Title:
METHOD FOR INDUCING STEM-CELLS TO DIFFERENTIATE INTO MUSCLE CELLS
Document Type and Number:
WIPO Patent Application WO/2013/032158
Kind Code:
A2
Abstract:
The present invention relates to a method which makes use of either Ang1 (angiopoietin 1) or COMP-Ang1 (cartilage oligomeric matrix protein-angiopoietin 1), which regulate the differentiation mechanism of stem cells, so as to induce specific differentiation into muscle cells. Provided are a composition which is highly efficient in inducing differentiation from stem cells into muscle cells, and a therapeutic composition for diseases involving muscle damage using the differentiation-inducing ability. Consequently, the outstanding activity of the composition of the present invention can be used to advantage in the alleviation or treatment of diseases involving muscle damage such as muscular dystrophy, muscle inflammation and fibrosis.
Inventors:
KIM HYO-SOO (KR)
LEE SAE-WON (KR)
YOUN SEOCK-WON (KR)
LEE SAE-WON (KR)
YOUN SEOCK-WON (KR)
Application Number:
PCT/KR2012/006572
Publication Date:
March 07, 2013
Filing Date:
August 17, 2012
Export Citation:
Assignee:
SNU R&DB FOUNDATION (KR)
KIM HYO-SOO (KR)
LEE SAE-WON (KR)
YOUN SEOCK-WON (KR)
KIM HYO-SOO (KR)
LEE SAE-WON (KR)
YOUN SEOCK-WON (KR)
International Classes:
C12N5/0775; A61K31/7088; C12N1/38
Other References:
DATABASE NCBI 30 December 2010 'angiopoietin-1 precursor [Mus musculus]' Database accession no. 033770.2
DALLABRIDA, SM. ET AL.: 'Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins' CIRCULATION RESEARCH vol. 96, no. 4, 04 March 2005, pages E8 - 24, XP003015952
JOO, HJ. ET AL.: 'Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cell' BLOOD vol. 118, no. 8, 25 August 2011, pages 2094 - 2104, XP055067620
MOFARRAHI, M. ET AL.: 'Expression and functional roles of angiopoietin-2 in skeletal muscles' PLOS ONE vol. 6, no. 7, 29 July 2011, page E22882
LEE, EH. ET AL.: 'Angiopoietin 1 enhances the proliferation and differentiation of skeletal myoblasts' JOURNAL OF CELLULAR PHYSIOLOGY vol. 228, no. 5, May 2013, pages 1038 - 1044, XP055067621
DALLABRIDA, SM. ET AL.: 'Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins' CIRCULATION RESEARCH vol. 96, no. 4, 04 March 2005, pages E8 - 24, XP003015952
JOO, HJ. ET AL.: 'Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cell' BLOOD vol. 118, no. 8, 25 August 2011, pages 2094 - 2104, XP055067620
MOFARRAHI, M. ET AL.: 'Expression and functional roles of angiopoietin-2 in skeletal muscles' PLOS ONE vol. 6, no. 7, 29 July 2011, page E22882
LEE, EH. ET AL.: 'Angiopoietin 1 enhances the proliferation and differentiation of skeletal myoblasts' JOURNAL OF CELLULAR PHYSIOLOGY vol. 228, no. 5, May 2013, pages 1038 - 1044, XP055067621
Attorney, Agent or Firm:
YANG, Boo-Hyun (1659-2 Inhundong Gwanak-gu, Seoul 151-832, KR)
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Claims: