Title:
METHOD FOR PRODUCING 6-(4,4-DIMETHYLCYCLOHEXYL)-4-[(1,1-DIOXO-1λ6-THIOMORPHOLIN-4-YL)METHYL]-2-METHYLTHIENO[2,3-D]PYRIMIDINE OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/048714
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel synthesis method for 6-(4,4-dimethylcyclohexyl)-4-[(1,1-dioxo-1λ6-thiomorpholin-4-yl)methyl]-2-methylthieno[2,3-d]pyrimidine and a salt thereof, which is efficient and is preferred from the viewpoint of green chemistry. 6-(4,4-Dimethylcyclohexyl)-4-[(1,1-dioxo-1λ6-thiomorpholin-4-yl)methyl]-2-methylthieno[2,3-d]pyrimidine is synthesized safely and efficiently by a method including a step for adding 4,4-dimethyl-cyclohexanone to position-6 in a compound represented by the formula shown below [in the formula, Hal represents a halogen atom].
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Inventors:
OTAKA ERIKO (JP)
OBITSU KAZUYOSHI (JP)
KOHMURA YOSHINORI (JP)
YAMASHITA YOHEI (JP)
TAKAMATSU YUSEI (JP)
HIRASAWA SHUN (JP)
FUKUYAMA TOHRU (JP)
OBITSU KAZUYOSHI (JP)
KOHMURA YOSHINORI (JP)
YAMASHITA YOHEI (JP)
TAKAMATSU YUSEI (JP)
HIRASAWA SHUN (JP)
FUKUYAMA TOHRU (JP)
Application Number:
PCT/JP2023/031795
Publication Date:
March 07, 2024
Filing Date:
August 31, 2023
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
International Classes:
C07D495/04
Domestic Patent References:
| WO2015056771A1 | 2015-04-23 |
Foreign References:
| JP2022522777A | 2022-04-20 |
Other References:
TABER DOUGLASS F., SCHUCHARDT JONATHAN L.: "Intramolecular carbon-hydrogen insertion: synthesis of (.+-.)-pentalenolactone E methyl ester", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 107, no. 18, 1 September 1985 (1985-09-01), pages 5289 - 5290, XP009552929, ISSN: 0002-7863, DOI: 10.1021/ja00304a052
Attorney, Agent or Firm:
YAMAMOTO, Osamu et al. (JP)
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