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Title:
METHOD FOR MANUFACTURING ANTIBODY-DRUG CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2020/075817
Kind Code:
A1
Abstract:
The present invention provides a method for manufacturing an antibody-drug conjugate (ADC) where an antibody and a drug are linked together through a linker. Provided is a method for manufacturing, for example: an antibody-drug conjugate (ADC) where an antibody and a drug are linked through a linker; or a pharmaceutical containing said ADC. The method includes mixing, using a microreactor, a solution containing tris carboxyethyl phosphine (TCEP) and IgG antibody in a reduction reaction initiated by TCEP, and a solution containing a TCEP inhibitor that is stoichiometrically in excess of TCEP.

Inventors:
SUENAGA MASATO (JP)
TAKENAKA KOSUKE (JP)
IWAMOTO KEIJI (JP)
Application Number:
PCT/JP2019/040059
Publication Date:
April 16, 2020
Filing Date:
October 10, 2019
Export Citation:
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Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
A61K39/395; A61K45/00; A61K47/65; A61K47/68; A61P35/00; A61P35/02; B01J19/00; C07K16/18
Domestic Patent References:
WO2005117986A22005-12-15
WO2001038318A12001-05-31
WO2017179353A12017-10-19
Foreign References:
JP2017189729A2017-10-19
JP2016531914A2016-10-13
JP2008501029A2008-01-17
Other References:
DORONINA S. 0. ET AL.: "Development of potent monoclonal antibody auristatin conjugates for cancer therapy", NATURE BIOTECHNOLOGY, vol. 21, no. 7, July 2003 (2003-07-01), pages 778 - 784, XP002280966, DOI: 10.1038/nbt832
DEBAENE F. ET AL., ANALYTICAL CHEMISTRY, vol. 86, 2014, pages 10674 - 10683
KATHERINE R. KOZAK ET AL., BIOCONJUGATE CHEMISTRY, vol. 24, 2013, pages 772 - 779
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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