Title:
METHOD FOR PREPARING ROCILETINIB
Document Type and Number:
WIPO Patent Application WO/2017/071419
Kind Code:
A1
Abstract:
Disclosed is a method for preparing Rociletinib. By means of a condensation reaction of easily obtainable raw materials 5-trifluoromethyluracil and 4-(4-acetylpiperazin-1-yl)-2-methoxyaniline to obtain 2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-pyrimidin-4-one, the intermediate is subjected to a halogenation reaction and an amination reaction to produce Rociletinib. The preparation method has easily obtainable raw materials, a simple process, is economic and environmentally friendly, and is suitable for industrial production.
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Inventors:
XU XUENONG (CN)
Application Number:
PCT/CN2016/098852
Publication Date:
May 04, 2017
Filing Date:
September 13, 2016
Export Citation:
Assignee:
SUZHOU MIRACPHARMA TECH CO LTD (CN)
International Classes:
C07D239/48
Domestic Patent References:
| WO2015158310A1 | 2015-10-22 | |||
| WO2012061299A1 | 2012-05-10 | |||
| WO2012064706A1 | 2012-05-18 |
Foreign References:
| CN105198821A | 2015-12-30 | |||
| CN104860890A | 2015-08-26 |
Attorney, Agent or Firm:
SUZHOU WISTONG INTELLECTUAL PROPERTY AGENCY(COMMON PARTNERSHIP) (CN)
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