Title:
METHOD FOR MANUFACTURING POLYMETHOXYFLAVONES THAT ARE HIGHLY STABLE OVER TIME AND HAVE REDUCED RESIDUAL PESTICIDE LEVELS
Document Type and Number:
WIPO Patent Application WO/2011/092840
Kind Code:
A1
Abstract:
Provided is a method for manufacturing inexpensive, highly safe, highly stable, versatile polymethoxyflavones that can be used in food products and easily incorporated into a variety of pharmaceutical formulations. Said method can, in one pass, isolate a large quantity of polymethoxyflavones from other components in a citrus peel oil. Also provided is a method for using said polymethoxyflavones. The provided method for manufacturing polymethoxyflavones from a citrus peel oil is characterized by the inclusion of: a step in which volatile components in a citrus peel oil are removed by distillation, yielding a distillation residue; a step in which said residue is distilled in a thin-film vacuum distillation device, yielding a fraction; a step in which an extract is extracted from said fraction using an aqueous ethanol solution; and a step in which insoluble oils are removed from said extract and the extract is then brought into contact with activated carbon and refined. This method produces polymethoxyflavones that are highly stable over time and have reduced residual pesticide levels.
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Inventors:
ADACHI KENJI (JP)
ARIMA TSUYOSHI (JP)
MURANISHI SHUICHI (JP)
ARIMA TSUYOSHI (JP)
MURANISHI SHUICHI (JP)
Application Number:
PCT/JP2010/051231
Publication Date:
August 04, 2011
Filing Date:
January 29, 2010
Export Citation:
Assignee:
OGAWA & CO LTD (JP)
ADACHI KENJI (JP)
ARIMA TSUYOSHI (JP)
MURANISHI SHUICHI (JP)
ADACHI KENJI (JP)
ARIMA TSUYOSHI (JP)
MURANISHI SHUICHI (JP)
International Classes:
A23L1/30; C07D311/30; A23L2/52; A23L27/12; A61K31/353; A61P35/04
Foreign References:
| JP2003292488A | 2003-10-15 | |||
| JPH11169148A | 1999-06-29 | |||
| JPH06335362A | 1994-12-06 | |||
| JP2008280282A | 2008-11-20 | |||
| JP2004223346A | 2004-08-12 | |||
| JP2008272594A | 2008-11-13 | |||
| JP2010037317A | 2010-02-18 | |||
| JPH06335362A | 1994-12-06 | |||
| JPH11169148A | 1999-06-29 | |||
| JP2003292488A | 2003-10-15 | |||
| JP2000072790A | 2000-03-07 | |||
| JP2006089414A | 2006-04-06 | |||
| JP2009511643A | 2009-03-19 |
Other References:
YOSHITOMO EGUCHI ET AL., KOJO SOSA SERIES KYUCHAKU, 1 July 1975 (1975-07-01), pages 84 - 97, 222 - 225, XP008169055
NIPPON NOGEIKAGAKU KAISHI, vol. 75, no. 12, 2001, pages 1283 - 1290
"Kouryou Kagaku Soran (I", 1967, HIROKAWA SHOTEN, pages: 232
"Kajitsu no Kagaku", 1991, ASAKURA PUBLISHING, pages: 130
See also references of EP 2530080A4
NIPPON NOGEIKAGAKU KAISHI, vol. 75, no. 12, 2001, pages 1283 - 1290
"Kouryou Kagaku Soran (I", 1967, HIROKAWA SHOTEN, pages: 232
"Kajitsu no Kagaku", 1991, ASAKURA PUBLISHING, pages: 130
See also references of EP 2530080A4
Attorney, Agent or Firm:
YUITA, Junji et al. (JP)
Junji Yuita (JP)
Junji Yuita (JP)
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Claims: