Title:
METHOD FOR PREDICTING SENSITIVITY OF CANCER CELLS TO HELICASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2021/100869
Kind Code:
A1
Abstract:
As a method for predicting the sensitivity of cancer cells to a helicase inhibitor, provided are: a method comprising a step for predicting that cancer cells have sensitivity to a helicase inhibitor when at least one mutation selected from a first group consisting of TTK mutation and RAD50 mutation is detected in the cancer cells; and a method comprising a step for predicting that cancer cells have sensitivity to a helicase inhibitor when at least one mutation selected from a second group consisting of the RAD50 mutation, MRE11 mutation, MBN mutation, DNA2 mutation, and RBBP8 mutation is detected in the cancer cells.
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Inventors:
SAKAMOTO HIROSHI (JP)
KASHIMA KENJI (JP)
OGASAWARA KIYOMOTO (JP)
OHTE YUKI (JP)
SOGA MAYUMI (JP)
KASHIMA KENJI (JP)
OGASAWARA KIYOMOTO (JP)
OHTE YUKI (JP)
SOGA MAYUMI (JP)
Application Number:
PCT/JP2020/043487
Publication Date:
May 27, 2021
Filing Date:
November 20, 2020
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C12N15/55; A61K45/00; A61P35/00; A61P43/00; C12Q1/02; C12Q1/68; G01N33/15
Domestic Patent References:
| WO1994011523A2 | 1994-05-26 |
Other References:
MEISS ALICE E.; THOMAS MARTHA; MODESITT SUSAN C.; RING KARI L.; ATKINS KRISTEN A.; MILLS ANNE M.: "Clinicopathologic characterization of breast carcinomas in patients with non-BRCAgermline mutations: results from a single institution’s high-risk population", HUMAN PATHOLOGY, SAUNDERS, PHILADELPHIA, PA, US, vol. 82, 26 June 2018 (2018-06-26), US, pages 20 - 31, XP085559332, ISSN: 0046-8177, DOI: 10.1016/j.humpath.2018.06.024
WESSENDORF, PETRA: "Deficiency of the DNA repair protein nibrin increases the basal but not the radiation induced mutation frequency in vivo", MUTAT RES., vol. 769, 11 July 2014 (2014-07-11), pages 11 - 16, XP055825745
JIA, PAN-PAN ET AL.: "Role of human DNA2 (hDNA2) as a potential target for cancer and other diseases: A systematic review", DNA REPAIR, vol. 59, 2017, pages 9 - 19, XP085212464, DOI: 10.1016/j.dnarep.2017.09.001
UCHIZAKA, NAOKI: "MRE11 point mutation from two brothers with lung cancer", THE 51ST ANNUAL MEETING OF THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY, THE 25TH ANNUAL MEETING OF THE JAPANESE SOCIETY OF PEDIATRIC ONCOLOGY, THE 7TH ANNUAL MEETING OF THE JAPANESE SOCIETY OF PEDIATRIC CANCER NURSING, AND THE 14TH ANNUAL MEETING OF, 30 November 2008 (2008-11-30) - 29 November 2009 (2009-11-29), JP, pages 101, XP009538103
CHENG, WEN-HSING ET AL.: "Targeting Werner syndrome protein sensitizes U-2 OS osteosarcoma cells to selenium-induced DNA damage response and necrotic death", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 420, 2012, pages 24 - 28, XP028479010, DOI: 10.1016/j.bbrc.2012.02.104
LIEB, SIMONE ET AL.: "Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells", ELIFE, vol. 8, 25 March 2019 (2019-03-25), pages e43333, XP055825746, Retrieved from the Internet
MAKOTO MAEMONDO ET AL., NEJM, vol. 362, no. 25, 24 June 2010 (2010-06-24), pages 2380 - 2388
PAUL B. CHAPMAN ET AL., NEJM, vol. 364, no. 26, 30 June 2011 (2011-06-30), pages 2507 - 2516
D. ROSS CAMIDGE ET AL., J THORAC ONCOL, vol. 14, no. 7, July 2019 (2019-07-01), pages 1233 - 1243
LORN KATEGAYA ET AL., ISCIENCE, vol. 13, 29 March 2019 (2019-03-29), pages 488 - 497
SIMONE LIEB ET AL., ELIFE, vol. 8, 2019, pages e43333
EDMOND M. CHAN ET AL., NATURE, vol. 68, no. 7753, 5 April 2019 (2019-04-05), pages 511 - 516
K. MOORE ET AL., NEJM, vol. 379, no. 26, 27 December 2018 (2018-12-27), pages 2495 - 2505
SOMMERS JA ET AL.: "A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease(WRN", PLOS ONE, vol. 14, no. 1, 9 January 2019 (2019-01-09), pages e0210525, XP055724955, DOI: 10.1371/journal.pone.0210525
LEI BIAN ET AL., MOLECULAR CANCER, vol. 18, 2019, pages 169
KWI H KOH ET AL., LABORATORY INVESTIGATION, vol. 85, 2005, pages 1130 - 1138
GREG OAKLEY ET AL., BIOCHEMISTRY, vol. 48, no. 31, 11 August 2009 (2009-08-11), pages 7473 - 7481
TING LIU ET AL., ACTA BIOCHIM BIOPHYS SIN, vol. 48, no. 7, 2016, pages 665 - 670
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495
P. J. DELVES: "Monoclonal Antibodies", 1997, OXFORD UNIVERSITY PRESS, article "Antibody Production: Essential Techniques"
VANDAMME AM ET AL., EUR. J. BIOCHEM., vol. 192, 1990, pages 767 - 775
MOL CELL, vol. 71, no. 2, 19 July 2018 (2018-07-19), pages 319 - 331
EUR J CANCER, vol. 36, no. 7, May 2000 (2000-05-01), pages 925 - 931
See also references of EP 4063507A4
WESSENDORF, PETRA: "Deficiency of the DNA repair protein nibrin increases the basal but not the radiation induced mutation frequency in vivo", MUTAT RES., vol. 769, 11 July 2014 (2014-07-11), pages 11 - 16, XP055825745
JIA, PAN-PAN ET AL.: "Role of human DNA2 (hDNA2) as a potential target for cancer and other diseases: A systematic review", DNA REPAIR, vol. 59, 2017, pages 9 - 19, XP085212464, DOI: 10.1016/j.dnarep.2017.09.001
UCHIZAKA, NAOKI: "MRE11 point mutation from two brothers with lung cancer", THE 51ST ANNUAL MEETING OF THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY, THE 25TH ANNUAL MEETING OF THE JAPANESE SOCIETY OF PEDIATRIC ONCOLOGY, THE 7TH ANNUAL MEETING OF THE JAPANESE SOCIETY OF PEDIATRIC CANCER NURSING, AND THE 14TH ANNUAL MEETING OF, 30 November 2008 (2008-11-30) - 29 November 2009 (2009-11-29), JP, pages 101, XP009538103
CHENG, WEN-HSING ET AL.: "Targeting Werner syndrome protein sensitizes U-2 OS osteosarcoma cells to selenium-induced DNA damage response and necrotic death", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 420, 2012, pages 24 - 28, XP028479010, DOI: 10.1016/j.bbrc.2012.02.104
LIEB, SIMONE ET AL.: "Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells", ELIFE, vol. 8, 25 March 2019 (2019-03-25), pages e43333, XP055825746, Retrieved from the Internet
MAKOTO MAEMONDO ET AL., NEJM, vol. 362, no. 25, 24 June 2010 (2010-06-24), pages 2380 - 2388
PAUL B. CHAPMAN ET AL., NEJM, vol. 364, no. 26, 30 June 2011 (2011-06-30), pages 2507 - 2516
D. ROSS CAMIDGE ET AL., J THORAC ONCOL, vol. 14, no. 7, July 2019 (2019-07-01), pages 1233 - 1243
LORN KATEGAYA ET AL., ISCIENCE, vol. 13, 29 March 2019 (2019-03-29), pages 488 - 497
SIMONE LIEB ET AL., ELIFE, vol. 8, 2019, pages e43333
EDMOND M. CHAN ET AL., NATURE, vol. 68, no. 7753, 5 April 2019 (2019-04-05), pages 511 - 516
K. MOORE ET AL., NEJM, vol. 379, no. 26, 27 December 2018 (2018-12-27), pages 2495 - 2505
SOMMERS JA ET AL.: "A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease(WRN", PLOS ONE, vol. 14, no. 1, 9 January 2019 (2019-01-09), pages e0210525, XP055724955, DOI: 10.1371/journal.pone.0210525
LEI BIAN ET AL., MOLECULAR CANCER, vol. 18, 2019, pages 169
KWI H KOH ET AL., LABORATORY INVESTIGATION, vol. 85, 2005, pages 1130 - 1138
GREG OAKLEY ET AL., BIOCHEMISTRY, vol. 48, no. 31, 11 August 2009 (2009-08-11), pages 7473 - 7481
TING LIU ET AL., ACTA BIOCHIM BIOPHYS SIN, vol. 48, no. 7, 2016, pages 665 - 670
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495
P. J. DELVES: "Monoclonal Antibodies", 1997, OXFORD UNIVERSITY PRESS, article "Antibody Production: Essential Techniques"
VANDAMME AM ET AL., EUR. J. BIOCHEM., vol. 192, 1990, pages 767 - 775
MOL CELL, vol. 71, no. 2, 19 July 2018 (2018-07-19), pages 319 - 331
EUR J CANCER, vol. 36, no. 7, May 2000 (2000-05-01), pages 925 - 931
See also references of EP 4063507A4
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
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