SEPARATION/ANALYSIS METHOD FOR MIXTURE OF OLIGONUCLEOTIDES

WIPO Patent Application WO/2018/235904

A1

The present invention relates to a method for separating and analyzing a mixture of oligonucleotides by liquid chromatography which uses a column packed with a filler of porous particles constituted of a crosslinking organic polymer having diol immobilized on the surface thereof. According to this method, the separation/analysis can be performed at a higher sensitivity compared to cases where columns having silica gel as a base material are used, and the column can be washed with an alkaline solution.

JPH03210474	METHOD FOR ANALYZING MOLECULAR WEIGHT DISTRIBUTION OF POLYTHIOETHER SOLFONE
WO/2023/138980	MODULAR LIQUID CHROMATOGRAPHY SYSTEM
JPH03118466	ASSAY OF SACCHARIFIED HEMOGLOBIN

SASUGA JUNJI (JP)
AOKI HIROBUMI (JP)
KOKIDO YUZURU (JP)

PCT/JP2018/023650

December 27, 2018

June 21, 2018

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SHOWA DENKO KK (JP)

G01N30/88; B01D15/32; B01J20/281; B01J20/285; G01N30/26; G01N30/34; G01N30/50; G01N30/72; G01N30/74

WO2016190043A1	2016-12-01
WO2016009077A1	2016-01-21

JP2010529431A	2010-08-26
JP2016524166A	2016-08-12
JPS5820235A	1983-02-05
JP2007522476A	2007-08-09

ALPERT, J. ANDREW: "HYDROPHILIC-INTERACTION CHROMATOGRAPHY FOR THE SEPARATION OF PEPTIDES, NUCLEIC ACIDS AND OTHER POLAR COMPOUNDS", JOURNAL OF CHROMATOGRAPHY, vol. 499, 1990, pages 177 - 196, XP026484536
JOURNAL OF CHROMATOGRAPHY A, vol. 1255, 2012, pages 237 - 243
JOURNAL OF CHROMATOGRAPHY B, vol. 1040, 2017, pages 282 - 288
See also references of EP 3644055A4

OHIE Kunihisa et al. (JP)

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