Title:
METHOD OF EVALUATING CAPACITY OF PROBIOTICS TO BE PHAGOCYTOSED AND SCREENING METHOD USING SAME
Document Type and Number:
WIPO Patent Application WO/2016/148168
Kind Code:
A1
Abstract:
Provided is a more accurate method of evaluating the capacity of probiotics to be phagocytosed at the cellular level, which is also a method of uniformly evaluating the capacity of probiotics to be phagocytosed, which can easily be performed in nearly in-vivo conditions without depending on burdensome surgical operations. The method of evaluating the capacity of probiotics to be phagocytosed comprises a step of contacting a probiotic with a phagocytic cell that has never contacted a bacterium.
Inventors:
KITAZAWA HARUKI (JP)
ASO HISASHI (JP)
MAKINO SEIYA (JP)
KANO HIROSHI (JP)
ASO HISASHI (JP)
MAKINO SEIYA (JP)
KANO HIROSHI (JP)
Application Number:
PCT/JP2016/058255
Publication Date:
September 22, 2016
Filing Date:
March 16, 2016
Export Citation:
Assignee:
UNIV TOHOKU (JP)
MEIJI CO LTD (JP)
MEIJI CO LTD (JP)
International Classes:
C12Q1/06; A61K35/747; A61P29/00; A61P31/12; A61P37/02; C12N1/20
Other References:
TAKUYA TAKAHASHI ET AL.: "Buta Masshoketsu Yurai Jujo Saibo no Bunka Yudo to Immunobiotic Hyokakei eno Riyosei", THE JAPANESE SOCIETY FOR ANIMAL SCIENCES DAI 116 KAI TAIKAI KOEN YOSHISHU, 2013, pages 214
TAKUYA TAKAHASHI ET AL.: "Buta Masshoketsu Tankyu Yurai Jujo Saibo ni yoru Immunobiotic Hyoka", THE JAPANESE SOCIETY FOR ANIMAL SCIENCES DAI 118 KAI TAIKAI KOEN YOSHISHU, 2014, pages 176
VAN BERGENHENEGOUWEN J. ET AL.: "Extracellular Vesicles Modulate Host-Microbe Responses by Altering TLR2 Activity and Phagocytosis", PLOS ONE, vol. 9, no. 2, February 2014 (2014-02-01), pages 1 - 11, XP055312063
SUDA Y. ET AL.: "Immunobiotic Lactobacillus jensenii as Immune-Health Promoting Factor to Improve Growth Performance and Productivity in Post-Weaning Pigs", BMC IMMUNOL., vol. 15, no. 1, 19 June 2014 (2014-06-19), pages 24, XP021189047
TAKUYA TAKAHASHI ET AL.: "Buta Masshoketsu Tankyu Yurai Jujo Saibo ni yoru Immunobiotic Hyoka", THE JAPANESE SOCIETY FOR ANIMAL SCIENCES DAI 118 KAI TAIKAI KOEN YOSHISHU, 2014, pages 176
VAN BERGENHENEGOUWEN J. ET AL.: "Extracellular Vesicles Modulate Host-Microbe Responses by Altering TLR2 Activity and Phagocytosis", PLOS ONE, vol. 9, no. 2, February 2014 (2014-02-01), pages 1 - 11, XP055312063
SUDA Y. ET AL.: "Immunobiotic Lactobacillus jensenii as Immune-Health Promoting Factor to Improve Growth Performance and Productivity in Post-Weaning Pigs", BMC IMMUNOL., vol. 15, no. 1, 19 June 2014 (2014-06-19), pages 24, XP021189047
Attorney, Agent or Firm:
KUZUWA, Kiyoshi (JP)
Seiji Kuzuwa (JP)
Seiji Kuzuwa (JP)
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