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Title:
METHOD FOR MANUFACTURING HYDROXYL GROUP SUBSTITUTION PRODUCT
Document Type and Number:
WIPO Patent Application WO/2010/071129
Kind Code:
A1
Abstract:
Disclosed is a method for manufacturing a hydroxyl group substitution product by causing an alcohol to react with sulfuryl fluoride (SO2F2) in the presence of an organic base and a nucleophilic agent (X-). This is an industrial method which is capable of using an inexpensive reactive agent for a large-scale use and for which the operations and the refining are performed easily, and for which there is little waste. This method also can be applied suitably to the manufacture of an optically active hydroxyl group substitution product; in particular, an optically active α-hydroxyl group substitution ester and an optically active 4-hydroxyl group substitution proline. This method solves all of the problems of the prior art and can be implemented industrially.

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Inventors:
ISHII AKIHIRO
YASUMOTO MANABU
UEDA KOJI
Application Number:
PCT/JP2009/070904
Publication Date:
June 24, 2010
Filing Date:
December 15, 2009
Export Citation:
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Assignee:
CENTRAL GLASS CO LTD (JP)
ISHII AKIHIRO
YASUMOTO MANABU
UEDA KOJI
International Classes:
C07C67/307; C07C69/63; C07D207/16
Domestic Patent References:
WO2006098444A12006-09-21
WO2008001718A12008-01-03
WO2008090755A12008-07-31
Foreign References:
JP2007537300A2007-12-20
JP2006290870A2006-10-26
Other References:
BIOORGANIC & MEDICINAL CHEMISTRY (U.S., vol. 16, 2008, pages 578 - 585
"Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
SYNTHETIC COMMUNICATIONS (U.S., vol. 21, 1991, pages 2165 - 2170
"Organic Synthesis IV, Acids, Amino Acids and Peptides", vol. 22, 1992, MARUZEN CO., LTD, article "Jikken Kagaku Koza", pages: 193 - 309
TETRAHEDRON LETTERS (UK, vol. 39, 1998, pages 1169 - 1172
JOURNAL OF MEDICINAL CHEMISTRY (U.S., vol. 49, 2006, pages 307 - 317
See also references of EP 2383252A4
Attorney, Agent or Firm:
HASHIMOTO, Takeshi et al. (JP)
Hashimoto 剛 (JP)
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