Title:
MITOCHONDRIA-SELECTIVE NITROXYL RADICAL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/264970
Kind Code:
A1
Abstract:
The present disclosure provides an examination/diagnosis drug for examining or diagnosing a mitochondria-related illness. The present disclosure relates to a composition containing a nitroxyl radical compound that selectively reacts with radicals present in mitochondria or a salt of said compound, or to an examination/diagnosis drug for examining or diagnosing a mitochondria-related illness by using said composition. The mitochondria-related illness includes circulatory diseases, respiratory diseases, cerebral nervous system diseases, digestive diseases, hematologic diseases, endocrine diseases, urinary diseases, dermatological diseases, supportive tissue diseases, ophthalmological diseases, tumor symptoms, iatrogenic disorders, environmental-pollution-type illnesses, operative stress, mental illnesses, inflammatory diseases, tumors, medicine-induced liver disease, and infertility.
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Inventors:
HYODO FUMINORI (JP)
MATSUO MASAYUKI (JP)
MATSUO MASAYUKI (JP)
Application Number:
PCT/JP2022/023654
Publication Date:
December 22, 2022
Filing Date:
June 13, 2022
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
International Classes:
G01N33/483; A61B5/055; A61K49/00; A61K49/20
Domestic Patent References:
| WO2017217340A1 | 2017-12-21 |
Foreign References:
| JPH1054812A | 1998-02-24 |
Other References:
HYODO, FUMINORI: "P249: In vivo Redox metabolic imaging of NASH model mice using DNP-MRI and its redox analysis by ESR", THE 58TH ANNUAL MEETING OF THE SOCIETY OF ELECTRON AND SPIN SCIENCE (SEST); NOVEMBER 7-9, 2019, vol. 58, 1 January 2019 (2019-01-01) - 9 November 2019 (2019-11-09), JP, pages 192 - 193, XP009542503
DIKALOV SERGEY I., DIKALOVA ANNA E., MOROZOV DENIS A., KIRILYUK IGOR A.: "Cellular accumulation and antioxidant activity of acetoxymethoxycarbonyl pyrrolidine nitroxides", FREE RADICAL RESEARCH, vol. 52, no. 3, 4 March 2018 (2018-03-04), GB , pages 339 - 350, XP093015683, ISSN: 1071-5762, DOI: 10.1080/10715762.2017.1390744
BAČIĆ GORAN, PAVIĆEVIĆ ALEKSANDRA, PEYROT FABIENNE: "In vivo evaluation of different alterations of redox status by studying pharmacokinetics of nitroxides using magnetic resonance techniques", REDOX BIOLOGY, vol. 8, 1 August 2016 (2016-08-01), NL , pages 226 - 242, XP093015682, ISSN: 2213-2317, DOI: 10.1016/j.redox.2015.10.007
HYODO, FUMINORI : "Development of in vivo redox imaging using DNP-MRI for nonalcoholic steatohepatitis", PRECISION MEDICINE, vol. 5, no. 1, 25 January 2022 (2022-01-25), pages 53 - 56, XP009542213, ISSN: 2434-3625
HYODO, FUMINORI : "Application of Dissolution Dynamic Nuclear Polarization and in vivo Dynamic Nuclear Polarization for Animal Disease Models", RADIATION BIOLOGY RESEARCH COMMUNICATIONS, vol. 56, no. 4, 10 January 2022 (2022-01-10), JP , pages 347 - 362, XP009542214, ISSN: 0441-747X
DIKALOV SERGEY I., DIKALOVA ANNA E., MOROZOV DENIS A., KIRILYUK IGOR A.: "Cellular accumulation and antioxidant activity of acetoxymethoxycarbonyl pyrrolidine nitroxides", FREE RADICAL RESEARCH, vol. 52, no. 3, 4 March 2018 (2018-03-04), GB , pages 339 - 350, XP093015683, ISSN: 1071-5762, DOI: 10.1080/10715762.2017.1390744
BAČIĆ GORAN, PAVIĆEVIĆ ALEKSANDRA, PEYROT FABIENNE: "In vivo evaluation of different alterations of redox status by studying pharmacokinetics of nitroxides using magnetic resonance techniques", REDOX BIOLOGY, vol. 8, 1 August 2016 (2016-08-01), NL , pages 226 - 242, XP093015682, ISSN: 2213-2317, DOI: 10.1016/j.redox.2015.10.007
HYODO, FUMINORI : "Development of in vivo redox imaging using DNP-MRI for nonalcoholic steatohepatitis", PRECISION MEDICINE, vol. 5, no. 1, 25 January 2022 (2022-01-25), pages 53 - 56, XP009542213, ISSN: 2434-3625
HYODO, FUMINORI : "Application of Dissolution Dynamic Nuclear Polarization and in vivo Dynamic Nuclear Polarization for Animal Disease Models", RADIATION BIOLOGY RESEARCH COMMUNICATIONS, vol. 56, no. 4, 10 January 2022 (2022-01-10), JP , pages 347 - 362, XP009542214, ISSN: 0441-747X
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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