Title:
METHOD FOR PREPARING 2-CHLORO-5-METHYLPYRIDINE THROUGH CONTINUOUS FLOW
Document Type and Number:
WIPO Patent Application WO/2024/016618
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing 2-chloro-5-methylpyridine through continuous flow. The method comprises the following steps: (1) mixing a pyridine oxide-organic nitrogen base homogeneous solution with a chlorinating agent solution to obtain a salifying solution; and (2) mixing the salifying solution with hydrogen chloride to obtain a chlorination reaction solution. A chlorinating agent in the chlorinating agent solution in step (1) comprises any one or a combination of at least two of phosgene, diphosgene, triphosgene, thionyl chloride, sulfuryl chloride, or cyanuric chloride. According to the preparation method provided by the present invention, the hydrogen chloride is used for a chlorination reaction, and a pyridine oxide, an organic nitrogen base, and the chlorinating agent are mixed in a solution form, so that compared with a traditional kettle type intermittent synthesis method, the present invention improves the quality stability of a product in a synthesis process, and achieves high productivity and yield of the 2-chloro-5-methylpyridine.
Inventors:
WANG YIMING (CN)
ZHANG WEIWEI (CN)
ZHAO HUI (CN)
YAN HUI (CN)
LIU XIA (CN)
GAO QIUMIN (CN)
ZHANG WEIWEI (CN)
ZHAO HUI (CN)
YAN HUI (CN)
LIU XIA (CN)
GAO QIUMIN (CN)
Application Number:
PCT/CN2023/072699
Publication Date:
January 25, 2024
Filing Date:
January 17, 2023
Export Citation:
Assignee:
JIANGSU RUIXIANG CHEMICAL CO LTD (CN)
JIANGSU YANGNONG CHEMICAL GROUP CO LTD (CN)
JIANGSU YANGNONG CHEMICAL GROUP CO LTD (CN)
International Classes:
C07D213/61; B01J19/00
Foreign References:
| CN115010657A | 2022-09-06 | |||
| CN1075476A | 1993-08-25 | |||
| CN104418798A | 2015-03-18 | |||
| CN106117128A | 2016-11-16 |
Other References:
LIU, ZHAOLI ET AL.: "Applications of Microreactor in Chemistry and Chemical Engineering", CHEMICAL INDUSTRY AND ENGINEERING PROGRESS, vol. 35, no. 1, 31 December 2016 (2016-12-31), pages 10 - 17, XP055817704, ISSN: 1000-6613, DOI: 10.16085/j.issn.1000-6613.2016.01.002
Attorney, Agent or Firm:
KANGXIN PARTNERS , P.C. et al. (CN)
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