Title:
METHOD FOR EVALUATION OF LUNG CANCER, LUNG CANCER EVALUATION APPARATUS, LUNG CANCER EVALUATION METHOD, LUNG CANCER EVALUATION SYSTEM, LUNG CANCER EVALUATION PROGRAM, AND RECORDING MEDIUM
Document Type and Number:
WIPO Patent Application WO/2008/016111
Kind Code:
A1
Abstract:
Disclosed are: a method for evaluation of lung cancer, which can evaluate the
state of lung cancer with high precision by utilizing a blood amino acid level,
particularly a blood amino acid level associated with the state of lung cancer;
a lung cancer evaluation apparatus; a lung cancer evaluation method; a lung cancer
evaluation system; a lung cancer evaluation program; and a recording medium.
The method for evaluation of lung cancer comprises the steps of: obtaining an
amino acid level data that relates to a value of an amino acid level from a blood
collected from a subject to be evaluated; and evaluating the state of lung cancer
in the subject based on a value of a blood level of at least one amino acid selected
from Orn, Lys, ABA, Arg, Glu, His, Tau, Pro, Ala, Cit and Ile included in the amino
acid level data.
Inventors:
IMAIZUMI AKIRA (JP)
ONO NOBUKAZU (JP)
SAKAI RYOSEI (JP)
ANDO TOSHIHIKO (JP)
OKAMOTO NAOYUKI (JP)
IMAMURA FUMIO (JP)
HIGASHIYAMA MASAHIKO (JP)
ONO NOBUKAZU (JP)
SAKAI RYOSEI (JP)
ANDO TOSHIHIKO (JP)
OKAMOTO NAOYUKI (JP)
IMAMURA FUMIO (JP)
HIGASHIYAMA MASAHIKO (JP)
Application Number:
PCT/JP2007/065179
Publication Date:
February 07, 2008
Filing Date:
August 02, 2007
Export Citation:
Assignee:
AJINOMOTO KK (JP)
IMAIZUMI AKIRA (JP)
ONO NOBUKAZU (JP)
SAKAI RYOSEI (JP)
ANDO TOSHIHIKO (JP)
OKAMOTO NAOYUKI (JP)
IMAMURA FUMIO (JP)
HIGASHIYAMA MASAHIKO (JP)
IMAIZUMI AKIRA (JP)
ONO NOBUKAZU (JP)
SAKAI RYOSEI (JP)
ANDO TOSHIHIKO (JP)
OKAMOTO NAOYUKI (JP)
IMAMURA FUMIO (JP)
HIGASHIYAMA MASAHIKO (JP)
International Classes:
G01N33/68; G16B20/00; G16B40/20; G16B40/30
Domestic Patent References:
| WO2004052191A1 | 2004-06-24 | |||
| WO2004052191A1 | 2004-06-24 | |||
| WO2006098192A1 | 2006-09-21 |
Other References:
PROENZA A.M. ET AL.: "Breast and lung cancer are associated with a decrease in blood cell amino acid content", J. NUTR. BIOCHEM., vol. 14, no. 3, 2003, pages 133 - 138, XP003021047
CASCINO A. ET AL.: "Plasma amino acid imbalance in patients with lung and breast cancer", ANTICANCER RESEARCH, vol. 15, no. 2, 1995, pages 507 - 510, XP003021048
EVANS W.K. ET AL.: "Perturbations in plasma amino acid profiles in small cell lung cancer (SCLC) and their response to treatment", PROC. AM. ASSOCIATION CANCER RES. ANN. MEET., vol. 29, 1988, pages 18 + ABSTR. NR. 69, XP008103478
PROENZA; A.M. ET AL.: "Breast and lung cancer are associated with a decrease in blood cell amino acid content", J NUTR BIOCHEM, vol. 14, no. 3, 2003, pages 133 - 8, XP003021047, DOI: doi:10.1016/S0955-2863(02)00225-5
CASCINO, A. ET AL.: "Plasma amino acid imbalance in patients with lung and breast cancer", ANTICANCER RES, vol. 15, no. 2, 1995, pages 507 - 10, XP003021048
RODRIGUEZ, P.C. ET AL.: "Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma", J EXP MED, vol. 202, no. 7, 2005, pages 931 - 9
See also references of EP 2081027A4
CASCINO A. ET AL.: "Plasma amino acid imbalance in patients with lung and breast cancer", ANTICANCER RESEARCH, vol. 15, no. 2, 1995, pages 507 - 510, XP003021048
EVANS W.K. ET AL.: "Perturbations in plasma amino acid profiles in small cell lung cancer (SCLC) and their response to treatment", PROC. AM. ASSOCIATION CANCER RES. ANN. MEET., vol. 29, 1988, pages 18 + ABSTR. NR. 69, XP008103478
PROENZA; A.M. ET AL.: "Breast and lung cancer are associated with a decrease in blood cell amino acid content", J NUTR BIOCHEM, vol. 14, no. 3, 2003, pages 133 - 8, XP003021047, DOI: doi:10.1016/S0955-2863(02)00225-5
CASCINO, A. ET AL.: "Plasma amino acid imbalance in patients with lung and breast cancer", ANTICANCER RES, vol. 15, no. 2, 1995, pages 507 - 10, XP003021048
RODRIGUEZ, P.C. ET AL.: "Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma", J EXP MED, vol. 202, no. 7, 2005, pages 931 - 9
See also references of EP 2081027A4
Attorney, Agent or Firm:
SAKAI, Hiroaki (Kasumigaseki Building 2-5, Kasumigaseki 3-chome, Chiyoda-k, Tokyo 19, JP)
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