Title:
METHOD FOR PRODUCING DIPEPTIDE DERIVATIVE CONTAINING DISUBSTITUTED AMINO ACID RESIDUE
Document Type and Number:
WIPO Patent Application WO/2015/033781
Kind Code:
A1
Abstract:
A method for producing a dipeptide that has a protected N-terminal and is represented by formula (1) or a salt of the dipeptide, said method comprising condensing an α-monosubstituted amino acid that has a protected N-terminal and is represented by formula (2) or glycine or a salt thereof with a disubstituted amino acid that is represented by formula (3) or a salt thereof in the presence of a condensing agent [in each of the formulae, substituents are as defined in the description or the like].
Inventors:
MATSUYAMA KEISUKE (JP)
KODAMA KAZUYA (JP)
KODAMA KAZUYA (JP)
Application Number:
PCT/JP2014/071804
Publication Date:
March 12, 2015
Filing Date:
August 20, 2014
Export Citation:
Assignee:
NAGASE & CO LTD (JP)
International Classes:
C07K1/10; C07B51/00; C07C231/02; C07C233/91
Foreign References:
| JPH01163197A | 1989-06-27 | |||
| JPS5931744A | 1984-02-20 |
Other References:
VERARDO, G. ET AL.: "a-N-Protected dipeptide acids: a simple and efficient synthesis via the easily accessible mixed anhydride method using free amino acids in DMSO and tetrabutylammonium hydroxide", JOURNAL OF PEPTIDE SCIENCE, vol. 19, no. 5, March 2013 (2013-03-01), pages 315 - 324, XP055322949
NEBEL, K. ET AL.: "Stereoselective synthesis of isovaline (IVA) and IVA-containing dipeptides for use in peptide synthesis", TETRAHEDRON, vol. 44, no. 15, 1988, pages 4793 - 6, XP055322950
TANTRY, S J. ET AL.: "Synthesis of Na-protected peptide acids by N?C chain extension employing O,N-bis-trimethylsilyl-amino acids using the mixed anhydride method", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 43 B, no. 6, 2004, pages 1282 - 1287, XP055322952
PAIRA, TAPAS K. ET AL.: "Peptide-Polymer Bioconjugates via Atom Transfer Radical Polymerization and Their Solution Aggregation into Hybrid Micro/Nanospheres for Dye Uptake", MACROMOLECULES, vol. 43, no. 9, 2010, pages 4050 - 4061, XP055322953
See also references of EP 3042911A4
NEBEL, K. ET AL.: "Stereoselective synthesis of isovaline (IVA) and IVA-containing dipeptides for use in peptide synthesis", TETRAHEDRON, vol. 44, no. 15, 1988, pages 4793 - 6, XP055322950
TANTRY, S J. ET AL.: "Synthesis of Na-protected peptide acids by N?C chain extension employing O,N-bis-trimethylsilyl-amino acids using the mixed anhydride method", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 43 B, no. 6, 2004, pages 1282 - 1287, XP055322952
PAIRA, TAPAS K. ET AL.: "Peptide-Polymer Bioconjugates via Atom Transfer Radical Polymerization and Their Solution Aggregation into Hybrid Micro/Nanospheres for Dye Uptake", MACROMOLECULES, vol. 43, no. 9, 2010, pages 4050 - 4061, XP055322953
See also references of EP 3042911A4
Attorney, Agent or Firm:
PATENTBOX IP LAW FIRM (JP)
Patent business corporation patent box (JP)
Patent business corporation patent box (JP)
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