Title:
METHOD FOR PREDICTING RISK OF OR DETECTING FATTY LIVER DISEASE, REAGENT KIT AND BIOMARKER FOR DETECTING FATTY LIVER DISEASE, METHOD FOR DETERMINING RATE OF PROGRESSION OF LIVER FIBROSIS IN SUBJECT, AND BIOMARKER FOR DETERMINING RATE OF PROGRESSION OF LIVER FIBROSIS IN SUBJECT
Document Type and Number:
WIPO Patent Application WO/2020/044500
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel method for diagnosing fatty liver disease that can be carried out more easily and that does not put a burden on patients or health care providers. The problem can be solved by measuring, in a body fluid sample, the amount of one or more long-chain acylcarnitines selected from the group consisting of octadecenoylcarnitine, tetradecenoylcarnitine, tetradecanoylcarnitine, hexadecanoylcarnitine, octadecanoylcarnitine, and octadecadienoylcarnitine, then comparing the result with a reference value.
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Inventors:
NAKAGAWA HAYATO (JP)
ENOOKU KENICHIRO (JP)
FUJIWARA NAOTO (JP)
KOIKE KAZUHIKO (JP)
ENOOKU KENICHIRO (JP)
FUJIWARA NAOTO (JP)
KOIKE KAZUHIKO (JP)
Application Number:
PCT/JP2018/032149
Publication Date:
March 05, 2020
Filing Date:
August 30, 2018
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
G01N33/68
Foreign References:
| JP2010500566A | 2010-01-07 | |||
| US20170370954A1 | 2017-12-28 |
Other References:
PENG, K.-Y. ET AL.: "Mitochondrial dysfunction- related lipid changes occur in non-alcoholic fatty liver disease progression", JOURNAL OF LIPID RESEARCH, vol. 59, no. 10, 24 July 2018 (2018-07-24), XP055690950
PEREZ-CARRERAS, M. ET AL.: "Defective Hepatic Mitochondrial Respiratory Chain in Patients With Nonalcoholic Steatohepatitis", HEPATOLOGY, vol. 38, no. 4, 2003, pages 999 - 1007, XP055690952
SAITO, K. ET AL.: "Characterization of hepatic lipid profiles in a mouse model with nonalcoholic steatohepatitis and subsequent fibrosis", SCIENTIFIC REPORTS, vol. 5, 20 August 2015 (2015-08-20), pages 12466, XP055345212, DOI: 10.1038/srep12466
PEREZ-CARRERAS, M. ET AL.: "Defective Hepatic Mitochondrial Respiratory Chain in Patients With Nonalcoholic Steatohepatitis", HEPATOLOGY, vol. 38, no. 4, 2003, pages 999 - 1007, XP055690952
SAITO, K. ET AL.: "Characterization of hepatic lipid profiles in a mouse model with nonalcoholic steatohepatitis and subsequent fibrosis", SCIENTIFIC REPORTS, vol. 5, 20 August 2015 (2015-08-20), pages 12466, XP055345212, DOI: 10.1038/srep12466
Attorney, Agent or Firm:
MOEGI PATENT OFFICE (JP)
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