Title:
METHOD FOR PRODUCING A BIOCOMPATIBLE LAYER ON AN IMPLANT SURFACE
Document Type and Number:
WIPO Patent Application WO/2019/034207
Kind Code:
A3
Abstract:
The invention relates to a method for producing a biocompatible layer on an implant surface of an implant consisting of polyetheretherketone. The aim of the invention is to specify a possibility, by which the positive properties of PEEK as an implant material can be improved with regard to growing-in behavior, biocompatibility and resorbability of the coating. According to the invention, said aim is achieved by a method for producing a biocompatible layer on an implant surface of an implant, consisting of polyetheretherketone, in which first the implant surface is provided with hydroxyl groups by the reduction of the keto group with hydroxyl groups or by applying a SiOx coating, then a coupling layer is applied by means of a coupling reagent selected from the substance class of mono-polyisocyanates, whereby a link to the hydroxyl groups of the implant surface is carried out via urethane bonds, and finally a biopolymer layer is applied by means of a modified biopolymer selected from the substance classes of polysaccharides and/or glycosaminoglycans, whereby a link to the coupling layer is carried out via urethane and/or urea bonds. Furthermore, the oligoester methacrylates and the oligoester urethane methacrylates can be cross-linked by means of photoinitiators on the substrate surface.
Inventors:
BERG ALBRECHT (DE)
SCHNABELRAUCH MATTHIAS (DE)
WEISSER JÜRGEN (DE)
PFUCH ANDREAS (DE)
BEIER OLIVER (DE)
SCHNABELRAUCH MATTHIAS (DE)
WEISSER JÜRGEN (DE)
PFUCH ANDREAS (DE)
BEIER OLIVER (DE)
Application Number:
PCT/DE2018/100708
Publication Date:
April 18, 2019
Filing Date:
August 13, 2018
Export Citation:
Assignee:
VEREIN ZUR FOERDERUNG VON INNOVATIONEN DURCH FORSCHUNG ENTWICKLUNG UND TECH E V VEREIN INNOVENT E V (DE)
International Classes:
A61L27/18; A61L27/34
Domestic Patent References:
| WO2016134819A1 | 2016-09-01 | |||
| WO2002000271A1 | 2002-01-03 | |||
| WO2013050554A1 | 2013-04-11 | |||
| WO2015103023A1 | 2015-07-09 |
Foreign References:
| DE102008036520A1 | 2010-02-18 | |||
| EP2631332A1 | 2013-08-28 |
Other References:
NOISET O ET AL: "ADHESION AND GROWTH OF CACO2 CELLS ON SURFACE-MODIFIED PEEK SUBSTRATA", JOURNAL OF BIOMATERIALS SCIENCE. POLYMER EDITION, VSP, UTRECHT, NL, vol. 11, no. 7, 1 January 2000 (2000-01-01), pages 767 - 786, XP001033578, ISSN: 0920-5063, DOI: 10.1163/156856200744002
DATABASE WPI Week 201381, Derwent World Patents Index; AN 2013-H51934, XP002786403
"PEEK Biomaterials Handbook", 1 January 2012, ELSEVIER, ISBN: 978-1-4377-4463-7, article ALEXANDRA H.C. POULSSON ET AL: "Surface Modification Techniques of Polyetheretherketone, Including Plasma Surface Treatment", pages: 145 - 161, XP055522059, DOI: 10.1016/B978-1-4377-4463-7.10010-7
DATABASE WPI Week 201381, Derwent World Patents Index; AN 2013-H51934, XP002786403
"PEEK Biomaterials Handbook", 1 January 2012, ELSEVIER, ISBN: 978-1-4377-4463-7, article ALEXANDRA H.C. POULSSON ET AL: "Surface Modification Techniques of Polyetheretherketone, Including Plasma Surface Treatment", pages: 145 - 161, XP055522059, DOI: 10.1016/B978-1-4377-4463-7.10010-7
Attorney, Agent or Firm:
OEHMKE, Volker et al. (DE)
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