Title:
FUNCTION MECHANISM OF GLYCEOLLIN I AND UTILIZATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/075816
Kind Code:
A1
Abstract:
Provided is a composition exerting an effect of inhibiting the growth of cancer cells, in particular endocrine therapy-resistant tumors, said composition comprising glyceollin I that inhibits eleanors without through ER and a polyphenol that inhibits eleanors through ER and/or a hormone as active ingredients. Further, it was clarified that glyceollin I evokes the inhibition of mitochondrial function and thus induces cell death. On the basis of these results, it becomes possible to provide a composition capable of exhibiting an effect of inhibiting the growth of cancer cells over a broader range by using glyceollin I together with a glycolysis inhibitor.
Inventors:
MATSUI TOSHIRO (JP)
YAMAMOTO TATSURO (JP)
TACHIWANA HIROAKI (JP)
WATANABE KENJI (JP)
DAN SHINGO (JP)
SAITOH NORIKO (JP)
NAKAO MITSUYOSHI (JP)
IDE TSUYOSHI (JP)
OCHIAI KOJI (JP)
YAMAMOTO TATSURO (JP)
TACHIWANA HIROAKI (JP)
WATANABE KENJI (JP)
DAN SHINGO (JP)
SAITOH NORIKO (JP)
NAKAO MITSUYOSHI (JP)
IDE TSUYOSHI (JP)
OCHIAI KOJI (JP)
Application Number:
PCT/JP2019/040052
Publication Date:
April 16, 2020
Filing Date:
October 10, 2019
Export Citation:
Assignee:
JAPANESE FOUND FOR CANCER RES (JP)
DAIZ INC (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
MATSUI TOSHIRO (JP)
DAIZ INC (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
MATSUI TOSHIRO (JP)
International Classes:
A61K31/353; A23L33/10; A23L33/105; A61K31/05; A61K31/19; A61K31/416; A61K31/565; A61K31/566; A61K31/7004; A61P35/00; A61P43/00
Domestic Patent References:
| WO2006118871A2 | 2006-11-09 |
Other References:
LECOMTE, S. ET AL.: "Glyceollins trigger anti- proliferative effects through estradiol-dependent and independent pathways in breast cancer cells", CELL COMMUN. SIGNAL., vol. 15, no. 1, 2017, pages 1 - 18, XP055702279, DOI: 10.1186/s12964-017-0182-1
CARRIERE, P. P. ET AL.: "Glyceollin I Reverses Epithelial to Mesenchymal Transition in Letrozole Resistant Breast Cancer through ZEB1", INT. J. ENVIRON. RES. PUBLIC HEALTH, vol. 13, no. 1, 2015, pages 1 - 17, XP055702283, DOI: 10.3390/ijerph13010010
LEE, S. H. ET AL.: "Glyceollins, a novel class of soy phytoalexins, inhibit angiogenesis by blocking the VEGF and bFGF signaling pathways", MOL. NUTR. FOOD RES., vol. 57, no. 2, 2013, pages 225 - 234, XP055702287, DOI: 10.1002/mnfr.201200489
TOMITA, S. ET AL.: "A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation", NAT COMMUN., vol. 6, no. 6966, 2015, pages 1 - 15, XP055702290, DOI: 10.1038/ncomms7966
KHAN, S. I. ET AL.: "Potential utility of natural products as regulators of breast cancer-associated aromatase promoters", REPROD. BIOL. ENDOCRINOL., vol. 9, no. 91, 2011, pages 1 - 10, XP021103765
LIU, H. ET AL.: "Hypersensitization of tumor cells to glycolytic inhibitors", BIOCHEMISTRY, vol. 40, no. 18, 2001, pages 5542 - 5547, XP002261273, ISSN: 0006-2960, DOI: 10.1021/bi002426w
CARRIERE, P. P. ET AL.: "Glyceollin I Reverses Epithelial to Mesenchymal Transition in Letrozole Resistant Breast Cancer through ZEB1", INT. J. ENVIRON. RES. PUBLIC HEALTH, vol. 13, no. 1, 2015, pages 1 - 17, XP055702283, DOI: 10.3390/ijerph13010010
LEE, S. H. ET AL.: "Glyceollins, a novel class of soy phytoalexins, inhibit angiogenesis by blocking the VEGF and bFGF signaling pathways", MOL. NUTR. FOOD RES., vol. 57, no. 2, 2013, pages 225 - 234, XP055702287, DOI: 10.1002/mnfr.201200489
TOMITA, S. ET AL.: "A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation", NAT COMMUN., vol. 6, no. 6966, 2015, pages 1 - 15, XP055702290, DOI: 10.1038/ncomms7966
KHAN, S. I. ET AL.: "Potential utility of natural products as regulators of breast cancer-associated aromatase promoters", REPROD. BIOL. ENDOCRINOL., vol. 9, no. 91, 2011, pages 1 - 10, XP021103765
LIU, H. ET AL.: "Hypersensitization of tumor cells to glycolytic inhibitors", BIOCHEMISTRY, vol. 40, no. 18, 2001, pages 5542 - 5547, XP002261273, ISSN: 0006-2960, DOI: 10.1021/bi002426w
Attorney, Agent or Firm:
SHIRAKATA Yumiko (JP)
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