Title:
METHOD FOR EVALUATION OF SAFETY OF DRUG
Document Type and Number:
WIPO Patent Application WO/2011/025014
Kind Code:
A1
Abstract:
A method for evaluating the xenobiotic metabolizing enzyme-inducing capability of a test compound, comprising exposing hepatocytes to the test compound in the presence and absence of a substance capable of inducing the activity of a xenobiotic metabolizing enzyme and comparing the activity of the enzyme in the presence of the substance with that in the absence of the substance.
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Inventors:
KAMIGUCHI NAOMI (JP)
OKUDA TERUAKI (JP)
AOYAMA EIJI (JP)
OKUDA TERUAKI (JP)
AOYAMA EIJI (JP)
Application Number:
PCT/JP2010/064747
Publication Date:
March 03, 2011
Filing Date:
August 30, 2010
Export Citation:
Assignee:
TAKEDA PHARMACEUTICAL (JP)
KAMIGUCHI NAOMI (JP)
OKUDA TERUAKI (JP)
AOYAMA EIJI (JP)
KAMIGUCHI NAOMI (JP)
OKUDA TERUAKI (JP)
AOYAMA EIJI (JP)
International Classes:
C12Q1/02; C12Q1/26; C12Q1/48; C12Q1/68; C12N15/09
Other References:
YASUHIRO YAMADA: "Soyaku ni Okeru Hito Kansaibo no Hitsuyosei to Shihan Hito Kansaibo no Mondaiten", ORGAN BIOLOGY, vol. 13, no. 2, 2006, pages 119 - 135
YOKO EJIRI ET AL: "Iyakuhin Kaihatsu no Tameno Shinki Hito Kansaibo Baiyokei no Kochiku", HAB KENKYU KIKO GAKUJUTSU NENKAI PROGRAM YOSHISHU, vol. 16, 22 May 2009 (2009-05-22), pages 63, XP008178621
YOKO EJIRI ET AL: "Iyakuhin Kaihatsu no Tameno Shinki Hito Kansaibo Baiyokei no Kochiku", HAB KENKYU KIKO GAKUJUTSU NENKAI PROGRAM YOSHISHU, vol. 16, 22 May 2009 (2009-05-22), pages 63, XP008178621
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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