Title:
METHOD FOR IDENTIFYING CELL CAPABLE OF REGENERATING FOLLICLES, AND METHOD FOR EVALUATING COMPOSITION FOR FOLLICLE REGENERATION USE
Document Type and Number:
WIPO Patent Application WO/2022/191149
Kind Code:
A1
Abstract:
The present invention provides a method for identifying a cell capable of regenerating follicles, a method for evaluating a composition for follicle regeneration use, and a method for evaluating a process for producing a composition for follicle regeneration use, in each of which an expression level of at least one gene selected from the group consisting of SERPINE2 gene, TIMP3 gene, RGS2 gene, NPDC1 gene, CAMK2N1 gene, COLEC12 gene, NID2 gene and ADGRE5 gene is employed as a measure.
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Inventors:
ISHIMATSU YUMIKO (JP)
JINGUJI HIDEMASA (JP)
SUGIMOTO TAKAKI (JP)
KISHIMOTO JIRO (JP)
JINGUJI HIDEMASA (JP)
SUGIMOTO TAKAKI (JP)
KISHIMOTO JIRO (JP)
Application Number:
PCT/JP2022/009819
Publication Date:
September 15, 2022
Filing Date:
March 07, 2022
Export Citation:
Assignee:
SHISEIDO CO LTD (JP)
International Classes:
C12Q1/6851; A61K45/00; A61P17/14; C12Q1/6837; G01N33/48; G01N33/53
Domestic Patent References:
| WO2019176881A1 | 2019-09-19 | |||
| WO2021015209A1 | 2021-01-28 |
Foreign References:
| JP2005349081A | 2005-12-22 | |||
| JP2005528916A | 2005-09-29 |
Other References:
TSUBOI RYOJI; NIIYAMA SHIRO; IRISAWA RYOKICHI; HARADA KAZUTOSHI; NAKAZAWA YOSUKE; KISHIMOTO JIRO: "Autologous cell–based therapy for male and female pattern hair loss using dermal sheath cup cells: A randomized placebo-controlled double-blinded dose-finding clinical study", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, MOSBY, INC, US, vol. 83, no. 1, 5 March 2020 (2020-03-05), US , pages 109 - 116, XP086181518, ISSN: 0190-9622, DOI: 10.1016/j.jaad.2020.02.033
S NIIYAMA, Y ISHIMATSU-TSUJI, Y NAKAZAWA, Y YOSHIDA, T SOMA, R IDETA, H MUKAI, J KISHIMOTO: "Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles", ACTA DERMATO-VENEREOLOGICA., TAYLOR & FRANCIS LTD., UNITED KINGDOM, vol. 98, no. 7, 1 January 2018 (2018-01-01), United Kingdom , pages 694 - 698, XP055638521, ISSN: 0001-5555, DOI: 10.2340/00015555-2949
MISAKI KINOSHITA-ISE, AKI TSUKASHIMA, TOMONARI KINOSHITA, YOSHIMI YAMAZAKI AND MANABU OHYAMA: "Altered FGF expression profile in human scalp-derived fibroblasts upon WNT activation: implication of their role to provide folliculogenetic microenvironment", ENSHOU, SAISEI - INFLAMMATION AND REGENERATION, NIHON ENSHOU SAISEI IGAKKAI, KAWASAKI, JP, vol. 40, 1 January 2020 (2020-01-01), JP , pages 1 - 10, XP009539498, ISSN: 1346-8022
RYOJI TSUBOI ET AL.: "Clinical research in the treatment of pattern hair loss using dermal sheath cup cells (DSCC)", REGENERATIVE MEDICINE, JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, JP, vol. 17, no. 1, 1 February 2018 (2018-02-01), JP , pages 53 - 58, XP009539700, ISSN: 1347-7919
S NIIYAMA, Y ISHIMATSU-TSUJI, Y NAKAZAWA, Y YOSHIDA, T SOMA, R IDETA, H MUKAI, J KISHIMOTO: "Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles", ACTA DERMATO-VENEREOLOGICA., TAYLOR & FRANCIS LTD., UNITED KINGDOM, vol. 98, no. 7, 1 January 2018 (2018-01-01), United Kingdom , pages 694 - 698, XP055638521, ISSN: 0001-5555, DOI: 10.2340/00015555-2949
MISAKI KINOSHITA-ISE, AKI TSUKASHIMA, TOMONARI KINOSHITA, YOSHIMI YAMAZAKI AND MANABU OHYAMA: "Altered FGF expression profile in human scalp-derived fibroblasts upon WNT activation: implication of their role to provide folliculogenetic microenvironment", ENSHOU, SAISEI - INFLAMMATION AND REGENERATION, NIHON ENSHOU SAISEI IGAKKAI, KAWASAKI, JP, vol. 40, 1 January 2020 (2020-01-01), JP , pages 1 - 10, XP009539498, ISSN: 1346-8022
RYOJI TSUBOI ET AL.: "Clinical research in the treatment of pattern hair loss using dermal sheath cup cells (DSCC)", REGENERATIVE MEDICINE, JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, JP, vol. 17, no. 1, 1 February 2018 (2018-02-01), JP , pages 53 - 58, XP009539700, ISSN: 1347-7919
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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