METHOD FOR IMPROVING STEM CELL MIGRATION USING ETHIONAMIDE

WIPO Patent Application WO/2019/088480

A3

The present invention relates to a culture medium composition comprising ethionamide for improving stem cell migration, and to uses for same. According to the present invention, stem cell migration can be effectively improved by means of a simple and safe method of controlling the culturing environment, without using gene manipulation, virus vectors and the like, and the stem cells having improved mobility due to the method are expected to be effectively utilized as a stem cell therapeutic agent that can rapidly migrate to and function in an area of damage following a transplantation.

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NA DUK LYUL (KR)
CHANG JONG WOOK (KR)
SON HYO JIN (KR)

PCT/KR2018/011811

July 18, 2019

October 08, 2018

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SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)

C12N5/0775; C12N5/0735

WO2015009884A1

2015-01-22

KR20150004762A	2015-01-13
KR20130085863A	2013-07-30

MILLER, R. J. ET AL.: "CXCR4 signaling in the regulation of stem cell migration and development", J NEUROITIMIIMOL., vol. 198, no. 0, 2008, pages 31 - 38, XP022939342, doi:10.1016/j.jneuroim.2008.04.008
KATRAHALLI, U. ET AL.: "The Effect of Anti-tubercular Drug, Ethionamide on the Secondary Structure of Serum Albumins: a Biophysical Study", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 59, 2012, pages 102 - 108, XP028599139, doi:10.1016/j.jpba.2011.09.013

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