Title:
METHOD FOR PREPARING PAEONIFLORIN-6-O'-BENZENE SULFONATE
Document Type and Number:
WIPO Patent Application WO/2023/000517
Kind Code:
A1
Abstract:
Provided in the present invention is a method for preparing paeoniflorin-6-O'-benzene sulfonate. The method uses crude paeoniflorin instead of paeoniflorin as a raw material, which more complies with actual requirements of an industrial production process of paeoniflorin-6-O'-benzene sulfonate, and uses an organic metal catalyst, an acid-binding agent and chemically active benzenesulfonyl chloride to react with paeoniflorin. Compared with the prior art, the method significantly increases the yield of crude paeoniflorin-6-O'-benzene sulfonate which is separated and purified by means of column chromatography and then refined to obtain paeoniflorin-6-O'-benzenesulfonate with a content of at least 98%, thereby realizing industrial production of the paeoniflorin-6-O'-benzene sulfonate.
Inventors:
XU WENDONG (CN)
YUAN CHENG (CN)
TANG SHUNZHI (CN)
LIU JUYAN (CN)
CAI HONGFEI (CN)
BAI BAI (CN)
LI JING (CN)
FU YUPING (CN)
LI SONGTAO (CN)
PENG WANCAI (CN)
LI YONGHUA (CN)
LI YAO (CN)
LI JIRONG (CN)
WEI SHAOHENG (CN)
LI JIALI (CN)
YUAN CHENG (CN)
TANG SHUNZHI (CN)
LIU JUYAN (CN)
CAI HONGFEI (CN)
BAI BAI (CN)
LI JING (CN)
FU YUPING (CN)
LI SONGTAO (CN)
PENG WANCAI (CN)
LI YONGHUA (CN)
LI YAO (CN)
LI JIRONG (CN)
WEI SHAOHENG (CN)
LI JIALI (CN)
Application Number:
PCT/CN2021/124536
Publication Date:
January 26, 2023
Filing Date:
October 19, 2021
Export Citation:
Assignee:
GUANGZHOU HANFANG PHARMACEUTICAL CO LTD (CN)
International Classes:
C07H17/04; C07H1/00
Domestic Patent References:
| WO2018133139A1 | 2018-07-26 |
Foreign References:
| CN102603827A | 2012-07-25 | |||
| JP2009215175A | 2009-09-24 | |||
| JP2009221161A | 2009-10-01 | |||
| CN109481453A | 2019-03-19 | |||
| CN109481452A | 2019-03-19 | |||
| CN103951717A | 2014-07-30 | |||
| CN102643316A | 2012-08-22 | |||
| CN102731522A | 2012-10-17 | |||
| CN112079883A | 2020-12-15 |
Other References:
DEMIZU YOSUKE, KUBO YUKI, MIYOSHI HIROKO, MAKI TOSHIHIDE, MATSUMURA YOSHIHIRO, MORIYAMA NORIAKI, ONOMURA OSAMU: "Regioselective Protection of Sugars Catalyzed by Dimethyltin Dichloride", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 21, 6 November 2008 (2008-11-06), US , pages 5075 - 5077, XP093026554, ISSN: 1523-7060, DOI: 10.1021/ol802095e
ZHOU PENG: "Studies on Synthetic Process Optimization and Disposition of CP-25 and Preliminary Study on 6-AP", CHINESE DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, UNIVERSITY OF CHINESE ACADEMY OF SCIENCES, CN, no. 12, 22 April 2017 (2017-04-22), CN , XP093026559, ISSN: 1674-022X
WANG CHUN, YUAN JUN; WEI WEI: "Study on Paeoniflorin-6’O-Benzene Sulfonate's Physicochemical Property", ACTA UNIVERSITATIS MEDICINALIS ANHUI, vol. 49, no. 2, 28 February 2014 (2014-02-28), pages 202 - 205, XP093026558, ISSN: 1000-1492, DOI: 10.19405/j.cnki.issn1000-1492.2014.02.016
ZHOU PENG: "Studies on Synthetic Process Optimization and Disposition of CP-25 and Preliminary Study on 6-AP", CHINESE DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, UNIVERSITY OF CHINESE ACADEMY OF SCIENCES, CN, no. 12, 22 April 2017 (2017-04-22), CN , XP093026559, ISSN: 1674-022X
WANG CHUN, YUAN JUN; WEI WEI: "Study on Paeoniflorin-6’O-Benzene Sulfonate's Physicochemical Property", ACTA UNIVERSITATIS MEDICINALIS ANHUI, vol. 49, no. 2, 28 February 2014 (2014-02-28), pages 202 - 205, XP093026558, ISSN: 1000-1492, DOI: 10.19405/j.cnki.issn1000-1492.2014.02.016
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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