METHOD FOR PREPARING CASPASE INHIBITOR - CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD

Title:

METHOD FOR PREPARING CASPASE INHIBITOR

Document Type and Number:

WIPO Patent Application WO/2019/174589

Kind Code:

A1

Abstract:

Disclosed herein a crystal structure of a caspase inhibitor, and more specifically a crystal structure of an (S)-3-((S)-2-(5-(2-chlorobenzyl) isoxazole-3-formyl amide) proponamide)-4-oxo-5-(2,3,5,6-tetraphenoxy)) valeric acid, a preparation method therefor, a crystal polymer, a pharmaceutical composition and uses thereof. The compound A of formula (I) disclosed herein exhibits high crystal structure stability, low hygroscopicity, and advantageously shows physical properties, safety and metabolic stability while having relatively high pharmaceutical value.

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Inventors:

WU SONGLIANG (CN)
MOU JIANFENG (CN)
HE HAIYING (CN)

Application Number:

PCT/CN2019/077939

Publication Date:

September 19, 2019

Filing Date:

March 13, 2019

Export Citation:

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Assignee:

CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
MEDSHINE DISCOVERY INC (CN)

International Classes:

C07D261/06

Domestic Patent References:

WO2018133870A1

2018-07-26

Foreign References:

CN1313846A	2001-09-19
CN1345332A	2002-04-17

Other References:

BARR ET AL., BIO/TECHNOLOGY, vol. 12, 1994, pages 487 - 497
"Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT, WILLIAMS & WILKINS
See also references of EP 3766873A4

Attorney, Agent or Firm:

SHANGHAI BESHINING LAW OFFICE (CN)

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