Title:
METHOD FOR PRODUCING 2-O-α-D-GLUCOSYL-L-ASCORBIC ACID ANHYDROUS CRYSTAL-CONTAINING POWDER
Document Type and Number:
WIPO Patent Application WO/2012/121297
Kind Code:
A1
Abstract:
[Problem] To provide a method for producing an ascorbic acid 2-glucoside anhydrous crystal-containing powder with which it is possible to produce a powder that will not show significant solidification, even when the percentage of ascorbic acid 2-glucoside produced is less than 35 mass%. [Solution] A method for producing an ascorbic acid 2-glucoside anhydrous crystal-containing powder comprising a step in which a solution containing either liquefied starch or dextrin and L-ascorbic acid is exposed to CGTase and then to glucoamylase in order to obtain a solution wherein the percentage of ascorbic acid 2-glucoside produced is 27 mass% or greater; a step for purifying the resulting solution such that the ascorbic acid 2-glucoside content exceeds 86 mass%; a step for precipitating the ascorbic acid 2-glucoside anhydrous crystals by controlled cooling or semi-controlled cooling; and a step for recovering, aging, and drying the precipitated ascorbic acid 2-glucoside anhydrous crystals.
Inventors:
SHIBUYA TAKASHI (JP)
IZAWA SEISUKE (JP)
NISHIMOTO TOMOYUKI (JP)
FUKUDA SHIGEHARU (JP)
MIYAKE TOSHIO (JP)
IZAWA SEISUKE (JP)
NISHIMOTO TOMOYUKI (JP)
FUKUDA SHIGEHARU (JP)
MIYAKE TOSHIO (JP)
Application Number:
PCT/JP2012/055849
Publication Date:
September 13, 2012
Filing Date:
March 07, 2012
Export Citation:
Assignee:
HAYASHIBARA CO (JP)
SHIBUYA TAKASHI (JP)
IZAWA SEISUKE (JP)
NISHIMOTO TOMOYUKI (JP)
FUKUDA SHIGEHARU (JP)
MIYAKE TOSHIO (JP)
SHIBUYA TAKASHI (JP)
IZAWA SEISUKE (JP)
NISHIMOTO TOMOYUKI (JP)
FUKUDA SHIGEHARU (JP)
MIYAKE TOSHIO (JP)
International Classes:
C07H17/04; A23L33/15; A61K31/7048
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Other References:
NORIAKI KUBOTA ET AL.: "Wakariyasui Batch Shoseki", THE SOCIETY OF SEPARATION PROCESS ENGINEERS, 30 April 2010 (2010-04-30), JAPAN, pages 32 - 41, XP008171161
MARKOSYAN A.A. ET AL.: "Transglycosylation of L- Ascorbic Acid", APPLIED BIOCHEMISTRY AND MICROBIOLOGY, vol. 43, no. 1, 2007, pages 36 - 40, XP019463547
SANYO-GIJYUTSU-ZASSHI, vol. 45, no. 1, 1997, pages 63 - 69
TAKAHIKO MANDAI ET AL., CARBOHYDRATE RESEARCH, vol. 232, 1992, pages 197 - 205
YUTAKA INOUE ET AL., INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 331, 2007, pages 38 - 45
APPLIED BIOCHEMISTRY AND MICROBIOLOGY, vol. 143, no. 1, 2007, pages 36 - 40
AGRICULTURAL BIOLOGICAL CHEMISTRY, vol. 7, 1991, pages 1751 - 1756
WAKOANALYTICAL CIRCLE, 2003, pages 6
NORIAKI KUBOTA,: "Wakariyasui-Batch-Shoseki", 30 April 2010, THE SOCIETY OF SEPARATION PROCESS ENGINEERS, pages: 32 - 47
KODANSHA SCIENTIFIC LTD.: "Kogyo-yo-Toshitsu-Koso-Handbook", 1999, KODANSHA LTD., pages: 56 - 63
P. H. HERMANS; A. WEIDINGER, JOURNAL OF APPLIED PHYSICS, vol. 19, 1948, pages 491 - 506
P. H. HERMANS; A. WEIDINGER, JOURNAL OF POLYMER SCIENCE, vol. 4, 1949, pages 135 - 144
MARKOSYAN A.A. ET AL.: "Transglycosylation of L- Ascorbic Acid", APPLIED BIOCHEMISTRY AND MICROBIOLOGY, vol. 43, no. 1, 2007, pages 36 - 40, XP019463547
SANYO-GIJYUTSU-ZASSHI, vol. 45, no. 1, 1997, pages 63 - 69
TAKAHIKO MANDAI ET AL., CARBOHYDRATE RESEARCH, vol. 232, 1992, pages 197 - 205
YUTAKA INOUE ET AL., INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 331, 2007, pages 38 - 45
APPLIED BIOCHEMISTRY AND MICROBIOLOGY, vol. 143, no. 1, 2007, pages 36 - 40
AGRICULTURAL BIOLOGICAL CHEMISTRY, vol. 7, 1991, pages 1751 - 1756
WAKOANALYTICAL CIRCLE, 2003, pages 6
NORIAKI KUBOTA,: "Wakariyasui-Batch-Shoseki", 30 April 2010, THE SOCIETY OF SEPARATION PROCESS ENGINEERS, pages: 32 - 47
KODANSHA SCIENTIFIC LTD.: "Kogyo-yo-Toshitsu-Koso-Handbook", 1999, KODANSHA LTD., pages: 56 - 63
P. H. HERMANS; A. WEIDINGER, JOURNAL OF APPLIED PHYSICS, vol. 19, 1948, pages 491 - 506
P. H. HERMANS; A. WEIDINGER, JOURNAL OF POLYMER SCIENCE, vol. 4, 1949, pages 135 - 144
Attorney, Agent or Firm:
SUMA Mitsuo (JP)
Suma Mitsuo (JP)
Suma Mitsuo (JP)
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