METHOD FOR PRODUCING CRYSTALS FROM ACTIVE INGREDIENTS IN MEDICAMENTS, AND THE USE THEREOF IN PHARMACEUTICAL FORMULATIONS

Title:

METHOD FOR PRODUCING CRYSTALS FROM ACTIVE INGREDIENTS IN MEDICAMENTS, AND THE USE THEREOF IN PHARMACEUTICAL FORMULATIONS

Document Type and Number:

WIPO Patent Application WO2003090721

Kind Code:

A3

Abstract:

The invention relates to a method for producing crystals from active ingredients in medicaments, the average particle size thereof lying within a given range and the maximum particle size thereof not exceeding a given value. During crystallisation, an oversaturated solution is subjected to wet milling by means of a wet milling device; as a result, a primary grain suspension is obtained. The invention also relates to crystals obtained according to said method and pharmaceutical formulations containing said crystals.

Inventors:

GRAWE DETLEF
GERECKE HAGEN
HOESEL PETER
EICHARDT ANNETTE
GLIESING SABINE
MUELLER UWE

Application Number:

PCT/EP2003/004153

Publication Date:

February 24, 2005

Filing Date:

April 22, 2003

Export Citation:

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Assignee:

SCHERING AG (DE)

International Classes:

A61K9/16; A61K9/36; A61K9/14; A61K9/62; A61K31/567; A61K31/568; B01D9/02; C07J1/00; C07J41/00; C07J75/00; (IPC1-7): A61K9/16; C07J75/00

Foreign References:

US4412838A	1983-11-01
GB838654A	1960-06-22
US4997637A	1991-03-05

Other References: