Title:
METHOD FOR PREPARING 2-IODO-ARYL ETHER ON BASIS OF O-HALOGEN IODOBENZENE IN ABSENCE OF CATALYST
Document Type and Number:
WIPO Patent Application WO/2022/178691
Kind Code:
A1
Abstract:
Disclosed is a method for preparing 2-iodo-aryl ether on the basis of o-halogen iodobenzene in the absence of a catalyst, comprising: adding an alkali metal hydride and a phenol into a solvent; and then adding o-halogen iodobenzene for reaction at 50-70°C to obtain a 2-iodo-aryl ether product. According to the present invention, the coupling process does not require the addition of a transition metal catalyst, and thus causes no metal pollution to the product.
Inventors:
ZHANG SHILEI (CN)
ZHU WENJING (CN)
HU YANWEI (CN)
YU LIANG (CN)
GUI JINGJING (CN)
JIANG YUANRUI (CN)
ZHU WENJING (CN)
HU YANWEI (CN)
YU LIANG (CN)
GUI JINGJING (CN)
JIANG YUANRUI (CN)
Application Number:
PCT/CN2021/077529
Publication Date:
September 01, 2022
Filing Date:
February 23, 2021
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07C255/40; C07C253/30; C07C255/54
Foreign References:
| CN112979497A | 2021-06-18 |
Other References:
WEN SONG YUE ET AL.: "A Concise Synthesis of All Four Possible Benzo[4, 5]furopyridines via Palladium-Mediated Reactions", ORGANIC LETTERS, vol. 4, no. 13, 31 December 2002 (2002-12-31), XP055042429, ISSN: 1523-7060, DOI: 10.1021/ol0260425
NARJES FRANK, XUE YAFENG, VON BERG STEFAN, MALMBERG JESPER, LLINAS ANTONIO, OLSSON ROINE I., JIRHOLT JOHAN, GRINDEBACKE HANNA, LEF: "Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 61, no. 17, 13 September 2018 (2018-09-13), US , pages 7796 - 7813, XP055961851, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b00783
NARJES FRANK, XUE YAFENG, VON BERG STEFAN, MALMBERG JESPER, LLINAS ANTONIO, OLSSON ROINE I., JIRHOLT JOHAN, GRINDEBACKE HANNA, LEF: "Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 61, no. 17, 13 September 2018 (2018-09-13), US , pages 7796 - 7813, XP055961851, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b00783
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
Download PDF: