Title:
PURIFICATION METHOD FOR PAEONIFLORIN-6-O'-BENZENE SULFONATE
Document Type and Number:
WIPO Patent Application WO/2023/000516
Kind Code:
A1
Abstract:
The present invention provides a purification method for paeoniflorin-6-O'-benzene sulfonate. According to the purification method, the purification process for paeoniflorin-6-O'-benzene sulfonate can be reduced, and impurities, such as benzenesulfonyl chloride and derivatives thereof, iron, and heavy metals, in the prepared paeoniflorin-6-O'-benzene sulfonate crude product can be effectively removed, to obtain paeoniflorin-6-O'-benzene sulfonate of which the content is 98% or more. In addition, under the condition of ensuring high content, the energy consumption is low, the solvent dosage is small, the time consumption is low, and the method is thus suitable for industrial production of paeoniflorin-6-O'-benzene sulfonate.
Inventors:
XU WENDONG (CN)
TANG SHUNZHI (CN)
YUAN CHENG (CN)
LIU JUYAN (CN)
CAI HONGFEI (CN)
BAI BAI (CN)
FU YUPING (CN)
LI JING (CN)
LI SONGTAO (CN)
PENG WANCAI (CN)
LI JIRONG (CN)
WEI SHAOHENG (CN)
LI JIALI (CN)
MAN XINGZHAN (CN)
TANG SHUNZHI (CN)
YUAN CHENG (CN)
LIU JUYAN (CN)
CAI HONGFEI (CN)
BAI BAI (CN)
FU YUPING (CN)
LI JING (CN)
LI SONGTAO (CN)
PENG WANCAI (CN)
LI JIRONG (CN)
WEI SHAOHENG (CN)
LI JIALI (CN)
MAN XINGZHAN (CN)
Application Number:
PCT/CN2021/124535
Publication Date:
January 26, 2023
Filing Date:
October 19, 2021
Export Citation:
Assignee:
GUANGZHOU HANFANG PHARMACEUTICAL CO LTD (CN)
International Classes:
C07H1/06; C07H17/04
Foreign References:
| CN102603827A | 2012-07-25 | |||
| CN102643316A | 2012-08-22 |
Other References:
WANG CHUN, YUAN JUN; WEI WEI: "Study on Paeoniflorin-6’O-Benzene Sulfonate's Physicochemical Property", ACTA UNIVERSITATIS MEDICINALIS ANHUI, vol. 49, no. 2, 28 February 2014 (2014-02-28), pages 202 - 205, XP093026558, ISSN: 1000-1492, DOI: 10.19405/j.cnki.issn1000-1492.2014.02.016
ASENSO JAMES, YU JUN, XIAO FENG, ZHAO MINGYI, WANG JIAN, WU YIJIN, WANG CHUN, WEI WEI: "Methotrexate improves the anti-arthritic effects of Paeoniflorin-6'-O-benzene sulfonate by enhancing its pharmacokinetic properties in adjuvant-induced arthritis rats", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 112, 1 April 2019 (2019-04-01), FR , pages 108644, XP093026698, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2019.108644
ASENSO JAMES, YU JUN, XIAO FENG, ZHAO MINGYI, WANG JIAN, WU YIJIN, WANG CHUN, WEI WEI: "Methotrexate improves the anti-arthritic effects of Paeoniflorin-6'-O-benzene sulfonate by enhancing its pharmacokinetic properties in adjuvant-induced arthritis rats", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 112, 1 April 2019 (2019-04-01), FR , pages 108644, XP093026698, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2019.108644
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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