METHOD FOR PREDICTING DEVELOPMENTAL TOXICITY WHILE CONSIDERING IN VIVO KINETICS

Title:

METHOD FOR PREDICTING DEVELOPMENTAL TOXICITY WHILE CONSIDERING IN VIVO KINETICS

Document Type and Number:

WIPO Patent Application WO/2013/162060

Kind Code:

A1

Abstract:

A method for predicting developmental toxicity of a chemical, said method being characterized by comprising a step for using a functional equation obtained by combining a variable based on the cytotoxicity of a chemical with a variable based on the differential inhibition by the chemical and a variable based on the physical properties of the chemical, substituting an assessment score relating to the cytotoxicity of a test substance, an assessment score relating to the differential inhibition by the test substance, and an assessment score relating to the physical properties of the test substance respectively into the corresponding variables in the aforesaid functional equation, comparing the determined value thus calculated with a control value, and then assessing the presence or absence of the developmental toxicity of the test substance or the extent thereof on the basis of the difference between these values.

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Inventors:

NAGAHORI HIROHISA (JP)
SAITO KOICHI (JP)
SUZUKI NORIYUKI (JP)

Application Number:

PCT/JP2013/062801

Publication Date:

October 31, 2013

Filing Date:

April 25, 2013

Export Citation:

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Assignee:

SUMITOMO CHEMICAL CO (JP)

International Classes:

G01N33/15; C12Q1/06

Foreign References:

JPH07218496A

1995-08-18

Other References:

NOBUYUKI HORIE ET AL.: "Safety Evaluation Study Using Embryonic Stem (ES) Cells", SUMITOMO KAGAKU, vol. 2007, no. L, 31 May 2007 (2007-05-31), pages 49 - 55
ABE T. ET AL.: "Embryonic development assay with Daphnia magna: Application to toxicity of chlorophenols.", WATER SCI. TECHNOL., vol. 42, no. 7-8, 2000, pages 297 - 304

Attorney, Agent or Firm:

NAKAYAMA, Tohru et al. (JP)
Nakayama 亨 (JP)

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