Title:
METHOD FOR EVALUATING QUALITY OF SPERM
Document Type and Number:
WIPO Patent Application WO/2022/264971
Kind Code:
A1
Abstract:
The present disclosure provides a method for evaluating the quality of sperm. The present disclosure provides a method for evaluating the quality of sperm, said method comprising: a step for obtaining a mixed solution by mixing a sperm population and an inspection liquid containing a nitroxyl radical compound; a step for measuring a signal obtained from the mixed liquid; and a step for evaluating the quality of the sperm on the basis of the signal.
Inventors:
HYODO FUMINORI (JP)
MATSUO MASAYUKI (JP)
MATSUO MASAYUKI (JP)
Application Number:
PCT/JP2022/023655
Publication Date:
December 22, 2022
Filing Date:
June 13, 2022
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
International Classes:
C12Q1/06; C07D207/46; C07D211/94; C07D401/04; C12M1/00; C12M1/34; C12N5/076; G01N33/50
Domestic Patent References:
| WO2017217340A1 | 2017-12-21 | |||
| WO2016194073A1 | 2016-12-08 |
Foreign References:
| JPH1054812A | 1998-02-24 |
Other References:
PHADKE RATNA S., SRIVASTAVA SUDHA, GOVIL GIRJESH: "Magnetic resonance methods for studying intact spermatozoa", JOURNAL OF BIOSCIENCES, SPRINGER INDIA, NEW DELHI, vol. 15, no. 3, 1 September 1990 (1990-09-01), New Delhi, pages 125 - 134, XP093015679, ISSN: 0250-5991, DOI: 10.1007/BF02703872
BAČIĆ GORAN, PAVIĆEVIĆ ALEKSANDRA, PEYROT FABIENNE: "In vivo evaluation of different alterations of redox status by studying pharmacokinetics of nitroxides using magnetic resonance techniques", REDOX BIOLOGY, ELSEVIER, NL, vol. 8, 1 August 2016 (2016-08-01), NL , pages 226 - 242, XP093015682, ISSN: 2213-2317, DOI: 10.1016/j.redox.2015.10.007
DIKALOV SERGEY I., DIKALOVA ANNA E., MOROZOV DENIS A., KIRILYUK IGOR A.: "Cellular accumulation and antioxidant activity of acetoxymethoxycarbonyl pyrrolidine nitroxides", FREE RADICAL RESEARCH, TAYLOR & FRANCIS, GB, vol. 52, no. 3, 4 March 2018 (2018-03-04), GB , pages 339 - 350, XP093015683, ISSN: 1071-5762, DOI: 10.1080/10715762.2017.1390744
IANNONE, A. ; BINI, A. ; SWARTZ, H.M. ; TOMASI, A. ; VANNINI, V.: "Metabolism in rat liver microsomes of the nitroxide spin probe tempol", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, vol. 38, no. 16, 15 August 1989 (1989-08-15), US , pages 2581 - 2586, XP025514154, ISSN: 0006-2952, DOI: 10.1016/0006-2952(89)90541-8
BAČIĆ GORAN, PAVIĆEVIĆ ALEKSANDRA, PEYROT FABIENNE: "In vivo evaluation of different alterations of redox status by studying pharmacokinetics of nitroxides using magnetic resonance techniques", REDOX BIOLOGY, ELSEVIER, NL, vol. 8, 1 August 2016 (2016-08-01), NL , pages 226 - 242, XP093015682, ISSN: 2213-2317, DOI: 10.1016/j.redox.2015.10.007
DIKALOV SERGEY I., DIKALOVA ANNA E., MOROZOV DENIS A., KIRILYUK IGOR A.: "Cellular accumulation and antioxidant activity of acetoxymethoxycarbonyl pyrrolidine nitroxides", FREE RADICAL RESEARCH, TAYLOR & FRANCIS, GB, vol. 52, no. 3, 4 March 2018 (2018-03-04), GB , pages 339 - 350, XP093015683, ISSN: 1071-5762, DOI: 10.1080/10715762.2017.1390744
IANNONE, A. ; BINI, A. ; SWARTZ, H.M. ; TOMASI, A. ; VANNINI, V.: "Metabolism in rat liver microsomes of the nitroxide spin probe tempol", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, vol. 38, no. 16, 15 August 1989 (1989-08-15), US , pages 2581 - 2586, XP025514154, ISSN: 0006-2952, DOI: 10.1016/0006-2952(89)90541-8
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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