Title:
METHOD FOR PREPARING 2-ARYLMALONIC ACID DERIVATIVE, INTERMEDIATE, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/199081
Kind Code:
A1
Abstract:
The present invention provides a method for preparing a 2-arylmalonic acid derivative, an intermediate, and an application thereof. In the method, a cyclohexadiene compound is taken as a raw material, and isomerization reaction, halogenating reaction in the presence of a halogenating agent, and dehydrohalogenation aromatization reaction at a certain temperature are performed sequentially to obtain a 2-arylmalonic acid derivative 3. Compared with the prior art, the following notable features and advantages are provided: (1) the reaction does not require expensive metal catalysts; (2) the reaction does not require use of strong bases having potential safety hazards; (3) the reaction is safe, conditions are mild, yield is high, costs are low, and the present invention is beneficial to industrial production.
Inventors:
CHEN BANGCHI (CN)
SUN YINWEI (CN)
WANG ZHONGYUAN (CN)
JIN TAO (CN)
SUN YINWEI (CN)
WANG ZHONGYUAN (CN)
JIN TAO (CN)
Application Number:
PCT/CN2019/080827
Publication Date:
October 08, 2020
Filing Date:
April 01, 2019
Export Citation:
Assignee:
ORIENTAL LUZHOU AGROCHEMICALS CO LTD (CN)
International Classes:
C07C67/30; C07C69/612; C07C253/30; C07C255/31; C07C255/34
Domestic Patent References:
| WO2018184196A1 | 2018-10-11 | |||
| WO2000078881A2 | 2000-12-28 | |||
| WO2000078712A1 | 2000-12-28 | |||
| WO2004050607A1 | 2004-06-17 | |||
| WO2018120094A1 | 2018-07-05 |
Foreign References:
| CN108264469A | 2018-07-10 | |||
| CN108264463A | 2018-07-10 | |||
| CN108264517A | 2018-07-10 | |||
| CN108689874A | 2018-10-23 | |||
| CN106928253A | 2017-07-07 | |||
| CN102617450A | 2012-08-01 |
Other References:
BENASSI, R. ET AL.: "Ground-state molecular stabilization of substituted ethylenes. A theoretical mo ab-initio thermochemical study", JOURNAL OF MOLECULAR STRUCTURE: THEOCHEM, vol. 572, 17 September 2001 (2001-09-17), XP029996271, DOI: 20191206182239X
DATABASE REGISTRY 24 August 2006 (2006-08-24), ANONYMOUS: "904241-50-5", XP055868843, retrieved from STN Database accession no. 904241-50-5
VIG, O. P. : "Terpenoids. XVII. New syntheses of (±)-lanceol and (±)-β-bisabolene", INDIAN JOURNAL OF CHEMISTRY, vol. 5, no. 10, 31 October 1967 (1967-10-31), pages 475 - 478, XP009531968, ISSN: 0019-5103
JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, vol. 14, 1984, pages 932 - 3
ZI, W.TOSTE, F.D., ANGEW. CHEM. INT. ED., vol. 54, no. 48, 2015, pages 14447 - 14451
DATABASE REGISTRY 24 August 2006 (2006-08-24), ANONYMOUS: "904241-50-5", XP055868843, retrieved from STN Database accession no. 904241-50-5
VIG, O. P. : "Terpenoids. XVII. New syntheses of (±)-lanceol and (±)-β-bisabolene", INDIAN JOURNAL OF CHEMISTRY, vol. 5, no. 10, 31 October 1967 (1967-10-31), pages 475 - 478, XP009531968, ISSN: 0019-5103
JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, vol. 14, 1984, pages 932 - 3
ZI, W.TOSTE, F.D., ANGEW. CHEM. INT. ED., vol. 54, no. 48, 2015, pages 14447 - 14451
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO.,LTD. (CN)
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