Title:
METHOD FOR PREPARING MYRICERONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2006/077801
Kind Code:
A1
Abstract:
A method for preparing a compound represented by the formula (II): (II), which comprises reacting a compound represented by the formula (I): (I), wherein each of R1 and R1' is independently a lower alkyl optionally having a substituent and R2 is hydrogen or a lower alkyl, by the use of hydrogen peroxide and a molybdenum catalyst.
Inventors:
KOIKE HARUO (JP)
ARAKI YOSHITAKA (JP)
FUJIOKA NAOKO (JP)
ARAKI YOSHITAKA (JP)
FUJIOKA NAOKO (JP)
Application Number:
PCT/JP2006/300465
Publication Date:
July 27, 2006
Filing Date:
January 17, 2006
Export Citation:
Assignee:
SHIONOGI & CO (JP)
KOIKE HARUO (JP)
ARAKI YOSHITAKA (JP)
FUJIOKA NAOKO (JP)
KOIKE HARUO (JP)
ARAKI YOSHITAKA (JP)
FUJIOKA NAOKO (JP)
International Classes:
C07J63/00; C07J75/00; C07B61/00
Domestic Patent References:
| WO1997027314A1 | 1997-07-31 |
Foreign References:
| JPH07316188A | 1995-12-05 | |||
| EP0628569A1 | 1994-12-14 | |||
| EP1489091A1 | 2004-12-22 |
Other References:
KONOIKE T. ET AL.: "Practical Partial Synthesis of Myriceric Acid A, an Endothelin Receptor Antagonist, from Oleanolic Acid", JOURNAL OF ORGANIC CHEMISTRY, vol. 62, no. 4, 1997, pages 960 - 966, XP002968888
KONOIKE T. ET AL.: "Synthesis of [2-13C]-oleanolic acid and [2-13C]-myricerone", TETRAHEDRON, vol. 55, no. 52, 1999, pages 14901 - 14914, XP004184684
SAKURAWI K. ET AL.: "Endothelin receptor antagonist triterpenoid, myriceric acid A, isolated from Myrica cerifera, and structure activity relationships of its derivatives", CHEM. PHARM. BULL., vol. 44, no. 2, 1996, TOKYO, pages 343 - 351, XP008064449
TROST B.M. ET AL.: "Chemoselectivity in molybdenum-catalyzed alcohol and aldehyde oxidations", TETRAHEDRON LETTERS, vol. 25, no. 2, 1984, pages 173 - 176, XP002998783
KONOIKE T. ET AL.: "Synthesis of [2-13C]-oleanolic acid and [2-13C]-myricerone", TETRAHEDRON, vol. 55, no. 52, 1999, pages 14901 - 14914, XP004184684
SAKURAWI K. ET AL.: "Endothelin receptor antagonist triterpenoid, myriceric acid A, isolated from Myrica cerifera, and structure activity relationships of its derivatives", CHEM. PHARM. BULL., vol. 44, no. 2, 1996, TOKYO, pages 343 - 351, XP008064449
TROST B.M. ET AL.: "Chemoselectivity in molybdenum-catalyzed alcohol and aldehyde oxidations", TETRAHEDRON LETTERS, vol. 25, no. 2, 1984, pages 173 - 176, XP002998783
Attorney, Agent or Firm:
Takayama, Hirotsugu (Ltd. Intellectual Property Department 12-4,
Sagisu 5-chome, Fukushima-ku, Osaka-sh, Osaka 02, JP)
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