Title:
METHOD FOR EVALUATING CELL HYPERSTIMULATION TOXICITY
Document Type and Number:
WIPO Patent Application WO/2019/107481
Kind Code:
A1
Abstract:
This method for evaluating hyperstimulation toxicity to a human neurocyte of a test substance comprises: (1) a step for bringing a test substance into contact with a human neurocyte prepared by inducing differentiation from pluripotent stem cells; (2) a step for imparting a stimulation to the human neurocyte; (3) a step for measuring the degree of hyperstimulation of the human neurocyte; and (4) a step for evaluating that the test substance has hyperstimulation toxicity to a human neurocyte when the hyperstimulation of the human neurocyte is enhanced in the presence of the test substance.
Inventors:
INOUE HARUHISA (JP)
KONDO TAKAYUKI (JP)
KONDO TAKAYUKI (JP)
Application Number:
PCT/JP2018/043917
Publication Date:
June 06, 2019
Filing Date:
November 29, 2018
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C12Q1/06; G01N33/15; G01N33/50; C12N5/10
Domestic Patent References:
| WO2016076435A1 | 2016-05-19 | |||
| WO2014148646A1 | 2014-09-25 |
Foreign References:
| JP2004533835A | 2004-11-11 |
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
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