Title:
METHOD FOR PRODUCING BENZOAMINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2023/249414
Kind Code:
A1
Abstract:
The present invention relates to a method for producing a benzoamine derivative, and more specifically, to a method for producing a benzoamine derivative at high yield and purity using 1,1'-carbonyldiimidazole as a coupling catalyst in order to improve the safety of the reaction and ease of operation. The production method according to the present invention uses cost-effective and safe reagents, thus providing a high degree of operational safety and being well-suited for commercial-scale production without the risk of equipment corrosion, and improves reaction yield and purity, thus maximizing production efficiency and being useful for mass production.
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Inventors:
LEE HYUN MYUNG (KR)
EO JIN-YONG (KR)
LEE KYUNG-HO (KR)
PARK DAE-HYUN (KR)
HONG JOONGYEOUN (KR)
KIM YOUNG-MIN (KR)
EO JIN-YONG (KR)
LEE KYUNG-HO (KR)
PARK DAE-HYUN (KR)
HONG JOONGYEOUN (KR)
KIM YOUNG-MIN (KR)
Application Number:
PCT/KR2023/008635
Publication Date:
December 28, 2023
Filing Date:
June 21, 2023
Export Citation:
Assignee:
DAEWOONG BIO INC (KR)
International Classes:
C07C231/02; C07C231/22; C07C235/56; C07C235/64
Foreign References:
| US20180002322A1 | 2018-01-04 | |||
| CN1626506A | 2005-06-15 | |||
| US20220017476A1 | 2022-01-20 |
Other References:
JUANG YU-PU; CHOU YU-TING; LIN RU-XIAN; MA HSIU-HUA; CHAO TAI-LING; JAN JIA-TSRONG; CHANG SUI-YUAN; LIANG PI-HUI: "Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 235, 19 March 2022 (2022-03-19), AMSTERDAM, NL , XP087022544, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2022.114295
WOODMAN EMILY K., CHAFFEY JULIAN G. K., HOPES PHILIP A., HOSE DAVID R. J., GILDAY JOHN P.: "N,N ′-Carbonyldiimidazole-Mediated Amide Coupling: Significant Rate Enhancement Achieved by Acid Catalysis with Imidazole·HCl", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 1, 16 January 2009 (2009-01-16), US , pages 106 - 113, XP093118667, ISSN: 1083-6160, DOI: 10.1021/op800226b
WOODMAN EMILY K., CHAFFEY JULIAN G. K., HOPES PHILIP A., HOSE DAVID R. J., GILDAY JOHN P.: "N,N ′-Carbonyldiimidazole-Mediated Amide Coupling: Significant Rate Enhancement Achieved by Acid Catalysis with Imidazole·HCl", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 1, 16 January 2009 (2009-01-16), US , pages 106 - 113, XP093118667, ISSN: 1083-6160, DOI: 10.1021/op800226b
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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