Title:
METHOD FOR MODIFYING T CELL POPULATION
Document Type and Number:
WIPO Patent Application WO/2016/104486
Kind Code:
A1
Abstract:
Provided is a method for increasing the proportion of memory T cells in a T cell population, said method comprising a step of adding a modulator for the retinoid metabolic pathway and/or a modulator for the retinoic acid signaling system to the T cell population.
Inventors:
SUGIYAMA HARUO (JP)
FUJIKI FUMIHIRO (JP)
FUJIKI FUMIHIRO (JP)
Application Number:
PCT/JP2015/085793
Publication Date:
June 30, 2016
Filing Date:
December 22, 2015
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61K45/00; A61K31/7105; A61K31/713; A61K38/55; A61K45/06; A61K48/00; A61P31/00; A61P35/00; A61P37/04; A61P43/00; C12N5/0783; C12N15/113
Domestic Patent References:
| WO2011024791A1 | 2011-03-03 |
Foreign References:
| JP2004506691A | 2004-03-04 | |||
| JP2009529572A | 2009-08-20 | |||
| JP2010531138A | 2010-09-24 |
Other References:
TAN, X. ET AL.: "Retinoic acid as a vaccine adjuvant enhances CD 8+ T cell response and mucosal protection from viral challenge", JOURNAL OF VIROLOGY, vol. 85, no. 16, 2011, pages 8316 - 8327, XP055459658, ISSN: 0022-538X
FURUGAKI, K. ET AL.: "DNA vaccination with alll- trans retinoic acid treatment induces long-term survival and elicits specific immune responses requiring CD 4+ and CD 8+ T- cell activation in an acute promyelocytic leukemia mouse model", BLOOD, vol. 115, no. 3, 2010, pages 653 - 656, XP055459669, ISSN: 0006-4971
GALVIN, K.C. ET AL.: "Blocking retinoic acid receptor-a enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells", CANCER IMMUNOL IMMUNOTHER, vol. 62, no. 7, 2013, pages 1273 - 1282, XP055459674, ISSN: 0340-7004
ALLIE, S.R. ET AL.: "Critical role for all-trans retinoic acid for optimal effector and effector memory CD 8 T cell differentiation", THE JOURNAL OF IMMUNOLOGY, vol. 190, no. 5, 2013, pages 2178 - 2187, XP055459748, ISSN: 0022-1767
NAPOLI, J.L.: "Physiological insights into alll-trans-retinoic acid biosynthesis", BIOCHIMICA BIOPHYSICA ACTA, vol. 1821, no. 1, 2012, pages 152 - 167, XP028391796, ISSN: 0006-3002
See also references of EP 3238744A4
FURUGAKI, K. ET AL.: "DNA vaccination with alll- trans retinoic acid treatment induces long-term survival and elicits specific immune responses requiring CD 4+ and CD 8+ T- cell activation in an acute promyelocytic leukemia mouse model", BLOOD, vol. 115, no. 3, 2010, pages 653 - 656, XP055459669, ISSN: 0006-4971
GALVIN, K.C. ET AL.: "Blocking retinoic acid receptor-a enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells", CANCER IMMUNOL IMMUNOTHER, vol. 62, no. 7, 2013, pages 1273 - 1282, XP055459674, ISSN: 0340-7004
ALLIE, S.R. ET AL.: "Critical role for all-trans retinoic acid for optimal effector and effector memory CD 8 T cell differentiation", THE JOURNAL OF IMMUNOLOGY, vol. 190, no. 5, 2013, pages 2178 - 2187, XP055459748, ISSN: 0022-1767
NAPOLI, J.L.: "Physiological insights into alll-trans-retinoic acid biosynthesis", BIOCHIMICA BIOPHYSICA ACTA, vol. 1821, no. 1, 2012, pages 152 - 167, XP028391796, ISSN: 0006-3002
See also references of EP 3238744A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
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