METHOD FOR PRODUCING BIS-PYRIDINIC DERIVATIVES WITH ACETYLCHOLINESTERASE INHIBITING PROPERTIES

WIPO Patent Application WO1993013100

A1

Method for obtaining bis-pyridinic derivatives having formulae (I) and (II) wherein R is hydrogen, alkyl or aralkyl, m, n, p, q may have the values 0, 1, 2, 3... providing that m + n + p + q < 9. X and Y may represent "connection bridges" which may be independent or joined to each other, directly through a bond, and/or through one or a plurality of "appropriate residues". (a) is (b) or (c), R1 being hydrogen, halogen, alkoxy or alkyl. The pharmacological tests of mono and bis-pyridinic derivatives of the invention have been initiated with the study of the reversion of the blocking effect of tubocurarine, with the valuation of the anticholinesterase activity.

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CAMPS GARCIA PELAYO (ES)
PUJOL DILME MA DOLORES (ES)
CONTREPAS LASCORZ JOAN (ES)
GOERBIG ROMEU DIANA MARINA (ES)
MUNOZ-TORRERO LOPEZ-IBARRA DIE (ES)
SIMON FORNELL MONTSERRAT (ES)
BADIA SANCHO ALBERT (ES)
BANOS DIEZ JOSEP E (ES)
BOSCH LLONCH FELIX (ES)

PCT/ES1992/000086

July 08, 1993

December 24, 1992

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BOEHRINGER INGELHEIM ESPANA (ES)

C07D471/04; C07D471/08; (IPC1-7): A61K31/435; C07D221/00; C07D221/18; C07D221/22; C07D471/04; C07D471/08

EP0311303A2

1989-04-12

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