Title:
METHOD FOR PREPARING AMINO ALCOHOL BY ASYMMETRIC HYDROGENATION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/082465
Kind Code:
A1
Abstract:
The present invention relates to the technical field of chemical catalytic reaction. Disclosed are a method for preparing an amino alcohol by asymmetric hydrogenation and an application thereof. A starting raw material of the chemical reaction is an amino ketone compound (I); the amino ketone compound (I) is subjected to asymmetric catalytic hydrogenation reduction to obtain a chiral amino alcohol intermediate (II), the yield of the intermediate (II) being almost quantitative, and the enantioselectivity being up to 99%ee; the intermediate (II) undergoes intramolecular cyclization under suitable conditions to obtain chiral pyrrolidine or piperidine having high optical activity. By utilizing the present method, a series of chiral pyrrolidine and piperidine compounds can be efficiently and highly selectively prepared, and the method has an important practical value and industrial prospect.
Inventors:
LANG QIWEI (CN)
GAO SHUANG (CN)
LIU CHUANGJI (CN)
CHEN LIRU (CN)
GAO SHUANG (CN)
LIU CHUANGJI (CN)
CHEN LIRU (CN)
Application Number:
PCT/CN2022/071760
Publication Date:
May 19, 2023
Filing Date:
January 13, 2022
Export Citation:
Assignee:
SHENZHEN CATALYS TECH CO LTD (CN)
International Classes:
C07C213/00; C07D207/08; C07D487/04
Foreign References:
| CN113527187A | 2021-10-22 | |||
| CN1678562A | 2005-10-05 | |||
| CN105732725A | 2016-07-06 | |||
| CN107021884A | 2017-08-08 | |||
| CA2642563A1 | 2010-04-30 | |||
| CN108484361A | 2018-09-04 | |||
| CN114315917A | 2022-04-12 |
Attorney, Agent or Firm:
SHENZHEN LANFENG SHENGSHI INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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