 80 14q11. 2 32 202298_at NDUFA1 -2. 03 6. 86E-05 7. 17E-02-1.47-5. 80 Xq24 33209439sat PHKA2-1.94 9.28E-05 7.30E-02-1. 48-5. 76 Xp22. 2-p22.1 34 227056_at -2. 04 1.42E-04 7.30E-02-1. 51-5.74 35 226547 at 2.20 5.26E-05 6.88E-02 1.43 5.72 36223990at DKFZP434G072 2. 05 6. 38E-05 6. 95E-02 1.41 5. 634q22. 3 37 218436_at SIL1 -2. 90 9.59E-05 7.30E-02-1. 42-5. 62 5q31 38238963at MGC2734 2. 61 3. 60E-04 8. 30E-02 1.52 5. 61 9q33. 3 39231101at PPP2R5E 1. 88 3. 79E-04 8. 40E-02 1.52 5. 60 14q23. 1 40243406_at 2.09 1.32E-04 7.30E-02 1.43 5.59 41 216032 s at SDBCAG84-2.65 2. 36E-04 7. 90E-02-1.50-5. 58 20pter-q12 42201432_at CAT-1.46 8.93E-05 7.30E-02-1. 41-5. 58 11p13 43 224062_x_at KLK4 2.05 1. 29E-04. 7.30E-02 1.43 5.56 19q13. 41 44241319_at 1.93 1. 31E-04 7.30E-02 1.42 5.55 45 208243_s_at CNR1 2.14 1.98E-04 7.56E-02 1.44 5. 54 6q14-q15 46 2183483_at C14orf94 -2. 01 1.17E-04 7. 30E-02-1. 41-5. 53 14q11. 2 47234998at 2.30 7.49E-05 7.30E-02 1.38 5.53 48 244751_at MGC41903-1.81 1. 83E-04 7. 38E-02-1.44-5. 52 19p13. 2 49200674sat RPL32 1.25 7. 81 E-05 7.30E-02 1.38 5. 51 3p25-p24 50 223834_at B7-H1 2. 19 2. 13E-04 7. 77E-02 1.43 5.51 9p24 2.44 AML_5q versus AML MLL # affy id HUGO name fc p q stn t Map Location 1 208843_s_at GORASP2 1.96 1. 32E-07 9. 48E-05 2.09 11. 16 2p24. 3-q21. 3 2201105at LGALS1-8.23 4. 09E-11 2. 72E-07-1.70-10. 44 22q13. 1 3228526at-3. 71 9.58E-12 1. 11E-07 -1. 66-10.35 4 228083_at CACNA2D4-14. 34 1.06E-11 1.11E-07 -1. 64-10. 05 12pu3. 33 5 202259_s_at CG005 2.30 2. 99E-06 7. 14E-04 2.02 9. 96 13q12-q13 6209705at 2. 16 7. 19E-06 1. 22E-03 2.01 9.59 7202423at RUNXBP2 2. 21 3. 74E-06 8. 23E-04 1.93 9. 59 8p11 8 204082_at PBX3-7. 48 1.25E-11 1.11E-07 -1. 51-9. 54 9q33-q34 9200952sat CCND2 2. 62 1. 39E-06 4. 56E-04 1.81 9. 46 12p13 10 202843_at DNAJB9 3. 72 1. 76E-05 2. 16E-03 2.03 9.19 7q31 11 224916_at -4.45 1.23E-10 5. 46E-07-1.46-9. 03 12 213372_at LOC152559 2. 34 1.10E-06 4. 15E-04 1.65 8. 92 4q21. 21 13 214651_s_at HOXA9-2.82 1. 15E-10 5. 46E-07-1.40-8. 85 7p15-p14 14 208717_at OXA1L -2. 34 1. 93E-10 7. 35E-07-1.37-8. 64 14q11. 2 15206555sat FLJ20274 2. 00 8. 06E-06 1. 29E-03 1.69 8. 51 16p13. 11 16 226547_at 2. 50 9. 04E-06 1. 37E-03 1.66 8.39 17 227045 at 2. 20 2. 62E-06 6. 65E-04 1.56 8.36 18 200764_s_at CTNNA1 -2. 22 1. 58E-09 4. 21E-06-1. 31-8.18 5q31 19 216032 s at SDBCAG84-3.57 7. 89E-10 2. 63E-06-1.30-8. 18 20pter-q12 20213025at FLJ20274 2. 36 2.19E-05 2. 46E-03 1.67 8. 08 16p13. 11 21 206648 at HSPC059 3. 76 3.31E-05 3. 22E-03 1.72 8. 07 19q13. 12 22 230872_s_at DKFZP434B103 -6. 71 2. 88E-09 6. 99E-06-1.31-7. 993p25. 3 23 209329_x_at MGC2198-1.95 1. 44E-08 1. 90E-05-1.29-7. 945q35. 3 24 228138_at 1.53 3.92E-09 8.70E-06 1.26 7.91 25 211016 x at HSPA4-2. 10 1.51E-09 4.21E-06 -1. 25-7. 91 5q31. 1-q31. 2 26211709sat SCGF-6. 11 1.21E-98 1. 86E-05-1.26-7. 80 19q13. 3 27225621_at FLJ14511 2. 72 1. 96E-05 2. 35E-03 1.56 7. 79 9q22.33 28208882sat DD5 2. 13 1.61E-05 2. 02E-03 1.53 7. 75 8q22 29200602at APP 15.56 1. 92E-04 9. 90E-03 2.17 7. 71 21q21. 3 30208967sat AK2-3.50 5. 37E-09 9. 90E-06-1.24-7. 66 1p34 31 208673sat SFRS3 1.76 2. 00E-06 5.72E-04 1.36 7.61 6p21 32 236398_s_at -4. 19 4. 75E-09 9. 74E-06-1.20-7. 60 33211063sat NCK1 2. 57 9. 92E-05 6. 55E-03 1.76 7. 60 3q21 34 226867_at FLJ20686 3.30 1.23E-04 7.63E-03 1.83 7. 59 9p21. 3 35 214500 at H2AFY-9.84 5. 57E-09 9. 90E-06-1.21-7. 58 5q31. 3-q32 36234998_at 2.22 9.66E-05 6.49E-03 1.75 7.58 37207236at ZNF345 2. 42 2. 93E-08 3. 30E-05 1.23 7. 56 19q13. 12 38208608sat SNTB1-3.31 1. 50E-08 1. 90E-05-1.19-7. 43 8q23-q24 39 212751_at UBE2N 1. 85 1. 38E-05 1. 83E-03 1.40 7. 36 12q22 40 213151_s_at CDC10 1. 60 1.20E-05 1.68E-03 1.38 7. 34 7p14. 3-p14. 1 41 223703 at CDA017-3.11 9. 63E-09 1. 60E-05-1.15-7. 30 10q23. 1 42201225sat SRRM1 1. 85 7. 84E-05 5. 60E-03 1.57 7. 28 1p36.11 43200829xat ZNF207 1. 99 1. 49E-04 8. 55E-03 1.73 7. 27 17q11. 2 44205382sat DF-6.20 1. 26E-08 1. 86E-05-1.16-7. 27 19p13. 3 45219360sat TRPM4-92.10 3. 47E-08 3. 70E-05-1.25-7. 21 19q13. 33 46229024_at 2.84 5. 11E-05 4. 42E-03 1.48 7.20 47 212213_x_at OPA1 1. 80 3. 43E-05 3. 29E-03 1.42 7. 18 3q28-q29 48 209905 at HOXA9-3.44 1. 48E-08 1. 90E-05-1.13-7. 16 7p15-p14 49202242_at TM4SF2 3.15 1.38E-04 8.16E-03 1.65 7. 16 Xq11. 4 50 235697_at 1. 77 2. 56E-05 2. 76E-03 1.39 7.16 2.45 AML_5q versus AML inv (16) # affy id HUGO name fc p q stn t Map Location 1 205382_s_at DF -6. 74 8. 81 E-13 2.48E-08-2. 08-11.78 19p13. 3 2 201496_x_at MYH11 -14. 41 1. 09E-11 1.42E-07-2. 14-11. 57 16p13. 13-p13. 12 3 201497_x_at MYH11 -29. 85 4. 50E-11 3.17E-07-2. 21-11. 26 16p13. 13-p13. 12 4 209365_s_at ECM1 -3. 79 1. 52E-11 1.42E-07-1. 86-10. 50 1q21 5208717_at OXA1L-2. 17 2. 70E-10 1. 52E-06-1.75-9. 81 14q11. 2 6 202259_s_at CG005 2. 28 1. 74E-06 6. 88E-04 1.99 9. 55 13q12-q13 7 223839_s_at SCD 8. 06 2. 08E-05 3. 93E-03 2.32 9. 50 10q23-q24 8200982sat ANXA6-5.20 5. 19E-10 2. 43E-06-1.65-9. 21 5q32-q34 9217963sat NGFRAP1 22.52 7.58E-05 9.17E-03 2.81 9. 20 Xq22. 1 10210024sat UBE2E3 2.76 7. 34E-09 1. 72E-05 1.64 9. 01 2q32. 1 11 214651_s_at HOXA9 7.83 4. 89E-05 7. 12E-03 2.19 8. 70 7p15-p14 12206380sat PFC-10.82 2. 67E-09 7. 52E-06-1.57-8. 66 Xp11.3-p11. 23 13 204197_s_at RUNX3 3.69 5. 91E-058. 03E-03 2. 19 8. 57 1p36 14 236091_at -3.38 1. 69E-09 6.79E-06 -1.51 -8. 51 15 200665_s_at SPARC-4.26 5. 97E-08 8. 84E-05-1.56-8. 45 5q31. 3-q32 16 206956_at BGLAP-3.31 2. 53E-09 7. 52E-06-1.50-8. 42 1q25-q31 17 212099_at -4. 22 2. 24E-09 7. 52E-06-1.49-8. 40 18 216015_s_at CIAS1 -6. 96 4. 34E-09 1.11E-05 -1. 45-8. 19 1q44 19 200093_s_at - HG-U133B HINT1 -1. 67 2. 81E-06 9. 88E-04-1.64-8. 19 5q31. 2 20 209190_s_at DIAPH1 -2. 28 5. 95E-07 3. 52E-04-1.53-8. 03 5q31 21205076sat CRA-5.73 1. 56E-08 3. 38E-05-1.47-8. 02 1q12-q21 22 201811_x_at SH3BP5 6.70 1.23E-04 1.24E-02 2.16 7. 983p24. 3 23 201360_at CST3-5.08 2. 02E-08 3. 56E-05-1.43-7. 97 20p11. 21 24224916at-3. 64 1. 93E-08 3. 56E-05-1.43-7. 88 25212062_at ATP9A 16.59 1. 81E-04 1.50E-02 2.36 7. 88 20q13.11-q13. 2 26211709sat SCGF-5.03 7. 59E-07 3. 75E-04-1.49-7. 83 19q13. 3 27224952at DKFZP564D166 4. 92 9. 83E-05 1. 09E-02 1.97 7. 81 17q23. 3 28213228_at PDE8B 1. 86 7. 72E-07 3. 75E-04 1.48 7. 79 5q13. 2 29 204198_s_at RUNX3 9. 52 1.87E-04 1.51E-02 2.30 7. 79 1p36 30231736xat MGST1-3.53 4. 06E-08 6. 72E-05-1.40-7. 77 12p12. 3-p12. 1 31 202340_x_at NR4A1 -7. 43 1. 72E-08 3. 46E-05-1.35-7. 63 12qu3 32 212906_at KIAA1201 2.26 1. 32E-05 2. 93E-03 1.59 7. 6311q24. 1 33 207961_x_at MYH11 -13. 70 4. 84E-08 7. 57E-05-1.40-7. 59 16p13. 13-p13. 12 34213372_at LOC152559 2.12 1.32E-06 5.72E-04 1.44 7. 56 4q21. 21 35218772xat FLJ10493 3.44 3. 13E-05 5. 15E-03 1.64 7. 54 9q31. 2 36241525_at LOC200772-54.84 8. 52E-08 1. 03E-04-1.46-7. 532q37. 3 37 200984_s_at CD59 4.96 2. 27E-04 1. 71E-02 2.11 7. 41 11p13 38218132sat LENG5 1. 74 3. 78E-07 2. 80E-04 1.36 7. 40 19q13. 4 39 224918_x_at MGST1-3.10 4. 43E-07 3. 11 E-04-1. 36-7. 39 12p12. 3-p12. 1 40239307at MYH11 2. 16 3. 57E-06 1. 15E-03 1.42 7. 33 16p13. 13-p13. 12 41 212751_at UBE2N 1. 74 6. 05E-05 8. 05E-03 1.65 7. 31 12q22 42 205718 at ITGB7-3. 25 7. 33E-07 3. 75E-04-1.36-7. 30 12q13. 13 43 204567_s_at ABCG1 4.35 1.68E-04 1.45E-02 1.87 7. 29 21q22. 3 44218414_s at NUDE1 2. 62 1. 79E-04 1. 49E-02 1.89 7. 28 16p13. 11 45208894at HLA-DRA-4.54 1. 56E-07 1. 60E-04-1.30-7. 246p21. 3 46 235381_at 1.82 1. 36E-07 1.47E-04 1.30 7.24 47 220099_s_at CGI-59 1. 64 4.53E-07 3.11E-04 1.33 7. 24 7q34 48 238151_at -3. 52 3. 04E-05 5. 06E-03-1.53-7. 22 49 212358_at CLIPR-59 -9. 23 7. 06E-08 9. 46E-05-1.28-7. 19 19q13. 12 50 211474_s_at SERPINB6 -2. 77 6. 79E-08 9. 46E-05-1.26-7. 12 6p25 2.46 AML_5q versus AML inv (3) &num affy id HUGO name fc p q stn t Map Location 1206860sat FLJ20323 1. 68 4. 94E-06 1. 58E-02 1.79 8. 09 7p22-p21 2 222047_s_at ARS2 1.71 8.78E-06 1.74E-02 1.78 7.92 7q21 3 213151_s_at CDC10 1. 89 4. 47E-07 3. 01E-03 1.60 7. 77 7p14. 3-p14. 1 4 220099_s_at CGI-59 1. 73 3.67E-07 3.01E-03 1.48 7. 32 7q34 5 200093_s_at - HG-U133B HINT1 -1. 76 4. 34E-07 3.01E-03 -1. 48-7. 30 5q31. 2 6212318at TRN-SR 2. 40 8. 18E-05 5. 99E-02 1.80 7. 29 7q32. 2 7218601at URG4 2. 18 2.70E-07 3.01E-03 1.46 7. 28 7p13 8 203538_at CAMLG-2.30 4. 00E-07 3.01 E-03-1. 46-7. 22 5q23 9 213951_s_at HUMGT198A 2. 41 1. 59E-04 7. 73E-02 1.75 6. 88 17q12-q21 10 221505_at LANPL 2. 06 7. 83E-05 5. 86E-02 1.59 6. 751q21. 2 11 224767_at -4. 68 1.02E-06 5.75E-03-1. 35-6.69 12 218039_at ANKT 3. 12 1. 95E-04 8. 10E-02 1.66 6. 58 15q14 13 202843_at DNAJB9 2. 42 2. 70E-05 3. 37E-02 1.39 6.43 7q31 14 206295_at IL18 -3. 15 2. 20E-06 1. 06E-02-1.28-6. 35 11q22. 2-q22.3 15 208826_x_at HINT1 -1.42 9.93E-06 1. 76E-02-1.31-6. 295q31. 2 16 204817_at ESPL1 2. 58 3. 22E-04 1. 05E-01 1.62 6.28 8 17200043_at-HG-U133A ERH 1. 79 1. 39E-05 2. 23E-02 1.32 6. 28 14q24. 1 18227708at EEF1A1-2. 20 5. 69E-06 1. 58E-02-1.28-6. 26 6q14. 1 19208843sat GORASP2 1. 57 3. 46E-06 1. 29E-02 1.26 6. 26 2p24.3-q21. 3 20 201978_s_at KIAA0141 -3. 17 7. 03E-06 1. 58E-02-1.25-6. 14 5q31. 3 21228526at-2. 71 3. 06E-06 1. 29E-02-1.22-6. 12 22201453_x_at RHEB2 1. 83 3. 46E-05 3. 87E-02 1.31 6. 10 7q36 23 45633_at FLJ13912 2. 49 2. 05E-04 8. 43E-02 1.43 6. 02 16q12. 2 24 204146_at PIR51 3.91 3.72E-04 1.10E-01 1.50 5. 97 12p13. 2-p13. 1 25 218421_at CERK 1.68 1.87E-04 7.89E-02 1.39 5. 95 22q13. 31 26 214863_at 2. 07 6. 14E-06 1. 58E-02 1.19 5.93 27212785_s at HDCMA18P 1.50 6. 13E-06 1. 58E-02 1.19 5. 92 4q25 28219510_at POLQ 2.06 2. 10E-04 8. 53E-02 1.37 5. 86 3q13. 33 29201496xat MYH11-4. 20 6. 93E-06 1. 58E-02-1.18-5. 85 16p13.13-p13. 12 30202705_at CCNB2 3.05 3. 91E-04 1.10E-01 1.46 5. 85 15q21. 2 31 226032_at CASP2 1. 97 2. 83E-04 9. 78E-02 1.38 5. 81 7q34-q35 32227778_at 1.64 7. 71 E-06 1.62E-02 1.15 5.73 33227056at-2. 51 1. 58E-05 2.41E-02 -1. 19-5.70 34 212711_at DKFZp434G2311 1. 44 9. 62E-06 1. 76E-02 1.14 5. 679q34. 3 35206066sat RAD51C 1. 67 5. 07E-05 4. 66E-02 1.19 5. 64 17q22-q23 36213970_at 1. 85 1. 27E-05 2. 14E-02 1.13 5.61 37200651_at GNB2L1-1. 35 1. 76E-05 2. 42E-02-1.12-5. 555q35. 3 38203467at PMM1 2. 04 1. 80E-05 2. 42E-02 1.12 5. 54 22q13. 2 39 224741_x_at -1.68 1.57E-04 7. 73E-02-1.21-5. 50 40228138_at 1. 48 1. 68E-05 2. 42E-02 1.11 5.48 41 204591_at CHL1 3. 40 6. 60E-04 1. 43E-01 1.35 5. 42 3p26. 1 42242957at FLJ32009 2. 45 2. 62E-04 9. 58E-02 1.22 5. 41 11q12. 2 43202589_at TYMS 2. 65 6. 06E-04 1. 35E-01 1.33 5. 40 18p11. 32 44 225533_at DKFZP727G051 1. 75 2. 29E-05 2. 97E-02 1.09 5. 40 9q33. 3 45 204444_at KIF11 3. 20 8. 24E-04 1. 56E-01 1.36 5. 34 10q24. 1 46 200593 s at HNRPU 1. 52 5. 96E-05 4. 94E-02 1.10 5.33 1q44 47201997sat SHARP 1. 50 3. 28E-05 3. 87E-02 1.08 5.33 1p36. 33-p36.11 48207547sat TU3A 1.60 8. 94E-05 6. 14E-02 1.12 5. 32 3p21. 1 49201705at PSMD7 1. 67 1. 56E-04 7. 73E-02 1.15 5. 30 16q23-q24 50 221952_x_at KIAA1393 1. 69 2. 70E-04 9. 64E-02 1.18 5. 28 14q23. 1 2.47 AML5q versus AML komplext &num affy id HUGO name fc p q stn t Map Location 1 236091 at-4. 35 6.49E-08 1.62E-03-1. 07-6.74 2231807at DKFZP761L0424-4. 58 9.16E-08 1.62E-03-1. 02-6. 5410p11. 22 3 208628_s_at NSEP1 -1.34 2.16E-06 8. 64E-03-1.08-6. 47 1 p34 4234801sat ACAS2L-2.52 7. 74E-06 1. 34E-02-1.05-6. 17 20p11.23-p11. 21 5227208at RPS25-1. 78 7. 57E-07 8. 64E-03-0.93-5. 92 11q23. 3 6237423at-6. 01 1. 32E-06 8. 64E-03-0.93-5. 80 7 240074_at -3. 83 1.04E-06 8.64E-03-0. 90-5.79 8 202843_at DNAJB9 2. 03 9. 48E-05 4. 12E-02 1.04 5.67 7q31 9 232478_at -2. 13 2.45E-06 8.64E-03-0. 87-5.57 10207563sat OGT-1.82 5. 70E-06 1. 18E-02-0. 89-5. 57 Xq13 11 233151_s_at TTTY7-2.80 2.25E-06 8.64E-03-0. 87-5.55 Y 12 230398 at CTEN-2.04 2.18E-06 8.64E-03-0. 87-5. 55 17q21. 1 13 233119_at -2. 25 2.22E-06 8.64E-03-0. 87-5.55 14 230872_s_at DKFZP434B103 -4. 10 3. 27E-06 9. 90E-03-0.88-5. 51 3p25. 3 15 228450_at LOC144100-3.02 3. 78E-06 9. 90E-03-0.86-5. 45 11p15. 1 16231480at-4. 69 4. 90E-06 1. 12E-02-0. 88-5.40 17 210639 s at APG5L-1. 59 3. 93E-06 9. 90E-03-0.84-5. 39 6q21 18 225482 at ATSV-1. 59 3. 72E-06 9. 90E-03-0.84-5. 39 2q37 19 238951_at -6. 69 5. 06E-06 1. 12E-02-0.87-5. 38 20242450_at FLJ90406-3. 02 2. 11E-05 2. 15E-02-0.88-5. 34 5q15 21 236998_at HSPC009-2. 43 1.85E-05 2. 11E-02-0. 86-5. 27 17q21 22232177_at-2. 29 1. 05E-05 1. 69E-02-0.84-5. 27 23 243201 at-2. 27 6. 63E-06 1. 30E-02-0.83-5. 26 24243503at-3. 28 7. 66E-06 1. 34E-02-0.81-5. 17 25 234148_at -3. 87 7. 95E-06 1. 34E-02-0.81-5. 15 26237330at-2. 88 1. 66E-05 2. 06E-02-0.82-5. 15 27 207809_s_at ATP6IP1 -1. 66 5.07E-05 3. 11E-02-0. 85-5. 10 Xq28 28201104xat DJ328E19. C1. 1-1.52 1. 34E-05 1. 88E-02-0.79-5. 02 1q12-1q21. 2 29210701at CFDP1-3.31 1. 17E-05 1. 80E-02-0.78-5. 02 16q22. 2-q22.3 30 235847_at -2. 26 4.58E-05 3.05E-02-0. 82-5.00 31209561at THBS3-1.91 1. 38E-05 1. 88E-02-0.78-4. 99 1q21 32 244548_at -3. 58 1.38E-05 1.88E-02-0. 78-4.97 33 201731_s_at TPR-1. 45 8. 35E-05 3. 98E-02-0.84-4. 97 1 q25 34216404at SCA8-3.59 1. 69E-05 2. 06E-02-0.79-4. 97 13q21 35 232867_at -1.97 1.48E-05 1. 94E-02-0.77-4. 96 36213928sat 1. 93 7. 48E-05 3. 82E-02 0. 83 4.95 37237078_at-2. 16 3.70E-05 3.05E-02-0. 79-4.93 38 228655_at -1. 76 1.79E-05 2. 11 E-02-0. 76-4.89 39 233494_at -2. 84 1. 93E-05 2. 13E-02-0.76-4. 88 40 202593_s_at MIR16 -2. 21 2. 12E-05 2. 15E-02-0.77-4. 87 16p12-p11. 2 41 234077_at -2. 17 2.13E-05 2.15E-02-0. 76-4.83 42 230880_at KIAA1652 -2. 89 2. 32E-05 2. 28E-02-0.75-4. 81 43 239220_at-1. 72 3.86E-05 3.05E-02-0. 76-4.79 44208608sat SNTB1-2.47 3. 51 E-05 3.05E-02-0. 75-4. 778q23-q24 45 232744_x_at -1. 68 2.62E-05 2.50E-02-0. 74-4.77 46 220202_s_at MNAB-1.67 6.54E-05 3. 61 E-02-0. 77-4. 75 9q34 47 232757_at -2. 55 3.27E-05 2.96E-02-0. 74-4.73 48239259_at-2. 49 3. 01 E-05 2.80E-02-0. 74-4.73 49225206sat LOC54516-1. 64 4. 50E-05 3. 05E-02-0.74-4. 706q25-q26 50 211574_s_at MCP-1. 67 1. 98E-04 4. 80E-02-0.80-4. 70 1q32 2.48 AML5q versus AMLnorma ! &num affy id HUGO name fc p q stn t Map Location 1 205366sat HOXB6-43.12 6.98E-33 2.49E-28-1. 20-15.24 17q21. 3 2224916at-3. 85 4.43E-27 3.95E-23-1. 18-14. 79 3228904at-8. 47 6.97E-28 1.24E-23-1. 06-13.55 4236892sat-14. 29 1.12E-27 1.33E-23-1. 06-13.51 5205382sat DF-6.07 4. 17E-17 1. 49E-13-1.15-13. 48 19p13. 3 6 239791_at -12. 53 1.07E-23 6.38E-20-1. 03-12.91 7230872sat DKFZP434B103-6. 32 1.04E-25 7.46E-22-0. 99-12. 633p25. 3 8238021sat-9. 021. 47E-21 7.50E-18-0. 97-12.09 9205601sat HOXB5-2.93 1.87E-14 4. 44E-11-1. 03-11.85 17q21. 3 10 217379_at -1. 99 6.15E-18 2.44E-14-0. 95-11.54 11 227056at-2. 01 1.22E-08 7.19E-06-1. 15-11.20 12213110sat COL4A5-6. 52 8. 07E-19 3. 60E-15-0.89-11. 05 Xq22 13 200093_s_at-HG-U133B HINT1 -1.85 5. 12E-07 1.54E-04-1. 29-10.95 5q31. 2 14 232979_at -4. 25 7. 03E-17 2.28E-13-0. 86-10.62 15 216032_s_at SDBCAG84-2.74 4. 38E-13 9.78E-10-0. 91-10.56 20pter-q12 16 231175_at FLJ30162-6.38 2. 11E-16 6.29E-13-0. 81-10. 06 6p11. 1 17 205899_at CCNA1 -5. 41 9. 05E-13 1. 70E-09-0.85-9. 91 13q12. 3-q13 18228526at-2. 87 2. 53E-08 1. 27E-05-0.97-9. 78 19223696at-2. 95 6. 19E-13 1. 30E-09-0.82-9. 72 20221750_at HMGCS1 1. 73 8. 29E-06 1. 57E-03 1.33 9. 695p14-p13 21 204082_at PBX3-4.51 2. 91E08 1. 44E-05-0.94-9. 53 9q33-q34 22238022at-6. 34 1. 24E-11 1. 77E-08-0.82-9. 52 23233825sat CD99L2-3. 07 1.61E-08 9. 20E-06-0.92-9. 50 Xq28 24224767at-3. 62 1. 54E-07 5. 87E-05-0.99-9. 50 25 236091_at -2. 88 3. 84E-11 4. 72E-08-0.82-9. 38 26208717_at OXA1L-1. 84 5. 08E-08 2. 35E-05-0.91-9. 21 14q11. 2 27 211016 x at HSPA4-1.70 1. 65E-08 9.21E-06-0. 88-9. 18 5q31. 1-q31. 2 28 202593_s_at MIR16 -1. 94 2. 30E-11 2. 93E-08-0.77-8. 98 16p12-p11. 2 29211922sat CAT-4.31 9. 58E-16 2. 63E-12-0.70-8. 94 11p13 30 208826_x_at HINT1 -1.51 2.42E-06 5. 58E-04-1.02-8. 86 5q31. 2 31 202113_s_at SNX2-2.18 6. 03E-08 2. 76E-05-0.86-8. 83 5q23 32 238951_at -5. 14 1.25E-14 3. 19E-11-0. 70-8.78 33 224968_at MGC15407 -1.86 1.52E-07 5. 85E-05-0.88-8. 76 2p16. 1 34 202259_s_at CG005 1. 88 3.01E-05 4. 07E-03 1.26 8. 63 13q12-q13 35 222422_s_at NDFIP1 -2. 39 1. 23E-08 7.19E-06-0. 80-8. 61 5q31. 3 36206967at CCNT1-2.07 1. 63E-12 2. 76E-09-0.70-8. 59 12pter-qter 37 208843_s_at GORASP2 1. 54 9. 69E-06 1. 73E-03 1.06 8. 50 2p24. 3-q21. 3 38 231736_x_at MGST1-3.00 2. 66E-06 5. 97E-04-0.94-8. 41 12p12. 3-p12. 1 39208967sat AK2-2.06 1. 41E-10 1. 48E-07-0.72-8. 39 1p34 40 244548_at -3. 90 8.27E-12 1.23E-08-0. 69-8.38 41 236738_at-5. 67 2. 06E-12 3.35E-09-0. 67-8.27 42208629sat HADHA-2.12 7. 59E-10 6. 95E-07-0.72-8. 24 2p23 43 213228_at PDE8B 1. 70 1. 59E-05 2. 54E-03 1.04 8. 23 2 44 226817_at-3. 81 1. OOE-10 1. 08E-07-0.68-8. 10 45 200764_s_at CTNNA1 -1.82 6.58E-07 1.91E-04 -0.83 -8.10 5q31 46 201635_s_at FXR1-2.28 7. 31 E-10 6. 87E-07-0.70-8. 09 3q28 47 210844_x_at CTNNA1 -2. 08 2. 17E-06 5. 18E-04-0.86-8. 05 5q31 48210549sat CCL23-11.04 7. 17E-13 1.42E-09 -0.63 -8.00 17q12 49 206562_s_at CSNK1A1 -1.88 2.65E-05 3. 70E-03-1.05-8. 00 5q32 50230757_at-3. 12 3.26E-09 2.53E-06-0. 70-7.99 2.49 AML_5q versus AMLt (15 ; 17) # affy id HUGO name fc p q stn t Map Location 1 205382sat DF-14.36 2.60E-15 6. 01 E-11-3. 72-18.89 19p13. 3 2216032sat SDBCAG84-5. 24 1. 67E-14 1.93E-10-3. 18-16. 38 20pter-q12 3212953 xat CALR-3.54 1.35E-13 6.23E-10-3. 12-15.80 19p13. 3-p13. 2 4231736 xat MGST1-6.71 4. 48E-14 3. 45E-10-2.94-15. 25 12p12.3-p12. 1 5224918-x-at MGSTI-5. 64 8. 01E-13 2.39E-09-2. 92-14.98 12p12. 3-p12. 1 6 214450_at CTSW-9.46 1.16E-13 6.23E-10-2. 79-14. 48 11q13. 1 7 38487_at STAB1-9.26 2.52E-13 9. 71E-10-2. 75-14.21 3p21. 31 8 238022_at -14. 29 8. 27E-13 2.39E-09-2. 71-13.90 9 208689_s_at RPN2-2. 50 1. 68E-08 1. 14E-05-2.49-11. 97 20q12-q13. 1 10 214575_s_at AZU1 -7. 22 1. 08E-11 2.78E-08 -2. 31-11. 97 19p13. 3 11 213150_at HOXA10 17.73 1. 61E-05 1. 27E-03 3.57 11.78 7p15-p14 12 208675_s_at DDOST-2.97 3. 41 E-10 5.25E-07-2. 25-11.45 1 p36. 1 13 28852_s_at CANX-2.56 4. 97E-11 1. 15E-07-2. 20-11.30 5q35 14211709sat SCGF-7.66 2.84E-10 4.69E-07-2. 16-11. 07 19q13. 3 15 217945_at BTBD1 2.90 6. 98E-07 1. 47E-04 2.41 10. 83 15q24 16204949at ! CAM3 2. 58 8. 96E-11 1.88E-07 2.06 10. 68 19p13. 3-p13. 2 17 204150_at STAB1-10. 27 4. 73E-10 5. 95E-07-2.12-10. 64 3p21. 31 18 210788_s_at retSDR4-2.75 2.26E-10 4.04E-07-2. 03-10.48 14q22.3 19 200008_s_at-HG-U133A GDl2 -3. 21 9. 80E-10 1. 04E-06-2.04-10. 43 10p15 20 205624_at CPA3-7.13 4. 06E-10 5. 86E-07-2.01-10. 38 3q21-q25 21 20915_at TETRAN-2.74 2. 27E-10 4.04E-07-2. 00-10.34 4p16. 3 22214651sat HOXA9 83.98 4. 91E-05 2. 52E-03 3.76 10. 28 7p15-p'14 23229168at DKFZp434K0621-4. 90 4.89E-10 5.95E-07-2. 02-10.28 5q35.3 24 224473 x at KIAA1813 2. 38 3. 38E-06 4. 44E-04 2.35 10. 16 10q24 25 208826_x_at HINT1 -1. 57 1.27E-06 2.29E-04-2. 23-10.07 5q31. 2 26 211934 x at G2AN-4.10 4.42E-10 5.95E-07-1. 91-9. 94 11q12. 2 27218132sat LENG5 2. 67 1.50E-09 1. 34E-06 1.92 9. 86 19q13. 4 28238021sat-11. 61 2. 21E-09 1. 83E-06-1.96-9. 80 29210338sat HSPA8-7.33 6. 22E-10 7. 19E-07-1.88-9. 74 11q24. 1 30 217379_at -2. 16 1. 16e-09 1.11E-06 -1. 89-9.68 31 201596_x_at KRT18-7.29 9. 86E-10 1. 04E-06-1.84-9. 54 12q13 32233072_at KIAA1857-6. 46 1. 29E-09 1. 19E-06-1.83-9. 49 9q34 33 206555_s_at FLJ20274 2. 62 2. 16E-07 6. 82E-05 1.96 9. 45 16p13. 11 34213147_at HOXA10 11.43 5. 86E-05 2. 84E-03 2.83 9. 44 7p15-p14 35200656sat P4HB-5.40 1. 10E-09 1. 11E-06-1. 81-9. 4017q25 36 205614_x_at MST1 -6. 91 4. 06E-09 3. 12E-06-1.87-9. 38 3p21 37 200093_s_at-HG-U133B HINT1 -1. 77 7.36E-07 1.53E-04-1. 98-9.32 5q31. 2 38 218772_x_at FLJ10493 5.66 2. 65E-05 1. 73E-03 2.39 9. 31 9q31. 2 39 AFFX-GAPD-2. 84 1. 72E-07 6. 03E-05-1.90-9. 28 12pu3 HUMGAPDH/M33197 5_at -HG-U133A 40 221500 s at NPEPL1 2.08 4. 60E-06 5. 45E-04 2.09 9. 25 20q13. 32 41 208629_s_at HADHA-3. 15 2. 89E-09 2. 30E-06-1.80-9. 22 2p23 42 228526 at-3. 51 1. 87E-09 1. 60E-06-1.77-9. 21 43236787 at-7. 47 8. 18E-09 5.91E-06 -1. 82-9.12 44 22798_x_at FLJ11535 -3. 75 6. 17E-09 4. 60E-06-1.76-9. 05 19p13. 3 45227999_at LOC170394 3.21 9. 66E-06 9. 14E-04 2.10 9. 03 10q26. 3 46 203948 s at MPO-4.37 8. 71 E-06 8. 45E-04-2.09-9. 03 17q23. 1 47201177sat UBA2 2. 73 1. 75E-07 6. 03E-05 1.82 8. 95 19q12 48 207375_s_at IL15RA 5. 28 3.56E-05 2.11E03 2.28 8. 89 10p15-p14 49 222047_s_at ARS2 1. 82 5. 65E-06 6. 30E-04 2.00 8.88 7q21 50210024sat UBE2E3 1. 90 5. 16E-06 5. 84E-04 1.98 8. 862q32. 1 2.5 AML_5q versus AML_t (8; 21) # affy id HUGO name fc p q stn t Map Location 1218132sat LENG5 2.51 1. 76E-08 5. 25E-05 2.42 12.27 19q13. 4 2213150at HOXA10 22.81 1. 69E-05 4. 29E-03 3.76 12.00 7p15-p14 3 214651_s_at HOXA9 73.42 4. 95E-05 8. 52E-03 3.71 10.26 7p15-p14 4 228827_at -51.55 5.28E-10 1.57E-05 -1. 93-9.93 5217963sat NGFRAP1 33.85 7. 77E-05 1. 14E-02 3.16 9. 41 Xq22. 1 6202259_s_at CG005 2. 23 2. 03E-06 1. 21E-03 1.95 9. 3813q12-q13 7 206940_s_at POU4F1 -27. 71 1. 77E-09 2. 64E-05-1.81-9. 33 13q21.1-q22 8 201997_s_at SHARP 1. 99 1. 02E-07 1. 78E-04 1.78 9. 301p36. 33-p36. 11 9213151sat CDC10 1. 79 4. 53E-06 1. 85E-03 1.92 9. 03 7p14. 3-p14. 1 10 211709 s at SCGF-5.89 3. 54E-08 8. 78E-05-1.68-9. 01 19q13. 3 11 213147_at HOXA10 8.21 6. 05E-05 9. 73E-03 2.44 8.98 7p15-p14 12 220099_s_at CGI-59 1. 81 6. 05E-08 1. 20E-04 1.64 8.81 7q34 13 205529_s_at CBFA2T1 -9. 36 4. 60E-09 3. 42E-05-1.65-8. 75 8q22 14225144_at 3.74 4. 77E-05 8. 35E-03 2.17 8.67 15208843sat GORASP2 1. 87 2. 54E-08 6. 89E-05 1.59 8. 66 2p24.3-q21. 3 16 213025_at FLJ20274 2. 67 8. 03E-06 2. 66E-03 1.83 8. 56 16p13. 11 17 212711_at DKFZp434G2311 1. 54 3. 76E-09 3. 42E-05 1.52 8. 559q34. 3 18 211341_at POU4F1 -115. 08 1. 05E-08 5. 25E-05-1.68-8. 50 13q21.1-q22 19 218772_x_at FLJ10493 3.85 6. 16E-05 9. 75E-03 2.14 8. 44 9q31. 2 20 205528_s_at CBFA2T1 -33. 01 1. 26E-08 5. 25E-05-1.60-8. 36 8q22 21 235381_at 1. 85 5. 58E-08 1. 19E-04 1.53 8.32 22 201811_x_at SH3BP5 7.81 1. 22E-04 1. 39E-02 2.36 8. 253p24. 3 23 201807_at VPS26 2. 33 3. 98E-06 1. 75E-03 1.68 8. 2510q21. 1 24 234998_at 2. 62 2. 39E-05 5. 52E-03 1.84 8.20 25221750at HMGCS1 1. 75 4. 76E-07 4. 57E-04 1.51 8. 00 5p14-p13 26208882sat DD5 2. 37 3. 53E-06 1. 67E-03 1.58 7.94 8q22 27226169_at LOC283105 3.98 1. 50E-04 1. 55E-02 2.18 7. 85 11p15. 3 28211728sat HYAL3-4.44 1. 44E-08 5. 25E-05-1.38-7. 81 3p21. 3 29206555sat FLJ20274 2. 23 4. 26E-07 4. 42E-04 1.46 7. 80 16p13.11 30 212553_at KIAA0460 1. 70 2.12E-07 3.01E-04 1.43 7. 76v 1q21. 2 31 212751_at UBE2N 1. 95 7. 96E-06 2. 66E-03 1.59 7. 76 12q22 32219433at BCoR 3. 67 7. 92E-05 1. 16E-02 1.88 7. 75xp11. 4 33 229406_at -7. 55 1. 51E-08 5. 25E-05-1.36-7. 68 34 211474_s_at SERPINB6 -3. 01 1. 76E-08 5. 25E-05-1.34-7. 61 6p25 35 205382_s_at DF -7. 57 4. 42E-08 1.01E-04 -1. 37-7.52 19p13. 3 36 201857 at ZFR 1. 89 4. 99E-07 4. 64E-04 1.39 7. 50 5p13. 3 37204567sat ABCG1 4.48 1.85E-04 1.68E-02 2.01 7. 4421q22. 3 38211423sat SC5DL 2. 54 3. 05E-05 6. 53E-03 1.60 7. 4311q23. 3 39200982sat ANXA6-5.13 7. 12E-08 1. 32E-04-1.33-7. 325q32-q34 40 202423_at RUNXBP2 1. 85 5. 52E-06 2. 13E-03 1.44 7.31 8p11 41 212534_at 2. 09 1. 10E-06 7. 52E-04 1.37 7.29 42 217975_at LOC51186 9.81 2.54E-04 1.99E-02 2.08 7. 27 Xq22. 1 43215884sat UBQLN2 2. 30 3. 87E-05 7. 53E-03 1.56 7. 23Xp11. 23-p11. 1 44225789at CENTG3 2. 34 1.37E-05 3.81E-03 1.47 7. 237q36. 1 45 238337 s at 2. 05 2. 66E-05 6. 03E-03 1.51 7.20 46 226547_at 2. 16 1.53E-05 4.00E-03 1.46 7.19 47 211746_x_at PSMA1 1.70 1. 16E-05 3. 40E-03 1.44 7. 17 11p15. 1 48212895sat ABR 3. 18 1.51E-04 1. 56E-02 1.76 7. 15 17p13. 3 49209905at HOXA9 200.05 3. 79E-04 2. 39E-02 2.68 7. 147p15-p14 50 209023 s at STAG2 2.61 3. 21E-05 6. 69E-03 1.51 7. 14 Xq25 2.51 AML_9q versus AML MLL # affy id HUGO name fc p q stn t Map Location 1203373at SOCS2-12.96 2. 55E-10 3. 71 E-06-1. 39-8. 74 12q 2228083at CACNA2D4-5.92 1.77E-10 3.71 E-06-1.35-8. 64 12pu3. 33 3203372sat SOCS2-19.21 8.51 E-10 8. 24E-06-1.39-8. 48 12q 4 203544_s_at STAM 2. 89 3. 24E-06 1. 81 E-03 1.51 7. 96 10p14-p13 5 220018_at HAKAI 2.21 2. 53E-06 1. 67E-03 1.46 7. 847q22. 2 6209028sat SSH3BP1 1. 89 1. 49E-07 3. 34E-04 1.31 7.83 10p11. 2 7 218036_x_at CGI-07 2. 08 3. 78E-06 1. 85E-03 1.48 7. 81 3q26. 1 8 217740_x_at RPL7A-1. 26 1.85E-08 7. 85E-05-1.23-7. 72 9q34 9 221923_s_at NPM1 1. 82 1. 02E-05 3. 18E-03 1.46 7. 45 5q35 10225185at MRAS-2.74 7. 56E-09 5.01E-05 -1. 14-7. 383q22. 3 11 244413_at DCAL1-7. 72 8. 63E-09 5. 01E-05-1.15-7. 37 12p13. 2 12213000_at NXP2 2. 53 3. 08E-05 5. 40E-03 1.60 7. 33 21q22. 13 13208810at DNAJB6 2. 44 8. 37E-06 2. 84E-03 1.39 7. 31 7q36. 3 14 211542_x_at RPS10 -1. 29 1. 48E-06 1. 43E-03-1.24-7. 166p21. 31 15 218448_at C20orf11 1. 67 2. 43E-06 1. 64E-03 1.25 7. 11 20q13. 33 16 202853_s_at RYK 2. 22 3. 09E-05 5. 40E-03 1.50 7. 11 3q22 17 219360_s_at TRPM4-42.07 4. 49E-08 1. 45E-04-1.19-7. 09 19q13. 33 18 204031_s_at PCBP2 1.29 1. 37E-06 1. 43E-03 1.21 7. 05 12q13. 12-q13. 13 19 208612_at GRP58 1. 54 1.10E-07 2.65E-04 1.12 7. 03 15q15 20 213995_at ATP5S 1. 73 2. 20E-06 1. 52E-03. 1.22 7. 02 14q21. 3 21226676at EHZF-8.96 1. 89E-08 7. 85E-05-1.08-7. 00 18q11. 1 22 200087_s_at-HG-U133A RNP24 1. 44 4.08E-06 1. 85E-03 1.23 6. 95 12q24.31 23 213918_s_at IDN3 1. 98 3. 92E-06 1. 85E-03 1.22 6. 93 5p13. 2 24 219038_at FLJ11565 -1.68 2.94E-08 1.07E-04 -1. 06-6. 88 Xq22. 2 25 201653 at CNIH 1. 66 1. 23E-05 3. 37E-03 1.28 6. 83 14q22. 1 26 204847 at ZNF-U69274 1. 83 5. 46E-06 2. 17E-03 1.21 6. 80 3q12. 3 27 239499_at -1.56 5.16E-08 1. 50E-04-1.03-6. 69 28 212418 at ELF1 2. 13 3. 06E-05 5. 40E-03 1.32 6. 67 13q13 29 208319_s_at RBM3 1.92 3.02E-05 5.40E-03 1.31 6. 65 Xp11. 2 30200686sat SFRS11 2. 02 3. 48E-05 5. 55E-03 1.32 6. 64 1p31 31 203624 at DXYS155E 1. 76 2. 63E-06 1. 68E-03 1.13 6. 62 Xp22. 32 32 217915_s_at C15orf15 1. 48 4. 51 E-06 1. 96E-03 1.15 6. 62 15q21 33 211967 at PORIMIN 1. 90 4. 76E-05 6. 24E-03 1.36 6. 60 11q22. 1 34 201548 s at PLU-1 1. 78 3. 12E-07 5. 66E-04 1.05 6. 60 1q32. 1 35 206055_s_at SNRPA1 1. 64 8. 17E-06 2. 84E-03 1.17 6. 57 15q26. 3 36 218411 s at MBIP 2. 47 8. 60E-05 8. 55E-03 1.43 6. 5014q13. 1 37 200809_x_at RPL12 -1.23 1.03E-07 2. 65E-04-1.00-6. 47 9q34 38202371at FLJ21174 3. 15 2. 59E-05 4. 99E-03 1.23 6. 47 Xq22. 1 39 213857_s_at 2. 06 4. 37E-05 6. 08E-03 1.28 6.46 40 217828_at FLJ13213 1. 80 2. 53E-05 4. 96E-03 1. 22 6. 44 15q21. 2 41 221381 s at 2. 06 7. 49E-05 7. 94E-03 1.37 6.44 42201197_at AMD1 2. 10 3.41E-05 5. 55E-03 1.23 6. 406q21-q22 43 200725_x_at RPL10 -1.19 2.86E-07 5. 53E-04-0.99-6. 35 Xq28 44 212973_at RPIA 2.06 7.62E-05 7.99E-03 1.29 6. 26 2p11. 1 45 206042 x at SNURF-3.24 3. 56E-07 6. 08E-04-0.98-6. 26 15q12 46 229238_at -2. 78 2.04E-07 4.24E-04-0. 97-6.26 47 53071_s_at FLJ22222 1. 97 2. 32E-05 4. 85E-03 1.15 6. 26 17q25. 3 48219094at HSPC056 2. 06 3. 89E-05 5. 84E-03 1.19 6. 243q22. 3 49 200674 s at RPL32-1. 29 1. 55E-06 1. 43E-03-1.01-6. 22 3p25-p24 50 202854_at HPRT1 1. 60 8. 74E-06 2. 88E-03 1.07 6. 19 Xq26. 1 2.52 AML_9q versus AML_inv (16) # affyid HUGO name fc p q stn t Map Location 1 201432_at CAT 2. 35 3. 82E-10 2. 61E-06 2.29 12. 36 11p13 2 213737_x_at 2. 86 2. 38E-07 1. 40E-04 2.49 11.53 3220560at C11orf21 3. 244. 48E-085. 10E-05 2. 25 11. 30all5. 5 4 201497_x_at MYH11 -23. 77 4. 71E-11 6.44E-07-2. 10-11. 10 16p13. 13-p13. 12 5 223385_at CYP2S1-3. 21 4. 27E-12 1. 17E-07-1.87-10. 82 19q13. 1 6 218414_s_at NUDE1 2. 88 2. 62E-06 5. 97E-04 2.24 9. 77 16p13. 11 7201496xat MYH11-5. 92 1. 36E-10 1.27E-06-1. 60-9. 29 16p13. 13-p13. 12 8203802xat WBSCR20A 2. 09 9. 22E-09 2. 29E-05 1.62 9.02 7q11. 23 940420at STK10 2.37 2. 41E-07 1. 40E-04 1.73 8. 975q35. 1 10209365sat ECM1-3.21 5. 37E-10 2. 94E-06-1.54-8. 95 1q21 11 224724 at SULF2-7.41 1.25E-09 5.71 E-06-1.57-8. 87 20q12-13. 2 12 223471_at RAB3IP 3. 55 2. 52E-06 5. 95E-04 1.89 8.87 13223044_at SLC11A3 10.65 1.07E-05 1.65E-03 2.19 8. 86 2q32 14 223299_at LOC90701 2. 74 8. 52E-07 3. 03E-04 1.65 8. 42 18q21. 31 15205330at MN1-10. 11 2. 62E-09 8. 96E-06-1.47-8. 41 22q12. 1 16 213842_x_at POM121 1. 92 8. 64E-09 2. 29E-05 1.44 8. 23 7qu 1. 23 17 202008_s_at NID -3. 22 2. 27E-09 8. 86E-06-1.41-8. 21 1q43 18 225745_at -3. 95 5. 47E-09 1. 66E-05-1.44-8. 21 19202370sat CBFB 3.28 2.43E-05 2. 61 E-03 2.05 8. 11 16q22. 1 20200665sat SPARC-4.84 7. 42E-08 6. 68E-05-1.46-8. 08 5q31. 3-q32 21227486at NT5E-18.05 2. 17E-08 3. 29E-05-1.52-8. 08 6q14-q21 22 212771_at LOC221061-6.01 2. 07E-08 3. 29E-05-1.49-8. 0410p13 23 222862_s_at AK5 -20. 38 2.01 E-08 3. 29E-05-1.48-8. 03 1p31 24203329at PTPRM-4.93 1. 25E-08 2. 45E-05-1.42-7. 97 18p11. 2 25208942sat TLOC1 1. 86 1. 22E-08 2. 45E-05 1.38 7. 92 3q26. 2-q27 26 212358_at CLIPR-59-13. 33 3. 64E-08 4. 52E-05-1.49-7. 87 19q13. 12 27207961xat MYH11-16. 70 4. 29E-08 5.l10E-05 -1. 52-7. 85 16p13. 13-p13. 12 28 227053_at PACSIN1 -8. 39 2. 71E-08 3. 90E-05-1.42-7. 82 6p21. 3 29227567at 3.96 1. 21E-05 1.82E-03 1.71 7.81 30222764at ASRGL1 4.42 1.03E-05 1. 61E-03 1.68 7.78 11q12. 2 31 205718_at ITGB7 -2. 80 1. 12E-08 2. 45E-05-1.34-7. 77 12q13. 13 32 209797_at TMEM4 2. 08 2. 43E-06 5. 87E-04 1.48 7. 61 12qu5 33 212854_x_at FLJ20719 1. 57 5. 20E-07 2. 19E-04 1.41 7.61 1p31 34 236646_at FLJ31166 -3. 64 1. 85E-07 1. 19E-04-1. 37-7. 60 12p13. 31 35 226137_at -3. 17 1. 52E-08 2. 77E-05-1.29-7. 51 36 241773_at 45 4. 93E-08 5. 40E-05-1.33-7. 47 37 208956_x_at DUT 1. 69 1. 04E-07 7. 36E-05 1.31 7. 45 15q15-q21.1 38202854_at HPRT1 1.82 9.24E-07 3.08E-04 1.39 7. 44 Xq26. 1 39 203356_at 1.75 6.39E-08 6.47E-05 1.30 7.43 40 206956_at BGLAP-2.55 3. 26E-08 4. 46E-05-1.30-7. 421q25-q31 41 202931_x_at BIN1 -2. 40 6. 68E-08 6. 53E-05-1.30-7. 42 2q14 42 218116_at LOC51759 1. 60 9. 08E-08 7. 09E-05 1.29 7. 36 9q34. 13 43 36545_s_at KIAA0542 1. 92 7. 62E-07 2. 82E-04 1.36 7. 36 22q12. 2 44222735_at FLJ10493 3. 90 2. 08E-05 2. 46E-03 1.61 7. 35 9q31. 2 45233467sat PHEMX 2. 33 4. 84E-05 3. 99E-03 1.80 7. 30 11p15. 5 46 213773_x_at WBSCR20A 2. 03 6. 44E-06 1. 12E-03 1.45 7. 27 7q11. 23 47 227151 at MGC32065-1.78 5. 09E-07 2. 19E-04-1.32-7. 27 15q23 48 2426896_at -2. 21 3. 50E-08 4. 52E-05-1.24-7. 24 49 218233_s_at C6orf49 1. 54 2. 46E-07 1. 40E-04 1.29 7. 23 6p21. 31 50201324at EMP1-7.97 1. 05E-07 7. 36E-05-1.30-7. 22 12p12. 3 2.53 AML_9q versus AML inv (3) # affy id HUGO name fc p q stn t Map Location 1 208639_x_at P5 2. 69 4. 14E-11 1.06E-06 2.20 11. 36 2p25. 1 2211709saut SCGF 5.30 8. 82E-09 1. 13E-04 2.31 11. 19 19q13. 3 3231300at LOC90835 4.13 1. 04E-06 7. 59E-04 2.28 9. 93 16p11. 2 4207668xat P5 2. 49 5. 16E-08 2. 21 E-04 1.86 9. 20 2p25. 1 5201226at NDUFB8 2. 42 3. 17E-07 4. 53E-04 1.80 8. 68 10q23. 2-q23.33 6217927at SPC12 1. 71 1. 08E-07 3. 08E-04 1.72 8. 573p21. 31 7216640sat P5 2. 18 1. 40E-08 1. 20E-04 1.65 8. 51 2p25. 1 8205084at BAP29 2. 40 6. 56E-07 6. 24E-04 1.77 8. 46 7q22. 2 9203938sat TAF1C 2. 46 1. 93E-08 1. 24E-04 1.58 8. 17 16q24 10 206851_at RNASE3 6. 04 7.81E-06 2. 47E-03 1.84 8. 03 14q24-q31 11 202589_at TYMS 2.26 4.29E-08 2. 21 E-04 1.55 7.99 18p11. 32 12206111_at RNASE2 3. 04 3. 54E-07 4. 79E-04 1.59 7. 91 14q24-q31 13 221739_at IL27w 1. 89 5. 23E-07 5. 70E-04 1.59 7.83 19p13. 3 14201552_at LAMP1 1. 91 1.91E-07 3. 89E-04 1.50 7. 6513q34 15208736_at ARPC3 1. 64 01E-073. 08E-04 1.47 7. 6012q24. 11 16 229011_at -2 82 6. 42E-08 2. 36E-04-1.46-7. 58 17 202487_s_at H2AV 2.32 5. 84E-06 2. 11 E-03 1.60 7.43 7p13 18 53071_s_at FLJ22222 2.32 6. 53E-06 2. 27E-03 1.60 7. 40 17q25. 3 19226414_s_at ANAPC11 1. 80 2. 76E-07 4. 17E-04 1.42 7. 28 17q25. 3 20 201973_s_at CGI-43 1. 64 2. 72E-07 4. 17E-04 1.42 7. 27 7p22. 2 21 209058 at EDF1 1. 68 1. 45E-07 3. 72E-04 1.40 7. 25 9q34. 3 22221972sat Cab45 1. 86 2. 43E-07 4. 17E-04 1.40 7. 21 1p36. 33 23 221848_at KIAA1847 3. 19 8. 69E-07 7. 44E-04 1.43 7. 18 20q13. 3 24 239988_at -2. 24 1. 97E-07 3. 89E-04-1.38-7. 16 25210201_x_at BIN1-2. 75 1. 71-07 3. 89E-04-1.38-7. 15 2q14 26202961sat ATP5J2 2. 19 1. 03E-06 7. 59E-04 1.42 7. 12 7q22. 1 27 203675_at NUCB2 3. 44 4. 06E-05 6. 17E-03 1.71 7. 09 11p15. 1-p14 28208795sat MCM7 2. 38 1. 04E-05 2. 84E-03 1.53 7. 07 7q21. 3-q22.1 29 211713_x_at KIAA0101 3. 10 2. 12E-05 4. 35E-03 1.60 7. 07 15q22. 1 30202990at PYGL 2. 88 4.81E-06 1. 84E-03 1.48 7. 07 14q21-q22 31 208757 at HSGP25L2G 2. 24 4.17E-06 1. 73E-03 1.46 7. 06 5q35. 3 32 233049_x_at STUB1 1. 60 2. 49E-07 4. 17E-04 1.35 7. 01 16pu3. 3 33 90610_at LRRN1 1. 84 4. 67E-07 5. 70E-04 1.34 6.91 7q22 34201405sat COPS6 1. 93 5. 35E-07 5. 70E-04 1.34 6. 907q22. 1 35 211747_s_at LSM5 2. 08 9. 43E-06 2. 82E-03 1.45 6. 84 7p14. 3 36218774_at DCPS 2. 44 1. 81 E-06 9. 71 E-04 1.36 6. 8311q24. 2 37 229312_s_at GKAP42-2.62 5. 87E-07 5. 80E-04-1.33-6. 82 9q21. 32 38213773_x_at WBSCR20A 2. 18 1. 89E-06 9. 74E-04 1.35 6. 79 7q11. 23 39 208532_x_at -2. 64 4. 36E-06 1. 75E-03-1.38-6. 77 40 203046-s-at TIMELESS 2. 82 5x20E-05 6. 94E-03 1.60 6. 75 12q12-q13 41 209439 s at PHKA2 2. 38 1. 02E-05 2. 84E-03 1.42 6. 75 Xp22. 2-p22.1 42217720at LOC51142 1. 51 5. 55E-07 5. 70E-04 1.31 6. 74 7p11. 1 43 220261 s at ZDHHC4 2. 35 2. 64E-05 4. 85E-03 1.50 6. 74 7p22. 2 44 228301_x_at NDUFB10 1. 74 1. 82E-06 9. 71 E-04 1.34 6. 73 16p13. 3 45 242647_at -1.99 4.78E-07 5.70E-04 -1. 30-6.73 46213404sat RHEB2 1.73 9. 61E-07 7. 59E-04 1.31 6. 72 7q36 47 203802_x_at WBSCR20A 2. 30 5. 35E-07 5. 70E-04 1.30 6.71 7q11. 23 48201259sat SYPL 1.92 1.38E-05 3.45E-03 1.43 6. 70 7q22. 1 49 217949_s_at IMAGE3455200 2. 21 1.52E-06 9.11E-04b 1.31 6. 67 16p11. 2 50202605at GUSB 3. 85 8. 26E-05 7. 96E-03 1.64 6. 637q21. 11 2.54 AML9q versus AML_komplext # affy id HUGO name fc p q stn t Map Location 1 223865at SOX6-4.38 4.06E-12 6.67E-08-1. 54-9.91 11p15. 3 2 217491 x at COX7C 2. 014. 11E-103. 37E-06 1. 46 9. 25 5qu4 3201134_x_at COX7C 2. 07 4. 45E-09 5. 74E-06 1. 39 8. 65 5qu4 4211709sat SCGF 3. 10 2. 23E-08 1. 44E-05 1.36 8. 34 19q13. 3 5234807xat-1. 626. 90E-098. 09E-06-1.32-8. 31 690610at LRRN1 1.80 3. 21 E-07 4. 71 E-05 1.44 8. 29 7q22 7229039at SYN2-2.89 6. 15E-10 3. 37E-06-1.24-8. 13 3p25 8213846at COX7C 1. 96 6. 19E-08 2. 16E-05 1.31 7. 97 5q14 9229900at CD109-4.74 1. 12E-09 4. 44E-06-1.20-7. 84 6q13 10239719at CD109-2.95 1. 35E-09 4. 44E-06-1.19-7. 80 6q13 11 235297_at -1. 84 2. 21 E-09 5.18E-06-1. 19-7.77 12208646at RPS14 2. 95 8. 51E-06 2. 30E-04 1.54 7. 775q31-q33 13 241602 at FLJ30927-1.88 2. 10E-09 5.18E-06-1. 17-7. 67 19q13. 43 14 233585 at SDK2-2.29 3. 00E-19 5.41E-16 -1.18 -7.766 17q25. 1 1553071sat FLJ22222 2.35 6.63E-06 2. 01 E-04 1.46 7. 62 17q25. 3 16 226545_at -6. 73 2. 70E-09 5.41E-06 -1. 16-7.58 17225383at ZNF275-1.83 3. 29E-09 5.41E-06 -1. 15-7. 55 Xq28 18 232834_at -2. 12 7. 98E-09 8. 73E-06-1.16-7. 50 19231172at-1. 83 8. 80E-09 9. 03E-06-1.16-7. 48 20 244375_at -2. 49 4. 55E-09 5. 74E-06-1.15-7. 46 21 233657_at -2. 46 4.35E-09 5.74E-06-1. 13-7.43 22 218436_at SIL1 2. 81 2. 19E-06 1. 24E-04 1.31 7.41 5q31 23223159sat NEK6-2.20 9. 80E-09 9. 46E-06-1.14-7. 379q33. 3-q34.11 24201568at QP-C 1. 95 2.20E-07 4.11E-05 1.20 7. 35 5q31. 1 25 200086 s at-HG-U133B COX411 1. 48 1.89E-08 1.41E-05 1.13 7. 27 16q22-qter 26 227056_at 2. 76 1. 88E-05 3. 52E-04 1.47 7.27 27 217751_at LOC51064 2. 18 2. 06E-06 1. 20E-04 1.26 7. 24 7q34 28 235484_at -2.69 1.17E-08 9.61E-06 -1. 11-7.24 29224316_at FLJ20038-1. 89 1.07E-08 9.61E-06 -1. 11-7. 23 8p21. 1 30 207585 s at RPL36AL 1. 38 1. 10E-07 2. 94E-05 1.15 7. 22 14q21 31 233168_s_at IMAGE3510317 -1.58 2.43E-08 1. 48E-05-1.11-7. 19 22q13. 33 32231300at LOC90835 2. 56 2. 33E-06 1. 26E-04 1.25 7. 15 16p11. 2 33 208639_x_at P5 1. 79 2. 09E-08 1. 44E-05 1.10 7. 14 2p25. 1 34 238740_at MGC2744-2.07 5. 68E-08 2. 16E-05-1.12-7. 13 17q21. 2 35 227108 at STARD9-2.81 2. 29E-08 1. 44E-05-1.10-7. 13 15q14 36229413sat RNF3-2.31 1. 12E-089. 61E-06-1. 09-7. 12 4p16. 3 37 225172_at CRAMP1L -1. 73 1. 46E-08 1. 14E-05-1.07-7. 04 16pu3. 3 38 244132_x_at -2. 19 3. 67E-08 1. 93E-05-1.09-7. 02 39 229626_at -2. 89 3. 77E-08 1. 93E-05-1.09-7. 02 40 222229 x at 1. 52 9. 25E-06 2. 36E-04 1.28 6.96 41 208628_s_at NSEP1-1. 27 2. 14E-08 1. 44E-05-1.06-6. 92 1p34 42 237879_at -4. 36 6. 05E-08 2. 16E-05-1.07-6. 88 43 227145_at LOXL4-1.95 4. 47E-08 2. 16E-05-1.08-6. 87 10q24 44 223385_at CYP2S1 -2. 62 2. 98E-08 1. 75E-05-1.05-6. 85 19q13. 1 45240501at-2. 25 8. 12E-08 2.47E-05 -1. 06-6.82 46 210201_x_at BIN1 -2. 91 3. 25E-08 1. 84E-05-1.04-6. 82 2q14 47 211787_s_at EIF4A1 1.48 5. 50E-08 2. 16E-05 1.05 6. 80 17p13 48 238580_at -3. 11 5. 60E-07 6. 30E-05-1.10-6. 79 49218236sat PRKCN-3. 84 3. 73E-08 1. 93E-05-1. 03-6. 75 2p21 50 242765_at -2. 69 2.34E-07 4.24E-05-1. 07-6.74 2.55 AML_9q versus MAL_normal # affy id HUGO name fc p q stn t Map Location 1 223865at SOX6-3.18 2. 99E-18 7.74E-14-1. 00-12.07 11p15. 3 2 208639_x_at P5 1. 89 6. 62E-09 1. 99E-06 1.16 10.92 2p25.1 3 201011_at RPN1 1.81 1. 74E-07 2. 56E-05 1.34 10. 78 3q21. 3-q25.2 4229836sat NUDT4-4.67 1. 33E-16 1. 72E-12-0. 81-10.07 5 232553_at PCYT1B -4. 39 1. 85E-12 3. 19E-09-0.84-9. 70 Xp22. 12 6236208at-2. 07 2. 05E-10 1. 43E-07-0.84-9. 30 7239856at-3. 09 3. 00E-15 2. 59E-11-0. 74-9.27 8 230939_at -2. 37 3. 11E-09 1. 12E-06-0.87-9. 14 9217328at TRB-3.66 5. 98E-14 3. 09E-10-0. 74-9.09 7q34 10200809xat RPL12-1. 18 1. 77E-08 4. 32E-06-0.89-8. 96 9q34 11 237401 at ACTN1-2.12 1. 83E-11 1. 97E-08-0.75-8. 78 14q24 12 242056_at TRIM45 -1. 98 3. 13E-10 2. 02E-07-0.78-8. 75 1p11. 2 13 228119 at MGC4126-3.29 6. 91E-15 4.47E-11 -0. 67-8.63 3q29 14 240464at-2. 00 3.60E-10 2.16E-07-0. 76-8.61 15234703at HHLA3-3.35 5. 01E-13 1. 30E-09-0.70-8. 59 1p31. 1 16205561at FLJ12242-2.32 5. 24E-11 4. 37E-08-0.74-8. 58 22q13. 1 17 242313_at -2. 91 4. 31E-09 1.41E-06 -0. 80-8.57 18 206273 at HFL-EDDG1-2.90 1. 39E-13 5. 15E-10-0.68-8. 56 18p11. 1 19 203938_s_at TAF1C 1. 75 2.32E-06 1.71E-04 1.07 8. 51 16q24 20 231473_at -3. 67 4. 28E-13 1. 23E-09-0.68-8. 48 21214842sat ALB-3. 28 7. 46E-14 3. 22E-10-0.67-8. 47 4q11-q13 22 235517 at MGC29898-3.64 7. 13E-10 3. 62E-07-0.75-8. 43 4p15. 32 23 211253_x_at PYY -2. 61 3. 59E-11 3. 23E-08-0.71-8. 39 17q21. 1 24 232651_at -3.35 1. 31 E-11 1. 54E-08-0.70-8. 37 25239828_at FLJ25791-2.83 5. 98E-13 1.41E-09 -0. 67-8. 32 6q21 26211709sat SCGF 2. 20 3. 89E-06 2. 53E-04 1.07 8. 30 19q13. 3 27201031 s at HNRPH1 1. 57 5. 53E-06 3. 13E-04 1.12 8. 295q35. 3 28 210425_x_at GOLGIN-67 -2. 34 6. 09E-12 8. 75E-09-0.67-8. 17 15q11. 2 29 237018_at -2. 98 6. 10E-09 1. 90E-06-0.75-8. 15 30214899at LOC284323-5.59 2. 90E-13 9. 38E-10-0.62-8. 02 19q13. 13 31 244110 at MLL-2.51 2. 37E-12 3. 84E-09-0.64-7. 97 11q23 32 226864_at PKIA -4. 56 4. 19E-09 1. 39E-06-0.71-7. 94 8q21.11 33 206143 at SLC26A3-3.96 8. 55E-12 1. 05E-08-0.64-7. 91 7q31 34 236666_s_at -2.89 8.67E-13 1. 87E-09-0.62-7. 90 35 200599_s_at TRA1 1. 55 3. 89E-06 2. 53E-04 0. 96 7. 89 12q24. 2-q24.3 36 244266_at AKR1C1 -2. 67 1. 06E-12 2.11E-09 -0. 62-7. 8610p15-p14 37 236890_at -1.93 1.47E-10 1. 06E-07-0.66-7. 85 38 204073_s_at C11orf9 -3. 55 2. 69E-08 6. 22E-06-0.73-7. 84 11q12-q13. 1 39 214217_at -3. 46 2. 65E-10 1. 76E-07-0.66-7. 83 40 241575_at -2. 81 1. 65E-11 1. 85E-08-0.63-7. 81 41 207470at DKFZp566H0824-3. 24 8. 85E-10 4.24E-07-0. 67-7.80 1p36. 22 42239640at-2. 78 3. 59E-10 2. 16E-07-0.66-7. 80 43 240539_at -2. 78 1.32E-09 5.81 E-07-0.67-7. 71 44229636at RAB7-2.88 1. 31E-12 2. 42E-09-0.60-7. 70 3q21. 3 45 235742_at ARHC-2.95 1. 39E-09 5. 99E-07-0.67-7. 691p13. 1 46 229413 s at RNF3-1.91 3. 75E-09 1. 27E-06-0.68-7. 69 rp16. 3 47208736at ARPC3 1. 45 1. 73E-06 1. 39E-04 0.85 7. 6812q24. 11 48239082at-1. 77 3. 31E-09 1. 17E-06-0.68-7. 68 49 209058_at EDF1 1. 39 9. 75E-06 4. 61 E-04 1.00 7. 65 9q34. 3 50 239875_at NAB1 -2.22 1.51E-06 1. 30E-04-0.83-7. 622q32. 3-q33 2.56 AML_9q versus AML t (15; 17) # affy id HUGO name fc p q stn t Map Location 1 212953_x_at CALR-3.10 3. 38E-13 8. 00E-09 -2. 87-14.87 19p13. 3-p13. 2 2214317_x_at RPS9 2.21 1. 66E-12 1. 96E-08 2.55 13.51 19q13. 4 3 38487 at STAB1-5.58 4. 24E-11 3.34E-07-2. 05-10. 99 3p21. 31 4 224451 x at ARHGAP9 2.98 2.67E-09 6.32E-06 2.13 10.89 12q14 5203356at 2.49 1. 93E-10 1.08E-06 2.02 10.72 6214450at CTSW-4.39 2.29E-10 1.08E-06-1. 97-10.45 11q13. 1 7208942sat TLOC1 2.11 1. 10E-09 4. 35E-06 1.96 10. 29 3q26. 2-q27 8208956xat DUT 2. 16 1. 30E-09 4. 38E-06 1.85 9. 78 15q15-q21.1 9 209112_at CDKN1B 3.65 5. 40E-07 1. 75E-04 2.09 9. 70 12p13.1-p12 10213995at ATP5S 2. 26 1. 10E-07 6. 70E-05 1. 96 9. 63 14q21. 3 11 241742 at PRAM-1 8.47 1. 14E-05 9. 08E-04 2.48 9. 16 19p13. 2 12 201596_x_at KRT18 -5. 87 1. 71E-09 5. 05E-06-1.69-9. 0212q13 13 200931 s at VCL 3. 82 3. 73E-06 4. 96E-04 2.08 9. 01 10q22. 1-q23 14 221004_s_at ITM2C -5. 30 1. 92E-07 9. 10E-05-1. 78-8. 86 2q37 15204150at STAB1-5.91 2. 39E-09 6. 27E-06-1.63-8. 763p21. 31 16218376sat M ! CAL 3. 00 3. 62E-06 4. 96E-04 1.96 8.70 6q21 17 200953 s at CCND2-3.12 4. 84E-09 1. 04E-05-1.62-8. 6812p13 18 202117_s_at NDUFB8 1.98 5. 48E-06 6. 15E-04 2.00 8. 66 10q23. 2-q23.33 19 209344 at TPM4-8.21 9. 51E-09 1. 73E-05-1.65-8. 62 19p13. 1 20228263at GRASP-3.01 5. 64E-08 4. 76E-05-1.65-8. 55 12q13. 13 21 220018 at HAKAI 2. 69 3. 13E-07 1. 19E-04 1.72 8. 54 7q22. 2 22 241383_at -3. 52 7. 56E-09 1. 49E-05-1.61-8. 52 23 213735 sat COX5B 1. 80 4. 10E-07 1. 46E-04 1.70 8. 452cen-q13 24 205191_at RP2 4.40 7.35E-06 6. 91E-04 1.95 8. 40 Xp11. 4-p11. 21 25 212481_s_at TPM4-5.17 2. 01E-08 2. 40E-05-1.61-8. 37 19p13. 1 26 222735 at FLJ10493 6. 03 9. 48E-06 8. 16E-04 1.98 8. 37 9q31. 2 27205624at CPA3-4.73 2. 81E-08 3. 03E-05-1.59-8. 36 3q21-q25 28 218334_at FLJ23445 1. 85 1. 65E-07 8. 13E-05 1.62 8. 28 3pu4. 3 29 36545_s_at KIAA0542 2.25 1. 01 E-07 6.70E-05 1.60 8. 25 22q12. 2 30219165at PDL ! M2 3. 01 4. 53E-06 5. 45E-04 1.81 8. 228p21. 2 31242520sat-4. 73 1. 05E-08 1. 77E-05-1.54-8. 21 32 209698_at C6orf18 2. 99 7. 18E-07 2. 08E-04 1.64 8. 106p21. 3 33 206055_s_at SNRPA1 2.10 1. 54E-07 7. 78E-05 1.57 8. 09 15q26. 3 34212350at TBC1D1 2. 00 3. 30E-08 3. 39E-05 1.53 8. 094p14 35227456sat MGC15854 1. 85 1. 10E-07 6. 70E-05 1.56 8. 09 6p21. 31 36 211755_s_at ATP5F1 1. 60 1. 37E-08 2. 16E-05 1.51 8. 07 1p13.1 37 213513_x_at ARPC2 1. 54 1. 74E-08 2. 40E-05 1.50 8. 02 2q36. 1 38 202901_s_at CTSS 7. 94 3. 39E-05 1. 70E-03 2.21 8.00 1q21 39 236554 x at EVER2 4. 25 1. 69E-05 1. 17E-03 1.93 7. 99 17q25. 3 40 229406_at -11.78 1.24E-07 7.00E-05 -1. 62-7.96 41 217540at 3.36 1. 10E-05 8.86E-04 1.83 7.95 42 200986_at SERPING1 -4. 20 2. 03E-08 2. 40E-05-1.48-7. 93 11q12-q13. 1 43 208771_s_at LTA4H 2. 61 1. 42E-05 1. 05E-03 1.86 7. 93 12q22 44 227145 at LOXL4-3.33 1. 69E-07 8. 18E-05-1.65-7. 9010q24 45 243129_at -2. 85 1. 80E-08 2. 40E-05-1.47-7. 89 46200952sat CCND2-2.47 2. 62E-08 2. 95E-05-1.48-7. 88 12q13 47 218520_at TBK1 2. 58 1. 38E-06 2. 69E-04 1.61 7. 87 13q14. 2-q14. 3 48 201028 s at CD99-3.36 1. 87E-08 2. 40E-05-1.46-7. 86 Xp22. 32 49 218971_s_at HSPC049 2. 39 1.41E-06 2. 69E-04 1.60 7.86 7q33 50229004at-8. 35 1. 36E-07 7. 17E-05-1.57-7. 82 2.57 AML_9q versus AML_t (8; 21) &num affy id HUGO name fc p q stn t Map Location 1220560at C11orf21 4. 53 2. 02E-09 1. 05E-05 2.24 11.91 11p15. 5 2228827at-168. 37 4.17E-10 1.05E-05-2. 01-10.08 3205529sat CBFA2T1-20. 77 1.46E-09 1.05E-05-1. 78-9.37 8q22 4219165_at PDLIM2 3.79 2. 38E-06 8. 27E-04 2.02 9. 258p21. 2 5229406at-12. 04 1.74E-09 1.05E-05-1. 66-9.08 6201938at CDK2AP1 2. 18 5.02E-08 1.01E-04 1.68 9. 05 12q24. 31 7230650at-5. 85 1. 07E-09 1.05E-05-1. 59-8.98 8 242845_at -8.11 3.32E-09 1. 44E-05-1.56-8. 66 9 208091_s_at DKFZP564K0822 4. 83 3. 49E-06 1. 03E-03 1.84 8. 62 7p14. 1 10205528sat CBFA2T1-58. 93 1. 02E-08 3. 33E-05-1.66-8. 50 8q22 11 222125_s_at PH-4 1.96 1. 36E-06 7. 18E-04 1.63 8. 26 3p21. 31 12 204073_s_at C11orf9 -9. 15 8. 36E-09 3. 11E-05-1. 47-8. 22 11q12-q13. 1 13 233467_s_at PHEMX 2. 97 8. 38E-06 1. 69E-03 1.80 8. 16 11p15. 5 14 202854_at HPRT1 2.03 1.36E-07 1.90E-04 1.47 8. 04 Xq26. 1 15 200788_s_at PEA15 2. 16 4. 22E-06 1. 16E-03 1.65 8.01 1q21. 1 16 213918_s_at IDN3 2. 21 1. 48E-06 7. 18E-04 1.50 7. 79 5p13. 2 17203356_at 1.77 3. 91E-08 9. 79E-05 1.37 7.78 18202006_at PTPN12 3. 26 1. 99E-05 2. 90E-03 1.77 7. 71 7q11. 23 19215230_x_at EIF3S8 2. 03 7. 50E-08 1. 30E-04 1.35 7. 63 16p11. 2 20 219598_s_at PTD013 1. 67 4. 77E-07 4. 01E-04 1.40 7. 60 6q13-q22. 33 21 202789_at -2. 98 2.82E-08 8.15E-05-1. 34-7.60 22201924_at MLLT2 2.22 7.35E-07 5. 21 E-04 1.38 7. 46 4q21 23209112at CDKN1B 2. 41 2. 95E-06 9. 60E-04 1.45 7. 44 12p13.1-p12 24213404sat RHEB2 1. 75 3. 42E-07 3. 16E-04 1. 33 7.36 7q36 25221972sat Cab45 1.82 1.39E-07 1.90E-04 1.30 7. 33 1p36. 33 26222735_at FLJ10493 3.64 3.05E-05 3. 51 E-03 1.65 7. 27 9q31. 2 27 235468_at -7. 12 6. 11E-08 1.14E-04 -1. 28-7.26 28 203837 at MAP3K5 1.89 1.85E-06 7.18E-04 1.37 7. 266q22. 33 29223865at SOX6-2.77 4. 13E-08 9. 79E-05-1.25-7. 22 11p15. 3 30 223299_at LOC90701 2.34 1.84E-06 7.18E-04 1.34 7. 15 18q21. 31 31 201552_at LAMP1 1.65 2. 36E-06 8. 27E-04 1.35 7. 13 13q34 32 209168 at-3. 27 4. 89E-08 1. 01 E-04-1. 22-7.10 33 31845_at ELF4 2. 44 7. 53E-06 1. 58E-03 1.40 7. 08 Xq26 34 200048_s_at - HG-U133A JTB 1. 46 7.26E-07 5.21E-04 1.28 7. 06 1q21 35 53071_s_at FLJ22222 2. 18 9. 68E-06 1. 86E-03 1.39 6. 98 17q25. 3 36 204094_s_at KIAA0669 2.20 1.63E-05 2. 51 E-03 1.43 6. 963q25. 1 37213408sat MGC14697 1.75 1. 41E-06 7. 18E-04 1.28 6. 9510q24. 32 38 209058_at EDF1 1. 54 2. 15E-07 2. 44E-04 1.21 6. 93 9q34. 3 39221547_at PRPF18 1.88 1.20E-05 2.13E-03 1.39 6.91 10p12. 33 40 214317 x at RPS9 1. 77 8. 97E-08 1. 44E-04 1.19 6. 90 19q13. 4 41 231334 at-4. 68 9. 40E-08 1. 44E-04-1.18-6. 87 42 227151_at MGC32065-1.71 1. 81E-06 7.18E-04-1. 26-6. 86 15q23 43 227853_at 2. 62 2. 03E-05 2. 90E-03 1.42 6.85 44239875_at NAB1-2.52 1. 49E-07 1. 94E-04-1.18-6. 832q32. 3-q33 45204811sat CACNA2D2-6.03 1. 74E-07 2. 16E-04-1.19-6. 823p21. 3 46 220558_x_at PHEMX 2. 59 4. 65E-05 4. 34E-03 1.52 6.81 11p15. 5 47202545_at PRKCD 4. 13 5. 52E-05 4. 78E-03 1.56 6. 81 3p21. 31 48 214394_x_at EEF1D 1. 54 3. 51E-07 3. 16E-04 1.19 6. 798q24. 3 49204086at FRAME-9. 78 4. 60E-07 4.00E-04 -1. 28-6. 78 22q11. 22 50 215051_x_at AIF1 2. 92 4. 96E-05 4. 51E-03 1.50 6. 746p21. 3 2.58 AML MLL versus AML_inv (16) # affy id HUGO name fc p q stn t Map Location 1 213737_x_at 3.65 1.30E-18 3. 71E-14 2.17 15.48 2 214651_s_at HOXA9 22.10 4. 22E-16 6. 01E-12 2.26 14. 60 7p15-p14 3200665saut SPARC-14.82 7. 41E-14 3. 52E-10-2.27-14. 07 5q31. 3-q32 4 200953_s_at CCND2-4.16 1. 61E-15 1. 53E-11-1.86-13. 20 12p13 5 202746_at ITM2A -16. 05 9. 80E-13 2. 15E-09-2.15-12. 88 Xq13. 3-Xq21. 2 6 202747_s_at ITM2A -16. 65 8.69E-13 2.06E-09-2. 09-12. 76 Xq13. 3-Xq21. 2 7 235753_at 14.15 1. 49E-13 6. 06E-10 1.98 12.10 8227567at 5. 31 5.68E-15 4.05E-11 1.66 11.93 9229215_at ASCL2 11.42 2. 22E-13 6. 34E-10 1.73 11. 48 11p15. 5 10206847sat HOXA7 7. 10 2.07E-13 6. 34E-10 1.70 11.41 7p15-p14 11 231310at-4. 40 2.33E-14 1.33E-10-1. 54-11.24 12 201497_x_at MYH11 -27. 86 4. 74E-11 4.22E-08-2. 16-11.23 16p13. 13-p13. 12 13 200951_s_at CCND2-4.96 2.30E-12 4.22E-09-1. 60-10.90 12p13 14 209905_at HOXA9 70.38 2.46E-12 4.22E-09 1.82 10.90 7p15-p14 15 224049 at KCNK17-4.35 2. 74E-11 2. 70E-08-1.66-10. 60 6p21. 1 16 213147_at HOXA10 5. 72 2. 97E-13 7. 68E-10 1.48 10.56 7p15-p14 17 203949_at MPO-3.36 1. 91 E-13 6. 34E-10-1.41-10. 32 17q23.1 18 213908 at 15.52 8. 76E-12 9. 99E-09 1.66 10.30 19 201496_x_at MYH11 -6.20 5.40E-11 4.67E-08-1. 56-10.14 16p13. 13-p13. 12 20202370sat CBFB 3. 09 3. 66E-12 5. 22E-09 1.46 10.07 16q22.1 21 202931_x_at BIN1 -3. 16 1. 41E-12 2.87E-09-1. 39-10.05 2q14 22 226517_at BCAT1 -10. 55 1.85E-10 1.15E-07-1. 66-10.05 12pter-q12 23204082at PBX3 5.42 2. 57E-11 2. 61 E-08 1.52 9. 769q33-q34 24212667at SPARC-7.96 2. 45E-10 1. 42E-07-1.54-9. 70 5q31. 3-q32 25 225831 at LOC148894-3.79 5. 89E-11 4. 89E-08-1.41-9. 59 1p36. 11 26 203733 at MYLE 3. 27 3.18E-12 5. 03E-09 1.30 9. 50 16p13. 2 27 223385_at CYP2S1 -2. 38 1. 24E-10 8. 39E-08-1.38-9. 34 19q13. 1 28 205330_at MN1 -16. 74 1. 73E-09 5. 37E-07-1.75-9. 33 22q12. 1 29 223471_at RAB3IP 3. 58 7.10E-12 8. 43E-09 1.28 9.29 30201830sat NET1-4.44 3. 73E-10 2.00E-07 -1. 42-9. 2610p15 31 202551_s_at CRIM1 -4. 62 2. 91E-10 1. 63E-07-1.39-9. 23 2p21 32 210139 s at PMP22-9.69 1. 47E-09 4.81E-07 -1. 55-9. 18 17p12-p11. 2 33 224772 at NAV1-2.82 3. 27E-10 1. 79E-07-1.37-9. 12 34 211012 s at PML-2.69 1. 13E-11 1. 24E-08-1.24-9. 09 15q22 35228058at LOC124220-5.16 4. 73E-12 6. 12E-09-1.22-9. 0916p13. 3 36 223299_at LOC90701 2. 79 4. 18E-12 5. 67E-09 1.20 9. 00 18q21. 31 37 214452_at BCAT1-4.30 3. 97E-10 2. 02E-07-1.34-8. 99 12pter-q12 38228497_at FLIPT1 7. 80 2. 17E-10 1. 29E-07 1. 41 8. 98 1p13. 1 39225102_at LOC152009 5. 25 8.41E-11 6. 48E-08 1.30 8. 95 3q21. 3 40 201828_x_at CXX1 2. 85 2. 52E-12 4. 22E-09 1.17 8.91 Xq26 41203948-s-at MPO-3.51 6. 09E-12 7. 55E-09-1.19-8. 91 17q23. 1 42200602at APP-6.96 1. 09E-10 7. 70E-08-1. 26-8. 90 21q21. 3 43 218041 x at SLC38A2-1.65 3. 59E-12 5. 22E-09-1.17-8. 90 12q 44 225285_at -9. 24 1. 04E-09 3. 97E-07-1.35-8. 82 45203373at SOCS2 13.18 2. 48E-10 1. 42E-07 1.34 8.82 12q 46201029sat CD99-1.85 1. 78E-11 1. 88E-08-1.18-8. 75 Xp22. 32 47213150_at HOXA10 8. 63 1. 06E-10 7. 70E-08 1.25 8. 74 7p15-p14 48 228496_s_at CRIM1 -2. 68 8. 74E-11 6.56E-08 -1. 20-8. 70 2p21 49221581sat WBSCR5 2. 78 3. 22E-11 3. 06E-08 1.19 8. 70 7p11. 23 50 205453 at HOXB2-6.83 3. 79E-10 2.00E-07 -1. 25-8. 69 17q21-q22 2.59 AML MLL versus AML_inv (3) # affy id HUGO name fc p q stn t Map Location 1204082at PBX3 8. 60 2.88E-12 2. 35E-08 1.63 10. 50 9q33-q34 2226789at 3.28 1.48E-13 1. 81E-09 1.47 10.39 3214651saut HOXA9 4.67 9.43E-14 1. 81E-09 1.45 10. 29 7p15-p14 4235753_at 4.92 3. 97E-12 2.43E-08 1.42 9.76 5228083_at CACNA2D4 11. 16 1.43E-11 5. 83E-08 1.46 9. 66 12p13. 33 6 214643_x_at BIN1 -4. 56 2. 50E-09 1. 64E-06-1.59-9. 58 2q14 7209905at HOXA9 7.79 3. 17E-11 1.11E-07 1.34 9. 13 7p15-p14 8 202054_s_at ALDH3A2 5. 02 6. 40E-12 3. 14E-08 1.27 9. 05 17p11. 2 9 208116_s_at MAN1A1 -4. 86 2. 19E-08 6. 38E-06-1.59-8. 95 6q22 10236398sat 5. 77 7.08E-11 1.58E-07 1.31 8.88 11 201829at NET1-3. 59 3.90E-08 9.18E-06-1. 61-8.81 10p15 12 203733_at MYLE 2. 69 6. 75E-11 1.58E-07 1.23 8.59 16p13. 2 13212318_at TRN-SR 2. 53 8.52E-11 1.67E-07 1.23 8.55 7p32. 2 14 233955_x_at HSPC195 -4. 61 1. 78E-08 5. 60E-06-1.41-8. 54 5q31. 3 15 213893_x_at PMS2L5 2. 4 3.81E-11 1.17E-07 1.19 8. 49 7p11-q22 16 208702 x at APLP2 2. 83 4. 39E-11 1. 19E-07 1.19 8. 45 11q24 17 231431_s_at -2. 62 7. 32E-08 1. 39E-05-1.54-8. 45 18202605at GUSB 3.28 9. 55E-11 1.67E-07 1.20 8. 44 7q21.11 19210006at DKFZP5640243 2.17 1. 66E-10 2.71E-07 1.21 8. 403p21. 1 20 210201_x_at BIN1 -2. 98 1. 82E-08 5. 64E-06-1.35-8. 34 2q14 21 214439_x_at BIN1 -3. 31 1. 27E-08 4. 55E-06-1.31-8. 27 2q14 22 212782_x_at POLR2J 2. 38 3.41E-10 4. 29E-07 1.18 8. 24 7p11. 2 23200602at APP-10.57 8. 51E-08 1. 58E-05-1.47-8. 24 21q21. 3 24 214875 x at APLP2 2. 72 9. 39E-11 1.67E-07 1.15 8. 23 11q24 25 219551 at TRAITS 3. 35 3.68E-10 4. 29E-07 1.19 8. 19 3q13. 33 26 206847 s at HOXA7 2. 98 2. 37E-10 3. 23E-07 1.16 8. 15 7p15-p14 27 218217 at RISC 4. 10 1.13E-09 9.89E-07 1.23 8. 14 17q23. 1 28223703at CDA017 3. 49 1.23E-09 1.00E-06 1.22 8. 09 10q23. 1 29201186at LRPAP1 3. 21 7.48E-10 7. 89E-07 1.18 8. 07 4p16. 3 30201105at LGALS1 2. 91 1. 88E-10 2. 88E-07 1.12 8. 00 22q13. 1 31 203725 at GADD45A-3.08 1. 71E-09 1. 27E-06-1.16-7. 99 1p31.2-p31. 1 32214430_at GLA 2. 03 2. 27E-10 3. 23E-07 1.12 7. 97 Xq22 33 206440_at LIN7A 8.55 1.13E-09 9. 89E-07 1.17 7. 97 12q21 34 211709_s_at SCGF 4. 44 4.41E-10 4.91E-07 1.11 7. 86 19q13. 3 35 219033_at FLJ21308 3.62 1.20E-09 1. 00E-06 1.14 7.85 5q11. 1 36219126at XAP135 1. 85 3. 53E-10 4. 29E-07 1.10 7.84 6q27 37 208967 s at AK2 3. 68 3. 22E-09 1. 84E-06 1.20 7.83 1p34 38 212174 at AK2 3. 63 1. 63E-09 1. 24E-06 1.15 7.83 1p34 39202053sat ALDH3A2 2. 61 9. 28E-10 8. 75E-07 1.11 7. 78 17p11. 2 40202961sat ATP5J2 2. 16 8. 60E-10 8. 43E-07 1.10 7. 77 7q22. 1 41201830sat NET1-5.62 3. 42E-07 3. 90E-05-1.47-7. 75 10p15 42231300at LOC90835 4.14 2. 74E-09 1. 68E-06 1.15 7. 74 16p11. 2 43 204951 at ARHH-3.59 3. 51E-08 8.51E-06 -1. 21-7.71 4p13 44211404sat APLP2 2. 23 1. 44E-09 1. 14E-06 1.09 7. 65 11q24 45219991_at SLC2A9 2.29 2. 55E-09 1. 64E-06 1.12 7. 64 4p16-p15. 3 46 223328_at MGC3195 2. 12 7.73E-10 7. 89E-07 1.07 7. 61 7q22. 1 47 213908_at 3. 56 4. 03E-09 2. 10E-06 1.12 7.58 48 228652_at FLJ38288-2.21 6. 80E-08 1.32E-05 -1.21 -7.58 19q13. 43 49 214953_s_at APP-5.50 1. 23E-07 1. 99E-05-1.23-7. 52 21q21. 3 50 202931_x_at BIN1 -3.09 1.11E-07 1.89E-05-1. 21-7. 50 2q14 2.6 AML MLL versus AML komplext # affy id HUGO name fc p q stn t Map Location 1 201377_at NICE-4 -2. 72 3.69E-15 2. 46E-11-1. 51-11.56 1q21. 3 2 201105_at LGALS1 4. 52 6. 07E-14 2. 57E-10 1.36 10. 55 22q13. 1 3200608sat RAD21-1.86 3. 88E-15 2. 46E-11-1. 28-10.40 8q24 4 228083_at CACNA2D4 11.81 1. 68E-11 9.93E-09 1.53 9. 94 12q13. 33 5201830sat NET1-5. 21 6. 70E-12 6. 55E-09-1.37-9. 77 10p15 6201225sat SRRM1-1. 72 1. 39E-13 4. 42E-10-1.18-9. 52 1p36. 11 7 208886_at H1F0 -7. 16 2. 03E-11 9. 93E-09-1.32-9. 40 22q13. 1 8 214700_x_at DKFZP434D193 -3.12 1.37E-11 9. 65E-09-1.27-9. 332q23. 3 9209022 at STAG2-1. 98 3. 31E-12 5. 25E-09-1.17-9. 17 Xq25 10 218041 x at SLC38A2-1.84 3. 42E-13 8. 70E-10-1.12-9. 13 12q 11 203544 5 at STAM-4.39 3. 49E-11 1. 48E-08-1.26-9. 11 10p14-p13 12218823sat FLJ20038-2.77 3. 12E-11 1.41E-08 -1. 25-9. 09 8p21. 1 13 201196_s_at AMD1-1.93 1. 72E-12 3. 49E-09-1.14-9. 09 6q21-q22 14 201560_at CLIC4 -4. 16 4. 61E-12 5. 33E-09-1.16-9. 07 1p36.11 15 202746_at ITM2A -10. 44 1. 47E-10 3. 83E-08-1.28-8. 85 Xq13.3-Xq21. 2 16209705at-2. 03 1. 78E-11 9. 93E-09-1.14-8. 80 17 205788_s_at KIAA0663 -1.79 1.87E-11 9. 93E-09-1.14-8. 78 1q32. 1 18 203519 s at UPF2-2.09 1. 91E-11 9. 93E-09-1.13-8. 75 10p14-p13 19 222902_s_at FLJ21144-1.92 1. 92E-12 3. 49E-09-1.08-8. 75 1p34. 1 20 233168_s_at IMAGE3510317 -1. 73 4. 52E-12 5. 33E-09-1.09-8. 75 22q13. 33 21 209362_at SURB7-2. 15 1. 91 E-11 9. 93E-09-1.11-8. 6712p11. 23 22204082at PBX3 4. 49 5.32E-11 2. 05E-08 1.14 8. 669q33-q34 23 201585 s at SFPQ-1.91 9. 60E-12 8.21E-09 -1. 09-8. 65 1p34. 3 24 200997 at RBM4-1.92 1. 18E-11 8. 79E-09-1. 09-8. 64 11q13 25201829at NET1-3. 30 1. 95E-10 4. 21 E-08-1. 21-8. 62 10p15 26 39071_at -1.83 3.72E-12 5. 25E-09-1.04-8. 51 27203725 at GADD45A-4. 33 6.08E-11 2.21E-08 -1. 11-8. 51 1p31.2-p31. 1 28 211137_s_at ATP2C1 -3. 12 4. 82E-10 7. 28E-08-1.26-8. 503q21-q24 29 202747_s_at ITM2A -10. 27 3. 18E-10 5.61E-08 -1. 20-8. 49 Xq13.3-Xq21. 2 30201166sat PUM1-1. 863. 89E-11 1.60E-08-1. 09-8. 49 1p35. 2 31 212232 at FNBP4-1.77 1. 15E-11 8. 79E-09-1. 05-8. 43 11p11. 12 32 200086_s_at - HG-U133B COX4I1 1. 64 5. 17E-12 5. 47E-09 1.03 8. 43 16q22-qter 33223318sat MGC10974 3. 61 2. 44E-10 4. 77E-08 1.14 8. 38 19q13. 3 34212463at-4. 101. 52E-103. 83E-08-1.11-8. 35 35 213549_at PRO2730 -4. 66 6. 44E-10 8. 52E-08-1.21-8. 333p21. 31 36 201358 s at COPB-1. 65 1. 96E-11 9. 93E-09-1.04-8. 33 11p15. 2 37 212031_at S164-2.00 1. 55E-11 9. 93E-09-1.03-8. 32 14q24. 3 38 228974_at -4. 54 1. 70E-10 4.01E-08 -1. 10-8.31 39 205849 s at UQCRB 1. 52 9.70E-12 8.21E-09 1. 02 8.31 8q22 40201061sat STOM-3.25 2. 69E-10 5. 17E-08-1.12-8. 31 9q34. 1 41 205639_at AOAH 3. 94 2.96E-10 5. 43E-08 1.12 8. 29 7p14-p12 42 218331_s_at FLJ20360-2.05 6. 54E-11 2.31E-08 -1. 06-8. 28 lops5. 1 43223592sat MGC13061 2.62 2. 99E-10 5. 43E-08 1.12 8. 28 17q11. 2 44 217887 s at EPS15-2.10 5. 29E-11 2. 05E-08-1.05-8. 26 1p32 45200985sat CD59-4.95 1. 95E-10 4.21E-08 -1. 09-8. 25 11p13 46 214439_x_at BIN1 -3. 72 2. 41E-10 4. 77E-08-1.09-8. 21 2q14 47 200071_at - HG-U133A SPF30 -1. 89 7. 53E-11 2. 52E-08-1.04-8. 19 10q23 48 202413_s_at USP1 1. 73 3. 43E-11 1. 48E-08-1.01-8. 16 1p32. 1-p31. 3 49 218846 at CRSP3-2.57 3. 67E-10 6. 13E-08-1.09-8. 15 6q22. 33-q24.1 50 202659_at PSMB10 3. 04 1. 05E-10 3. 27E-08 1.04 8. 15 16q22. 1 2.61 AML MLL versus Ami anormal # affy id HUGO name fc p q stn t Map Location 1 205453 at HOXB2-10.77 2. 71E-38 6.45E-34-1. 20-16.52 17q21-q22 2205601sat HOXB5-3.36 1. 55E-33 1. 84E-29-1.08-14. 87 17q21. 3 3231767at HOXB4-3.76 2.85E-30 2.26E-26-1. 00-13. 77 17q21-q22 4 239791_at -15. 07 1.48E-29 8.81 E-26-0.99-13. 58 5228904at-11. 58 1.98E-29 9.40E-26-0. 97-13.47 6236892sat-13. 39 8.02E-29 3.17E-25-0. 97-13.34 7 211137_s_at ATP2C1 -2. 04 5.75E-26 1.95E-22-0. 91-12. 47 3q21-q24 8205366sat HOXB6-12.67 4.12E-25 1.09E-21-0. 89-12.20 17q21. 3 9 213258_at -8. 36 2.60E-25 7.72E-22-0. 89-12.18 10220306at FLJ20202-3.48 1. 71E-23 4. 06E-20-0.87-11. 77 1p11.1 11 200923at LGALS3BP-9.40 2.58E-23 5.57E-20-0. 86-11.59 17q25 12205624at CPA3-12.32 8. 38E-23 1. 66E-19-0.85-11. 46 3q21-q25 13 225344 at ERAP140-3. 19 1. 20E-22 2. 19E-19-0.82-11. 276q22. 33 14 205600 x at HOXB5-1.85 2.92E-22 4.62E-19-0. 82-11.20 17q21. 3 15233955_x_at HSPC195-3.34 4. 81E-19 3.94E-16-0. 87-11. 15 5q31. 3 16 226517_at BCAT1 -6.92 1.90E-22 3. 23E-19-0.81-11. 14 12pter-q12 17 236513_at -2. 75 3.55E-22 5.27E-19-0. 81-11.10 18222996sat HSPC195-2. 79 7.22E-20 8.17E-17-0. 83-10.91 5q31. 3 19 232424 at PRDM16-16.32 5. 20E-21 6. 18E-18-0. 83-10. 89 1p36. 23-p33 20 230743_at -2.37 1. 25E-21 1.75E-18-0. 79-10.86 21 210993_s_at MADH1-5.39 3.18E-21 4.20E-18-0. 78-10. 75 4q28 22210365at RUNX1-3.27 3. 77E-21 4. 72E-18-0.77-10. 69 21q22. 3 23224516sat HSPC195-3.60 3. 05E-19 2. 89E-16-0. 79-10. 56 5q31. 3 24 222920_s_at KIAA0748 -4. 27 2. 60E-19 2.57E-16-0. 77-10.37 12q13. 13 25201242sat ATP1B1-4. 09 2. 03E-19 2. 09E-16-0. 76-10.36 1 q22-q25 26 210664_s_at TFPI -5. 30 1. 34E-19 1.45E-16-0. 74-10.21 2q31-q32. 1 27225974_at DKFZp762C1112-4. 47 3.62E-18 2.73E-15-0. 75-10. 07 8q21. 3 28 232979_at 62 3. 32E-19 3.03E-16-0. 73-10.05 29205383sat ZNF288-1.73 2. 09E-18 1. 65E-15-0. 74-10. 043q13. 2 30 236198_at -6. 24 3. 81E-19 3. 35E-16-0.72-9. 99 31 225532 at LOC91768-2.86 4. 81E-19 3.94E-16-0. 72-9. 97 18q11. 1 32204951at ARHH-3.51 6. 08E-18 4. 25E-15-0.73-9. 83 4p13 33200829xat ZNF207-1. 529. 52E-163. 54E-13-0.78-9. 80 17q11. 2 34 206761_at TACTILE-12. 07 8. 60E-18 5. 68E-15-0.74-9. 68 3q13. 13 35 241756_at -2.61 4.52E-16 1.95E-13 -0. 75-9.67 36 213549_at PRO2730 -2. 74 4. 86E-18 3. 50E-15-0. 70-9. 66 3p21. 31 37 223298 s at NT5C3-1. 72 6. 55E-18 4. 45E-15-0. 71-9. 66 7p14. 3 38 213156_at -2. 30 8. 36E-17 4. 22E-14-0. 73-9.65 39 210665_at TFPI -7. 88 3. 68E-18 2. 73E-15-0. 70-9. 65 2q31-q32. 1 40 208116_s_at MAN1A1 -2. 95 1. 61E-17 1.00E-14 -0. 71-9.61 6q22 41 203897 at LOC57149-1.97 1. 28E-17 8.22E-15 -0.69 -9.53 16p11. 2 42213110sat COL4A5-4. 71 2. 15E-17 1.31E-14 -0. 70-9.51 Xq22 43 203544 s at STAM-2.57 1. 23E-16 5. 86E-14-0.71-9. 50 10p14-p13 44 209676_at TFPI -2. 63 2. 62E-17 1. 56E-14-0.69-9. 48 2q31-q32. 1 45 225285_at -5. 64 4.93E-17 2.70E-14-0. 70-9.44 46 219094_at HSPC056 -2. 08 2. 85E-16 1.30E-13 -0. 71-9. 433q22. 3 47 233849_s_at ARHGAP5 -5.97 2.74E-17 1. 59E-14-0.68-9. 39 14q12 48 201830_s_at NET1-3.03 3. 39E-17 1. 92E-14-0.68-9. 38 10p15 49209014_at MAGED1-2.11 4. 99E-17 2. 70E-14-0.68-9. 36 Xp11. 23 50218966at MY05C-2. 10 1. 67E-16 7. 78E-14-0.68-9. 25 15q21 2.62 AML MLL versus AML_t (15; 17) # affy id HUGO name fc p q stn t Map Location 1 221004_s_at ITM2C -9. 69 6.96E-15 2. 78E-11-2. 63-16.45 2q37 2 38487 at STAB1-16.22 3. 38E-13 4. 51E-10 -2. 90-16. 13 3p21. 31 3203948sat MPO-6.32 8. 76E-21 2. 10E-16-2.19-15. 83 17q23.1 4 214651_s_at HOXA9 237.17 2. 30E-16 1. 84E-12 2.66 15.41 7p15-p14 5205624at CPA3-36.02 6. 17E-12 3. 79E-09-3.01-14. 75 3q21-q25 6212953rat CALR-3.21 2.50E-14 6. 66E-11-2. 22-14.41 19p13. 3-p13. 2 7214450at CTSW-6.11 7. 04E-14 1. 41E-10-2. 21-14. 15 11q13. 1 8203949at MPO-4.43 9. 42E-19 1. 13E-14-1.91-13. 87 17q23. 1 9200953sat CCND2-6.10 3.06E-12 2.45E-09-2. 26-13. 42 12p13 10213147_at HOXA10 23.93 1. 62E-14 4. 85E-11 2.12 13. 06 7p15-p14 11 238022at-5. 73 4.14E-12 3. O0E-09-1. 96-12.30 12 235753_at 16.83 1.12E-13 1.79E-10 2.04 12.26 13 233072_at KIAA 1857 -11 75 7. 57E-11 2. 44E-08-2.24-12. 25 9q34 14 205771_s_at AKAP7 10.25 3. 35E-14 8.02E-11 1.82 12. 10 6q23 15 206871_at ELA2-3.69 4.90E-16 2.94E-12-1. 64-11.89 19p13. 3 16206847sat HOXA7 9. 48 6. 90E-14 1. 41E-10 1.80 11. 89 7p15-p14 17 209448 at HTATIP2 10.38 2. 48E-13 3. 64E-10 1.79 11. 54 11p15. 1 18 204150 at STAB1-19.25 3.63E-10 8.30E-08-2. 23-11. 50 3p21. 31 19 213587_s_at LOC155066 7. 64 6. 58E-13 7. 88E-10 1.79 11. 29 7q36. 1 20205663at PCBP3-3. 93 3. 63E-11 1. 36E-08-1.79-11. 19 21q22. 3 21201522xat SNRPN 4. 63 51E-151. 20E-11 1.54 11. 19 15q12 22212509sat-6. 33 1.53E-10 4.37E-08-1. 87-11.08 23209905_at HOXA9 720.22 1.83E-12 1.75E-09 1.92 11. 06 7p15-p14 24205349at GNA15-4.14 1. 47E-12 1. 53E-09-1.62-11. 03 19p13. 3 25 200951_s_at CCND2-6.76 2. 21 E-10 5.88E-08-1. 88-10. 98 12p13 26 206761_at TACTILE -28.74 1.21E-09 2. 02E-07-2.29-10. 90 3q13. 13 27201029sat CD99-2.16 1.08E-14 3. 69E-11-1. 48-10. 74 Xp22. 32 28217848_s at PP 3.89 1. 09E-13 1.79E-10 1.49 10. 59 10q11. 1-q24 29225532at LOC91768-5.64 9. 02E-10 1. 64E-07-1.92-10. 59 18q11.1 30200952sat CCND2-4.07 2. 77E-10 6.83E-08-1. 76-10.57 12p13 31 204425_at ARHGAP4 15.58 4. 11E-12 3. 00E-09 1.65 10. 49 Xq28 32204082at PBX3 8. 50 2. 90E-12 2. 40E-09 1.61 10. 47 9q33-q34 33 231736_x_at MGST1 -2. 80 2.58E-13 3.64E-10-1. 46-10.42 12p12. 3-p12. 1 34210788sat retSDR4-2.38 2. 11E-11 9.75E-09-1. 57-10.41 14q22.3 35 224918_x_at MGST1-2.62 9.12E-14 1.68E-10-1. 42-10. 30 12p12. 3-p12. 1 36201596xat KRT18-8.14 5.16E-10 1.08E-07-1. 69-10.20 12q13 37213150_at HOXA10 45.69 1. 41E-11 7.20E-09 1.71 10. 17 7p15-p14 38218404at SNX10 6. 77 5.71e-12 3. 60E-09 1.53 10. 097p15. 2 39225386sat LOC92906 34.47 1. 65E-11 8.20E-09 1.66 10. 082p22. 2 40 211474_s_at SERPINB6 4. 55 2. 77E-12 2. 40E-09 1.47 10. 04 6p25 41 221253_s_at MGC3178-2.99 2.44E-10 6.44E-08-1. 59-10. 03 6p24.3 42 228083_at CACNA2D4 11.77 1. 68E-11 8. 20E-09 1.57 9. 93 12p13. 33 43213571_s_at EIF4EL3 2.54 6. 08E-13 7. 67E-10 1.37 9. 842q37. 1 44208852sat CANX-2.26 6. 45E-11 2.18E-08-1. 46-9. 78 5q35 45227999_at LOC170394 3. 11 7. 06E-13 8. 06E-10 1.36 9. 76 10q26. 3 46217716sat SEC61A1-1. 93 1. 04E-11 5. 68E-09-1.40-9. 72 3q21. 3 47202265_at BMI1 4. 29 8. 23E-12 4. 70E-09 1.43 9. 71 10p11. 23 48 217853_at TEM6 6.43 1.19E-11 6. 31E-09 1.43 9. 66 7p15. 1 49223663at FLJ37970 6. 99 2. 35E-12 2. 17E-09 1.37 9. 66 11q12. 3 50228263at GRASP-2.66 3. 59E-12 2. 77E-09-1.36-9. 63 12qu3. 13 2.63 AML MLL versus AML_t (8; 21) # affyid HUGO name fc p q stn t Map Location 1 214651_s_at HOXA9 207.35 2. 33E-16 6.38E-12 2.65 15. 40 7p15-p14 2 221581_s_at WBSCR5 10.61 3. 46E-15 2.36E-11 2.04 13. 41 7q11. 23 3213147_at HOXA10 17.19 2. 21E-14 1.01E-10 2.00 12. 78 7p15-p14 4 235753_at 15.72 1. 24E-13 4. 83E-10 2.01 12.20 5201105at LGALS1 7. 06 3.40E-15 2.36E-11 1.63 11.87 22q13. 1 6 206847_s_at HOXA7 7. 80 1.77E-13 6.06E-10 1.79 11.69 7p15-p14 7 227853_at 3. 59 7.38E-15 4.04E-11 1.54 11.33 8203949at MPO-4. 06 7. 26E-16 9. 92E-12-1.47-11. 16 17q23. 1 9209905at HOXA9 687.57 1. 83E-12 4. 55E-09 1.92 11. 06 7p15-p14 10 213908_at 16.07 8. 41E-12 1. 53E-08 1.68 10.33 11 213150_at HOXA10 58.80 1. 26E-11 2. 16E-08 1.73 10.23 7p15-p14 12 210314_x_at TNFSF13 4. 81 5.81E-13 1. 59E-09 1.42 10.22 17p13. 1 13 228827_at -110. 08 4. 44E-10 2.89E-07-1. 99-10.05 14 228083_at CACNA2D4 12.77 1. 51E-11 2. 29E-08 1.60 10. 05 12pu3. 33 15 209500_x_at TNFSF13 4.18 3. 77E-12 7. 93E-09 1.39 9.82 17p13. 1 16 204082_at PBX3 6. 63 5. 42E-12 1. 06E-08 1.39 9. 77 9q33-q34 17228058_at LOC124220-6.07 2. 57E-12 5. 84E-09-1.33-9. 70 16p 13. 3 18 203948_s_at MPO -4. 62 4. 25E-13 1. 29E-09-1.28-9. 66 17q23. 1 19 206940_s_at POU4F1 -41. 89 1. 43E-09 6. 02E-07-1.86-9. 46 13q21.1-q22 20212423at FLJ90798 5. 26 1.45E-11 2. 29E-08 1.34 9. 42 10q22. 3 21 201944_at HEXB 3. 49 5. 23E-11 5. 29E-08 1.44 9.41 5q13 22 223562_at PARVG 3.11 2. 14E-11 2.67E-08 1.34 9. 35 22q13. 2-q13 23229406at-12. 04 2. 06E-09 7. 54E-07-1.65-9. 19 24205639_at AOAH 5.75 2. 05E-11 2. 67E-08 1.29 9. 18 7p14-p12 25 204202_at KIAA1023 3.45 2. 15E-11 2.67E-08 1.28 9. 137p22. 3 26205529sat CBFA2T1-12. 90 2. 76E-09 8. 88E-07-1.70-9. 10 8q22 27230650at-5. 19 2. 41E-09 8. 23E-07-1.55-9. 01 28 206009_at ITGA9 -3. 49 2. 03E-10 1. 50E-07-1.30-8. 95 3p21. 3 29203859sat PALM-5.31 1. 28E-09 5. 66E-07-1.39-8. 88 19p13. 3 30217853_at TEM6 5. 32 2.90E-11 3. 44E-08 1.22 8. 87 7p15. 1 31 201850 at CAPG 8. 40 4.01E-10 2. 67E-07 1.37 8. 73 2cen-q24 32 224415_s_at HINT2 1.98 1. 84E-11 2.65E-08 1.16 8. 66 9p13.1 33 216417_x_at HOXB9 3. 56 3.49E-11 3.81E-08 1.17 8. 64 17q21. 3 34203733_at MYLE 2. 65 6. 93E-11 6. 53E-08 1.18 8. 59 16p13. 2 35 211341_at POU4F1 -266. 20 9. 63E-09 2. 23E-06-1.69-8. 54 13q21.1-q22 36 225245_x_at H2AFJ 4. 56 3. 12E-11 3. 55E-08 1.15 8. 54 12p12 37 204069_at MEIS1 20.28 8. 95E-10 4.51E-07 1.42 8. 54 2p14-p13 38 205528_s_at CBFA2T1 -41.63 1.17E-08 2. 56E-06-1.63-8. 45 8q22 39 206761_at TACTILE-19.71 1. 31E-08 2. 72E-06-1.57-8. 38 3q13. 13 40204880at MGMT-2.31 1. 57E-10 1. 26E-07-1.14-8. 36 10q26 41 225386sat LOC92906 7.38 1. 95E-10 1.48E-07 1.15 8.31 2p22.2 42 225009_at CKLFSF4 4. 99 6. 86E-10 3. 83E-07 1.22 8. 29 16q21 43 202746_at ITM2A -6. 60 3. 24E-09 9. 84E-07-1.25-8. 28 Xq13.3-Xq21. 2 44 218217_at RISC 4.76 3. 65E-10 2. 49E-07 1.17 8. 28 17q23. 1 45 232227_at -11.48 1.52E-08 2. 99E-06-1.50-8. 27 46238756_at 3.91 6. 11E-10 3.55E-07 1.20 8.26 47 224301_x_at H2AFJ 3. 97 1.00E-10 8. 64E-08 1.11 8. 24 12p12 48 212459_x_at SUCLG2 3. 21 4.89E-11 5. 14E-08 1.09 8. 21 3pu4. 2 49 241706_at LOC144402 6. 44 1. 09E-09 5. 31 E-07 1.19 8. 13 12q 11 50225344_at ERAP140-4.28 9. 94E-09 2. 25E-06-1.30-8. 136q22. 33 2.64 AML inv (16) versus AML_inv(3) # affy id HUGO name fc p q stn t Map Location 1203949at MPO 4. 50 1.34E-17 3. 70E-13 2.52 16.16 17q23.1 2203948_s_at MPO 5. 13 3.61E-16 4. 97E-12 2.05 13. 3717q23. 1 3205382sat DF 5. 63 3. 26E-13 2. 99E-09 1.85 11. 66 19p13. 3 4 201497_x_at MYH11 19.05 6. 47E-11 3. 56E-07 2.09 11. 02 16p13.13-p13. 12 5209365sat ECM1 3. 55 3. 80E-12 2. 62E-08 1.68 10.58 1q21 6210755at HGF 6. 55 1.77E-10 6. 09E-07 1.70 9. 96 7q21.1 7217963sat NGFRAP1-22.83 1. 95E-08 1. 45E-05-1.97-9. 62 Xq22. 1 8 205718_at ITGB7 3.13 8. 99E-11 4. 12E-07 1.41 9. 03 12q13. 13 9208248rat APLP2 2. 15 1. 31E-10 5. 17E-07 1.35 8. 78 11q24 10 202605_at GUSB 2.31 2. 30E-10 7. 03E-07 1.35 8. 72 7q21. 11 11 224841_x_at -1. 65 4.68E-09 5.86E-06-1. 42-8.60 12 224741_x_at -1. 65 4.37E-09 5.73E-06-1. 41-8.57 13 200985 s at CD59-7.88 6. 95E-08 3.10E-05 -1. 58-8. 43 11p13 14 223136_at AIG-1 -5. 64 1. 52E-08 1. 25E-05-1.40-8. 336q24. 1 15 222862_s_at AK5 27.90 1. 73E-08 1. 36E-05 1.54 8.23 1p31 16201496xat MYH11 3. 43 1. 98E-09 4. 53E-06 1.31 8.22 16p13.13-p13. 12 17 211709_s_at SCGF 3. 66 3.59E-10 9. 87E-07 1.25 8. 20 19q13. 3 18 212358_at CLIPR-59 18.74 2. 53E-08 1. 66E-05 1.56 8. 09 19q13. 12 19 226197 at 2. 63 3. 14E-09 4. 93E-06 1.25 7.94 20 200984 s at CD59-3.23 8. 03E-08 3. 39E-05-1.39-7. 92 11p13 21 218217_at RISC 2. 67 3. 47E-09 4. 93E-06 1.24 7. 88 17q23. 1 22 201462_at KIAA0193 -5. 53 4. 85E-08 2. 30E-05-1.33-7. 86 7p14.3-p14. 1 23 210997_at HGF 22.58 4. 15E-08 2. 12E-05 1.46 7. 82 7q21.1 24226121at MGC23280-2.43 3. 57E-08 1. 91E-05-1.30-7. 81 17q11. 1 25 228497_at FLIPT1 -3. 42 1. 25E-07 4. 52E-05-1.39-7. 80 1p13. 1 26 208702 x at APLP2 2. 40 2. 97E-09 4. 93E-06 1.20 7. 78 11q24 27 220668sat DNMT3B-5.06 3.67E-07 9.36E-05-1. 54-7.76 20q11. 2 28 214875_x_at APLP2 2. 55 1. 88E-09 4. 53E-06 1.19 7. 75 11q24 29 207961_x_at MYH11 13.58 5. 40E-08 2. 52E-05 1.43 7.71 16p13. 13-p13. 12 30 204198 s at RUNX3-5.88 2. 49E-07 7. 54E-05-1.42-7. 69 1p36 31 201029_s_at CD99 1. 55 1.51E-08 1. 25E-05 1.23 7. 67 Xp22.32 32205076sat CRA 4.58 4. 39E-08 2. 16E-05 1.35 7. 66 1q12-q21 33 231736_x_at MGST1 3.21 2. 85E-09 4. 93E-06 1.16 7. 56 12p12.3-p12. 1 34 223640_at PIK3AP 2. 38 3. 34E-09 4. 93E-06 1.15 7. 53 19q13. 1 35 200078_s_at-HG-U133B ATP6V0B 2. 01 3. 17E-09 4. 93E-06 1.15 7. 51 1p32. 3 36 209975_at CYP2E1 3. 78 2. 34E-08 1. 61E-05 1.22 7. 50 10q24. 3-qter 37 224918 x at MGST1 2. 97 3. 48E-09 4. 93E-06 1.14 7. 49 12p12. 3-p12. 1 38 202185_at PLOD3 1. 83 3. 58E-09 4. 93E-06 1.14 7.49 7q22 39 200872_at S100A10 3. 00 7. 76E-09 7. 90E-06 1.16 7. 47 1q21 40241525at LOC200772 37.93 9. 78E-08 3. 74E-05 1.41 7. 47 2q37. 3 41 230896_at -41. 32 9. 11E-07 1.71E-04 -1. 70-7.47 42208704xat APLP2 2. 39 4. 96E-09 5. 93E-06 1.14 7. 44 11q24 43 243244 at 3. 09 6. 78E-09 7. 47E-06 1.14 7.41 44212463at-4. 59 5. 24E-07 1. 13E-04-1.39-7. 39 45 202283_at SERPINF1 4. 66 2. 32E-08 1. 61E-05 1.17 7. 33 17p13. 1 46 205859 at LY86 3. 57 7.41E-09 7. 84E-06 1.12 7. 32 6p24. 3 47 204122 at TYROBP 2. 73 6. 45E-09 7. 40E-06 1.12 7. 31 19q13. 1 48 223091_x_at GL004 -1.53 1.84E-08 1.41E-05 -1. 14-7. 30 2q36. 3 49 205131 x at SCGF 4. 95 3. 38E-08 1. 90E-05 1.17 7. 29 19q13. 3 50 238151_at 2. 68 3.62E-08 1.91E-05 1.16 7.27 2.65 AML inv (16) versus AML_komplext # affy id HUGO name fc p q stn t Map Location 1 209190_s_at DIAPH1 2. 58 2. 08E-14 1. 34E-10 1.64 11. 80 5q31 2 201497_x_at MYH11 20.34 5. 66E-11 2. 80E-08 2.00 11. 03 16p 13.13-p13. 12 3 201496_x_at MYH11 8. 16 1. 93E-11 1.38E-08 1.63 10. 61 16p13. 13-p13. 12 4 200984_s_at CD59-5.61 1. 78E-12 3. 27E-09-1.54-10. 44 11p13 5 212463at-8. 87 3.40E-12 4.96E-09-1. 59-10.41 6209619at CD74 2. 48 3. 74E-13 9. 64E-10 1.42 10.41 5q32 7222229xat 1.45 1.28E-14 1.34E-10 1.35 10.37 8 200985_s_at CD59-13.21 5. 81E-12 6. 02E-09-1.54-10. 16 11p13 9 200093 s at-HG-U133B HINT1 1. 79 8. 03E-14 3. 45E-10 1.28 9. 82 5q31. 2 10205382sat DF 3. 68 3. 91 E-12 5. 04E-09 1.31 9.62 19p13. 3 11 206847_s_at HOXA7-3.70 1. 36E-12 2. 91 E-09-1. 30-9. 60 7p15-p14 12217846at QARS 1.68 3. 05E-13 9. 64E-10 1.24 9. 52 3p21.3-p21. 1 13 232247 at FLJ14855-2.34 1. 13E-11 9. 74E-09-1.26-9. 183p21. 31 14 204198_s_at RUNX3-7.48 5. 36E-11 2. 76E-08-1.33-9. 13 1p36 15 208886_at H1F0 -5. 94 4. 78E-11 2. 56E-08-1.28-9. 01 22q13. 1 16207332sat TFRC-2.71 6. 34E-11 2. 90E-08-1.29-8. 98 3q26. 2-qter 17201360at CST3 4.32 4. 84E-10 1. 18E-07 1.34 8. 97 20p11. 21 18 241706_at LOC144402-5.96 4. 36E-11 2. 56E-08-1.26-8. 96 12q11 19 202413_s_at USP1 -1. 86 3. 47E-12 4. 96E-09-1.16-8. 85 1p32. 1-p31. 3 20223276_at NID67 2. 53 9. 44E-11 3. 80E-08 1.23 8. 855q33. 1 21217963sat NGFRAP1-19.01 2. 22E-10 6. 97E-08-1.35-8. 83 Xq22. 1 22 200675 at CD81-3.56 6. 30E-12 6. 02E-09-1.16-8. 82 11p15. 5 23218040at FLJ10330-2.22 6. 54E-12 6. 02E-09-1.16-8. 82 1p13. 2 24 210715_s_at SPINT2 -3. 66 1. 37E-11 1. 10E-08-1.17-8. 76 19q13. 1 25209523at TAF2-2.75 5. 20E-12 6. 02E-09-1.14-8. 74 8q24. 12 26244552at-4. 00 6. 01E-11 2. 86E-08-1.19-8. 64 27 200983 x at CD59-8.23 3. 32E-10 9. 44E-08-1.29-8. 61 11 p13 28 244741_s_at -6. 23 3. 17E-10 9. 29E-08-1.27-8. 58 29 235753_at -6. 27 5. 94E-10 1. 32E-07-1.32-8. 50 30 200665 s at SPARC 3.15 4. 51 E-11 2. 56E-08 1.13 8. 49 5q31. 3-q32 31 202406_s_at TIAL1 -1.66 1.81E-11 1. 37E-08-1.11-8. 47 10q 32 213779 at LOC129080-3.29 1. 78E-10 5. 89E-08-1.19-8. 46 22q12. 1 33 212066_s_at KIAA0570 -1.86 4.63E-11 2. 56E-08-1.12-8. 39 2p14 34208033sat ATBF1 3.73 1. 09E-09 1. 97E-07 1.20 8. 3516q22. 3-q23.1 35224724at SULF2 5. 32 3. 98E-09 4. 79E-07 1.29 8. 35 20q12-13. 2 36214651sat HOXA9-11.93 7. 94E-10 1. 57E-07-1.26-8. 34 7p15-p14 37 225383_at ZNF275 -1.92 8.65E-11 3. 59E-08-1.12-8. 32 Xq28 38 213737_x_at -2. 31 1. 73E-10 5. 89E-08-1.14-8. 30 39201663sat SMC4L1-2. 67 2. 46E-10 7. 54E-08-1.14-8. 26 3q26. 1 40203965at USP20-2.20 3. 14E-11 2. 13E-08-1.07-8. 21 9q34. 13 41 205718_at ITGB7 3. 46 6. 54E-11 2. 90E-08 1.08 8. 20 12q13. 13 42 218414_s_at NUDE1-2.89 7. 27E-10 1. 49E-07-1.19-8. 19 16p13. 11 43 201377_at NICE-4 -1. 89 8. 01E-11 3. 44E-08-1.08-8. 16 1q21. 3 44212826sat SLC25A6 1. 63 3.95E-11 2.54E-08 1. 06 8. 15 Xp22. 32 and Yp 45 223769 x at HT036-2.28 3. 80E-10 1. 01 E-07-1. 13-8. 13 1 p34. 1 46 202265_at BMI1 -2. 97 4. 98E-10 1. 18E-07-1.13-8. 10 10p11. 23 47 230219_at NUDE1 -2. 08 1. 63E-10 5. 82E-08-1.08-8. 10 16p13. 11 48 207992_s_at AMPD3-2. 91 3. 85E-10 1. 01E-07-1. 11-8. 08 11p15 49200620at C1orf8-1. 54 1. 23E-10 4. 67E-08-1.07-8. 051p36-p31 50208691_at TFRC-2.54 8. 50E-10 1. 63E-07-1.14-8. 043q26. 2-qter 2.66 AML inv (16) versus AML normal # affy id HUGO name fc p q stn t Map Location 1 214651sat HOXA9-15.60 1. 51E-50 3.70E-46-1. 56-21.11 7p15-p14 2 235753_at -9. 87 2.28E-43 2.79E-39-1. 43-18.94 3202370sat CBFB-2.88 5.35E-39 2.62E-35-1. 37-18.11 16q22. 1 4209905at HOXA9-42.82 1. 78E-40 1. 45E-36-1.37-17. 97 7p15-p14 5 206847_s_at HOXA7-5.53 2. 77E-39 1. 70E-35-1.28-17. 237p15-p14 6227567at-4. 62 4.65E-33 1.35E-29-1. 28-16.62 7 225055_at DKFZp667M2411-4. 40 5. 34E-31 7.27E-28-1. 26-16.22 17q11. 2 8 235521_at HOXA3-16.02 4.97E-33 1.35E-29-1. 15-15.15 7p15-p14 9 226352_at -5. 91 2.86E-33 1. 00E-29 -1. 11-15.00 10 217963_s_at NGFRAP1 -13. 11 1. 67E-33 6. 83E-30-1.11-14. 98 Xq22. 1 11 209406at BAG2-4.64 7.16E-33 1.76E-29-1. 10-14.82 6p12. 3-p11. 2 12 205600_x_at HOXB5-2.62 1.69E-30 2.04E-27-1. 12-14.77 17q21. 3 13 213737_x_at -2. 46 6.60E-29 6.75E-26-1. 12-14.63 14230894sat-12. 81 2.08E-32 4.64E-29-1. 08-14.60 15 239791_at -20. 47 3.77E-31 5.44E-28-1. 12-14.55 16205366sat HOXB6-16.15 3.25E-31 4.98E-28-1. 10-14.52 17q21. 3 17213844_at HOXA5-8.69 8. 84E-31 1. 14E-27-1.08-14. 47 7p15-p14 18219304sat SCDGF-B-3. 99 1. 01E-31 2. 07E-28-1.06-14. 39 11q22. 3 19236892sat-17. 80 1.75E-30 2.04E-27-1. 11-14.35 20 223044_at SLC11A3-9. 53 1. 57E-31 2. 97E-28-1.06-14. 33 2q32 21 219218 at FLJ23058-7.40 1. 93E-31 3. 39E-28-1.06-14. 33 17q25.3 22222786at C4S-2-3.63 3.17E-31 4.98E-28-1. 05-14. 20 7p22 23 213353_at ABCA5 -3. 36 5.69E-22 2. 15E-19-1. 16-13.98 17q24.3 24 213147 at HOXA10-4.11 4. 96E-23 2. 10E-20-1.12-13. 86 7p15-p14 25205601sat HOXB5-3.21 1. 20E-29 1. 34E-26-1.03-13. 83 17q21. 3 26201432at CAT-2.16 1.50E-20 4.32E-18-1. 15-13.65 11p13 27 223471_at RAB3IP -3. 45 6.74E-26 3.84E-23-1. 05-13.63 28218477_at PTD011-3. 14 2. 57E-27 1. 97E-24-1.03-13. 60 6p12. 1 29 241706_at LOC144402-6.07 6.58E-29 6.75E-26-1. 01-13. 54 12q11 30 213110 s at COL4A5-16.80 2. 11E-28 2.07E-25-1. 02-13.49 Xq22 31 225102at LOC152009-4.58 3.57E-28 3.24E-25-1. 00-13.40 3q21. 3 32224952at DKFZP564D166-3. 65 8.18E-22 2. 99E-19-1. 09-13.36 17q23.3 33 226134_s_at -6. 42 2. 25E-28 2.12E-25-0. 98-13.22 34216920sat TRGV9-4.98 5. 46E-28 4.79E-25-0. 97-13.15 7p15 35211031sat CYLN2-7.02 5.93E-28 5. 01E-25-0. 97-13. 13 7q11. 23 36228904at-6. 03 1.55E-27 1.23E-24-0. 98-13.07 37235749at UGCGL2-6.19 1.36E-27 1. 11E-24 -0. 96-13.01 13q32.1 38 235391 at LOC137392-11.22 7.87E-27 5.68E-24-0. 97-12.91 8q21. 3 39 213779_at LOC129080-2. 94 4. 00E-25 2.04E-22-0. 98-12.87 22q12. 1 40 200985_s_at CD59-7.70 4.63E-27 3.44E-24-0. 94-12.78 11p13 41 200984sat CD59-3.69 1.84E-26 1.25E-23-0. 94-12.68 11p13 42201669sat MARCKS-11.88 2. 19E-26 1.41E-23 -0. 95-12. 68 6q22. 2 43 215806_x_at TRGC2-4.58 1. 90E-26 1. 26E-23-0.94-12. 66 7p15 44206289at HOXA4-3.00 6.37E-26 3.72E-23-0. 95-12. 66 7p5-p14 45 218445 at H2AFY2-5.09 1. 78E-26 1. 24E-23-0.94-12. 63 10q22 46228365at LOC144402-8.67 5.70E-26 3. 41E-23-0. 94-12.59 12q11 47213150at HOXA10-6.21 2. 24E-22 8. 86E-20-0.99-12. 59 7p15-p14 48 210425_x_at GOLGIN-67 -4. 62 2. 27E-26 1. 43E-23-0.93-12. 56 15q11. 2 49 227224 at FLJ25604-4. 81 1. 44E-23 6. 30E-21-0.97-12. 55 1q24. 2 50 203949_at MPO 2. 08 5. 62E-21 1.72E-18 1.00 12.50 17q23.1 2.67 AML inv (16) versus AML_t (15; 17) affy id HUGO name fc p q stn t Map Location 1211990at HLA-DPA1 12.87 6. 59E-19 1. 76E-14 3.40 20.83 6p21. 3 2 214450at CTSW-7.68 6.17E-13 5. 50E-10-2. 95-15.78 11q13. 1 3204661at CDW52 33.90 2. 84E-14 7. 34E-11 2.75 15. 39 1p36 4 38487_at STAB1-7. 92 2.48E-12 1. 89E-09-3.00-15. 223p21. 31 5209732at CLECSF2 30.41 1. 19E-13 1. 77E-10 2.75 14. 76 12p13-p12 6 217478_s_at HLA-DMA 7. 72 5.11E-15 2.13E-11 2.38 14. 68 6p21. 3 7 221004_s_at ITM2C -4. 93 9. 59E-14 1. 51E-10-2. 43-14. 58 2q37 8 34210_at CDW52 43.95 1. 36E-13 1. 92E-10 2.64 14.51 1p36 9200654at P4HB-2.26 2. 17E-15 1. 16E-11-2.24-14. 34 17q25 10203535_at S100A9 8. 87 5. 77E-16 5. 14E-12 2.17 14. 08 1q21 11 209619_at CD74 5. 65 4. 69E-17 6. 26E-13 2.09 13.92 5q32 12238022at-8. 04 2. 75E-12 2. 00E-09 -2. 31-13.37 13200931sat VCL 3. 99 1. 89E-15 1. 16E-11 2.04 13. 29 10q22. 1-q23 14201923at PRDX4 7.40 5.83E-14 1. 11E-10 2.12 13. 18Xp22. 13 15 209312_x_at HLA-DRB1 8. 91 4. 83E-14 9. 92E-11 2.10 13.11 6p21. 3 16 208306_x_at HLA-DRB4 9.68 8. 26E-14 1. 47E-10 2.12 13.11 6p21. 3 17205624at CPA3-8.88 1. 01E-11 5.61E-09 -2. 34-13. 07 3q21-q25 18204563at SELL 9. 19 5.06E-13 5.01E-10 2.18 12. 90 1q23-q25 19 204670_x_at HLA-DRB5 6. 82 5.58E-15 2.13E-11 1.94 12. 69 6p21. 3 20231310at 4. 86 4.39E-14 9.77E-11 1.98 12.63 21 208891_at DUSP6 7. 87 1.16E-14 3.88E-11 1.92 12. 52 12q22-q23 22 212953 x at CALR-2.83 3. 00E-14 7. 34E-11-1. 93-12.49 19p13. 3-p13. 2 23238365sat-10. 18 1.04E-10 3.05E-08-2. 44-12.36 24 207375_s_at IL15RA 4.86 3.02E-14 7. 34E-11 1.86 12.14 10p15-p14 25221059sat CHST6 6. 79 8.00E-13 6. 89E-10 1.98 12.11 16q22 26 208982_at PECAM1 4. 84 3. 84E-13 4. 22E-10 1.91 11.99 17q23 27 205718_at ITGB7 6. 51 4. 60E-13 4. 72E-10 1.91 11. 97 12q13. 13 28205663at PCBP3-4.82 1. 21E-11 6.17E-09-2. 01-11. 95 21 q22. 3 29 229168_at DKFZp434K0621 -6. 66 3. 87E-10 8.47E-08-2. 35-11. 575q35. 3 30 233072_at KIAA1857 -7. 11 2. 16E-10 5. 54E-08-2.13-11. 47 9q34 31 211991_s_at HLA-DPA1 25.47 2. 35E-11 1.07E-08 2.09 11.45 6p21. 3 32224583_at COTL1 5. 47 3. 94E-13 4. 22E-10 1.78 11. 4416q23. 3 33 232617_at CTSS 8. 68 2. 07E-11 9. 71E-09 2.05 11.43 1q21 34 224839_s_at GPT2-8. 67 4.98E-11 1. 73E-08-1.95-11. 38 16q12. 1 35 201497_x_at MYH11 29.05 4. 61E-11 1.65E-08 2.19 11. 25 16p13.13-p13. 12 36 241742_at PRAM-1 11.62 2. 96E-11 1. 22E-08 2.01 11.23 19p13. 2 37226878_at 4. 23 4.00E-12 2.61E-09 1. 81 11.18 38201137sat HLA-DPB1 15.27 5. 30E-11 1. 81E-08 1.99 10. 99 6p21. 3 39208689sat RPN2-1.74 1. 74E-13 2. 32E-10-1.65-10. 96 20q12-q13. 1 40 201496_x_at MYH11 10.95 8. 48E-12 5. 03E-09 1.78 10. 95 16p13.13-p13. 12 41 202803_s_at ITGB2 5. 33 5. 45E-13 5. 20E-10 1.66 10.86 21q22. 3 42204150at STAB1-9. 251. 13E-092. 11E-07-2. 20-10. 85 3p21. 31 43238376_at 3.13 1.34E-12 1. 11E-09 1.68 10.82 44202820_at AHR 7. 11 91E-122. 05E-09 1.69 10. 77 7p15 45 202644_s_at TNFAIP3 2. 63 9.42E-14 1.51E-10 1.60 10. 76 6q23 46 223280_x_at MS4A6A 24.32 1. 17E-10 3. 37E-08 2.00 10. 68 11q12. 1 47228046_at LOC152485 3.11 5.33E-12 3.39E-09 1.69 10. 68 4q31.1 48228113_at STAT3 3. 41 2.65E-13 3.31E-10 1.60 10. 63 17q21 49 213779_at LOC129080-6.48 1. 04E-09 1. 96E-07-2.02-10. 63 22q12. 1 50210982sat HLA-DRA 7.45 1.37E-12 1. 11E-09 1.63 10. 60 6p21. 3 2.68 AML_inv(16) versus AML t (8; 21) # affy id HUGO name fc p q stn t Map Location 1 207075_at CIAS1 6.20 6.53E-13 4.40E-09 2.14 12. 84 1q44 2 205718_at ITGB7 7. 97 2. 06E-13 2. 37E-09 1.94 12. 42 12q13. 13 3208890sat PLXNB2 5. 47 2.82E-13 2. 37E-09 1.95 12. 41 22q13. 33 4224764at ARHGAP10 9. 78 6.18E-12 1. 89E-08 2.04 11. 88 10 5 205419_at EBI2 7. 28 3. 55E-12 1. 52E-08 1.93 11. 76 13q32. 2 6218795_at ACP6-4.43 2.56E-13 2.37E-09-1. 71-11.41 1q21 7 224049_at KCNK17 4. 96 2.15E-11 5. 57E-08 1.93 11. 23 6p21. 1 8 201497_x_at MYH11 27.72 4. 77E-11 7. 64E-08 2.18 11. 23 16p13.13-p13. 12 9218236sat PRKCN 5.61 2.01E-12 1.13E-08 1.65 10.88 2p21 10 238604_at 3.46 2.13E-13 2.37E-09 1. 50 10.47 11 205453_at HOXB2 15.78 1. 65E-10 1. 74E-07 1.88 10.41 17q21-q22 12 201596 x at KRT18 9. 11 3.90E-11 6.91E-08 1.67 10.37 12q13 13 224724 at SULF2 26.58 2. 51E-10 2. 26E-07 1.96 10.31 20q12-13. 2 14209365sat ECM1 3. 32 5. 67E-12 1. 89E-08 1.52 10. 17 1q21 15228827at-100. 56 4. 49E-10 3.22E-07-1. 97-10.04 16201496xat MYH11 6. 61 2.98E-11 6. 14E-08 1.55 10. 02 16p13.13-p13. 12 17200665sat SPARC 3. 67 6.00E-12 1. 89E-08 1.49 10. 02 5q31. 3-q32 18201739_at SGK 4.55 3.60E-12 1.52E-08 1.46 9. 97 6q23 19201944_at HEXB 2.26 3. 09E-11 6.14E-08 1.52 9. 92 5q13 20 209500_x_at TNFSF13 4. 26 1. 51E-10 1. 70E-07 1.52 9. 61 17p13. 1 21 235359_at 3. 06 5.86E-11 8. 57E-08 1.46 9.56 22203320_at LNK 2. 89 7. 98E-11 1. 12E-07 1.47 9. 5612q24 23208683_at CAPN2 3. 25 1.30E-11 3. 66E-08 1.39 9. 47 1q41-q42 24 211084_x_at PRKCN 4.90 2. 81 E-11 6.14E-08 1.40 9. 46 2p21 25 217849_s_at CDC42BPB 5. 22 3. 31E-11 6. 19E-08 1.41 9. 4614q32. 3 26 210314_x_at TNFSF13 5.02 1.80E-10 1.80E-07 1.48 9. 45 17p13. 1 27206940sat POU4F1-37. 07 1. 50E-09 8. 29E-07-1.82-9. 42 13q21.1-q22 28 201887_at IL13RA1 4. 32 3.65E-10 2. 73E-07 1.52 9. 40 Xq24 29223249_at CLDN12 3. 44 5.41E-11 8.27E-08 1.41 9. 40 7q21 30240572sat 3.50 3. 10E-11 6.14E-08 1.39 9.40 31 220974_x_at BA108L7. 2 4. 98 1. 02E-10 1. 33E-07 1.39 9. 22 10q24. 31 32205529sat CBFA2T1-14. 03 2. 39E-09 1. 17E-06-1. 70-9.16 8q22 33236738_at 7. 02 4.91E-10 3. 38E-07 1.44 9.10 34201005at CD9 7. 50 3.32E-10 2. 65E-07 1.40 9. 04 12pu3. 3 35201360_at CST3 4. 55 3. 35E-10 2. 65E-07 1.39 9. 02 20p11. 21 36225102at LOC152009-3.87 3. 38E-10 2. 65E-07-1.34-8. 83 3q21. 3 37 218237_s_at SLC38A1 3. 46 4. 08E-10 2. 98E-07 1.35 8. 82 12q12 38205330_at MN1 9. 47 3. 99E-09 1. 74E-06 1.56 8. 81 22q12. 1 39225602at C9orf19 2. 74 4. 53E-11 7. 63E-08 1.26 8. 759p13-p12 40220591sat FLJ22843 3. 10 7.60E-10 4. 74E-07 1.35 8. 72 Xp11. 3 41 229309_at 10. 85 4.42E-09 1.91E-06 1.52 8.71 42229383_at 5. 16 3. 78E-09 1. 67E-06 1.46 8.66 43 201425_at ALDH2 6. 54 3.46E-10 2. 65E-07 1.29 8. 64 12q24. 2 44 229406_at -8. 50 3. 12E-09 1. 48E-06-1.43-8. 63 45 208033_s_at ATBF1 4. 00 81E-104. 41E-07 1.30 8. 57 16q22. 3-q23.1 46 205859_at LY86 3. 64 2. 66E-09 1. 28E-06 1.38 8. 57 6p24. 3 47 211341_at POU4F1 -162. 01 1. 01E-08 3. 29E-06-1.68-8. 52 13q21.1-q22 48224579_at 3.69 1. 71E-09 9.28E-07 1.33 8.52 49202283_at SERPINF1 8. 19 2. 29E-09 1. 15E-06 1.35 8. 51 17p13. 1 50 226818_at LOC219972 10.78 6. 29E-09 2. 38E-06 1.45 8. 48 11q12. 1 2.69 AML inv (3) versus AML komplext &num affy id HUGO name fc p q stn t Map Location 1222229xat 1. 59 1. 43E-12 2. 58E-08 1.49 10.36 2206781_at DNAJC4 2. 26 7.27E-11 4. 54E-07 1.37 9. 35 11q13 3 208730_x_at RAB2 2. 22 1. 23E-09 1. 71E-06 1.38 9. 00 8q12. 1 4 200093_s_at-HG-U133B HINT1 1. 88 6. 67E-10 1. 71 E-06 1.21 8. 35 5q31. 2 5213682at NUP50-1.96 7. 52E-11 4. 54E-07-1. 14-8. 23 22q13. 31 6227708at EEF1A1 2. 34 1. 67E-08 8. 16E-06 1.30 8. 20 6q14. 1 7 208826_x_at HINT1 1.52 5.20E-10 1.64E-06 1.14 8. 05 5q31. 2 8 201202_at PCNA-2.84 2. 31E-10 1. 05E-06-1.10-7. 93 20pter-p12 9209122at ADFP-4.15 1. 08E-09 1.71E-06 -1. 12-7. 829p21. 3 10200700sat KDELR2-2.80 1. 13E-09 1.71E-06 -1. 09-7. 677p22. 2 11 201377_at NICE-4 -1. 90 5. 46E-10 1.64E-06-1. 06-7. 67 1q21. 3 12203538_at CAMLG 2. 07 4.91E-08 1.51E-05 1.20 7. 65 5q23 13205436sat H2AFX-3.79 2. 79E-09 2. 71 E-06-1. 12-7. 64 11 q23. 2-q23.3 14218883sat FLJ23468-2.56 8. 92E-10 1.71E-06 -1. 07-7. 634q35. 1 15 200094_s_at-HG-U133A EEF2 1. 41 4. 93E-09 3. 72E-06 1.09 7. 56 19pter-q12 16201663sat SMC4L1-2. 49 1. 36E-09 1. 76E-06-1.06-7. 55 3q26. 1 17201386sat DDX15-1.79 9. 01E-10 1.71E-06 -1. 05-7. 53 4p15. 3 18222047sat ARS2-1.55 1. 08E-09 1.71E-06 -1. 04-7. 50 7q21 19 212491 s at DNAJC8-1.75 2. 35E-09 2. 61 E-06-1. 05-7. 47 1 p35. 2 20206550sat NUP155-2.08 2. 18E-09 2.61E-06 -1. 04-7. 40 5p13. 1 21 203421_at PIG11 -6. 24 1. 66E-08 8. 16E-06-1.14-7. 30 11p11. 2 22 212031 at S164-1.92 2. 84E-09 2.71E-06 -1. 02-7. 28 14q24. 3 23213008at FLJ10719-2. 96 2. 45E-09 2.61E-06 -1. 01-7. 25 15q25-q26 24202580xat FOXM1-3.95 7. 57E-09 4. 72E-06-1.05-7. 25 12pu3 25 218115_at ASF1B -2. 62 4. 20E-09 3. 55E-06-1.02-7. 24 19p13. 12 26213088sat DNAJC9-2.44 7. 48E-09 4. 72E-06-1.03-7. 18 10q22. 2 27213292sat SNX13-2.17 6. 26E-09 4. 35E-06-1.01-7. 16 7p21. 1 28 204695 at CDC25A-4. 38 1.11E-08 6.26E-06-1. 03-7. 14 3p21 29 218585_s_at RAMP-3.20 1. 41E-08 7. 48E-06-1.04-7. 12 30208715at LOC54499-2.21 4. 16E-09 3. 55E-06-0.99-7. 11 1q22-q25 31 201457_x_at BUB3-1. 73 4. 55E-09 3. 57E-06-0.99-7. 10 10q26 32222680sat RAMP-2.06 4. 32E-09 3. 55E-06-0.98-7. 10 33 211950_at RBAF600-2.14 6. 18E-09 4. 35E-06-0.99-7. 08 1p36. 13 34223157_at MGC3232 2. 00 4. 48E-07 5. 23E-05 1.18 7. 074q12 35 215123_at -3. 06 7. 02E-09 4. 70E-06-0.97-6. 98 36 227165_at C13orf3 -2.41 1.84E-08 8.51E-06 -1. 01-6. 98 13q11 37218350sat GMNN-2.41 1. 04E-08 6. 07E-06-0.97-6. 93 6p22. 1 38202954_at UBE2C-3.17 3. 02E-08 1.21E-05 -1. 02-6. 91 20q13. 11 39 232247_at FLJ14855-2.01 8. 55E-09 5. 15E-06-0.96-6. 91 3p21. 31 40 214141_x_at SFRS7-1.77 1. 72E-08 8. 17E-06-0.98-6. 902p22. 1 41 201680_x_at ARS2-1. 59 1. 17E-08 6. 43E-06-0.95-6. 82 7q21 42 202413_s_at USP1 -1. 82 3. 54E-08 1.31E-05 -0. 97-6. 82 1p32.1-p31. 3 43 209619_at CD74 2. 00 1. 60E-07 2. 89E-05 1.03 6.82 5q32 44200094sat-HG-U133B EEF2 1.39 4. 08E-08 1. 44E-05 0.98 6. 81 19pter-q12 45 226123_at LOC286180-3.56 2. 20E-08 9. 47E-06-0.96-6. 80 8q12. 1 46 204709_s_at KIF23 -4. 17 6. 32E-08 1. 77E-05-1.03-6. 80 15q22. 31 47210140at CST7-4.76 5. 60E-08 1. 66E-05-1.01-6. 78 20p11. 21 48 210178_x_at FUSIP1 -1. 97 1. 54E-08 7. 94E-06-0.94-6. 77 1p36. 11 49 227056 at 3.40 1.85E-06 1.23E-04 1.20 6.72 50 204023_at RFC4-2.23 1. 88E-08 8.51 E-06-0.93-6. 70 3q27 2.7 AML inv (3) versus AML_normal # affy id HUGO name fc p q stn t Map Location 1 236892sat-14. 20 7.34E-30 2.13E-25-1. 08-14.07 2 239791_at -12. 32 1.45E-29 2.13E-25-1. 05-13.83 3204082at PBX3-5.18 1. 68E-28 1. 65E-24-1.04-13. 72 9q33-q34 4 213844 at HOXA5-6.93 1. 73E-26 1. 27E-22-1.06-13. 71 7p15-p14 5205382sat DF-5.07 6.49E-26 3. 81 E-22-1. 05-13.50 19p13. 3 6205601sat HOXB5-2.88 1. 71E-23 7. 17E-20-0.97-12. 47 17q21. 3 7228904at-6. 49 2. 08E-25 1.02E-21-0. 94-12.42 8219304sat SCDGF-B-3.13 1. 52E-21 5. 58E-18-0.90-11. 63 11q22. 3 9 235753_at -3. 43 2. 90E-18 6.08E-15-0. 93-11.44 10205366sat HOXB6-8.17 5.26E-20 1.72E-16-0. 88-11.27 17q21. 3 11 212318_at TRN-SR-2. 01 8.59E-14 6.31E-11 -1. 03-11. 17 7q32. 2 12231300at LOC90835-2.77 1. 31E-15 1. 67E-12-0.94-11. 02 16p11. 2 13 230480_at HIWI2 -3. 07 8.76E-20 2.57E-16-0. 85-10.92 11q21 14 209905 at HOXA9-4.74 5. 26E-16 7. 77E-13-0.88-10. 63 7p15-p14 15 226789_at -2. 42 1.39E-14 1. 41E-11 -0. 89-10.39 16 204301_at KIAA0711 -3. 97 6. 35E-19 1. 56E-15-0.79-10. 33 8p23.2 17 205600_x_at HOXB5 -2. 11 1. 75E-14 1.61E-11 -0. 88-10. 32 17q21. 3 18 204647_at HOMER3 -4.57 4.01E-19 1. 07E-15-0.77-10. 13 19p13. 11 19205624at CPA3-6.29 2. 57E-18 5. 80E-15-0.74-9. 833q21-q25 20214651sat HOXA9-3.29 5. 38E-12 2. 82E-09-0.90-9. 77 7p15-p14 21 230743_at-2. 34 5. 74E-17 1.05E-13-0. 76-9.75 22 204548 at STAR-4. 32 4. 25E-16 6. 93E-13-0.77-9. 73 8p11. 2 23201186at LRPAP1-2.62 7. 03E-17 1.21E-13 -0. 75-9. 70 4p16. 3 24 213893_x_at PMS2L5-1. 89 5. 37E-11 2. 15E-08-0.95-9. 68 7q11-q22 25 228293_at LOC91614 -5. 69 5. 52E-15 6. 01E-12-0. 77-9. 5711p13 26213150at HOXA10-2. 92 6. 05E-14 4. 68E-11-0. 79-9.49 7p15-p14 27213110sat COL4A5-8.16 3. 41 E-14 2. 87E-11-0. 78-9. 43 Xq22 28 216973_s_at HOXB7-3.31 3. 55E-17 6. 96E-14-0.71-9. 40 17q21. 3 29 210006_at DKFZP5640243-1. 71 1. 87E-13 1. 28E-10-0.78-9. 31 3p21. 1 30223703at CDA017-2. 17 8. 30E-15 8. 71E-12-0. 74-9. 24 10q23. 1 31 231175 at FLJ30162-5.53 1. 87E-15 2. 29E-12-0.71-9. 16 6p11. 1 32206847sat HOXA7-2.32 1. 32E-12 8. 07E-10-0.79-9. 16 7p15-p14 33 202487_s_at H2AV-1. 92 7.76E-11 2. 82E-08-0.87-9. 15 7p13 34236398sat-3. 16 1. 05E-12 6. 59E-10-0.78-9. 14 35212820_at RC3-2.79 2. 34E-15 2. 65E-12-0.70-9. 01 15q15. 3 36 201069_at MMP2-4.50 5. 29E-16 7. 77E-13-0.67-8. 95 16q13-q21 37 204779 s at HOXB7-3.55 7. 82E-16 1. 09E-12-0.68-8. 95 17q21. 3 38204332sat AGA-1.82 3. 51 E-14 2. 87E-11-0. 71-8. 944q32-q33 39 203746_s_at HCCS-1.53 1. 16E-15 1. 55E-12-0.67-8. 89 Xp22. 3 40 208967_s_at AK2-2.17 1. 76E-14 1.61E-11 -0. 70-8. 89 1p34 41 217496_s_at IDE -1. 70 4. 79E-11 1. 96E-08-0.80-8. 83 10q23-q25 42 201940_at CPD-2.14 3. 21E-14 2.77E-11 -0. 70-8. 81 17p11. 1-q11. 2 43 206289 at HOXA4-2.62 1. 79E-11 8. 23E-09-0.77-8. 76 7p15-p14 44 239503_at -4. 39 2. 32E-15 2. 65E-12-0.66-8. 75 45 213292 s at SNX13-1.74 1. 08E-10 3. 78E-08-0.81-8. 73 7p21. 1 46 219551_at TRAITS -2. 37 6. 59E-13 4.21E-10 -0. 72-8. 73 3q13. 33 47226556at-2. 643. 72E-121. 98E-09-0.73-8. 68 48209256sat KIAA0265-2. 55 1. 89E-11 8. 33E-09-0.76-8. 657q32. 2 49220261sat ZDHHC4-1. 85 6. 73E-10 1. 94E-07-0.84-8. 647p22. 2 50 243134_at -2. 09 1. 18E-11 5. 67E-09-0.74-8. 62 2.71 AML_inv (3) versus AMLt (15 ; 17) &num affy id HUGO name fc p q stn t Map Location 1 203948_s_at MPO-9.22 7.85E-20 8.48E-16-3. 33-20.18 17q23.1 2203949 at MPO-5.92 7. 32E-21 1. 58E-16-3.19-19. 69 17q23. 1 3205382sat DF-12.00 3. 95E-15 1. 07E-11-3. 44-18.83 19p13. 3 4 212953_x_at CALR-4.97 5.32E-16 2.30E-12-2. 76-16. 36 19p13. 3-p13. 2 5200654at P4HB-3.54 5. 30E-18 3. 81 E-14-2. 62-16.13 17q25 6 224918 x at MGST1-5.40 5.25E-17 2. 83E-13-2. 49-15.29 12p12. 3-p12. 1 7 231736_x_at MGST1 -6. 11 7. 03E-16 2. 53E-12-2.51-15. 14 12p12. 3-p12. 1 8214450at CTSW-6.80 4. 70E-14 1. 02E-10-2.44-14. 29 11q13. 1 9205624at CPA3-18.38 6.13E-12 5. 51E-09-2. 76-14. 18 3q21-q25 10206871_at ELA2-5.26 1.18E-15 3.64E-12-2. 20-13. 53 19p13. 3 11 211990_at HLA-DPA1 12.46 4. 97E-11 2. 98E-08 2.67 13.52 6p21. 3 12 38487_at STAB1-5. 47 4. 81E-13 6. 92E-10-2.24-13. 06 3p21. 31 13 217716_s_at SEC61A1 -2. 52 1. 00E-13 1. 65E-10-2.15-12. 88 3q21. 3 14 214575_s_at AZU1-8.67 1. 00E-13 1. 65E-10-2.12-12. 73 19p 13. 3 15238022at-7. 63 7. 53E-13 9.07E-10-2. 12-12.49 16208852sat CANX-3.04 3. 58E-12 3. 68E-09-2.18-12. 48 5q35 17 221739_at IL27w -2. 20 1.28E-14 3. 06E-11-2. 02-12. 47 19p13. 3 18 208689_s_at RPN2-2.59 1. 07E-13 1. 65E-10-2.02-12. 26 20q12-q13. 1 19 221004_s_at ITM2C -4. 37 5.63E-14 1. 11E-10 -1 99-12. 16 2q37 20 23372_at KIAA1857 -9. 87 1.26E-10 6.35E-08-2. 39-12. 10 9q34 21 210788sat retSDR4-2.78 4.14E-12 4.06E-09-2. 00-11.71 14q22.3 22 206914_at CRTAM 6. 73 2.22E-11 1.60E-08 2.03 11. 62 11q22-q23 23 211709_s_at SCGF-5.57 6.43E-13 8.68E-10-1. 91-11. 55 19q13. 3 24213716sat SECTM1 10. 56 1. 74E-09 5. 54E-07 2.25 11.11 17q25 25 227353_at EVER2 5.13 2. 92E-10 1. 24E-07 2.00 11.00 17q25.3 26 209021_x_at KIAA0652 -5.31 1.35E-11 1. 12E-08-1.84-10. 90 11p11. 12 27 214797_s_at PCTK3 5. 81 2. 43E-10 1. 05E-07 1.95 10.87 1q31-q32 28208730xat RAB2 2. 63 4. 23E-10 1. 72E-07 1.98 10.86 8q12. 1 29 202487 s at H2AV-2.35 7. 56E-13 9.07E-10-1. 76-10.82 7p13 30203675_at NUCB2-3.45 1. 59E-11 1. 27E-08-1.83-10. 81 11p15. 1-p14 31 217225rat LOC283820-2.26 2.10E-12 2.26E-09-1. 77-10.77 16p13. 13 32 200652_at SSR2-1.99 1. 05E-12 1. 19E-09-1.73-10. 68 1q21-q23 33 209215_at TETRAN-3.46 4.99E-12 4.68E-09-1. 75-10. 63 4pu 6. 3 34 229168_at DKFZp434K0621 -4. 90 5.86E-10 2.30E-07-1. 95-10.53 5q35.3 35 209619_at CD74 4.55 1. 98E-11 1.47E-08 1.72 10.36 5q32 36221253sat MGC3178-3.26 1. 04E-10 5. 78E-08-1.78-10. 33 6p24.3 37210140_at CST7-8.32 1. 51E-09 5.06E-07-1. 98-10.31 20p11. 21 38224839sat GPT2-6.24 6. 83E-11 3. 88E-08-1.74-10. 23 16q12. 1 39 217770_at PIGT -2.32 1.69E-11 1. 30E-08-1.68-10. 17 20q12-q13. 12 40 205614_x_at MST1-9.35 3. 11E-09 8.56E-07-2. 03-10. 12 3p21 41 209732 at CLECSF2 29.15 1. 41E-08 2. 74E-06 2.22 10.02 12p13-p12 42201004 at SSR4-2.56 2. 78E-11 1. 82E-08-1.64-9. 95 Xq28 43204897 at PTGER4 5. 27 1.51E-10 7.41E-08 1.68 9. 90 5p13. 1 44 201029 s at CD99-1. 81 1. 13E-11 9. 73E-09-1.61-9. 89 Xp22. 32 45 241696_at 3. 13 3.64E-11 2. 25E-08 1.62 9.81 46 214789 x at SRP46 4.12 8. 67E-10 3. 28E-07 1.71 9. 76 11q22 47 201825_s_at CGI-49 -3. 27 2. 66E-11 1. 79E-08-1.57-9. 61 1q44 48 204150 at STAB1-5.48 2.26E-09 6.96E-07-1. 74-9. 57 3p21. 31 49 241383_at -4. 21 2. 75E-09 7. 92E-07-1.75-9. 55 50200068sat-HG-U133B CANX-1. 652. 98E-11 1.89E-08-1. 55-9. 52 5q35 2.72 AML_inv (3) versus AML_t (8; 21) # affy id HUGO name fc p q stn t Map Location 1 203949 at MPO-5.44 5.57E-18 1.52E-13-2. 29-14.96 17q23.1 2203948_s_at MPO-6.74 3.58E-14 4.89E-10-1. 89-12.11 17q23.1 3209122at ADFP-3.38 1.03E-12 9.42E-09-1. 55-10. 15 9p21. 3 4228827at-92. 61 4.57E-10 2.08E-06-1. 97-10.03 5217963sat NGFRAP1 34.31 1. 80E-08 2. 47E-05 2.15 9. 83 Xq22. 1 6211709sat SCGF-4.29 8. OIE-12 5. 47E-08-1.44-9. 45 19q13. 3 7211084rat PRKCN 5. 66 3. 98E-09 9. 88E-06 1.59 9. 24 2p21 8205529sat CBFA2T1-14. 76 2.25E-09 6.83E-06 -1. 74-9.20 8q22 9233955_x_at HSPC195 5. 01 2. 80E-08 3. 47E-05 1.80 9. 19 5q31. 3 10207839sat LOC51754 3. 06 2.36E-10 1. 29E-06 1.45 9. 13 9p13. 1 11 213716_s_at SECTM1 4. 93 3. 75E-09 9. 88E-06 1.55 9.11 17q25 12229406at-12. 12 1. 70E-09 6. 39E-06-1.60-9. 09 13 202887 s at RTP801 4. 18 5. 07E-08 4. 62E-05 1.52 8. 39 10pter-q26. 12 14 205528_s_at CBFA2T1 -27. 75 1. 41E-08 2. 15E-05-1.56-8. 32 8q22 15212895sat ABR 2. 87 3. 10E-08 3. 53E-05 1.36 8. 06 17p13. 3 16212423at FLJ90798 3.77 4. 04E-08 4. 42E-05 1.34 7. 93 10q22. 3 17 206871_at ELA2-4.45 1. 87E-09 6. 39E-06-1.22-7. 88 19p13. 3 18 217226_s_at BA108L7. 2 3. 17 4.71E-08 4. 62E-05 1.31 7. 79 10q24.31 19 204494_s_at DKFZP434H132 4. 61 3. 95E-07 1. 37E-04 1.56 7. 76 15q22.33 20225010at D10S170 2. 54 1. 04E-08 1. 77E-05 1.23 7. 75 10q21 21210150sat LAMA5-3.67 7. 23E-09 1. 52E-05-1.23-7. 73 20q13. 2-q13. 3 22 226865_at 9. 73 5. 70E-07 1. 64E-04 1.64 7.68 23211728sat HYAL3-3.34 8. 95E-09 1. 75E-05-1.22-7. 67 3p21. 3 24 228058_at LOC124220-2.54 9. 74E-09 1. 77E-05-1.20-7. 59 16p13. 3 25 210613_s_at SYNGR1 -2. 97 4. 40E-09 1.00E-05 -1. 17-7. 58 22q13. 1 26233467sat PHEMX 2.46 6. 91E-08 5. 05E-05 1.26 7.56 11p15. 5 27 227276_at TEM7R 3.51 3.09E-07 1.23E-04 1.39 7. 55 10p12. 1 28 233072_at KIAA1857 -4. 59 5. 06E-08 4.62E-05 -1. 28-7. 499q34 29 206478_at KIAA0125 22.61 9. 17E-07 1. 95E-04 1.71 7. 46 14q32. 33 30222996sat HSPC195 4. 19 7. 29E-07 1. 77E-04 1.52 7. 46 5q31. 3 31 235468at-6. 55 8.20E-08 5.47E-05-1. 32-7.42 32 201243_s at ATP1B1 5. 00 4. 26E-07 1. 42E-04 1.37 7. 42 1q22-q25 33 204495_s_at DKFZP434H132 5. 13 9. 12E-07 1. 95E-04 1.53 7. 37 15q22. 33 34205382sat DF-6.33 7. 39E-08 5. 05E-05-1.26-7. 35 19p13. 3 35 201281 at ADRM1-2.12 1. 71E-08 2. 45E-05-1.16-7. 35 20q13. 33 36 227853 at 2. 46 5. 80E-08 4. 96E-05 1.18 7.30 37 213908_at 4.51 5.12E-07 1.57E-04 1.34 7.30 38 219183 s at PSCD4 2. 35 2. 77E-07 1. 16E-04 1.26 7. 27 22q12.3-q13. 1 39217975_at LOC51186 14.36 1.13E-06 2.26E-04 1.51 7. 26 Xq22. 1 40221773_at 3. 52 2. 17E-07 1. 02E-04 1.24 7.24 41 215051_x_at AIF1 2.45 9. 99E-08 6. 07E-05 1.19 7. 236p21. 3 42 242845_at -4. 10 4.98E-08 4.62E-05-1. 17-7.21 43218854_at SART2 6. 30 1. 20E-06 2. 34E-04 1.48 7. 20 6q22 44 222955_s_at HT011 -2. 24 6. 72E-08 5. 05E-05-1.19-7. 19 Xq26. 1 45 201811_x_at SH3BP5 8. 59 1.30E-06 2.41E-04 1.46 7. 153p24. 3 46 203820 s at KOC1 3.81 9.22E-07 1.95E-04 1.36 7. 15 7p11 47 201288_x_at ARHGDIB -1. 41 1. 29E-08 2. 07E-05-1.10-7. 15 12p12. 3 48210115_at RPL39L-8.57 2. 10E-07 1. 02E-04-1.33-7. 12 3q27 49 204548_at STAR-7.93 1. 56E-07 8. 38E-05-1.23-7. 08 8p11. 2 50202759sat AKAP2-3.83 2. 73E-08 3. 47E-05-1.10-7. 08 9q31-q33 2.73 AML komplext versus AMLnormat # affy id HUGO name fc p q stn t Map Location 1 227056 at-2. 72 3.60E-25 1.83E-21-1. 18-14.77 2 200093_s_at - HG-U133B HINT1 -1. 98 1.27E-19 2.16E-16-1. 11-13.02 5q31. 2 3 218645_at ZNF277-2.28 7. 98E-20 1. 53E-16-1.01-12. 34 7q31.1 4 222229xat-1. 48 2. 01 E-16 1. 81 E-13-1. 17-12.31 5223157_at MGC3232-1.85 6. 18E-22 1. 89E-18-0.95-12. 24 4qu2 6236892sat-7. 12 1.09E-25 1.68E-21-0. 89-12.24 7 239791_at -6. 54 2.57E-25 1.83E-21-0. 87-12.10 8235502at PPP2CA-3.28 3. 00E-23 1. 15E-19-0.87-11. 76 5q23-q31 9 208826_x_at HINT1 -1. 62 4.74E-18 6. 04E-15-0. 95-11.51 5q31. 2 10223318sat MGC10974-2.92 1. 64E-21 4. 19E-18-0.83-11. 21 19p13. 3 11 205382_s_at DF-3.31 8. 20E-19 1. 25E-15-0.79-10. 45 19p13. 3 12 228904at-3. 89 2.82E-20 6.16E-17-0. 75-10.42 13 200093_s_at - HG-U133A HINT1 -1. 64 6. 38E-15 4.24E-12-0. 90-10.33 5q31. 2 14 223276_at NID67 -2. 19 1. 07E-17 1. 26E-14-0. 80-10. 33 5q33. 1 15205366sat HOXB6-4.77 1. 02E-18 1. 42E-15-0.74-10. 05 17q21. 3 16 222983_s_at PAIP2 -1. 60 1. 92E-14 1. 13E-11-0.87-10. 02 5q31. 3 17 227708_at EEF1A1 -1. 84 4. 28E-15 2. 98E-12-0.84-10. 02 6q14. 1 18200608sat RAD21 1. 60 1. 39E-12 4. 16E-10 1.03 9. 95 8q24 19 231840 x at LOC90624-2.20 2. 35E-17 2. 57E-14-0.73-9. 79 5q31. 1 20 207721_x_at HINT1 -1. 71 1. 81E-14 1. 11E-11 -0. 82-9.73 5q31. 2 21 224935_at -1. 53 1. 92E-13 8.38E-11 -0. 83-9. 50 22 226142_at GLIPR1 -2. 91 9. 34E-17 9. 53E-14-0.70-9. 46 12q21.1 23 222902_s_at FLJ21144 1.79 2. 53E-12 6. 36E-10 0.91 9. 431p34. 1 24 202659 at PSMB10-2. 58 9. 86E-16 8. 38E-13-0.73-9. 42 16q22. 1 25 202413_s_at USP1 1.75 4. 90E-12 1. 09E-09 0.93 9. 34 1p32.1-p31. 3 26 218436_at SIL1 -2. 55 2. 03E-14 1.14E-11 -0. 75-9. 30 5q31 27208646at RPS14-2.07 2. 53E-13 1. 08E-10-0.80-9. 28 5q31-q33 28 203955_at KIAA0649 -2. 99 2. 99E-14 1.58E-11 -0. 74-9. 229q34. 3 29 224936_at EIF2S3 -1. 49 5. 17E-13 1. 88E-10-0.78-9. 09Xp22. 2-p22.1 30 235521_at HOXA3-2.82 1. 90E-16 1.81E-13 -0. 66-9. 08 7p15-p14 31 200974_at ACTA2-2.21 1. 50E-15 1.21E-12 -0. 67-9. 00 10q23. 3 32 224821_at MGC15429-1.91 8. 05E-14 4.11E-11 -0. 73-8. 993p21. 31 33 218220_at C12orf10 -1. 77 9. 35E-15 5. 96E-12-0.69-8. 97 12q13 34226656_at CRTAP-2.21 1. 27E-12 3. 87E-10-0.76-8. 86 3p22 35201377_at NICE-4 1.85 8. 28E-11 1. 42E-08 0.97 8. 83 1q21. 3 36223592sat MGC13061-1.98 2. 76E-15 2.11E-12 -0. 65-8. 83 17q11. 2 37 223671_x_at FLJ20139 -1. 80 4. 14E-13 1. 58E-10-0.73-8. 81 1p21. 1 38226236at QP-C-1. 61 1.86E-13 8.36E-11 -0. 71-8.81 5q31. 1 39 227153_at IMMP2L -2. 41 4. 17E-15 2. 98E-12-0.65-8. 76 7q31 40 201977_s_at KIAA0141 -1. 67 2. 33E-12 6. 04E-10-0.75-8. 72 5q31. 3 41 228730_s_at LOC90507 -2. 00 1. 07E-12 3.41E-10 -0. 73-8. 70 17q21. 32 42 224875_at -1.85 1.50E-13 6.98E-11 -0. 69-8.69 43224968at MGC15407-1.91 8. 55E-13 2.91E-10 -0. 70-8. 59 2p16. 1 44232488_at MGC15875-2.54 2. 30E-12 6. 04E-10-0.72-8. 555q35. 3 45225223at-2. 08 9. 77E-14 4.82E-11 -0. 66-8.55 46226835sat-1. 67 3. 41E-12 8. 15E-10-0.71-8. 46 47 225326_at KIAA1311 -1. 64 2. 17E-12 5. 84E-10-0.69-8. 40 5q32 48201922at YR-29-1.50 5. 24E-11 9. 33E-09-0.79-8. 39 5q13. 2 49217751_at LOC51064-2.00 7. 40E-13 2. 64E-10-0.66-8. 34 7q34 50 229693_at -1. 97 1. 07E-12 3.41E-10 -0. 66-8.33 2.74 AML komplext versus AMLt (15 ; 17) &num affy id HUGO name fc p q stn t Map Location 1 205382sat DF-7.84 1. 62E-15 2.79E-12-2. 74-17.32 19p13. 3 2 212953_x_at CALR-3.21 1. 30E-13 9. 18E-11-2.45-15. 03 19p13. 3-p13. 2 3 203948_s_at MPO-4.01 3. 68E-19 4. 69E-15-2. 02-14. 64 17q23.1 4214450at CTSW-6.67 6. 70E-14 6. 09E-11-2. 28-14.52 11q13. 1 5 38487_at STAB1-5. 91 5. 67E-13 2. 67E-10-2.18-13. 64 3p21. 31 6 216032_s_at SDBCAG84-3.37 2.16E-14 2. 29E-11-2. 03-13. 59 20pter-q12 7 208826_x_at HINT1 -1. 69 7. 49E-18 4. 77E-14 -1.76 -12.96 5q31. 2 8238022at-7. 84 7. 82E-13 3. 55E-10-1. 99-12.81 9 213147_at HOXA10 11.01 4. 54E-15 5.75E-12 1.91 12. 80 7p15-p14 10 200931_s_at VCL 4. 91 6. 72E-16 1. 71E-12 1.82 12.74 10q22. 1-q23 11 209732_at CLECSF2 35.32 4. 46E-14 4. 37E-11 2.04 12.46 12p13-p12 12 200654 at P4HB-2.34 2.10E-16 8.89E-13-1. 70-12.36 17q25 13 207721_x_at HINT1 -1. 89 6. 21E-16 1.71E-12 -1.57 -11. 54 5q31. 2 14200047sat-HG-U133A YY1 2. 32 1. 07E-15 2. 27E-12 1.55 11. 37 14q 15 203949_at MPO-2.48 1. 75E-15 2. 79E-12-1. 53-11.23 17q23.1 16 200093_s_at - HG-U133B HINT1 -1. 89 2. 93E-15 4. 15E-12-1.50-11. 06 5q31. 2 17201923at PRDX4 8.38 3. 10E-13 1.80E-10 1.63 11. 02 Xp22. 13 18204897at PTGER4 5.03 4. 97E-15 5.75E-12 1.48 10.91 5p13. 1 19217225xat LOC283820-2.07 6.98E-12 1.85E-09-1. 59-10.73 16p13. 13 20227353_at EVER2 4. 55 1.06E-13 7.94E-11 1.51 10.69 17q25.3 21 206847_s_at HOXA7 4. 94 9.60E-14 7.94E-11 1.47 10.53 7p15-p14 22 227999_at LOC170394 3. 30 1. 56E-13 1. 04E-10 1.41 10.21 10q26. 3 23 202600_s_at NRIP1 12.57 3. 27E-12 9. 68E-10 1.52 10. 19 21q11. 2 24 207375_s_at IL15RA 5. 82 1. 33E-12 5. 36E-10 1.46 10.16 10p15-p14 25 214789_x_at SRP46 3. 86 1. 77E-13 1. 13E-10 1.40 10.14 11q22 26 221004_s_at ITM2C -3. 41 2. 27E-13 1. 38E-10-1.40-10. 14 2q37 27204150at STAB1-6. 71 1. 26E-09 8. 02E-08-1.73-10. 063p21. 31 28 200934_at DEK 2.41 1. 06E-13 7.94E-11 1.36 10.01 6p23 29208892sat DUSP6 6. 46 1. 35E-12 5. 36E-10 1.39 9. 84 12q22-q23 30 202413_s_at USP1 2.49 4.61E-13 2. 37E-10 1.35 9. 841p32. 1-p31. 3 31 217848_s_at PP 3. 96 1. 63E-12 6. 11E-10 1.38 9. 7810q11. 1-q24 32 208891_at DUSP6 6. 82 9.06E-13 3.98E-10 1.36 9. 77 12q22-q23 33 220798_x_at FLJ11535 -3. 66 2. 63E-11 5. 28E-09-1.42-9. 75 19p13. 3 34 224473_x_at KIAA1813 2. 33 9. 97E-13 4. 23E-10 1.36 9. 75 1 Oq24 35225547_at 1.73 3. 36E-13 1.86E-10 1.33 9.75 36 200008_s_at - HG-U133A GDI2 -2. 39 1. 53E-11 3.41E-09 -1. 40-9. 74 10p15 37 238949_at FLJ31951 8.00 5. 50E-12 1. 49E-09 1.41 9. 71 5q33. 3 38203535_at S100A9 7. 92 3. 22E-12 9. 68E-10 1. 38 9. 68 1q21 39210788sat retSDR4-2.19 8. 24E-11 1.17E-08 -1. 44-9. 6714q22. 3 40 226460_at KIAA1450 3. 63 1. 79E-12 6. 33E-10 1.35 9. 664q32. 1 41 200093_s_at - HG-U133A HINT1 -1. 69 5. 55E-13 2. 67E-10-1.32-9. 63 5q31. 2 42 225172_at CRAMP1L 2. 61 4. 65E-13 2. 37E-10 1.31 9. 60 16p13. 3 43 229693_at -2. 78 1. 07E-10 1. 42E-08-1.42-9. 56 44203302_at DCK 4. 08 4. 56E-12 1. 30E-09 1.33 9. 44 4q13.3-q21. 1 45 200656_s_at P4HB-4.16 1. 53E-09 9. 31E-08-1. 51-9.39 17q25 46205033sat DEFA1 5. 34 2. 50E-12 8. 36E-10 1.30 9. 378p23. 2-p23.1 47 227308_x_at SCYL1 4.60 1. 47E-11 3.34E-09 1.35 9.36 48 205663 at PCBP3-3.06 1. 14E-10 1. 44E-08-1.37-9. 35 21q22. 3 49 202599_s_at NRIP1 8. 20 2.13E-11 4. 38E-09 1.36 9.31 21q11. 2 50221087sat APOL3 3.50 4. 58E-12 1. 30E-09 1.29 9. 29 22q13. 1 2.75 AML_komplext versus AML t (8; 21) # affy id HUGO name fc p q stn t Map Location 1213147at HOXA10 7. 91 8. 54E-15 1. 20E-10 1.70 12.02 7p15-p14 2201920at SLC20A1 3. 17 3. 09E-14 2. 18E-10 1.46 10. 83 2q11-q14 3 206847_s_at HOXA7 4. 06 5. 19E-13 1. 46E-09 1.43 10. 297p15-p14 4222229xat-1. 45 5. 56E-14 2. 61 E-10-1. 29-9.90 5200833_s_at RAP1B 2. 26 3. 79E-13 1. 33E-09 1.27 9. 62 12q14 6228827at-24. 12 6. 82E-10 1. 35E-07-1.66-9. 62 7209523at TAF2 3. 00 6.58E-13 1. 55E-09 1.23 9. 37 8q24. 12 8206940sat POU4F1-26. 63 1. 75E-09 2. 40E-07-1.69-9. 29 13q21.1-q22 9 224481_s_at HECTD1 1. 84 8. 52E-13 1. 72E-09 1.20 9. 20 14q12 10 214651_s_at HOXA9 111.95 1. 42E-10 4. 64E-08 1.55 9. 15 7p15-p14 11 211423_s_at SC5DL 2. 73 2. 78E-12 3. 64E-09 1.21 9. 12 11q23. 3 12217963sat NGFRAP1 28.57 1. 56E-10 4. 76E-08 1.46 9. 07 Xq22. 1 13209022_at STAG2 2.17 1. 59E-12 2. 50E-09 1.18 9. 04 Xq25 14 201807_at VPS26 2.21 1. 60E-12 2. 50E-09 1.17 8. 99 10q21.1 15 241706_at LOC144402 5. 97 4.36E-11 2. 06E-08 1.27 8. 98 12q11 16 206003_at KIAA0635 2. 44 2. 87E-12 3. 64E-09 1.16 8.90 4q12 17212232at FNBP4 1. 87 3. 36E-12 3. 64E-09 1.16 8. 85 11p11. 12 18 202406_s_at TIAL1 1. 77 3. 16E-12 3. 64E-09 1.15 8.84 10q 19203079sat CUL2 2. 44 3. 64E-12 3. 66E-09 1.15 8. 83 10p11. 21 20 212585 at OSBPL8 2. 34 5. 76E-12 4. 77E-09 1.16 8. 80 12q14 21201663sat SMC4L1 3. 00 4.61E-11 2. 06E-08 1.22 8. 78 3q26. 1 22 218577_at FLJ20331 2.34 4. 62E-12 4.21E-09 1.15 8. 77 1p31. 1 23 227853_at 2.75 1.14E-11 8.46E-09 1.15 8.72 24222902sat FLJ21144 1. 96 4.78E-12 4.21E-09 1.13 8. 701p34. 1 25211061sat MGAT2 1. 93 4.68E-11 2. 06E-08 1.19 8. 69 14q21 26 235753 at 6.97 3. 87E-10 9. 05E-08 1.36 8.68 27 203949 at MPO-2.28 6. 50E-12 5. 09E-09-1.13-8. 64 17q23. 1 28205529sat CBFA2T1-8. 73 4. 85E-09 4. 90E-07-1.44-8. 61 8q22 29218236sat PRKCN 7. 50 2. 70E-10 7. 68E-08 1.26 8. 60 2p21 30201972at ATP6V1A1 2. 49 3.96E-11 2. 06E-08 1.16 8. 57 3q13. 2 31 226460_at KIAA1450 2. 94 3.24E-11 1.90E-08 1.14 8. 53 4q32. 1 32212397_at RDX 2. 69 6.23E-11 2. 58E-08 1.15 8. 4711q23 33 203320 at LNK 2. 62 1.00E-10 3. 76E-08 1.16 8. 45 12q24 34 211341_at POU4F1 -75. 39 1. 11E-08 8.38E-07 -1. 57-8. 44 13q21. 1-q22 35 218754 at FLJ23323 1. 87 4.40E-11 2. 06E-08 1.12 8. 42 1p36. 23 36235521at HOXA3 7. 65 7.60E-10 1. 44E-07 1. 31 8.42 7p15-p14 37 211746_x_at PSMA1 1. 68 1. 55E-11 1. 09E-08 1.09 8. 39 11p15. 1 38203948_s at MPO-2. 93 5. 41E-11 2. 31E-08-1. 11-8. 3617q23. 1 39212463at 4.11 1. 59E-10 4. 76E-08 1.15 8.36 40218040 at FLJ10330 2. 14 2. 71E-11 1.73E-08 1.10 8. 361p13. 2 41 201425_at ALDH2 10.22 4. 43E-10 9. 67E-08 1.21 8. 35 12q24. 2 42 201377_at NICE-4 2. 04 2. 58E-11 1.73E-08 1.09 8. 31 1q21. 3 43215051xat A ! F1 2. 38 3.60E-11 2. 03E-08 1.08 8. 256p21. 3 44 217846 at QARS-1. 58 3.17E-11 1.90E-08 -1. 08-8. 25 3p21. 3-p21.1 45 214700_x_at DKFZP434D193 2. 73 1. 20E-10 4. 22E-08 1.11 8. 222q23. 3 46 220936_s_at H2AFJ 4. 97 1. 58E-10 4. 76E-08 1.11 8. 21 12pu2 47201994_at MORF4L2 1. 68 4. 03E-11 2. 06E-08 1.07 8. 18 Xq22 48202775sat SFRS8 1. 86 1.01E-10 3. 76E-08 1.09 8. 16 12q24.33 49 226545_at 7. 60 8. 73E-10 1. 56E-07 1. 19 8.16 50200934_at DEK 1. 96 4. 59E-11 2. 06E-08 1.06 8. 136p23 2.76 AML normal versus AMLt (15 ; 17) &num affy id HUGO name fc p q stn t Map Location 1 213147 at HOXA10 17.19 1.59E-56 2.98E-52 1.79 23.81 7p15-p14 2 214651_s_at HOXA9 167.47 9. 79E-54 9. 16E-50 1.87 23. 69 7p15-p14 3209732at CLECSF2 20.24 1. 47E-52 9. 17E-49 1.70 22.51 12p13-p12 4 217848_s_at PP 4. 61 6. 27E-34 5. 10E-31 1.71 21. 0310q11. 1-q24 5204425at ARHGAP4 17.29 1. 91E-49 8.96E-46 1.58 20. 98 Xq28 6235753_at 11.73 3. 46E-44 1. 10E-40 1.48 19.40 7 205453_at HOXB2 18.69 4. 28E-44 1. 14E-40 1.47 19.28 17q21-q22 8213150at HOXA10 32.85 1. 27E-43 2. 97E-40 1.47 19.21 7p15-p14 9 213587_s_at LOC155066 5. 72 3. 54E-44 1. 10E-40 1.42 18. 88 7q36. 1 10 203948_s_at MPO-4.22 1. 32E-17 1. 03E-15-1.95-18. 55 17q23.1 11 209905_at HOXA9 438.18 2. 29E-41 3. 90E-38 1. 47 18.53 7p15-p14 12206847sat HOXA7 7. 38 5. 46E-41 8. 52E-38 1.38 18. 257p15-p14 13204362_at SCAP2 14.76 8. 37E-42 1. 74E-38 1.35 18. 02 7p21-p15 14 213844_at HOXA5 26.62 6. 87E-41 9. 89E-38 1.37 18.00 7p15-p14 15 205771_s_at AKAP7 10.95 9. 75E-42 1. 83E-38 1.35 17. 99 6q23 16241742_at PRAM-1 6. 37 5. 19E-40 6. 95E-37 1.35 17. 82 19p13. 2 17 201923_at PRDX4 5.63 2.16E-32 1.50E-29 1. 41 17.79 Xp22. 13 18204563at SELL 6. 23 1. 42E-37 1. 66E-34 1.35 17. 681q23-q25 19211990at HLA-DPA1 8. 62 8. 36E-40 1. 04E-36 1.31 17. 43 6p21. 3 20 214797_s_at PCTK3 4. 97 3.00E-27 9.21E-25 1.38 16.91 1q31-q32 21 225639_at SCAP2 12.00 1. 98E-37 2. 18E-34 1.27 16.78 7p21-p15 22203949_at MPO-2.74 1. 49E-20 1.81E-18 -1. 51-16. 72 17q23. 1 23 212953_x_at CALR-3.70 3. 43E-13 1.17E-11-2. 59-16. 64 19p13. 3-p13. 2 24 228113_at STAT3 4. 46 1.99E-30 1.01E-27 1.31 16. 59 17q21 25236322_at 6.21 7. 60E-30 3.31E-27 1.30 16.42 26 200654 at P4HB-2.39 2. 91 E-15 1. 50E-13-1.73-15. 87 17q25 27 221004_s_at ITM2C -6. 11 1. 34E-13 4. 92E-12-2. 04-15. 83 2q37 28216899sat SCAP2 6. 76 4. 61 E-35 4. 55E-32 1.18 15. 72 7p21-p15 29 238058_at 4. 05 4. 06E-35 4. 22E-32 1.18 15.66 30 235521_at HOXA3 25.02 4. 74E-34 4. 03E-31 1.21 15. 66 7p15-p14 31 231767_at HOXB4 5. 10 6. 90E-35 6. 46E-32 1.17 15. 61 q22 32 205600_x_at HOXB5 2. 95 5. 35E-30 2. 39E-27 1.21 15.51 17q21. 3 33 204361_s_at SCAP2 10.06 8. 56E-34 6. 68E-31 1.17 15.51 7p21-p15 34227598_at LOC113763 4. 44 1. 18E-32 8. 48E-30 1. 17 15. 39 7q35 35225314at MGC45416 2. 87 2.21E-30 1. 09E-27 1.19 15. 36 4p11 36 201719_s_at EPB41L2 10.38 3. 91 E-34 3. 49E-31 1.15 15. 30 6q23 37 205366_s_at HOXB6 43.97 6. 60E-33 4. 94E-30 1. 18 15. 23 17q21. 3 38 207375_s_at IL15RA 4. 80 1. 66E-28 6. 09E-26 1.18 15.06 10p15-p14 39 214450_at CTSW-5.81 1. 36E-12 4.02E-11 -2. 15-14.99 11q13. 1 40 228904_at 14.98 3.46E-32 2.23E-29 1.16 14.97 41 226106_at ZFP26 4. 84 2. 55E-32 1. 70E-29 1.13 14.96 11p15. 3 42 236554_x_at EVER2 3. 47 1. 31 E-23 2. 62E-21 1.22 14.85 17q25.3 43 200931 s at VCL 3. 56 6. 05E-27 1. 77E-24 1.17 14. 83 10q22. 1-q23 44 213388_at 6. 20 2. 10E-28 7. 42E-26 1.15 14.77 45239081 at 2. 70 1. 38E-22 2.37E-20 1.23 14.76 4638487 at STAB1-6. 80 2. 51E-12 7. 01E-11 -2. 19-14. 723p21. 31 47236892sat 26.07 3. 41 E-31 1.93E-28 1.11 14.54 48 205601_s_at HOXB5 3. 44 2. 99E-31 1.80E-28 1.09 14.51 17q21. 3 49201753sat ADD3 5. 74 9. 08E-30 3. 86E-27 1.11 14. 49 10q24. 2-q24.3 50204069at ME) S1 16.58 1. 09E-30 5. 69E-28 1.10 14. 37 2p14-p13 2.77 AMLnormat versus AML t (8; 21) &num affy id HUGO name fc p q stn t Map Location 1 214651_s_at HOXA9 146.41 1. 07E-53 1. 44E-49 1.86 23.67 7p15-p14 2 213147 at HOXA10 12.35 1. 87E-54 5. 03E-50 1.67 22.56 7p15-p14 3 205453_at HOXB2 24.89 9. 17E-45 8.21E-41 1.50 19.64 17q21-q22 4213150at HOXA10 42.29 6. 50E-44 3. 55E-40 1.49 19.42 7p15-p14 5 235753_at 10.96 6. 61 E-44 3. 55E-40 1.45 19.21 6209905at HOXA9 418.31 2.32E-41 8.89E-38 1.47 18. 53 7p15-p14 7 206847_s_at HOXA7 6.07 4. 41 E-43 1. 97E-39 1.35 18. 32 7p15-p14 8 213844 at HOXA5 17.18 7. 35E-40 2. 47E-36 1.31 17.51 7p15-p14 9 221581_s_at WBSCR5 6. 45 4. 95E-38 1. 48E-34 1.23 16. 57 7q11. 23 10 217963_s_at NGFRAP1 19.70 1. 77E-36 4. 75E-33 1.22 16. 29 Xq22. 1 11 235521_at HOXA3 21.55 9. 06E-34 1. 87E-30 1.20 15.56 7p15-p14 12 243806_at 4. 55 4. 15E-34 1. 01 E-30 1.13 15.28 13 205366_s_at HOXB6 34.37 1. 22E-32 2. 20E-29 1.18 15.16 17q21. 3 14 225615 at LOC126917 6. 55 4. 86E-34 1. 09E-30 1.12 15. 16 1p36 13 15 228904 at 14.63 4. 07E-32 6. 42E-29 1.15 14.94 16 233955_x_at HSPC195 3. 63 1. 23E-32 2. 20E-29 1.11 14.91 5q31. 3 17 231767 at HOXB4 4. 28 1. 74E-32 2. 93E-29 1.09 14. 66 17q21-q22 18 236892_s_at 21. 66 6. 70E-31 9. 00E-28 1.12 14.50 19 205600 x at HOXB5 2. 64 9.25E-29 8.87E-26 1. 10 14.44 17q21. 3 20204069at ME) S1 15.83 1. 41E-30 1.65E-27 1.10 14.34 2p14-p13 21 241370_at 3.29 2.28E-31 3. 41 E-28 1.06 14.31 22205601sat HOXB5 3.20 3. 11 E-31 4.40E-28 1.05 14. 23 17q21. 3 23 203017_s_at SSX2IP 4. 14 2. 33E-30 2. 60E-27 1.06 14.22 24 239791_at 13.40 5. 14E-30 5. 30E-27 1.07 14.07 25 230894 s at 8. 75 8. 22E-31 1.05E-27 1.04 14.06 26 228365_at LOC144402 8. 64 3. 12E-30 3. 35E-27 1.05 14. 04 12q11 27215087_at 3.75 1. 11E-30 1.35E-27 1.04 14.01 28 227853 at 3. 23 3.10E-26 1. 98E-23 1.06 13.77 29241706_at LOC144402 6. 07 3. 70E-29 3. 68E-26 1.01 13. 60 12q11 30226865 at 6.85 1.05E-28 9.70E-26 1.00 13.46 31 206310_at SPINK2 65.13 8. 49E-28 6.91E-25 1.05 13. 40 4q12 32222996sat HSPC195 2.85 1.69E-28 1.52E-25 0.99 13. 33 5q31. 3 33226134sat 5. 83 2.21E-28 1. 85E-25 0.98 13.26 34208890sat PLXNB2 3. 99 2. 98E-27 2. 29E-24 0.99 13. 24 22q13. 33 35224516sat HSPC195 3. 82 2. 10E-28 1. 82E-25 0.98 13. 24 5q31. 3 36 208091_s_at DKFZP564K0822 5. 79 1. 19E-27 9. 40E-25 0.98 13. 12 7p14. 1 37206289_at HOXA4 3. 59 3. 48E-26 2. 18E-23 0.99 13. 12 7p15-p14 38226206at FLJ32205 2. 47 1. 60E-24 8. 77E-22 1.01 13. 04 7p22. 3 39 217975_at LOC51186 6. 88 3. 94E-27 2. 94E-24 0.97 13.01 Xq22.1 40213110sat COL4A5 10.94 4. 55E-27 3. 30E-24 0.98 12. 98 Xq22 41 204495_s_at DKFZP434H132 2.74 3.97E-26 2.43E-23 0.95 12.73 15q22.33 42203680at PRKAR2B 5. 71 7. 67E-27 5. 42E-24 0.94 12.70 7q22-q31. 1 43 204494_s_at DKFZP434H132 2. 83 7. 93E-26 4. 53E-23 0.95 12. 6815q22. 33 44 224764_at ARHGAP10 5.13 1.78E-26 1.20E-23 0.93 12.61 10 45238756at 4.22 1.49E-26 1.03E-23 0.93 12.61 46225240sat 4. 95 2. 07E-26 1. 36E-23 0.93 12.58 47229971_at GPR114 6. 82 5. 96E-26 3. 55E-23 0.93 12. 55 16q12. 2 48 215051_x_at AIF1 2. 46 1.38E-17 2. 95E-15 1.09 12. 48 6p21. 3 49219062_s_at FLJ20281 3. 15 3.51E-24 1. 88E-21 0.95 12. 47 18q21. 32 50 238077_at MGC27385 3. 50 3. 92E-25 2. 19E-22 0.93 12.41 3p21. 1 2.78 AMLt (15 ; 17) versus AML_t (8; 21) # affy id HUGO name fc p q stn t Map Location 1 209732_at CLECSF2-31.87 6. 61E-16 1. 83E-11-3. 41-18.50 12p13-p12 2214450at CTSW 32.70 1. 75E-13 8. 07E-10 3.62 17.85 11q13. 1 3 38487_at STAB1 23.73 4. 75E-13 1. 20E-09 3.30 16. 703p21. 31 4211990at HLA-DPA1-11. 38 8. 43E-15 1. 17E-10-2.54-15. 15 6p21. 3 5 212509_s_at 10.56 1. 02E-10 8. 07E-08 2.39 12.28 6 221004_s_at ITM2C 3. 38 3. 94E-13 1. 20E-09 1.92 12.13 2q37 7 217478_s_at HLA-DMA-5.37 1. 31E-13 8. 07E-10-1.90-12. 10 6p21. 3 8 212953_x_at CALR 2. 46 4.33E-13 1. 20E-09 1.86 11.84 19p13. 3-p13. 2 9 224839_s_at GPT2 9. 84 6.52E-11 6.28E-08 2.10 11. 80 16q12. 1 10 204150_at STAB1 26.03 3. 22E-10 1. 88E-07 2.39 11. 71 3p21. 31 11 226878_at -5. 22 3.86E-12 7.65E-09-1. 95-11.66 12205663at PCBP3 4.49 1. 54E-11 2.38E-08 1.95 11. 65 21q22. 3 13 201596 x at KRT18 23.76 3. 19E-10 1. 88E-07 2.32 11.63 12q13 14 204316at RGS10-2.58 2.53E-13 8.78E-10-1. 78-11.47 10q25 15 205349 at GNA15 3. 44 3. 85E-11 4. 45E-08 1.90 11. 27 19p13. 3 16 211991_s_at HLA-DPA1 -17. 13 2. 84E-11 3. 58E-08-1.96-11. 15 6p21. 3 17 208689 s at RPN2 1. 81 1. 12E-13 8. 07E-10 1.61 10.80 20q12-q13. 1 18 209619 at CD74-4.53 1. 48E-13 8.07E-10 -1. 62-10.79 5q32 19200986_at SERPING1 10.67 1. 48E-09 6. 06E-07 2.04 10.51 11q12-q13. 1 20208826xat H) NT1 1.43 2. 32E-13 8.78E-10 1.56 10.48 5q31. 2 21 227326at 5.21 3. 26E-10 1. 88E-07 1.81 10.47 22 204319_s_at RGS10-5.48 8. 04E-11 7.19E-08-1. 76-10.34 10q25 23 209312_x_at HLA-DRB1 -6. 71 1. 16E-11 1. 89E-08-1.63-10. 33 6p21. 3 24201522xat SNRPN-3.69 5. 83E-13 1.35E-09-1. 55-10.31 15q12 25 211474_s_at SERPINB6 -5. 66 8. 59E-11 7. 28E-08-1.73-10. 26 6p25 26 217716_s_at SEC61A1 1. 98 7.38E-12 1. 36E-08 1.57 10. 18 3q21. 3 27 228113_at STAT3-4.67 2. 42E-11 3. 20E-08-1.62-10. 17 17q21 28 200953_s_at CCND2 2. 76 4.76E-10 2. 49E-07 1.73 10.12 12p13 29228827at-103. 40 4.47E-10 2.43E-07-1. 98-10.04 30 207721_x_at HINT1 1. 57 1. 19E-12 2. 54E-09 1.48 9. 94 5q31. 2 31 208306_x_at HLA-DRB4-6.81 4. 41E-11 4. 89E-08-1.57-9. 88 6p21. 3 32227353_at EVER2-3.90 1. 85E-11 2. 70E-08-1.53-9. 8317q25. 3 33 201137 s at HLA-DPB1-12.31 4. 76E-10 2. 49E-07-1.76-9. 82 6p21. 3 34208852sat CANX 2. 25 8.79E-11 7. 28E-08 1.55 9.79 5q35 35 238022_at 4.12 1. 01E-11 1.76E-08 1.47 9.70 36201923at PRDX4-6.62 1. 94E-10 1. 38E-07-1.60-9. 69 Xp22. 13 37 218795 at ACP6-2.77 4. 94E-11 5. 27E-08-1.50-9. 56 1q21 38 206940_s_at POU4F1 -45. 36 1. 38E-09 5. 89E-07-1.87-9. 48 13q21. 1-q22 39 205614_x_at MST1 6.64 5. 11E-09 1. 59E-06 1.73 9. 46 3p21 40223321sat FGFRL1 4. 08 3. 37E-09 1. 17E-06 1.65 9.40 4p16 41 205771 s at AKAP7-5.88 1. 70E-10 1. 28E-07-1.50-9. 39 6q23 42 215193_x_at HLA-DRB1 -6. 64 5. 32E-11 5. 46E-08-1. 45-9. 35 6p21. 3 43222307_at LOC282997-2.74 3. 08E-11 3. 71 E-08-1. 43-9. 34 10q25. 2 44 55093_at CSGIcA-T 1. 90 3. 36E-10 1. 90E-07 1. 49 9. 33 7q36. 1 45201952_at ALCAM 4. 60 2. 47E-09 9. 13E-07 1.58 9. 27 3q13. 1 46201136_at PLP2 2.92 7. 82E-11 7.19E-08 1.42 9. 25 Xp11. 23 47221865at DKFZp547P234-3.09 8. 93E-11 7.28E-08 -1. 43-9. 21 9q33. 1 48 205529_s_at CBFA2T1 -14. 51 2. 28E-09 8. 69E-07-1.73-9. 18 8q22 49 224356 x at MS4A6A-6.39 9. 01E-10 4. 23E-07-1.55-9. 18 11 q12. 1 50 202732 at PKIG 2. 71 2. 63E-09 9. 36E-07 1.55 9. 17 20q12-q13. 1