Title:
METHOD FOR INDUCING HEMOBLAST DIFFERENTIATION
Document Type and Number:
WIPO Patent Application WO/2014/042432
Kind Code:
A1
Abstract:
The present invention relates to the in vitro production of erythrocytes/granulocytes and to the treatment of myelodysplastic syndrome using a method for inducing hemoblast differentiation. The present invention provides a media composition comprising gelsolin as an active ingredient for inducing the differentiation of hematopoietic precursor cells into erythrocytes/granulocytes, and a pharmaceutical composition comprising gelsolin as an active ingredient for treating myelodysplastic syndrome. Since the composition of the present invention improves the efficiency of differentiation of hematopoietic precursor cells into erythrocytes/granulocytes while maintaining a low rate of occurrence of cell dysplasia and having the effect of improving the enucleation rate and cell survivability, the present invention can be effectively used for producing erythrocytes/granulocytes in vitro and for treating myelodysplastic syndrome.
Inventors:
BAEK EUN JUNG (KR)
LEE EUN MI (KR)
LEE EUN MI (KR)
Application Number:
PCT/KR2013/008226
Publication Date:
March 20, 2014
Filing Date:
September 11, 2013
Export Citation:
Assignee:
UNIV SOGANG IND UNIV COOP FOUN (KR)
International Classes:
C12N5/078; A61K35/14; A61K35/15; A61K35/18; C12N5/02
Foreign References:
| KR20120003760A | 2012-01-11 | |||
| KR20100081678A | 2010-07-15 | |||
| KR20050008757A | 2005-01-21 |
Other References:
TIMMINS, N.E.; NIELSEN, N.K.: "Manufactured RBC--Rivers of blood, or an oasis in the desert?", BIOTECHNOLOGY ADVANCES, vol. 29, no. 6, 2011, pages 661 - 6, XP028306402, DOI: doi:10.1016/j.biotechadv.2011.05.002
OLSSON, M. L.; CLAUSEN, H.: "Modifying the red cell surface: towards an ABO-universal blood supply", BR. J. HAEMATOL., vol. 140, 2008, pages 3 - 12
"Remington's Pharmaceutical Science, 18th,", 1990, MACK PUBLISHING COMPANY
PARTINGTON ET AL., J. IMMUNOL. METHODS., vol. 223, no. 2, 4 March 1999 (1999-03-04), pages 195 - 205
See also references of EP 2896689A4
OLSSON, M. L.; CLAUSEN, H.: "Modifying the red cell surface: towards an ABO-universal blood supply", BR. J. HAEMATOL., vol. 140, 2008, pages 3 - 12
"Remington's Pharmaceutical Science, 18th,", 1990, MACK PUBLISHING COMPANY
PARTINGTON ET AL., J. IMMUNOL. METHODS., vol. 223, no. 2, 4 March 1999 (1999-03-04), pages 195 - 205
See also references of EP 2896689A4
Attorney, Agent or Firm:
YANG, Boo-Hyun (Chungdong Building1659-2 Inhundong,Gwanak-gu, Seoul 151-832, KR)
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